189 Matching Annotations
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    TM6SF2 acts at ER membrane contact sites to enable RAB7-dependent endolysosomal VLDL secretion and maintain Golgi structure
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    sciencedirect.com/science/article/pii/S2211124726011952
  3. Oct 2026
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    Dopamine-induced mitochondrial dysfunction activates cGAS-sTING to drive IL-6 secretion in macrophages
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    sciencedirect.com/science/article/pii/S2211124726011976
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    Targeting ZDHHC15-mediated S-acylation of CD155 reactivates anti-tumor immunity
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    sciencedirect.com/science/article/pii/S245194562600334X
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    Nitrate-responsive Sialin2 couples stress granule assembly and clearance to maintain neuronal homeostasis
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    sciencedirect.com/science/article/pii/S1534580726003497
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    Cell-intrinsic functions of PD-L1 activate autophagy and prevent cytokine-induced apoptosis
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    science.org/doi/10.1126/sciadv.aec7037
  8. Sep 2026
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATP13A4 gates extracellular polyamine levels to control excitatory synaptogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13534584/
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    TBK1 phosphorylates HDAC3 to promote NDP52 deacetylation and accelerate intracellular bacterial clearance
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    sciencedirect.com/science/article/pii/S2211124726010053
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    Fast tumor accumulation and payload release of c-Met targeting aptamer-drug conjugate enables robust anti-tumor efficacy
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  12. Aug 2026
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    BLTP2 bridges the ER and MVB for exosome biogenesis at SCAMP3-dependent ER contacts
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    BUB1 regulates cell proliferation and apoptosis in cervical cancer by AKT signaling and autophagosome-lysosome fusion via ACTN1
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    sciencedirect.com/science/article/pii/S2589004226024181
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    A stress-adaptive lipid kinase axis defines metabolic vulnerabilities in neuroendocrine prostate cancer
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    A Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer
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  17. Jul 2026
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    A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions
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    Trans-synaptic signaling through GRID1/glutamate receptor delta-1 and CBLN1/cerebellin-1 facilitates autophagic flux in central amygdala and prevents chronic pain
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  20. Jun 2026
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    Lipid transfer protein ORP3 mediates lysosomal repair via LC3B and ubiquitin-TAK1-p38 signaling
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    biorxiv.org/content/10.64898/2026.06.09.731146v1
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    Annexin A6 controls multi-organelle contact site formation and endolysosomal positioning, and remodels the STARD3 interactome
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    A multi-subunit autophagic capture complex facilitates degradation of ER-stalled MHC class I in pancreatic cancer
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    Ferroptosis inhibition enhances liver and lung graft function
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    Subcellular Redistribution of Endomembrane GPR15 Promotes NAD+-Mediated Metabolic Reprogramming and Boosts 5-FU Chemosensitivity in Colorectal Cancer
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    It’s Not Rewarding for Mitochondria: Dopamine-Induced Mitochondrial Dysfunction Activates cGAS-STING to Drive IL-6 Secretion in Macrophages
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  29. Apr 2026
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    Phosphoproteomics identifies Rho-Kinase-associated phospho-signaling and autophagy-associated alterations in the medial prefrontal cortex of a schizophrenia-related mouse model
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    Ubiquilin1 restricts influenza viral replication through trapping vRNP in the late endosomes
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    FAM134B Controls Collagen I Dynamics in Hepatic Stellate Cell-Driven Fibrosis
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    Graded activation of the CLEAR network through mTORC1 suppression on cargo-harboring lysosomes
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  34. Mar 2026
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    Targeting the ferritinophagy-lysosome axis as a therapeutic vulnerability in gastroenteropancreatic neuroendocrine tumors
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    Control of lysosome function by the GTPase-activating protein TBC1D9B and its binding partner TMEM55B
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    Mouse germline cysts contain a fusome-like structure that mediates oocyte development
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  38. Feb 2026
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    The lipid-metabolic enzyme HSD17B12 drives lysosomal degradation of PD-L1 potentiating anti-tumor immunity in a mouse model
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  41. Jan 2026
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    FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion
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    Lysosome-localized IRTKS condensates promote mTORC1 activity leading to MASLD and HCC
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    Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder
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    Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer
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  46. Dec 2025
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    Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons
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    PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment
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    TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence
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  52. Nov 2025
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    Claudin-4 as a dual regulator of genome stability and immune evasion in high grade serous ovarian cancer
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  55. Oct 2025
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL
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  57. Sep 2025
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    Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    PKD3 localizes to late endosomes to maintain Rab7-dependent endolysosomal homeostasis
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    Impaired MAPT/tau-secretory lysosomes are linked to cognitive vulnerability in Alzheimer patients
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  63. Aug 2025
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    A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
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    RNF13 Regulates the Endolysosomal Pathway Through Interaction with the Small GTPase Arl8B
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  66. Jul 2025
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    Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling
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    Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens
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    RNF13 is a novel interactor of iduronate 2-sulfatase that modifies its glycosylation and maturation
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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  72. Jun 2025
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    Cytokine-induced reprogramming of human macrophages toward Alzheimer’s disease-relevant molecular and cellular phenotypes in vitro
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    DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation
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    The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy
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  80. May 2025
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    Large-scale manufacturing of human gallbladder epithelial cell products and derived hepatocytes via a chemically defined approach
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  82. Apr 2025
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    RabGAP1L modulates Rab7A and Rab10 to orchestrate cell-autonomous immunity
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    The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage
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    Astrocytic polyamine transport by ATP13A4 tunes excitatory synaptic transmission
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    RAF1 kinase contributes to autophagic lysosome reformation
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    LAMP2A-mediated neuronal hyperexcitability by enhancing NKAβ1 degradation underlies depression-induced allodynia
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  90. Mar 2025
  91. www.biorxiv.org www.biorxiv.org
    Neuropilin 2 stabilises adherens junctions and protects against endothelial activation by promoting the interaction between VE cadherin and p120 catenin
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    PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD
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  93. Feb 2025
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    BACE1-dependent cleavage of GABAA receptor contributes to neural hyperexcitability and disease progression in Alzheimer’s disease
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  95. Jan 2025
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    Virus adaptation to heparan sulfate comes with capsid stability tradeoff
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  97. Dec 2024
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    Physiological shedding and C-terminal proteolytic processing of TMEM106B
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    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity
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  101. Nov 2024
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    Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis
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  103. Oct 2024
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    Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11449124/
  105. Sep 2024
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    A TBK1-independent primordial function of STING in lysosomal biogenesis
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    TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival
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  108. Aug 2024
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    Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo
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