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  1. Last 7 days
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    CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism
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    1. scibot 23 Aug 2024
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    sciencedirect.com/science/article/pii/S2211124724010131
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    Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration
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      DOI: 10.1016/j.neuron.2024.07.020

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    sciencedirect.com/science/article/pii/S0896627324005427
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    Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread
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    sciencedirect.com/science/article/pii/S2211124724008131
  5. Aug 2024
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    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S266637912400377X
  7. pubs.acs.org pubs.acs.org
    Herpotrichone A Exerts Neuroprotective Effects by Relieving Ferroptosis
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    pubs.acs.org/doi/full/10.1021/acs.jafc.4c02418
  8. May 2024
  9. www.sciencedirect.com www.sciencedirect.com
    Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers
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    sciencedirect.com/science/article/pii/S1097276524003241
  10. Mar 2024
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    ATF4-SLC7A11-GSH axis mediates the acquisition of immunosuppressive properties by activated CD4+ T cells in low arginine condition
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  12. Jan 2024
  13. www.science.org www.science.org
    Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2
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    science.org/doi/10.1126/scisignal.adi9018
  14. Dec 2023
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TXNDC12 inhibits lipid peroxidation and ferroptosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10690572/
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    SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation
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    sciencedirect.com/science/article/pii/S1097276523009139
  17. Oct 2023
  18. www.cell.com www.cell.com
    AMER1 deficiency promotes the distant metastasis of colorectal cancer by inhibiting SLC7A11- and FTL-mediated ferroptosis
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    1. scibot 06 Oct 2023
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    cell.com/cell-reports/abstract/S2211-1247(23)01121-X
  19. Aug 2023
  20. 52.53.155.43 52.53.155.43
    HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1
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    1. scibot 12 Aug 2023
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  21. Jul 2023
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    The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2
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    sciencedirect.com/science/article/pii/S2211124723007350
  23. Jun 2023
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    Modulation of cellular metabolism by protein crotonylation regulates pancreatic cancer progression
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    sciencedirect.com/science/article/pii/S2211124723006770
  25. May 2023
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    IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance
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  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reprogramming of Iron Metabolism Confers Ferroptosis Resistance in ECM-Detached Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10209538/
  28. Oct 2022
  29. elifesciences.org elifesciences.org
    GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
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    1. scibot 19 Oct 2022
      RRID:AB_2687474

      DOI: 10.7554/eLife.81083

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    elifesciences.org/articles/81083
  30. Apr 2022
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stem cell factor SOX2 confers ferroptosis resistance in lung cancer via upregulation of SLC7A11
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      DOI: 10.1158/0008-5472.CAN-21-0567

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    ncbi.nlm.nih.gov/pmc/articles/PMC8530936/
  32. Mar 2022
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    Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling
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    sciencedirect.com/science/article/pii/S1097276522001125
  34. Jan 2022
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    Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness
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    sciencedirect.com/science/article/pii/S1550413121006203
  36. Dec 2021
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    Redox-sensitive cyclophilin A elicits chemoresistance through realigning cellular oxidative status in colorectal cancer
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    sciencedirect.com/science/article/pii/S2211124721015552
  38. Jun 2021
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition
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    ncbi.nlm.nih.gov/pmc/articles/PMC8193145/
  40. May 2021
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    Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential
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    sciencedirect.com/science/article/pii/S107476132100176X
  42. Apr 2021
  43. link.springer.com link.springer.com
    Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation
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      DOI: 10.1007/s00018-021-03818-6

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    link.springer.com/article/10.1007/s00018-021-03818-6
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    Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas
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      DOI: 10.1016/j.ccell.2020.07.008

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    sciencedirect.com/science/article/pii/S153561082030369X
  45. www.cell.com www.cell.com
    Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS
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    1. scibot 14 Apr 2021
      RRID:AB_2687474

      DOI: 10.1016/j.molcel.2021.02.033

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    cell.com/molecular-cell/fulltext/S1097-2765(21)00143-X
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
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    1. scibot 06 Apr 2021
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      DOI: 10.7554/eLife.63326

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    ncbi.nlm.nih.gov/pmc/articles/PMC7997658/
  47. Dec 2020
  48. www.sciencedirect.com www.sciencedirect.com
    HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications
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    1. scibot 13 Dec 2020
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      DOI: 10.1016/j.celrep.2020.108487

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    sciencedirect.com/science/article/pii/S2211124720314765
  49. Jan 2020
  50. www.sciencedirect.com www.sciencedirect.com
    Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.cmet.2019.09.009

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    sciencedirect.com/science/article/pii/S1550413119305121
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    Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer
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      DOI: 10.1016/j.celrep.2019.08.076

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    sciencedirect.com/science/article/pii/S2211124719311313
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    Untitled document
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.ccell.2018.12.009

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    sciencedirect.com/science/article/pii/S1535610818305816
  53. Nov 2018
  54. www.sciencedirect.com www.sciencedirect.com
    AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity
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    sciencedirect.com/science/article/pii/S0960982218307644
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    Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase
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    sciencedirect.com/science/article/pii/S153561081730555X
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    NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression
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    sciencedirect.com/science/article/pii/S1097276517306573
  57. Nov 2017
  58. www.sciencedirect.com www.sciencedirect.com
    mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
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    1. scibot 08 Nov 2017
      Rabbit Monoclonal anti-xCT/SLC7A11, Clone D2M7ACell SignalingCat#12691

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1097276517303945