37 Matching Annotations
  1. Jul 2026
  2. 54.241.53.176 54.241.53.176
    LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death
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    54.241.53.176/0f38fc1e7fe7e28d4caf2728d0ad871f97ce0b85/jcs264977-html.html
  3. Jun 2026
  4. www.sciencedirect.com www.sciencedirect.com
    Single-cell RNA profiling of oligodendroglial lineage cells derived from iPSCs carrying Parkinson’s disease-relevant LRRK2-G2019S mutation
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    sciencedirect.com/science/article/pii/S2589004226017438
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13196427/
  6. May 2026
  7. www.science.org www.science.org
    GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis
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    science.org/doi/10.1126/sciadv.adv1434
  8. Apr 2026
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting leucine-rich repeat kinase 2 overcomes resistance to oncolytic herpes simplex virus-based therapies in glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13066370/
  10. Sep 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12397289/
  12. Jul 2025
  13. www.science.org www.science.org
    Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2
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    science.org/doi/10.1126/sciadv.adt2050
  14. elifesciences.org elifesciences.org
    PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation
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    elifesciences.org/reviewed-preprints/107556
  15. link.springer.com link.springer.com
    Generation of Leucine-Rich Repeat Kinase 2 (LRRK2) Knockout Neuroblastoma Cells SH-SY5Y by CRISPR/Cas9-Mediated Genome Editing
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    link.springer.com/article/10.1007/s10528-025-11174-4
  16. Jun 2025
  17. www.science.org www.science.org
    Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2
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    science.org/doi/10.1126/sciadv.adt2050
  18. Jan 2025
  19. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/04879393ca39922a7c00ba26ca5d51a54504677a/PDF-html.html
  20. Sep 2024
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Type-II kinase inhibitors that target Parkinson’s Disease-associated LRRK2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11565912/
  22. Jun 2024
  23. www.sciencedirect.com www.sciencedirect.com
    A designed ankyrin-repeat protein that targets Parkinson’s disease-associated LRRK2
    1
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    sciencedirect.com/science/article/pii/S0021925824019707
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell-autonomous role of leucine-rich repeat kinase in the protection of dopaminergic neuron survival
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11164531/
  25. May 2024
  26. elifesciences.org elifesciences.org
    Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survival
    1
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    elifesciences.org/reviewed-preprints/92673
  27. Feb 2024
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysosomal stress drives the release of pathogenic α-synuclein from macrophage lineage cells via the LRRK2-Rab10 pathway
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10835446/
  29. Oct 2023
  30. www.biorxiv.org www.biorxiv.org
    Cell autonomous role of leucine-rich repeat kinase in protection of dopaminergic neuron survival
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    biorxiv.org/content/10.1101/2023.10.06.561293v5
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LRRK2 G2019S promotes astrocytic inflammation induced by oligomeric α-synuclein through NF-κB pathway
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10590863/
  32. Mar 2023
  33. www.sciencedirect.com www.sciencedirect.com
    Secretion of VGF relies on the interplay between LRRK2 and post-Golgi v-SNAREs
    1
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    sciencedirect.com/science/article/pii/S2211124723002322
  34. Feb 2023
  35. www.nature.com www.nature.com
    Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology
    1
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    nature.com/articles/s41531-023-00465-5
  36. Nov 2022
  37. www.nature.com www.nature.com
    R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations
    1
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    nature.com/articles/s42003-022-04136-8
  38. Oct 2022
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9579025/
  40. Jul 2022
  41. www.nature.com www.nature.com
    LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease
    1
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    nature.com/articles/s41531-022-00354-3
  42. www.sciencedirect.com www.sciencedirect.com
    Rapid macropinocytic transfer of α-synuclein to lysosomes
    1
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    sciencedirect.com/science/article/pii/S2211124722009044
  43. Dec 2021
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson’s disease
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8660019/
  45. Nov 2021
  46. link.springer.com link.springer.com
    Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein
    1
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    link.springer.com/article/10.1186/s40478-021-01283-7
  47. Oct 2021
  48. link.springer.com link.springer.com
    NME1 Protects Against Neurotoxin-, α-Synuclein- and LRRK2-Induced Neurite Degeneration in Cell Models of Parkinson’s Disease
    2
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    link.springer.com/article/10.1007/s12035-021-02569-6
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LRRK2 Kinase Activity Does Not Alter Cell-Autonomous Tau Pathology Development in Primary Neurons
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8461695/
  50. Aug 2021
  51. link.springer.com link.springer.com
    Untitled document
    1
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    link.springer.com/article/10.1186/s40478-019-0679-5
  52. Jul 2021
  53. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
    Untitled document
    1
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    actaneurocomms.biomedcentral.com/articles/10.1186/s40478-019-0679-5
  54. Mar 2021
  55. www.sciencedirect.com www.sciencedirect.com
    Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes
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    sciencedirect.com/science/article/pii/S0960982221003055
  56. Sep 2020
  57. www.sciencedirect.com www.sciencedirect.com
    The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network
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    sciencedirect.com/science/article/pii/S2211124720305635
  58. Jan 2020
  59. onlinelibrary.wiley.com onlinelibrary.wiley.com
    LRRK2 phosphorylation on synapsin I regulates glutamate release at presynaptic sites
    1
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14778
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC6391792/
  61. Nov 2018
  62. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
    LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons
    1
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    actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0550-0
  63. Nov 2017
  64. www.sciencedirect.com www.sciencedirect.com
    Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways
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    sciencedirect.com/science/article/pii/S2405471216304458