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Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12

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1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116262
  
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sciencedirect.com/science/article/pii/S2211124725010332
Aug 2025
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Nrf2 drives activation-driven expansion of CD4+T cells by modulating glucose and glutamine metabolism

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116177
  
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sciencedirect.com/science/article/pii/S2211124725009489
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Distinct microRNA signatures define sporadic PSP-RS and PD in patient-derived midbrain organoids

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1. scibot 05 Aug 2025
  
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  DOI: 10.1016/j.isci.2025.113162
  
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sciencedirect.com/science/article/pii/S2589004225014233
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Nrf2/Nlrp3 Signaling in Aging BMSCs: Traf6 Intervention as a Novel Approach to Osteoporosis Treatment

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1. scibot 01 Aug 2025
  
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  DOI: 10.1016/j.redox.2025.103804
  
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sciencedirect.com/science/article/pii/S2213231725003179
Jul 2025
journals.lww.com journals.lww.com

Mechanism by which hydrogen-rich water mitigates... : Medical Gas Research

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1. scibot 11 Jul 2025
  
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  DOI: 10.4103/mgr.MEDGASRES-D-24-00148
  
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journals.lww.com/mgar/fulltext/2026/03000/mechanism_by_which_hydrogen_rich_water_mitigates.5.aspx
Jun 2025
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PDF-html.html

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pmc.ncbi.nlm.nih.gov/articles/PMC12270665/
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TR-107, An Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells

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1. scibot 11 Jun 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0170
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11614700/
May 2025
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Inflammatory targeted nanoplatform incorporated with antioxidative nano iron oxide to attenuate ulcerative colitis progression

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.isci.2025.112448
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12059676/
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Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115627
  
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sciencedirect.com/science/article/pii/S2211124725003985
Apr 2025
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Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance

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1. scibot 11 Apr 2025
  
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  DOI: 10.1016/j.ccell.2025.03.031
  
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sciencedirect.com/science/article/pii/S1535610825001321
Feb 2025
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The roles of Growth Hormone dependent JAK-STAT5 and Lyn kinase signalling in determining lifespan and cancer incidence

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1. scibot 20 Feb 2025
  
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  DOI: 10.1210/endocr/bqae136
  
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dx.doi.org/10.1210/endocr/bqae136
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Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma

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  DOI: 10.1158/2159-8290.CD-24-0187
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11803400/
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Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12

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1. scibot 07 Feb 2025
  
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  AB_2715528
  
  DOI: 10.1101/2024.11.25.625235
  
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52.53.155.43/a7ca056b00d74853454bbdd4617f42c52e9cd355/2024.11.25.625235.full-html.html
Jan 2025
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Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.jep.2025.119393
  
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sciencedirect.com/science/article/pii/S0378874125000765
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Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1

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1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.cmet.2024.11.012
  
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sciencedirect.com/science/article/pii/S1550413124004807
Dec 2024
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MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115104
  
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sciencedirect.com/science/article/pii/S2211124724014554
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Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115016
  
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sciencedirect.com/science/article/pii/S2211124724013676
Nov 2024
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Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress

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1. scibot 16 Nov 2024
  
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  DOI: 10.1016/j.cell.2024.10.012
  
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sciencedirect.com/science/article/pii/S0092867424011887
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Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance

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1. scibot 11 Nov 2024
  
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  DOI: 10.1016/j.ccell.2024.10.010
  
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sciencedirect.com/science/article/pii/S1535610824003982
Sep 2024
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Muscle-derived IL-1β regulates EcSOD expression via the NBR1-p62-Nrf2 pathway in muscle during cancer cachexia

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1. scibot 27 Sep 2024
  
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  DOI: 10.1113/JP286460
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP286460
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Treatment with a combination of myricitrin and exercise alleviates myocardial infarction in rats via suppressing Nrf2/HO-1 antioxidant pathway

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1. scibot 12 Sep 2024
  
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  DOI: 10.1016/j.abb.2024.110153
  
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sciencedirect.com/science/article/pii/S0003986124002753
Aug 2024
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Macrophage ILF3 promotes abdominal aortic aneurysm by inducing inflammatory imbalance in male mice

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1. scibot 27 Aug 2024
  
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  DOI: 10.1038/s41467-024-51030-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11344041/
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TFE3 fusions direct an oncogenic transcriptional program that drives OXPHOS and unveils vulnerabilities in translocation renal cell carcinoma

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1. scibot 26 Aug 2024
  
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  DOI: 10.1101/2024.08.09.607311
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11326252/
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Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.cmet.2024.07.014
  
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cell.com/cell-metabolism/fulltext/S1550-4131(24)00285-7
Jul 2024
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CircEZH2 Promotes Gallbladder Cancer Progression and Lipid Metabolism Reprogramming through the miR-556-5p/SCD1 Axis

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sciencedirect.com/science/article/pii/S2589004224016535
Mar 2024
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A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease

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1. scibot 27 Mar 2024
  
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  DOI: 10.4103/1673-5374.389356
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10960274/
Feb 2024
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SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway

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  DOI: 10.1016/j.devcel.2024.01.024
  
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Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo

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  DOI: 10.1126/sciadv.adk1835
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10866549/
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Sleep fragmentation induces heart failure in a hypertrophic cardiomyopathy mouse model by altering redox metabolism

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  DOI: 10.1016/j.isci.2024.109075
  
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sciencedirect.com/science/article/pii/S2589004224002967
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Lumbricus Extract Prevents LPS-Induced Inflammatory Activation of BV2 Microglia and Glutamate-Induced Hippocampal HT22 Cell Death by Suppressing MAPK/NF-κB/NLRP3 Signaling and Oxidative Stress

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mdpi.com/1467-3045/45/12/620
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Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells

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  DOI: 10.1016/j.cmet.2024.01.008
  
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sciencedirect.com/science/article/pii/S1550413124000081
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Genome-wide p63-target gene analyses reveal TAp63/NRF2-dependent oxidative stress responses

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  DOI: 10.1158/2767-9764.CRC-23-0358
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10832605/
Jan 2024
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ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis

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1. scibot 11 Jan 2024
  
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  DOI: 10.1016/j.cmet.2023.12.015
  
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sciencedirect.com/science/article/pii/S1550413123004655
Nov 2023
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Stress-induced β cell early senescence confers protection against type 1 diabetes

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1. scibot 17 Nov 2023
  
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  DOI: 10.1016/j.cmet.2023.10.014
  
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sciencedirect.com/science/article/pii/S1550413123003832
Oct 2023
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CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression

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1. scibot 28 Oct 2023
  
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  DOI: 10.1016/j.cmet.2023.09.012
  
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Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1

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Glucosinolate-rich broccoli sprouts protect against oxidative stress and improve adaptations to intense exercise training

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4-Octyl itaconate restricts STING activation by blocking its palmitoylation

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Ketogenic diet alleviates cognitive dysfunction and neuroinflammation in APP/PS1 mice via the Nrf2/HO-1 and NF-κB signaling pathways

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A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons

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Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism

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Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons

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Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblasts

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Effects of Dietary Oleacein Treatment on Endothelial Dysfunction and Lupus Nephritis in Balb/C Pristane-Induced Mice

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Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression

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Investigating the effects of 7-ketocholesterol on retinal pigment epithelium bioenergetics

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AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells

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Ubiquitin-independent proteasomal degradation driven by C-degron pathways

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Lysimachiae Herba Inhibits Inflammatory Reactions and Improves Lipopolysaccharide/D-Galactosamine-Induced Hepatic Injury

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Knockdown of NADPH oxidase 4 reduces mitochondrial... : Neural Regeneration Research

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Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

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Generation of two human NRF2 knockout iPSC clones using CRISPR/Cas9 editing

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Inhibiting tau protein improves the recovery of spinal cord ... : Neural Regeneration Research

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PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy

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Neuroprotective and Anti-Neuroinflammatory Properties of Vignae Radiatae Semen in Neuronal HT22 and Microglial BV2 Cell Lines

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The Neuroprotective Effects of Arecae Pericarpium against Glutamate-Induced HT22 Cell Cytotoxicity

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A systemic cell stress signal confers neuronal resilience toward oxidative stress in a Hedgehog-dependent manner

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The protease DDI2 regulates NRF1 activation in response to cadmium toxicity

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Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain

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Multiomics reveal the central role of pentose phosphate pathway in resident thymic macrophages to cope with efferocytosis-associated stress

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FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity

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Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis

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Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling

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The Protective Effects of Trans-Cinnamaldehyde against D-Galactose and Aluminum Chloride-Induced Cognitive Dysfunction in Mice

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Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages

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Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells

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The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2

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EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion

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Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis

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Structural basis and regulation of the reductive stress response

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A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

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A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

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  DOI: 10.1016/j.celrep.2018.10.092
  
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KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition

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Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection

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Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential

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3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis

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Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers

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A Cellular Mechanism to Detect and Alleviate Reductive Stress

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Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis

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Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway

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Effect of Treadmill Exercise and Trans-Cinnamaldehyde against d-Galactose- and Aluminum Chloride-Induced Cognitive Dysfunction in Mice

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Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection

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The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

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Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer

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Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway

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Alpha-lipoic acid protects against pressure overload-induced heart failure via ALDH2-dependent Nrf1-FUNDC1 signaling

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The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

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Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity

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Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury

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IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β–Nrf2–BNIP3 Pathway

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  rabbit anti-NFE2L2/Nrf2
  
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HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice

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Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer

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Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

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Protective effects of GHK-Cu in bleomycin-induced pulmonary fibrosis via anti-oxidative stress and anti-inflammation pathways

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BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

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Mitohormesis Primes Tumor Invasion and Metastasis

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Neuronal activity induces glutathione metabolism gene expression in astrocytes

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Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase

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Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer

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