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Mechanisms of transcription control by distal enhancers from single-gene nanoscopy

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1. scibot 15 Oct 2026
  
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  DOI: 10.1016/j.cell.2026.09.028
  
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sciencedirect.com/science/article/pii/S009286742601130X
Jul 2026
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Condensates of the chromatin regulator ANKRD11 restrict hypertranscribed genes to safeguard development

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1. scibot 23 Jul 2026
  
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  DOI: 10.1016/j.cell.2026.07.006
  
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sciencedirect.com/science/article/pii/S0092867426008044
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RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity

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1. scibot 21 Jul 2026
  
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  DOI: 10.1016/j.molcel.2026.06.036
  
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sciencedirect.com/science/article/pii/S1097276526004259
Jun 2026
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SETDB1 and HUSH modulate Xist RNA levels during establishment of X chromosome inactivation

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1. scibot 10 Jun 2026
  
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  DOI: 10.1038/s41467-026-71569-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13243529/
Apr 2026
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Alu repeat-containing RNAs spatially organize actively transcribed genomic regions around nuclear speckles

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1. scibot 24 Apr 2026
  
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  DOI: 10.1016/j.molcel.2026.03.031
  
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sciencedirect.com/science/article/pii/S1097276526002078
Feb 2026
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CPSF73 activation and 3′ RNA polymerase II pausing are lost during readthrough transcription after heat shock

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1. scibot 27 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.117039
  
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sciencedirect.com/science/article/pii/S2211124726001178
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Cytoplasmic mRNA decay by the antiviral nuclease RNase L promotes transcriptional repression

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1. scibot 27 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.117028
  
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sciencedirect.com/science/article/pii/S2211124726001063
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Nuclear speckles enable processing of RNA from GC-rich isochores

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1. scibot 26 Feb 2026
  
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  DOI: 10.1016/j.cell.2026.01.011
  
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sciencedirect.com/science/article/pii/S009286742600098X
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HSPA1A and DNAJB1 regulate NELF condensate dynamics to safeguard transcriptional recovery under heat stress

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1. scibot 10 Feb 2026
  
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  DOI: 10.1016/j.molcel.2026.01.015
  
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sciencedirect.com/science/article/pii/S1097276526000353
Jan 2026
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BRD2 bridges TFIID and MOF-H4K16ac-containing nucleosomes to promote transcriptional initiation

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1. scibot 06 Jan 2026
  
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  DOI: 10.1016/j.molcel.2025.12.010
  
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sciencedirect.com/science/article/pii/S1097276525009840
Dec 2025
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PAF1C-mediated activation of CDK12/13 kinase activity is critical for CTD phosphorylation and transcript elongation

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1. scibot 03 Dec 2025
  
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  DOI: 10.1016/j.molcel.2025.04.012
  
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sciencedirect.com:5037/science/article/pii/S1097276525003156
Nov 2025
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1-s2.0-S2589004225024678-main-html.html

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.isci.2025.114206
  
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54.241.53.176/2cfc5b8ad2f9272e3f881028ee22a4318423a04e/1-s2.0-S2589004225024678-main-html.html
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Potentiation of noncanonical NF-κB signaling and marginal zone B cell expansion by CARD11-mediated regulation of p100 processing

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116616
  
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sciencedirect.com:5037/science/article/pii/S2211124725013889
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CDK7 is a novel therapeutic target in fibrolamellar carcinoma

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.isci.2025.113925
  
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A role for human senataxin in contending with pausing and backtracking during transcript elongation

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1. scibot 13 Nov 2025
  
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  DOI: 10.1016/j.molcel.2025.10.019
  
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sciencedirect.com/science/article/pii/S1097276525008603
Aug 2025
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A CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.molcel.2025.08.001
  
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sciencedirect.com/science/article/pii/S1097276525006513
www.cell.com www.cell.com

RNA Pol II inhibition activates cell death independently from the loss of transcription

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1. scibot 19 Aug 2025
  
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  DOI: 10.1016/j.cell.2025.07.034
  
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cell.com/cell/abstract/S0092-8674(25)00856-6
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Integrator promotes the association of TFIID and RNA polymerase II to maintain pluripotency during development

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1. scibot 08 Aug 2025
  
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  DOI: 10.1016/j.molcel.2025.07.006
  
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sciencedirect.com/science/article/pii/S1097276525006070
Jun 2025
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Multi-omics and biochemical reconstitution reveal CDK7-dependent mechanisms controlling RNA polymerase II function at gene 5′- and 3′ ends

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115904
  
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sciencedirect.com/science/article/pii/S2211124725006758
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Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation

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1. scibot 17 Jun 2025
  
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  DOI: 10.1016/j.molcel.2025.05.029
  
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Targeting CDK7/12/13 functional synergism reverses myofibroblast activation and ameliorates lung fibrosis

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.isci.2025.112778
  
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sciencedirect.com/science/article/pii/S2589004225010399
May 2025
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KDM3A and KDM3B regulate alternative splicing in mouse pluripotent stem cells

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.isci.2025.112612
  
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Super RNA Pol II domains enhance minor ZGA through 3D interaction to ensure the integrity of major transcriptional waves in late-ZGA mammals

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1. scibot 19 May 2025
  
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  DOI: 10.1016/j.xgen.2025.100856
  
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sciencedirect.com/science/article/pii/S2666979X25001120
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PAF1C-mediated activation of CDK12/13 kinase activity is critical for CTD phosphorylation and transcript elongation

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.molcel.2025.04.012
  
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sciencedirect.com:5037/science/article/pii/S1097276525003156
Mar 2025
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Transcription-coupled AID deamination damage depends on ELOF1-associated RNA polymerase II

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1. scibot 06 Mar 2025
  
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  DOI: 10.1016/j.molcel.2025.02.006
  
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Feb 2025
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Pcf11/Spt5 condensates stall RNA polymerase II to facilitate termination and piRNA-guided heterochromatin formation

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1. scibot 27 Feb 2025
  
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  DOI: 10.1016/j.molcel.2025.01.023
  
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Jan 2025
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LDB1 establishes multi-enhancer networks to regulate gene expression

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  DOI: 10.1016/j.molcel.2024.11.037
  
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Dec 2024
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TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.007
  
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CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription

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1. scibot 12 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.024
  
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The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.10.046
  
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Nov 2024
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STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair

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1. scibot 21 Nov 2024
  
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  DOI: 10.1016/j.cell.2024.10.018
  
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sciencedirect.com/science/article/pii/S0092867424012005
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Redundant pathways for removal of defective RNA polymerase II complexes at a promoter-proximal pause checkpoint

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1. scibot 15 Nov 2024
  
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  DOI: 10.1016/j.molcel.2024.10.012
  
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sciencedirect.com/science/article/pii/S1097276524008359
Sep 2024
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Multi-omics analysis using antibody-based in situ biotinylation technique suggests the mechanism of Cajal body formation

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1. scibot 17 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114734
  
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sciencedirect.com/science/article/pii/S2211124724010854
Aug 2024
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RNA interacts with topoisomerase I to adjust DNA topology

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1. scibot 23 Aug 2024
  
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  DOI: 10.1016/j.molcel.2024.07.032
  
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sciencedirect.com/science/article/pii/S1097276524006300
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Pharmacological preconditioning by TERT inhibitor BIBR1532 confers neuronal ischemic tolerance through TERT-mediated transcriptional reprogramming

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1. scibot 02 Aug 2024
  
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  DOI: 10.1111/jnc.15515
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.15515
Jul 2024
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CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection

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DOT1L/H3K79me2 represses HIV-1 reactivation via recruiting DCAF1

1
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YY1-mediated enhancer-promoter communication in the immunoglobulin μ locus is regulated by MSL/MOF recruitment

1
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FACT maintains chromatin architecture and thereby stimulates RNA polymerase II pausing during transcription in vivo

1
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Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence

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SAFB restricts contact domain boundaries associated with L1 chimeric transcription

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Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape

1
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Collisions of RNA polymerases behind the replication fork promote alternative RNA splicing in newly replicated chromatin

1
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Pluripotency state transition of embryonic stem cells requires the turnover of histone chaperone FACT on chromatin

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Protocol for rapidly inducing genome-wide RNA Pol II hyperphosphorylation by selectively disrupting INTAC phosphatase activity

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Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1

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A hyper-quiescent chromatin state formed during aging is reversed by regeneration

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RNA Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits

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INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II

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SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia

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Acute depletion of human core nucleoporin reveals direct roles in transcription control but dispensability for 3D genome organization

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Targeted protein degradation reveals RNA Pol II heterogeneity and functional diversity

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SPT6 functions in transcriptional pause/release via PAF1C recruitment

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Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy

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RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex

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Novel role of UHRF1 in the epigenetic repression of the latent HIV-1

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SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape

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SPT5 stabilization of promoter-proximal RNA polymerase II

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SCAF4 and SCAF8, mRNA Anti-Terminator Proteins

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Untitled document

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Jun 2021
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A role for the Cockayne Syndrome B (CSB)-Elongin ubiquitin ligase complex in signal-dependent RNA polymerase II transcription

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Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis

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Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing

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Distinct properties and functions of CTCF revealed by a rapidly inducible degron system

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CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci

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WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin

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Chromatin Hyperacetylation Impacts Chromosome Folding by Forming a Nuclear Subcompartment

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Regulation of the RNAPII Pool Is Integral to the DNA Damage Response

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The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts

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TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma

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A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2

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  DOI: 10.1016/j.celrep.2019.10.011
  
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  DOI: 10.1016/j.cell.2019.04.038
  
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A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis

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  DOI: 10.1016/j.ccell.2018.10.004
  
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Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy

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The Nucleosome Remodeling and Deacetylation Complex Modulates Chromatin Structure at Sites of Active Transcription to Fine-Tune Gene Expression

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Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription of Arc/Arg3.1 and Other Immediate Early Genes

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1. scibot 08 Nov 2017
  
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