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Sep 2026
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PPM1L-dependent PD-L1 dephosphorylation orchestrates tumor-type-specific ubiquitin ligase recognition to govern its degradation

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sciencedirect.com/science/article/pii/S2211124726010338
Aug 2026
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FKBP52 dictates the dual role of p53 in hepatocellular carcinoma: mutation-specific prognostic stratification and therapeutic implications

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sciencedirect.com/science/article/pii/S0021925826022623
Apr 2026
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Identification of an STING inhibitor targeting the allosteric transmembrane domains

1
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  DOI: 10.1016/j.chembiol.2026.04.001
  
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sciencedirect.com/science/article/pii/S2451945626001108
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesis

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pmc.ncbi.nlm.nih.gov/articles/PMC13056290/
Mar 2026
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Hijacking ERAD for targeted degradation of transmembrane proteins

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  DOI: 10.1016/j.cell.2026.01.018
  
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sciencedirect.com/science/article/pii/S0092867426001054
Feb 2026
journals.plos.org journals.plos.org

The lipid-metabolic enzyme HSD17B12 drives lysosomal degradation of PD-L1 potentiating anti-tumor immunity in a mouse model

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journals.plos.org/plosbiology/article
Jan 2026
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AAVLINK: A potent DNA-recombination method for large cargo delivery in gene therapy

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  DOI: 10.1016/j.cell.2025.12.039
  
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sciencedirect.com/science/article/pii/S0092867425014886
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Lysosome-localized IRTKS condensates promote mTORC1 activity leading to MASLD and HCC

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sciencedirect.com/science/article/pii/S2211124725016651
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Effector-mediated transcriptional rewiring resolves interbacterial conflict through conserved c-di-GMP antagonism

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  DOI: 10.1016/j.cub.2025.11.071
  
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sciencedirect.com/science/article/pii/S0960982225016124
54.241.53.176 54.241.53.176

1-s2.0-S2589004226000246-main-html.html

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54.241.53.176/cba3b4e924e0e58357109065cf0529a30b9ba294/1-s2.0-S2589004226000246-main-html.html
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Endometrial stromal cell-derived TMAO sustains decidualization to prevent recurrent spontaneous abortion

1
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  DOI: 10.1016/j.cmet.2025.11.014
  
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sciencedirect.com/science/article/pii/S1550413125005285
Nov 2025
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Nanoscale conformational dynamics of human propionyl-CoA carboxylase

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sciencedirect.com/science/article/pii/S096921262500396X
Oct 2025
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TMK-PIN1 drives a short self-organizing circuit for auxin export and signaling in Arabidopsis

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  DOI: 10.1016/j.devcel.2025.09.009
  
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sciencedirect.com/science/article/pii/S1534580725005696
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AMPKα2 signals amino acid insufficiency to inhibit protein synthesis

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sciencedirect.com/science/article/pii/S1550413125003894
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Phosphorylation-dependent suppression of SERRATE balances miRNA metabolism in planta

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  DOI: 10.1016/j.celrep.2025.116367
  
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sciencedirect.com/science/article/pii/S2211124725011386
Aug 2025
www.cell.com www.cell.com

A mechano-resistance mechanism in skin adapts to terrestrial locomotion

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  DOI: 10.1016/j.cell.2025.07.012
  
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cell.com/cell/abstract/S0092-8674(25)00801-3
Jul 2025
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TRAF6 regulates ubiquitination-independent TDP-43 condensation and related neurodegeneration

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1. scibot 22 Jul 2025
  
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  DOI: 10.1038/s41380-025-03122-w
  
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nature.com/articles/s41380-025-03122-w
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CFAP70 is a solid and valuable target for the genetic diagnosis of oligo-astheno-teratozoospermia in infertile men

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1. scibot 16 Jul 2025
  
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  i
  
  DOI: 10.1016/j.ebiom.2023.104675
  
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sciencedirect.com/science/article/pii/S2352396423002402
Jun 2025
www.tandfonline.com www.tandfonline.com

Heat-shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via restoration of autophagic flux

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  DOI: 10.1080/15548627.2025.2466144
  
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tandfonline.com/doi/abs/10.1080/15548627.2025.2466144
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Manipulation of host-plant preference by virus-induced changes to its insect vector’s olfactory system

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Protocol for genetic dissection of class switch recombination using genome-editing tools

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  DOI: 10.1016/j.xpro.2025.103882
  
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sciencedirect.com/science/article/pii/S2666166725002886
Apr 2025
52.53.155.43 52.53.155.43

1-s2.0-S0016508525005426-main-html.html

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52.53.155.43/417f7e11cf34a4a05dabce5f916b0d6ed71a75c4/1-s2.0-S0016508525005426-main-html.html
Mar 2025
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Transcription-coupled AID deamination damage depends on ELOF1-associated RNA polymerase II

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  DOI: 10.1016/j.molcel.2025.02.006
  
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sciencedirect.com/science/article/pii/S109727652500111X
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A negatively-charged region within carboxy-terminal domain maintains proper CTCF DNA binding

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pmc.ncbi.nlm.nih.gov/articles/PMC11667065/
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Antagonistic systemin receptors integrate the activation and attenuation of systemic wound signaling in tomato

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sciencedirect.com/science/article/pii/S1534580724006701
Aug 2024
www.embopress.org www.embopress.org

Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans

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  DOI: 10.15252/embj.2020106864
  
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embopress.org/doi/full/10.15252/embj.2020106864
Jul 2024
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Tumor suppressor KEAP1 promotes HSPA9 degradation, controlling mitochondrial biogenesis in breast cancer

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sciencedirect.com/science/article/pii/S2211124724008362
May 2024
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Peptide REF1 is a local wound signal promoting plant regeneration

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  DOI: 10.1016/j.cell.2024.04.040
  
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52.53.155.43 52.53.155.43

Disruption in<i>CYLC1</i>leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice

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  DOI: 10.1101/2024.01.11.24301040
  
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  DOI: 10.1101/2024.01.11.24301040
  
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52.53.155.43/db83a72e264c6715c8b712c9f10e49747778439c/2024.01.11.24301040v1.full-html.html
Apr 2024
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Photoregulatory protein kinases fine-tune plant photomorphogenesis by directing a bifunctional phospho-code on HY5 in Arabidopsis

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sciencedirect.com/science/article/pii/S1534580724002326
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CBX7C•PHC2 interaction facilitates PRC1 assembly and modulates its phase separation properties

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  DOI: 10.1016/j.isci.2024.109548
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11004992/
Feb 2024
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ATG5 attenuates inflammatory signaling in mouse embryonic stem cells to control differentiation

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Histone methylation readers MRG1/2 interact with PIF4 to promote thermomorphogenesis in Arabidopsis

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  DOI: 10.1016/j.celrep.2024.113726
  
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sciencedirect.com/science/article/pii/S2211124724000548
Dec 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Novel EYA1 Mutation Causing Alternative RNA Splicing in a Chinese Family With Branchio-Oto Syndrome: Implications for Molecular Diagnosis and Clinical Application

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1. scibot 15 Dec 2023
  
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  DOI: 10.21053/ceo.2023.00668
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10710918/
Nov 2023
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The FERONIA-YUELAO module participates in translational control by modulating the abundance of tRNA fragments in Arabidopsis

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Bacterial effector restricts liquid-liquid phase separation of ZPR1 to antagonize host UPRER

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SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex

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16p11.2 CNV gene Doc2α functions in neurodevelopment and social behaviors through interaction with Secretagogin

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UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders

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Long noncoding RNA ARTA controls ABA response through MYB7 nuclear trafficking in Arabidopsis

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cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning

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Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response

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Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity

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Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease

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A bat MERS-like coronavirus circulates in pangolins and utilizes human DPP4 and host proteases for cell entry

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Capture and mass spectrometry analysis of effector-substrate complexes using genetically incorporated photo-crosslinkers in host cells

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The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice

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ZFP541 maintains the repression of pre-pachytene transcriptional programs and promotes male meiosis progression

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An Inducible CRISPR/Cas9 Screen Identifies DTX2 as a Transcriptional Regulator of Human Telomerase

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A nonautophagic role of ATG5 in regulating cell growth by targeting c-Myc for proteasome-mediated degradation

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Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation

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Genetically incorporated crosslinkers reveal NleE attenuates host autophagy dependent on PSMD10

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Untitled document

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Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss

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Phytophthora sojae LRR-RLKs: Diverse and essential roles in Development and Pathogenicity

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Muscle regeneration controlled by a designated DNA dioxygenase

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TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis

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Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans

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METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation

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Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling

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ELT‐2 promotes O‐GlcNAc transferase OGT‐1 expression to modulate Caenorhabditis elegans lifespan

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Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

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Magneto is ineffective in controlling electrical properties of cerebellar Purkinje cells

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Untitled document

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Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal

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Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations

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