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Aug 2026
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Subtype-specific secretion of extracellular vesicles by LRRK2 and Rab GTPases under lysosomal stress

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Progranulin deficiency-induced lysosomal dysfunction drives maladaptive myeloid cell states through the MITF/TFE transcription factors

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Jul 2026
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huang-et-al-2025-cdk5rap3-mediated-regulation-of-lysosomal-and-er-membrane-proteins-is-pivotal-for-the-survival-and-html.html

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Mar 2026
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An atom-edged magnetic nanomotor for cancer mechanotherapy

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Jan 2026
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Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder

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Aug 2025
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TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation

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Ridaifen derivatives function as potent lysosomotropic agents, depending on their basic side chains.

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Mitochondrial damage triggers the concerted degradation of negative regulators of neuronal autophagy

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Jul 2025
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BPS Publications

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Lactoferrin attenuates renal fibrosis and uremic sarcopenia in a mouse model of adenine-induced chronic kidney disease

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Jun 2025
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DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation

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Feb 2025
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The Effects of Cathepsin B Inhibition in the Face of Diffuse Traumatic Brain Injury and Secondary Intracranial Pressure Elevation

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Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST

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Jan 2025
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Lysosomal activity in response to the incubation of pristine and functionalized carbon nanodots

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PDF-html.html

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Dec 2024
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PDF-html.html

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Nov 2024
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Inhibition of cathepsin L ameliorates inflammation through the A20/NF-κB pathway in endotoxin-induced acute lung injury

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Hub genes and key pathways of traumatic brain injury:... : Neural Regeneration Research

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enhanced_autophagic_clearance_of_amyloid___via.25-html.html

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52.53.155.43/f837a450e4d673727102c6a319547882bc299234/enhanced_autophagic_clearance_of_amyloid___via.25-html.html
Aug 2024
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Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread

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Jul 2024
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The Effects of Cathepsin B Inhibition in the Face of Diffuse Traumatic Brain Injury and Secondary Intracranial Pressure Elevation

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Aging Differentially Affects Axonal Autophagosome Formation and Maturation

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May 2024
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scRank infers drug-responsive cell types from untreated scRNA-seq data using a target-perturbed gene regulatory network

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Mar 2024
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P-tau217 correlates with neurodegeneration in Alzheimer’s disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy

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Feb 2024
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Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion

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Lysosomal stress drives the release of pathogenic α-synuclein from macrophage lineage cells via the LRRK2-Rab10 pathway

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Jan 2024
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ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis

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Oct 2023
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Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

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Sep 2023
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Effects of HMGB1/RAGE/cathespin B inhibitors on alleviating hippocampal injury by regulating microglial pyroptosis and caspase activation in neonatal hypoxic–ischemic brain damage

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  DOI: 10.1111/jnc.15965
  
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CCDC50 promotes tumor growth through regulation of lysosome homeostasis

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Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection

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Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion

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Apr 2023
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An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation

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  DOI: 10.1126/sciadv.adf8966
  
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ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis

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Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis

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Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein

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Enhanced delivery of antibodies across the blood-brain barrier via TEMs with inherent receptor-mediated phagocytosis

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Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance

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Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

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Itaconate is a lysosomal inducer that promotes antibacterial innate immunity

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May 2022
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Cathepsin B Relocalization in Late Membrane Disrupted Neurons Following Diffuse Brain Injury in Rats - Martina L. Hernandez, Michael Marone, Karen M. Gorse, Audrey D. Lafrenaye, 2022

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Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells

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The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

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  DOI: 10.1021/acsinfecdis.0c00349
  
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Oncogene-regulated release of extracellular vesicles

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Mar 2021
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Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis

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Sep 2020
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Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma

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Jan 2020
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Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-trans Retinal

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Untitled document

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  DOI: 10.1016/j.devcel.2019.03.011
  
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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

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1. scibot 08 Nov 2017
  
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