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Dual blockade of PD-1 and NKG2A prevents NK cell senescence and reprograms the immunosuppressive microenvironment in pancreatic cancer

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1. scibot 24 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117583
  
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sciencedirect.com/science/article/pii/S2211124726006613
Jun 2026
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DGAT1 Inhibition Induces Ferroptosis and Enhances Cancer Immunotherapy Efficacy

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1. scibot 17 Jun 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-0840
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13266341/
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TIGIT-targeted IL-12 fusion protein engages NK and CD8+ T cells for potent tumor immunotherapy

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1. scibot 17 Jun 2026
  
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  DOI: 10.1016/j.xcrm.2026.102876
  
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Mar 2026
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Myofibroblast programming blocks differentiation of TLS-organizing fibroblastic reticular cells in pancreatic cancer

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1. scibot 27 Mar 2026
  
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  DOI: 10.1016/j.ccell.2026.03.004
  
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Microglia Display Heterogeneous Initial Responses to Disseminated Tumor Cells

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1. scibot 26 Mar 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3425
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13012254/
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Radiotherapy synergizes with an inducible AAV-based immunotherapy platform to program local and systemic antitumor immunity

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1. scibot 24 Mar 2026
  
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  DOI: 10.1016/j.ccell.2026.02.013
  
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sciencedirect.com/science/article/pii/S153561082600111X
Feb 2026
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Programmable iPSC-derived CAR-NK vesicles remodel the immune microenvironment and eradicate tumors

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1. scibot 06 Feb 2026
  
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  DOI: 10.1016/j.xcrm.2025.102545
  
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An intranasal adenoviral-vectored vaccine protects against highly pathogenic avian influenza H5N1 in naive and antigen-experienced animals

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1. scibot 03 Feb 2026
  
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  DOI: 10.1016/j.xcrm.2025.102582
  
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sciencedirect.com/science/article/pii/S266637912500655X
Dec 2025
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Positioning and reversible suppression of CCR7+ dendritic cells in perivascular tumor niches shape cancer immunity

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1. scibot 20 Dec 2025
  
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  DOI: 10.1016/j.immuni.2025.11.020
  
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An IL-12 partial agonist sustains intratumoral lymphocyte activation and detoxifies systemic IL-12 therapy

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1. scibot 20 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116757
  
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sciencedirect.com:5037/science/article/pii/S2211124725015293
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Sensitized mast cells for targeted drug delivery and augmented cancer immunotherapy

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1. scibot 10 Dec 2025
  
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  DOI: 10.1016/j.cell.2025.11.015
  
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sciencedirect.com:5037/science/article/pii/S009286742501311X
Oct 2025
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Local delivery of IL-15 and anti-PD-L1 nanobody by in vitro-transcribed circILNb elicits superior antitumor immunity in cold tumors

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1. scibot 11 Oct 2025
  
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  DOI: 10.1016/j.xcrm.2025.102413
  
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sciencedirect.com/science/article/pii/S2666379125004860
Aug 2025
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TRIM6 ablation reverses ICB resistance in MSS gastric cancer by unleashing cGAS-STING-dependent antitumor immunity

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1. scibot 19 Aug 2025
  
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  DOI: 10.1186/s13046-025-03513-5
  
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jeccr.biomedcentral.com/articles/10.1186/s13046-025-03513-5
Jul 2025
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BRD9 inhibition overcomes oncolytic virus therapy resistance in glioblastoma

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1. scibot 31 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102258
  
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Combined KRAS inhibition and immune therapy generates durable complete responses in an autochthonous PDAC model

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1. scibot 15 Jul 2025
  
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  DOI: 10.1158/2159-8290.CD-24-0489
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11858029/
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Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity

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1. scibot 01 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.006
  
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Apr 2025
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Epigenomic regulation of stemness contributes to the low immunogenicity of the most mutated human cancer

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1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115561
  
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sciencedirect.com/science/article/pii/S2211124725003328
Jan 2025
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Identification of indirect CD4+ T cell epitopes associated with transplant rejection provides a target for donor-specific tolerance induction

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1. scibot 31 Jan 2025
  
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  DOI: 10.1016/j.immuni.2025.01.008
  
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sciencedirect.com/science/article/pii/S1074761325000330
Dec 2024
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Commensal papillomavirus immunity preserves the homeostasis of highly mutated normal skin

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1. scibot 14 Dec 2024
  
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Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.ccell.2024.10.014
  
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Nov 2024
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Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint

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1. scibot 24 Nov 2024
  
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A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice

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1. scibot 24 Nov 2024
  
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  DOI: 10.1016/j.chom.2024.10.016
  
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Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity

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1. scibot 20 Nov 2024
  
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Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

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1. scibot 08 Nov 2024
  
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  DOI: 10.1158/2326-6066.CIR-24-0463
  
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Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma

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1. scibot 08 Nov 2024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532787/
Sep 2024
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Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps

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1. scibot 25 Sep 2024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11393545/
Jul 2024
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VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

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1. scibot 27 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110285
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11267025/
Jun 2024
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A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML

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  DOI: 10.1016/j.xcrm.2024.101592
  
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Apr 2024
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IGSF8 is an innate immune checkpoint and cancer immunotherapy target

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  DOI: 10.1016/j.cell.2024.03.039
  
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Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells

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sciencedirect.com/science/article/pii/S0092867424003039
Mar 2024
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Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity

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1. scibot 27 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.114003
  
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A tetravalent nanovaccine that inhibits growth of HPV-associated head and neck carcinoma via dendritic and T cell activation

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1. scibot 27 Mar 2024
  
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  DOI: 10.1016/j.isci.2024.109439
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10957412/
Feb 2024
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Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment

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1. scibot 16 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113797
  
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Jan 2024
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Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade

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1. scibot 11 Jan 2024
  
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  DOI: 10.1158/2159-8290.CD-22-1301
  
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aacrjournals.org/cancerdiscovery/article/13/12/2566/731588/Formate-Supplementation-Enhances-Antitumor-CD8-T
Dec 2023
52.53.155.43 52.53.155.43

cd-22-1301-html.html

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1. scibot 01 Dec 2023
  
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  DOI: 10.1158/2159-8290.cd-22-1301
  
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Nov 2023
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A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression

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CD115+ monocytes protect microbially experienced mice against E. coli-induced sepsis

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Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers

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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

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Sep 2023
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Adenosine A2A receptor is a tumor suppressor of NASH-associated hepatocellular carcinoma

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Jul 2023
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Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks

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Jun 2023
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Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses

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Apr 2023
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Synergistic effects of combined immunotherapy strategies in a model of multifocal hepatocellular carcinoma

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Jan 2023
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SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy

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  DOI: 10.1158/0008-5472.CAN-21-3523
  
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Dec 2022
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Anti-4-1BB immunotherapy enhances systemic immune effects of radiotherapy to induce B and T cell-dependent anti-tumor immune activation and improve tumor control at unirradiated sites

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  DOI: 10.1007/s00262-022-03325-y
  
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Sep 2022
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Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma

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Jul 2022
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Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

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Jun 2022
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Optimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates FcγR-independent GITR agonism and antitumor activity

1
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Apr 2022
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Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches

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  DOI: 10.1016/j.immuni.2022.03.006
  
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Jan 2022
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Adenosine 2A receptor and TIM3 suppress cytolytic killing of tumor cells via cytoskeletal polarization

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  DOI: 10.1038/s42003-021-02972-8
  
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nature.com/articles/s42003-021-02972-8
Nov 2021
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Mice with diverse microbial exposure histories as a model for preclinical vaccine testing

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  DOI: 10.1016/j.chom.2021.10.001
  
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Aug 2021
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Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors

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  DOI: 10.1016/j.chom.2021.08.001
  
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May 2021
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Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis

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  DOI: 10.1016/j.chom.2021.04.008
  
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DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells

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  DOI: 10.1016/j.molcel.2021.01.038
  
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In vivo screens using a selective CRISPR antigen removal lentiviral vector system reveal immune dependencies in renal cell carcinoma

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Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy

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  DOI: 10.1016/j.immuni.2020.09.006
  
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Apr 2021
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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

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1. scibot 24 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.11.009
  
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Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity

1
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  DOI: 10.1016/j.ccell.2020.05.020
  
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Feb 2021
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DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity

1
1. scibot 28 Feb 2021
  
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  DOI: 10.1016/j.ccell.2020.11.006
  
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Sep 2020
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CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

1
1. scibot 16 Sep 2020
  
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  DOI: 10.1016/j.immuni.2020.03.001
  
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Nov 2018
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Dysregulated IL-18 Is a Key Driver of Immunosuppression and a Possible Therapeutic Target in the Multiple Myeloma Microenvironment

1
1. scibot 05 Nov 2018
  
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TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer

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