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Sep 2026
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Discovery and preclinical validation of a translationally optimized mitochondrial complex I modulator for Alzheimer’s disease

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pmc.ncbi.nlm.nih.gov/articles/PMC13538682/
Aug 2026
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Adiponectin promotes AMPA receptor trafficking and enhances excitatory synaptic transmission at hippocampal synapses via AMP-activated protein kinase signalling

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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70600
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A stress-adaptive lipid kinase axis defines metabolic vulnerabilities in neuroendocrine prostate cancer

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sciencedirect.com/science/article/pii/S1535610826003120
Jul 2026
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The Legionella pneumophila effector SidL is an adenylyltransferase that modifies the glycolytic intermediate 3-phosphoglycerate

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Apr 2026
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The cytotoxic effect of prexasertib is a consequence of dual inhibition on both CHK1 and AMPK

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sciencedirect.com/science/article/pii/S2451945626001121
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Discovery and Preclinical Validation of a Clinically Optimized Mitochondrial Complex I Modulator for Alzheimer’s Disease

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biorxiv.org/content/10.64898/2026.04.10.717554v1
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Genetically encoded manipulation of ATP/ADP ratio in human cells uncovers proteomic and physiological signatures of energy stress

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pmc.ncbi.nlm.nih.gov/articles/PMC13159532/
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Nutrient Availability Dictates Cancer Metabolism–Based Therapeutic Responses to Nononcology Drugs

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pmc.ncbi.nlm.nih.gov/articles/PMC13055633/
Mar 2026
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Targeting systemic and tumor metabolic balances with ketogenic diets enhance efficacy of therapy in FLT3-ITD acute myeloid leukemia

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sciencedirect.com/science/article/pii/S2211124726002639
Feb 2026
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Neuronal PPP2R5C in plasma is a potential biomarker for early diagnosis of Alzheimer’s disease

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sciencedirect.com/science/article/pii/S2666379126000480
Jan 2026
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DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function

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  DOI: 10.1016/j.cmet.2025.12.009
  
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sciencedirect.com/science/article/pii/S1550413125005406
Nov 2025
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Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan

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pmc.ncbi.nlm.nih.gov/articles/PMC12626231/
Sep 2025
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The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity

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1. scibot 24 Sep 2025
  
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  DOI: 10.1016/j.molcel.2025.08.035
  
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sciencedirect.com/science/article/pii/S1097276525007415
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Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer's disease

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  DOI: 10.1016/j.ebiom.2025.105924
  
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sciencedirect.com/science/article/pii/S2352396425003688
Aug 2025
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High matrix stiffness triggers testosterone decline in aging males by disrupting stem Leydig cell pool homeostasis

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1. scibot 30 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116207
  
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sciencedirect.com/science/article/pii/S2211124725009787
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Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism

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  DOI: 10.1016/j.cell.2025.07.041
  
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sciencedirect.com/science/article/pii/S0092867425008633
May 2025
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KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation

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  DOI: 10.1016/j.celrep.2025.115444
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12091147/
Mar 2025
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The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity

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1. scibot 23 Mar 2025
  
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  DOI: 10.1101/2025.02.17.638704
  
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biorxiv.org/content/10.1101/2025.02.17.638704v1
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Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling

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sciencedirect.com/science/article/pii/S1550413125000658
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Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer’s disease

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  DOI: 10.1101/2025.02.12.637918
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11870434/
Feb 2025
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USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation

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  DOI: 10.1038/s41467-025-56564-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11791202/
Jan 2025
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Mitochondrial uncouplers inhibit oncogenic E2F1 activity and prostate cancer growth

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Nov 2024
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Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond

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  DOI: 10.3389/fphar.2024.1496639
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11537861/
Sep 2024
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Crosstalk between butyrate oxidation in colonocyte and butyrate-producing bacteria

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sciencedirect.com/science/article/pii/S2589004224020789
Aug 2024
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Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy

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  DOI: 10.1016/j.celrep.2024.114573
  
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cell.com/cell-reports/abstract/S2211-1247(24)00902-1
May 2024
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Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle

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  DOI: 10.1113/JP285719
  
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ajpcell.00718.2023.pdf

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  DOI: 10.1152/ajpcell.00718.2023
  
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journals.physiology.org/doi/pdfdirect/10.1152/ajpcell.00718.2023
Apr 2024
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Endothelial progenitor cells control remodeling of uterine spiral arteries for the establishment of utero-placental circulation

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25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages

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  DOI: 10.1016/j.immuni.2024.03.021
  
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sciencedirect.com/science/article/pii/S1074761324001420
Mar 2024
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Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment

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PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle

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  DOI: 10.1016/j.celrep.2024.113868
  
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sciencedirect.com/science/article/pii/S2211124724001967
Jan 2024
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BAY-3827 and SBI-0206965: Potent AMPK Inhibitors That Paradoxically Increase Thr172 Phosphorylation

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1. scibot 07 Jan 2024
  
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  DOI: 10.3390/ijms25010453
  
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mdpi.com/1422-0067/25/1/453
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Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers

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1. scibot 05 Jan 2024
  
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  DOI: 10.1042/BCJ20230380
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10754287/
Nov 2023
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A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113453
  
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sciencedirect.com/science/article/pii/S2211124723014651
Sep 2023
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Molecular, metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control

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ATROPHIC REMODELING OF THE HEART DURING VITAMIN D DEFICIENCY AND INSUFFICIENCY IN A RAT MODEL

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Senomorphic effect of diphenyleneiodonium through AMPK/MFF/DRP1 mediated mitochondrial fission

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Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins

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AMPK is required for recovery from metabolic stress induced by ultrasound microbubble treatment

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Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex

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The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations

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Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer

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Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy

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Itaconate is a lysosomal inducer that promotes antibacterial innate immunity

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Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

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BPS Publications

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Lactate rewires lipid metabolism and sustains a metabolic-epigenetic axis in prostate cancer

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Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells

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TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment

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Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors

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Untitled document

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Untitled document

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Arctigenin improves lipid metabolism by regulating AMP‐activated protein kinase and downstream signaling pathways

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Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets

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A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression

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Transient phases of OXPHOS inhibitor resistance reveal underlying metabolic heterogeneity in single cells

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The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability

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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

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SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways

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S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation

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Metabolic conditioning of CD8 + effector T cells for adoptive cell therapy

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Pulmonary inflammation-induced alterations in key regulators of mitophagy and mitochondrial biogenesis in murine skeletal muscle

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A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation

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AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

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Mechanism of Activation of AMPK by Cordycepin

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BPS Publications

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Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer

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Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

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PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia

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BPS Publications

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Immunometabolic Cross-Talk and Regulation of Endocrine and Metabolic Functions: Transgenic overexpression of CTRP3 prevents alcohol-induced hepatic triglyceride accumulation

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α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development

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γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A

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Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

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Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models

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Combined treatment with GSNO and CAPE accelerates functional recovery via additive antioxidant activities in a mouse model of TBI

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The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer

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Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy

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The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency

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Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib

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