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  1. Last 7 days
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    TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome
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  3. Aug 2024
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    Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies
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    The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma
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  6. Jul 2024
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    Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance
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    Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis
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    cell.com/cell-reports/fulltext/S2211-1247(24)00760-5
  9. Jun 2024
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    Protocol for the comprehensive biochemical and cellular profiling of small-molecule degraders using CoraFluor TR-FRET technology
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  11. May 2024
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    Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma
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  13. Apr 2024
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    HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
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    STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma
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  16. Feb 2024
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    A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis
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    Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting
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    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
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    The cyclimids: Degron-inspired cereblon binders for targeted protein degradation
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  21. Nov 2023
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    Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells
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  23. Oct 2023
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    PIIS0092867423009650-html.html
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  25. Jul 2023
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    Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation
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  27. Apr 2023
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    Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis
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      DOI: 10.1126/sciadv.ade3422

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  29. Feb 2023
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    Loss of VOPP1 Contributes to BET Inhibitor Acquired Resistance in Non–Small Cell Lung Cancer Cells
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      DOI: 10.1158/1541-7786.MCR-21-1000

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    aacrjournals.org/mcr/article/20/12/1785/710999/Loss-of-VOPP1-Contributes-to-BET-Inhibitor
  31. Nov 2022
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cloning BRD4 long isoform into overexpression vectors for stable overexpression of BRD4-L in mammalian cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9617197/
  33. Sep 2022
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    BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer
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  35. Jun 2022
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    A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader
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  37. Mar 2022
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases
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  39. Feb 2022
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    The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation
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  41. Sep 2021
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    A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes
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    SPT5 stabilization of promoter-proximal RNA polymerase II
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  44. Aug 2021
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.7554/eLife.39023

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    ncbi.nlm.nih.gov/pmc/articles/PMC6279352/
  46. www.nature.com www.nature.com
    Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
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      DOI: 10.1038/s41467-021-24687-4

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  47. Mar 2021
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    TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains
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    sciencedirect.com/science/article/pii/S1097276521000435
  49. Jan 2020
  50. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Expression and clinical value of PD‐L1 which is regulated by BRD4 in tongue squamous cell carcinoma
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      DOI: 10.1002/jcb.29420

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  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6336405/
  52. Nov 2018
  53. www.sciencedirect.com www.sciencedirect.com
    Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy
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    sciencedirect.com/science/article/pii/S009286741831239X
  54. www.cell.com www.cell.com
    Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors
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    cell.com/cell/fulltext/S0092-8674(18)31119-X
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    BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency
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    sciencedirect.com/science/article/pii/S1535610818300199
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC5926201/
  57. Nov 2017
  58. www.sciencedirect.com www.sciencedirect.com
    Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
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    1. scibot 08 Nov 2017
      Rabbit monoclonal anti-BRD4 (clone E2A7X) (human specific) (long isoform)Cell Signaling TechnologyCat#: 13440S

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