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BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes

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  DOI: 10.1016/j.molcel.2026.01.012
  
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sciencedirect.com/science/article/pii/S1097276526000328
Feb 2026
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HOXC6 overexpression stimulates cell migration and correlates with poor prognosis in head and neck squamous cell carcinoma

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  DOI: 10.1007/s00018-025-06039-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12858702/
Jan 2026
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Cocaine-induced changes in the BRD4 interactome identifies casein kinase 1 epsilon as a therapeutic target

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1. scibot 23 Jan 2026
  
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  DOI: 10.1111/jnc.70336
  
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BRD2 bridges TFIID and MOF-H4K16ac-containing nucleosomes to promote transcriptional initiation

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1. scibot 06 Jan 2026
  
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  DOI: 10.1016/j.molcel.2025.12.010
  
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Nov 2025
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A triple-action PROTAC for wild-type p53 cancer therapy

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.xcrm.2025.102467
  
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sciencedirect.com:5037/science/article/pii/S2666379125005403
Oct 2025
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arroyo-gomez-et-al-2025-functional-landscape-of-ubiquitin-linkages-couples-k29-linked-ubiquitylation-to-epigenome-html.html

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  DOI: 10.1038/s44318-025-00599-7
  
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54.241.53.176/9315414eccf1e15b040c95d437c7e801ecba4152/arroyo-gomez-et-al-2025-functional-landscape-of-ubiquitin-linkages-couples-k29-linked-ubiquitylation-to-epigenome-html.html
Jul 2025
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Chromosomal tethering and mitotic transcription promote ecDNA nuclear inheritance

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Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells

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  DOI: 10.1158/2767-9764.CRC-25-0058
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12202856/
Jun 2025
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Bromodomain and Extra-Terminal Family Proteins BRD2, BRD3, and BRD4 Contribute to H19-Dependent Transcriptional Regulation of Cell Adhesion Molecules, Modulating Metastatic Dissemination Program in Prostate Cancer

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PDF-html.html

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52.53.155.43/6f95ee3860ed32eb2fc3447b03e264cd8239544f/PDF-html.html
Mar 2025
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BET inhibitor in combination with BCG vaccine enhances antitumor efficacy and orchestrates T cell reprogramming for melanoma

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  DOI: 10.1016/j.xcrm.2025.101995
  
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Dec 2024
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TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.007
  
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sciencedirect.com/science/article/pii/S1097276524009122
Aug 2024
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Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies

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1. scibot 20 Aug 2024
  
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  DOI: 10.1016/j.chembiol.2024.07.005
  
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The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma

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1. scibot 18 Aug 2024
  
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  DOI: 10.1186/s12885-024-12691-y
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11292958/
Jul 2024
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Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance

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1. scibot 18 Jul 2024
  
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  DOI: 10.1016/j.cell.2024.06.012
  
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Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis

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1. scibot 12 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114431
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00760-5
Jun 2024
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Protocol for the comprehensive biochemical and cellular profiling of small-molecule degraders using CoraFluor TR-FRET technology

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1. scibot 27 Jun 2024
  
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  DOI: 10.1016/j.xpro.2024.103129
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11193044/
May 2024
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Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma

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1. scibot 09 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114211
  
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sciencedirect.com/science/article/pii/S2211124724005394
Apr 2024
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HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression

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1. scibot 24 Apr 2024
  
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  DOI: 10.1093/narcan/zcae018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11034028/
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STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma

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  DOI: 10.1016/j.xcrm.2024.101472
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10983107/
Feb 2024
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A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis

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Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting

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HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

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  DOI: 10.1101/2023.12.05.570182
  
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  DOI: 10.1101/2023.12.05.570182
  
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The cyclimids: Degron-inspired cereblon binders for targeted protein degradation

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Nov 2023
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Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells

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1. scibot 28 Nov 2023
  
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Oct 2023
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PIIS0092867423009650-html.html

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  DOI: 10.1016/j.cell.2023.08.032
  
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Jul 2023
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Distinct layers of BRD4-PTEFb reveal bromodomain-independent function in transcriptional regulation

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Apr 2023
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Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis

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  DOI: 10.1126/sciadv.ade3422
  
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  DOI: 10.1126/sciadv.ade3422
  
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Feb 2023
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Loss of VOPP1 Contributes to BET Inhibitor Acquired Resistance in Non–Small Cell Lung Cancer Cells

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  DOI: 10.1158/1541-7786.MCR-21-1000
  
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aacrjournals.org/mcr/article/20/12/1785/710999/Loss-of-VOPP1-Contributes-to-BET-Inhibitor
Nov 2022
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Cloning BRD4 long isoform into overexpression vectors for stable overexpression of BRD4-L in mammalian cells

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  DOI: 10.1016/j.xpro.2022.101785
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9617197/
Sep 2022
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BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer

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  DOI: 10.1016/j.celrep.2022.111304
  
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Jun 2022
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A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader

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  DOI: 10.1016/j.chembiol.2022.05.003
  
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sciencedirect.com/science/article/pii/S2451945622001659
Mar 2022
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Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases

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  DOI: 10.1016/j.isci.2022.103985
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8919295/
Feb 2022
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The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation

1
1. scibot 23 Feb 2022
  
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  RRID:AB_2687578
  
  DOI: 10.1016/j.molcel.2022.01.024
  
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sciencedirect.com/science/article/pii/S1097276522001009
Sep 2021
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A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes

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1. scibot 09 Sep 2021
  
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  RRID:AB_2687578
  
  DOI: 10.1016/j.chembiol.2021.08.007
  
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sciencedirect.com/science/article/pii/S2451945621003962
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SPT5 stabilization of promoter-proximal RNA polymerase II

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1. scibot 04 Sep 2021
  
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  RRID:AB_2687578
  
  DOI: 10.1016/j.molcel.2021.08.006
  
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Aug 2021
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Untitled document

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1. scibot 09 Aug 2021
  
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  RRID:AB_2687578
  
  DOI: 10.7554/eLife.39023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6279352/
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Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer

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1. scibot 05 Aug 2021
  
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  RRID:AB_2687578
  
  DOI: 10.1038/s41467-021-24687-4
  
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nature.com/articles/s41467-021-24687-4
Mar 2021
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TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains

1
1. scibot 29 Mar 2021
  
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  RRID:AB_2687578
  
  DOI: 10.1016/j.molcel.2021.01.023
  
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Jan 2020
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Expression and clinical value of PD‐L1 which is regulated by BRD4 in tongue squamous cell carcinoma

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1. scibot 13 Jan 2020
  
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  RRID:AB_2687578
  
  DOI: 10.1002/jcb.29420
  
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onlinelibrary.wiley.com/doi/10.1002/jcb.29420
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_2687578
  
  DOI: 10.7554/eLife.41913
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6336405/
Nov 2018
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Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2687578
  
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Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2687578
  
  Curator: @Jmenke
  
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cell.com/cell/fulltext/S0092-8674(18)31119-X
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BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency

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1. scibot 05 Nov 2018
  
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  RRID:AB_2687578
  
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Systematic Functional Annotation of Somatic Mutations in Cancer

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2687578
  
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pmc.ncbi.nlm.nih.gov/articles/PMC5926201/
Nov 2017
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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

1
1. scibot 08 Nov 2017
  
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  Rabbit monoclonal anti-BRD4 (clone E2A7X) (human specific) (long isoform)Cell Signaling TechnologyCat#: 13440S
  
  Curator: @Jmenke
  
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