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Targeting Cancer-Associated PCNA with AOH1996 Induces Mitotic Catastrophe and Enhances Cisplatin Therapy in Cervical Cancer

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  DOI: 10.1158/2767-9764.CRC-25-0648
  
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aacrjournals.org/cancerrescommun/article/6/5/1220/785408/Targeting-Cancer-Associated-PCNA-with-AOH1996
May 2026
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Phenylalanyl-tRNA synthetase FARS-1/FARSA balances longevity and immunity by downregulating endogenous mitochondrial double-stranded RNAs

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sciencedirect.com/science/article/pii/S1097276526002844
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Loss of payload sensitivity and other mechanisms of resistance to T-DXd in HER2-mutant NSCLC: implications for subsequent responsiveness to HER2 TKIs

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  DOI: 10.1016/j.jtho.2026.01.007
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13169646/
Apr 2026
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SCD1 and SCD5 modulate PARP-dependent DNA repair via fatty acid desaturation in glioblastoma

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  DOI: 10.1016/j.celrep.2026.117223
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13181748/
Mar 2026
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Jagged1 regulates extracellular matrix deposition and remodeling in triple-negative breast cancer

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  DOI: 10.1126/sciadv.aea9562
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12998526/
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Dominant interfering CARD11 variants disrupt JNK signaling to promote GATA3 expression in T cells

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  DOI: 10.1084/jem.20240272
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11924952/
Feb 2026
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TNF-⍺-mediated myeloid-instructed CD14+CD4+ T cells are associated with poor survival in lung adenocarcinoma

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  DOI: 10.1016/j.xcrm.2026.102593
  
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sciencedirect.com/science/article/pii/S2666379126000108
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Targeting ATR signaling in sarcoma with homologous recombination deficiency

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  DOI: 10.1016/j.canlet.2026.218300
  
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sciencedirect.com/science/article/pii/S0304383526000637
Jan 2026
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Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

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  DOI: 10.1002/advs.202516965
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202516965
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The ionotropic AMPA receptor contributes to autoimmunity via altered regulatory T cell differentiation

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  DOI: 10.1016/j.isci.2025.114267
  
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sciencedirect.com/science/article/pii/S2589004225025283
Oct 2025
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Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGF-β axis

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  DOI: 10.1158/2159-8290.CD-24-1224
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7618275/
Jun 2025
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A Novel Mouse Model for LAMA2-Related Muscular Dystrophy: Analysis of Molecular Pathogenesis and Clinical Phenotype

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1. scibot 11 Jun 2025
  
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  DOI: 10.7554/eLife.94288.2
  
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elifesciences.org/reviewed-preprints/94288v2
Apr 2025
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SLIRP amplifies antiviral signaling via positive feedback regulation and contributes to autoimmune diseases

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  DOI: 10.1016/j.celrep.2025.115588
  
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sciencedirect.com/science/article/pii/S2211124725003596
Feb 2025
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1-s2.0-S2589004225003785-main-html.html

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  DOI: 10.1016/j.isci.2025.112118
  
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52.53.155.43/d1f964056b3dd00ef17176fded1971b6e20e47a3/1-s2.0-S2589004225003785-main-html.html
Jan 2025
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Nuclear adenine activates hnRNPA2B1 to enhance antibacterial innate immunity

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  DOI: 10.1016/j.cmet.2024.11.014
  
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sciencedirect.com/science/article/pii/S1550413124004820
Dec 2024
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EOMES establishes mesoderm and endoderm differentiation potential through SWI/SNF-mediated global enhancer remodeling

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1. scibot 12 Dec 2024
  
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  DOI: 10.1016/j.devcel.2024.11.014
  
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cell.com/developmental-cell/fulltext/S1534-5807(24)00696-8
Oct 2024
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Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation

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1. scibot 02 Oct 2024
  
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  DOI: 10.1016/j.chembiol.2024.09.001
  
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sciencedirect.com/science/article/pii/S2451945624003933
Sep 2024
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Multivariate analysis of metabolic state vulnerabilities across diverse cancer contexts reveals synthetically lethal associations

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  DOI: 10.1016/j.celrep.2024.114775
  
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cell.com/cell-reports/fulltext/S2211-1247(24)01126-4
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Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway

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  DOI: 10.7554/eLife.90854
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11390110/
Jul 2024
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RNA 5-methylcytosine marks mitochondrial double-stranded RNAs for degradation and cytosolic release

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  DOI: 10.1016/j.molcel.2024.06.023
  
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sciencedirect.com/science/article/pii/S1097276524005306
Apr 2024
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Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation

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  DOI: 10.1016/j.cmet.2024.03.016
  
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sciencedirect.com/science/article/pii/S1550413124001207
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Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors

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  DOI: 10.1016/j.chembiol.2024.03.004
  
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sciencedirect.com/science/article/pii/S245194562400120X
Feb 2024
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Alternative polyadenylation determines the functional landscape of inverted Alu repeats

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  DOI: 10.1016/j.molcel.2024.01.008
  
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sciencedirect.com/science/article/pii/S1097276524000091
Jul 2023
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Structural basis for membrane-proximal proteolysis of substrates by ADAM10

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  DOI: 10.1016/j.cell.2023.06.026
  
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sciencedirect.com/science/article/abs/pii/S009286742300733X
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A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression

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  DOI: 10.1016/j.celrep.2023.112833
  
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sciencedirect.com/science/article/pii/S2211124723008446
Jun 2023
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MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma

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  DOI: 10.1016/j.ccell.2023.05.015
  
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Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity

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  DOI: 10.1016/j.cell.2023.05.013
  
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sciencedirect.com/science/article/pii/S0092867423005329
Apr 2023
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The mechanism of STING autoinhibition and activation

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  DOI: 10.1016/j.molcel.2023.03.029
  
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sciencedirect.com/science/article/pii/S1097276523002435
Mar 2023
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Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 Stabilization and Chromatin Condensation

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  DOI: 10.1158/2767-9764.CRC-22-0255
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9949381/
Feb 2023
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CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance

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  DOI: 10.1016/j.ccell.2023.01.007
  
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sciencedirect.com/science/article/pii/S1535610823000077
Jan 2023
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GOT1 regulates CD8+ effector and memory T cell generation

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  DOI: 10.1016/j.celrep.2022.111987
  
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sciencedirect.com/science/article/pii/S2211124722018915
Sep 2022
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Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance

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  DOI: 10.1016/j.ccell.2022.08.012
  
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sciencedirect.com/science/article/pii/S1535610822003762
Aug 2022
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Knockout of Sirt2 alleviates traumatic brain injury in mice

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  DOI: 10.4103/1673-5374.346457
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9396492/
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Mitochondrial double-stranded RNAs govern the stress response in chondrocytes to promote osteoarthritis development

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  DOI: 10.1016/j.celrep.2022.111178
  
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sciencedirect.com/science/article/pii/S2211124722009913
May 2022
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Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response

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  DOI: 10.1016/j.str.2022.04.006
  
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sciencedirect.com/science/article/pii/S0969212622001332
Mar 2022
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Interleukin-18mediated inflammatory brain injury after intracerebral hemorrhage in male mice

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  DOI: 10.1002/jnr.25044
  
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onlinelibrary.wiley.com/doi/10.1002/jnr.25044
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BPS Publications

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  DOI: 10.1111/bph.15744
  
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Jul 2021
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Salmonella Typhi Colonization Provokes Extensive Transcriptional Changes Aimed at Evading Host Mucosal Immune Defense During Early Infection of Human Intestinal Tissue

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  DOI: 10.1016/j.ebiom.2018.04.005
  
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May 2021
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A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation

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Ectopically expressed olfactory receptors OR51E1 and OR51E2 suppress proliferation and promote cell death in a prostate cancer cell line

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sciencedirect.com/science/article/pii/S0021925821002490
Feb 2021
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Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development

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  DOI: 10.7554/eLife.55263
  
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Jan 2021
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Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation

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  DOI: 10.1016/j.celrep.2020.108635
  
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Cilium Axoneme Internalization and Degradation in Chytrid Fungi

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  DOI: 10.1002/cm.21637
  
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Sep 2020
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Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer

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Jan 2020
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The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma

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  DOI: 10.1016/j.celrep.2019.07.107
  
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Neuroprotective Peptide NAPVSIPQ Antagonizes Ethanol Inhibition of L1 Adhesion by Promoting the Dissociation of L1 and Ankyrin-G

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Immunometabolic Cross-Talk and Regulation of Endocrine and Metabolic Functions: Transgenic overexpression of CTRP3 prevents alcohol-induced hepatic triglyceride accumulation

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Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells

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PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs

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The Monocot-Specific Receptor-like Kinase SDS2 Controls Cell Death and Immunity in Rice

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