35 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13196427/
  3. May 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13142706/
  5. Apr 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting leucine-rich repeat kinase 2 overcomes resistance to oncolytic herpes simplex virus-based therapies in glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13066370/
  7. Sep 2025
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12397289/
  9. Jul 2025
  10. www.science.org www.science.org
    Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2
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    science.org/doi/10.1126/sciadv.adt2050
  11. elifesciences.org elifesciences.org
    PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation
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    elifesciences.org/reviewed-preprints/107556
  12. link.springer.com link.springer.com
    Generation of Leucine-Rich Repeat Kinase 2 (LRRK2) Knockout Neuroblastoma Cells SH-SY5Y by CRISPR/Cas9-Mediated Genome Editing
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    link.springer.com/article/10.1007/s10528-025-11174-4
  13. Jun 2025
  14. www.science.org www.science.org
    Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2
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    science.org/doi/10.1126/sciadv.adt2050
  15. Jan 2025
  16. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/04879393ca39922a7c00ba26ca5d51a54504677a/PDF-html.html
  17. Sep 2024
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Type-II kinase inhibitors that target Parkinson’s Disease-associated LRRK2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11565912/
  19. Jun 2024
  20. www.sciencedirect.com www.sciencedirect.com
    A designed ankyrin-repeat protein that targets Parkinson’s disease-associated LRRK2
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    sciencedirect.com/science/article/pii/S0021925824019707
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell-autonomous role of leucine-rich repeat kinase in the protection of dopaminergic neuron survival
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    ncbi.nlm.nih.gov/pmc/articles/PMC11164531/
  22. May 2024
  23. elifesciences.org elifesciences.org
    Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survival
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    elifesciences.org/reviewed-preprints/92673
  24. Feb 2024
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysosomal stress drives the release of pathogenic α-synuclein from macrophage lineage cells via the LRRK2-Rab10 pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10835446/
  26. Oct 2023
  27. www.biorxiv.org www.biorxiv.org
    Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survival
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    biorxiv.org/content/10.1101/2023.10.06.561293v5
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LRRK2 G2019S promotes astrocytic inflammation induced by oligomeric α-synuclein through NF-κB pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10590863/
  29. Mar 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Secretion of VGF relies on the interplay between LRRK2 and post-Golgi v-SNAREs
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    sciencedirect.com/science/article/pii/S2211124723002322
  31. Feb 2023
  32. www.nature.com www.nature.com
    Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology
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    nature.com/articles/s41531-023-00465-5
  33. Nov 2022
  34. www.nature.com www.nature.com
    R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations
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    nature.com/articles/s42003-022-04136-8
  35. Oct 2022
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia
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    ncbi.nlm.nih.gov/pmc/articles/PMC9579025/
  37. Jul 2022
  38. www.nature.com www.nature.com
    LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease
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    nature.com/articles/s41531-022-00354-3
  39. www.sciencedirect.com www.sciencedirect.com
    Rapid macropinocytic transfer of α-synuclein to lysosomes
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    sciencedirect.com/science/article/pii/S2211124722009044
  40. Dec 2021
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson’s disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC8660019/
  42. Nov 2021
  43. link.springer.com link.springer.com
    Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein
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    link.springer.com/article/10.1186/s40478-021-01283-7
  44. Oct 2021
  45. link.springer.com link.springer.com
    NME1 Protects Against Neurotoxin-, α-Synuclein- and LRRK2-Induced Neurite Degeneration in Cell Models of Parkinson’s Disease
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    link.springer.com/article/10.1007/s12035-021-02569-6
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LRRK2 Kinase Activity Does Not Alter Cell-Autonomous Tau Pathology Development in Primary Neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC8461695/
  47. Aug 2021
  48. link.springer.com link.springer.com
    Untitled document
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    link.springer.com/article/10.1186/s40478-019-0679-5
  49. Jul 2021
  50. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
    Untitled document
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    actaneurocomms.biomedcentral.com/articles/10.1186/s40478-019-0679-5
  51. Mar 2021
  52. www.sciencedirect.com www.sciencedirect.com
    Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes
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    sciencedirect.com/science/article/pii/S0960982221003055
  53. Sep 2020
  54. www.sciencedirect.com www.sciencedirect.com
    The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network
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    sciencedirect.com/science/article/pii/S2211124720305635
  55. Jan 2020
  56. onlinelibrary.wiley.com onlinelibrary.wiley.com
    LRRK2 phosphorylation on synapsin I regulates glutamate release at presynaptic sites
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14778
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6391792/
  58. Nov 2018
  59. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
    LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons
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    actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0550-0
  60. Nov 2017
  61. www.sciencedirect.com www.sciencedirect.com
    Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways
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    sciencedirect.com/science/article/pii/S2405471216304458