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Transcriptomic conservation defines autoimmune stem-like T cells and uncovers their dependence on Apex1

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  DOI: 10.1016/j.isci.2026.118067
  
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sciencedirect.com/science/article/pii/S2589004226034504
Jul 2026
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Tobemstomig, a novel bispecific antibody, preferentially blocks PD-1 and LAG-3 on CD8 TILs to expand stem-like T-cells for sustained tumor control

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1. scibot 12 Jul 2026
  
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  DOI: 10.1158/2767-9764.CRC-26-0207
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13347385/
Apr 2026
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Removal of Interstitial Hyaluronan Facilitates Subcutaneous Administration and Lymphatic Delivery of Anti-CTLA4 and Improves Antitumor Efficacy

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1. scibot 28 Apr 2026
  
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  DOI: 10.1158/2326-6066.CIR-25-0256
  
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aacrjournals.org/cancerimmunolres/article/14/3/450/774856/Removal-of-Interstitial-Hyaluronan-Facilitates
Feb 2026
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Law-NQO1 redox boosts the pentose phosphate pathway to confer stem-like properties and antitumor durability in effector CD8+ T cells

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1. scibot 26 Feb 2026
  
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  DOI: 10.1016/j.chembiol.2026.02.001
  
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sciencedirect.com/science/article/pii/S2451945626000334
Dec 2025
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The transcription factor Helios restrains the anti-tumor capacity of CD8+ T cells

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1. scibot 13 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116680
  
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sciencedirect.com:5037/science/article/pii/S2211124725014524
Oct 2025
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Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGF-β axis

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1. scibot 25 Oct 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1224
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7618275/
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Eomesodermin+ CD4+ T cells are critical for curative immunotherapy outcomes

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1. scibot 04 Oct 2025
  
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  DOI: 10.1016/j.immuni.2025.09.004
  
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sciencedirect.com/science/article/pii/S1074761325004157
Aug 2025
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Stress-induced glucocorticoids enhance acute inflammation by promoting the differentiation of Th17 cells

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1. scibot 05 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116093
  
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sciencedirect.com/science/article/pii/S2211124725008642
Jul 2025
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Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102251
  
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1-s2.0-S2589004225014087-main-html.html

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1. scibot 22 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.113147
  
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52.53.155.43/3e67ae4731f75e6f120a4c7a7c507c84a3acae93/1-s2.0-S2589004225014087-main-html.html
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The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells

1
1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.001
  
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sciencedirect.com/science/article/pii/S1074761325002481
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Presentation of immunoregulatory sialoglycans on T cells is divergent between mice and humans

1
1. scibot 02 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.115933
  
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sciencedirect.com/science/article/pii/S2211124725007041
Jun 2025
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Single-cell analysis of temporal immune cell dynamics in alopecia areata reveals a causal role for clonally expanded CD8+ T cells in disease

1
1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115798
  
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sciencedirect.com/science/article/pii/S2211124725005698
May 2025
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Combinatorial treatment with upadacitinib abrogates systemic toxicity of a tumor-targeted IL-2 fusion protein

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1. scibot 20 May 2025
  
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  DOI: 10.1136/jitc-2024-010831
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12067867/
Mar 2025
www.cell.com www.cell.com

IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis

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1. scibot 05 Mar 2025
  
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  DOI: 10.1016/j.immuni.2025.02.005
  
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cell.com/immunity/fulltext/S1074-7613(25)00073-1
Dec 2024
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Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion

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1. scibot 28 Dec 2024
  
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  DOI: 10.1016/j.immuni.2024.11.026
  
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sciencedirect.com/science/article/pii/S1074761324005417
Aug 2024
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LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity

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1. scibot 20 Aug 2024
  
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  AB_2687845
  
  DOI: 10.1016/j.cell.2024.07.018
  
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sciencedirect.com/science/article/pii/S0092867424007785
Jul 2024
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Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance

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1. scibot 18 Jul 2024
  
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  DOI: 10.1016/j.cell.2024.06.012
  
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sciencedirect.com/science/article/pii/S0092867424006524
May 2024
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Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity

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1. scibot 17 May 2024
  
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  DOI: 10.1016/j.chembiol.2024.04.005
  
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sciencedirect.com/science/article/pii/S2451945624001673
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CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8+ T cells in diabetic autoimmunity

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1. scibot 16 May 2024
  
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  DOI: 10.1016/j.immuni.2024.04.017
  
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sciencedirect.com/science/article/pii/S107476132400222X
Mar 2024
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NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment

2
1. scibot 06 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113898
  
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  DOI: 10.1016/j.celrep.2024.113898
  
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sciencedirect.com/science/article/pii/S2211124724002262
Feb 2024
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Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks

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1. scibot 14 Feb 2024
  
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  DOI: 10.1016/j.immuni.2024.01.011
  
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Cell-intrinsic PD-L1 ablation sustains effector CD8+ T cell responses and promotes antitumor T cell therapy

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1. scibot 02 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113712
  
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sciencedirect.com/science/article/pii/S2211124724000408
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Reversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision

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1. scibot 02 Feb 2024
  
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  DOI: 10.1016/j.immuni.2023.12.006
  
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sciencedirect.com/science/article/pii/S107476132300537X
Jan 2024
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Bispecific dendritic-T cell engager potentiates anti-tumor immunity

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1. scibot 19 Jan 2024
  
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  DOI: 10.1016/j.cell.2023.12.011
  
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sciencedirect.com/science/article/pii/S0092867423013430
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Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells

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1. scibot 19 Jan 2024
  
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  DOI: 10.1016/j.xcrm.2023.101377
  
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sciencedirect.com/science/article/pii/S2666379123006067
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Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer

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1. scibot 12 Jan 2024
  
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  DOI: 10.1016/j.ccell.2023.12.013
  
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sciencedirect.com/science/article/pii/S1535610823004415
Dec 2023
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Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection

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1. scibot 29 Dec 2023
  
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  DOI: 10.1016/j.immuni.2023.11.018
  
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Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure

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1. scibot 17 Dec 2023
  
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  DOI: 10.1016/j.immuni.2023.11.005
  
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sciencedirect.com/science/article/pii/S1074761323004879
Oct 2023
www.embopress.org www.embopress.org

IL-27 produced during acute malaria infection regulates Plasmodium-specific memory CD4+ T cells

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1. scibot 20 Oct 2023
  
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  DOI: 10.15252/emmm.202317713
  
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embopress.org/doi/10.15252/emmm.202317713
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Antigen presentation by tumor-associated macrophages mediates progenitor to terminal exhaustion transition in GBM and other solid tumors

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1. scibot 14 Oct 2023
  
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  DOI: 10.1101/2023.08.11.553007
  
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2. scibot 14 Oct 2023
  
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  DOI: 10.1101/2023.08.11.553007
  
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52.53.155.43/7eb24570d443d458f8fd7700f91970ed0d945838/2023.08.11.553007v1.full-html.html
Sep 2023
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STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells

1
1. scibot 16 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113108
  
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sciencedirect.com/science/article/pii/S2211124723011191
Aug 2023
52.53.155.43 52.53.155.43

CD39 inhibition and VISTA blockade may overcome radiotherapy resistance by targeting exhausted CD8+ T cells and immunosuppressive myeloid cells

2
1. scibot 17 Aug 2023
  
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  DOI: 10.1016/j.xcrm.2023.101151
  
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2. scibot 11 Aug 2023
  
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SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine

2
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Selective targeting of IL2Rβγ combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC

1
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Transcription factor TCF-1 regulates the functions, but not the development, of lymphoid tissue inducer subsets in different tissues

2
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Homeostatic PD-1 signaling restrains EOMES-dependent oligoclonal expansion of liver-resident CD8 T cells

2
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Jul 2023
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A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity

1
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Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses

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The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells

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PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion

1
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Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis

1
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Mar 2023
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Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity

1
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Jan 2023
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CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor

1
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Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages

1
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The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity

1
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Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy

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Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

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Sep 2022
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Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity

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Jun 2022
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Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity

1
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  DOI: 10.1016/j.immuni.2022.05.012
  
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May 2022
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Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

1
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Sep 2021
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CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection

1
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  DOI: 10.1016/j.celrep.2021.109696
  
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Aug 2021
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Untitled document

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Jul 2021
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Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells

1
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  DOI: 10.1016/j.celrep.2018.10.074
  
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Apr 2021
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A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer

1
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In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer

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Mar 2021
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Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

1
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Feb 2021
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Combined TCR Repertoire Profiles and Blood Cell Phenotypes Predict Melanoma Patient Response to Personalized Neoantigen Therapy plus Anti-PD-1

1
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Nov 2020
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Combined TCR Repertoire Profiles and Blood Cell Phenotypes Predict Melanoma Patient Response to Personalized Neoantigen Therapy plus Anti-PD-1

1
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Sep 2020
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Optimal Maturation of the SIV-Specific CD8+ T Cell Response after Primary Infection Is Associated with Natural Control of SIV: ANRS SIC Study

1
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  DOI: 10.1016/j.celrep.2020.108174
  
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Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

1
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Jan 2020
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Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells

1
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  DOI: 10.1016/j.immuni.2019.12.001
  
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TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision

1
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  DOI: 10.1016/j.immuni.2019.09.013
  
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Discovery of Small Molecules for the Reversal of T Cell Exhaustion

1
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  DOI: 10.1016/j.celrep.2019.10.119
  
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Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States

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  DOI: 10.1016/j.immuni.2019.03.004
  
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sciencedirect.com/science/article/pii/S1074761319300949
Nov 2018
www-sciencedirect-com.ezproxy.is.ed.ac.uk www-sciencedirect-com.ezproxy.is.ed.ac.uk

CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_2687845
  
  Curator: @Jmenke
  
  Resource used:
  
  (BD Biosciences Cat# 564217, RRID:AB_2687845)
  
  SciCrunch record: RRID:AB_2687845
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_2687845 RRIDCUR:Validated
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RRID:AB_2687845

RRIDCUR:Validated

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scibot

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www-sciencedirect-com.ezproxy.is.ed.ac.uk/science/article/pii/S107476131830342X
www.sciencedirect.com www.sciencedirect.com

Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_2687845
  
  Resource used:
  
  (BD Biosciences Cat# 564217, RRID:AB_2687845)
  
  SciCrunch record: RRID:AB_2687845
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_2687845
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scibot

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sciencedirect.com/science/article/pii/S1074761318300335
Nov 2017
www.sciencedirect.com www.sciencedirect.com

Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade

1
1. scibot 08 Nov 2017
  
  in Public
  
  Anti-mouse TCF1 (clone S33-966)BDCat# 564217
  
  Curator: @Jmenke
  
  Resource used:
  
  (BD Biosciences Cat# 564217, RRID:AB_2687845)
  
  SciCrunch record: RRID:AB_2687845
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_2687845 RRIDCUR:Missing
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scibot

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sciencedirect.com/science/article/pii/S0092867417308310

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