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An SMN2 splicing-correcting antisense oligonucleotide promotes gene looping and transcription activation

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  DOI: 10.1016/j.molcel.2026.10.009
  
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sciencedirect.com/science/article/pii/S1097276526007148
Oct 2026
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ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation

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1. scibot 28 Oct 2026
  
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  DOI: 10.1016/j.cell.2025.01.027
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11928284/
Aug 2026
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Sphingosine kinase 2 regulates adipocyte browning and whole-body metabolism

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1. scibot 27 Aug 2026
  
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  DOI: 10.1126/sciadv.aec7066
  
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  DOI: 10.1126/sciadv.aec7066
  
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science.org/doi/10.1126/sciadv.aec7066
54.241.53.176 54.241.53.176

Comparative ASCL1 interactome analysis reveals CDK2-Cyclin A2 as suppressors of differentiation in MYCN-amplified neuroblastoma

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  DOI: 10.1101/2025.11.11.687869
  
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54.241.53.176/ac55aaa7dd054e10d1ec78375f1460fa75afc780/2025.11.11.687869.full-html.html
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MDM2 binds and suppresses RNA polymerase III to restrain the innate immune response to cytosolic DNA

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  DOI: 10.1038/s41418-026-01834-2
  
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nature.com/articles/s41418-026-01834-2
Jul 2026
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The Drosophila CEBPG homolog Irbp18 partners with crc (ATF4) to mediate the integrated stress response in degenerative disease models

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pmc.ncbi.nlm.nih.gov/articles/PMC13585082/
Feb 2026
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Functional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction

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sciencedirect.com/science/article/pii/S1097276526000973
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The Histone Methyltransferase KMT2D is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration Resistant Prostate Cancer

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1. scibot 14 Feb 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-2053
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12900249/
Nov 2025
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Off-pore nucleoporin sPOM121 transcriptionally propels β-Catenin driven tumor progression and immune escape in prostate cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12580793/
Sep 2025
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TELS1 stabilizes t-loops independently of TRF2 and controls telomere length in pluripotent cells

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sciencedirect.com/science/article/pii/S2211124725010319
Aug 2025
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USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment

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  DOI: 10.1158/2326-6066.CIR-24-1194
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12314529/
Jul 2025
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Inhibition of KAT6A Enhances Immunotherapy Efficacy in Colorectal Cancer by Activating Interferon Response

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1. scibot 23 Jul 2025
  
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  DOI: 10.1016/j.canlet.2025.217946
  
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sciencedirect.com/science/article/pii/S0304383525005154
May 2025
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The relationship between acid-sensing ion channel, ASIC2, and oncogenic β-catenin signaling in ovarian cancer

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1. scibot 29 May 2025
  
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  DOI: 10.1038/s41598-025-03429-2
  
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nature.com/articles/s41598-025-03429-2
Feb 2025
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Targeting GPC2 on intraocular and CNS metastatic retinoblastomas with local and systemic delivery of CAR T-cells

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  DOI: 10.1158/1078-0432.CCR-24-0221
  
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aacrjournals.org/clincancerres/article/30/16/3578/746772/Targeting-GPC2-on-Intraocular-and-CNS-Metastatic
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ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation

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1. scibot 13 Feb 2025
  
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  DOI: 10.1016/j.cell.2025.01.027
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11928284/
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KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition

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  DOI: 10.1016/j.celrep.2025.115272
  
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sciencedirect.com/science/article/pii/S2211124725000439
Dec 2024
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Mapping protein–DNA interactions with DiMeLo-seq

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1. scibot 29 Dec 2024
  
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  DOI: 10.1038/s41596-024-01032-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11674881/
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TBP bookmarks and preserves neural stem cell fate memory by orchestrating local chromatin architecture

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  DOI: 10.1016/j.molcel.2024.11.019
  
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sciencedirect.com/science/article/pii/S1097276524009444
Oct 2024
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Long noncoding RNA TUG1 regulates smooth muscle cell differentiation via KLF4-myocardin axis

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1. scibot 02 Oct 2024
  
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  DOI: 10.1152/ajpcell.00275.2023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10635660/
May 2024
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Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3/GSDMD-mediated pyroptosis in colorectal cancer

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  DOI: 10.1002/ctm2.1692
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11131357/
Feb 2024
52.53.155.43 52.53.155.43

Dual amylin and calcitonin receptor agonist treatment reduces biomarkers associated with kidney fibrosis in diabetic rats

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52.53.155.43/04456dd5a135449c94626e0786262a1d58d4410c/melander-et-al-2023-dual-amylin-and-calcitonin-receptor-agonist-treatment-reduces-biomarkers-associated-with-kidney-html.html
52.53.155.43 52.53.155.43

bvae029-html.html

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52.53.155.43/91f4741c570f637c33beb2463bb95c19a65c82ea/bvae029-html.html
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EP300 restores glycolytic activity and anti-tumor function of CD8+ cytotoxic T cells in nasopharyngeal carcinoma

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  DOI: 10.1016/j.isci.2024.108957
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10850748/
Jan 2024
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Cell-cycle-linked growth reprogramming encodes developmental time into leaf morphogenesis

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  DOI: 10.1016/j.cub.2023.12.050
  
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sciencedirect.com/science/article/pii/S0960982223017505
Oct 2023
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PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly

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sciencedirect.com/science/article/pii/S1097276523007554
Sep 2023
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Ethylene produced in carpel primordia controls CmHB40 expression to inhibit stamen development

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  DOI: 10.1038/s41477-023-01511-z
  
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nature.com/articles/s41477-023-01511-z
Aug 2023
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The Achromobacter type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes

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sciencedirect.com/science/article/pii/S2211124723010239
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A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent apoptosis

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  DOI: 10.1016/j.celrep.2023.112961
  
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52.53.155.43/e4339d2342058d0ba733e06b854674a1d2f752a1/PIIS2211124723009725-html.html
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Histone variants shape chromatin states in Arabidopsis

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  DOI: 10.7554/eLife.87714
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10393023/
Apr 2023
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A hyper-quiescent chromatin state formed during aging is reversed by regeneration

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  DOI: 10.1016/j.molcel.2023.04.005
  
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sciencedirect.com/science/article/pii/S1097276523002496
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SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology

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  DOI: 10.1016/j.molcel.2023.02.004
  
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sciencedirect.com/science/article/pii/S1097276523000837
Dec 2022
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Survivin promotes a glycolytic switch in CD4+ T cells by suppressing the transcription of PFKFB3 in rheumatoid arthritis

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  DOI: 10.1016/j.isci.2022.105526
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9678772/
Sep 2022
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Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses

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1. scibot 30 Sep 2022
  
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  DOI: 10.1016/j.ccell.2022.09.007
  
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Aberrant Epigenetic Alteration of PAX1 Expression Contributes to Parathyroid Tumorigenesis

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Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development

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Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy

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MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression

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miRNA/mRNA co-profiling identifies the miR-200 family as a central regulator of SMC quiescence

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Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells

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SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers

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The mitochondrial iron transporter ABCB7 is required for B cell development, proliferation, and class switch recombination in mice

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An epigenetic mechanism underlying chromosome 17p deletion-driven tumorigenesis

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H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity

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Long noncoding RNA lnc-POP1-1 upregulated by VN1R5 promotes cisplatin resistance in head and neck squamous cell carcinoma through interaction with MCM5

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Untitled document

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GCM2 Silencing in Parathyroid Adenoma is associated with Promoter Hypermethylation and Gain of Methylation on Histone 3

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A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing

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Disruption of SND1–MTDH Interaction by a High Affinity Peptide Results in SND1 Degradation and Cytotoxicity to Breast Cancer Cells In Vitro and In Vivo

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Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells

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DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1

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Nuclei isolation of multiple brain cell types for omics interrogation

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TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions

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Zinc Finger Protein SALL4 Functions through an AT-Rich Motif to Regulate Gene Expression

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G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program

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Alveolar macrophage‐derived extracellular vesicles inhibit endosomal fusion of influenza virus

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Hepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication

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Cortical Neurogenesis Requires Bcl6-Mediated Transcriptional Repression of Multiple Self-Renewal-Promoting Extrinsic Pathways

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A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer

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Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor

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The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability

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The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation

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Tracing MYC Expression for Small Molecule Discovery

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METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation

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Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate

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Argonaute-miRNA Complexes Silence Target mRNAs in the Nucleus of Mammalian Stem Cells

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Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import

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T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation

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Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element

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The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins

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Epigenetic Therapy: Novel Translational Implications for Arrest of Environmental Dioxin-Induced Disease in Females

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A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis.

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Nov 2017
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The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity

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