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Pharmacologically targeting CDK12 induces BRCAness and synergizes with merestinib to exacerbate DNA damage in high-risk neuroblastoma

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1. scibot 15 Oct 2026
  
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  RRID:AB_2715688
  
  DOI: 10.1016/j.celrep.2026.117997
  
  Resource: (Cell Signaling Technology Cat# 11973, RRID:AB_2715688)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2211124726010752
Sep 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CDK12/13 inhibition overcomes platinum resistance by impairing RNA metabolism

1
1. scibot 10 Sep 2026
  
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  RRID:AB_2715688
  
  DOI: 10.1038/s41392-026-02932-w
  
  Resource: (Cell Signaling Technology Cat# 11973, RRID:AB_2715688)
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13538385/
Feb 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Pre-clinical efficacy of CDK7 inhibitor-based combinations against myeloproliferative neoplasms (MPN) transformed to AML

1
1. scibot 07 Feb 2026
  
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  RRID AB_2715688)
  
  DOI: 10.1182/blood.2024026388
  
  Resource: (Cell Signaling Technology Cat# 11973, RRID:AB_2715688)
  
  Curator: @bandrow
  
  SciCrunch record: RRID:AB_2715688
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11811934/
Nov 2025
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CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability

1
1. scibot 06 Nov 2025
  
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  RRID:AB_2715688
  
  DOI: 10.1016/j.celrep.2025.116495
  
  Resource: (Cell Signaling Technology Cat# 11973, RRID:AB_2715688)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2715688
  
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sciencedirect.com/science/article/pii/S2211124725012665
Jan 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

THOC5 complexes with DDX5, DDX17, and CDK12 to regulate R loop structures and transcription elongation rate

1
1. scibot 06 Jan 2023
  
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  RRID:AB_2715688
  
  DOI: 10.1016/j.isci.2022.105784
  
  Resource: (Cell Signaling Technology Cat# 11973, RRID:AB_2715688)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2715688
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9800341/
Jul 2021
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Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer

1
1. scibot 22 Jul 2021
  
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  RRID:AB_2715688
  
  DOI: 10.1016/j.celrep.2021.109394
  
  Resource: (Cell Signaling Technology Cat# 11973, RRID:AB_2715688)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2715688
  
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sciencedirect.com/science/article/pii/S2211124721007920
Sep 2020
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Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors

1
1. scibot 26 Sep 2020
  
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  RRID:AB_2715688
  
  DOI: 10.1016/j.chembiol.2020.02.003
  
  Resource: (Cell Signaling Technology Cat# 11973, RRID:AB_2715688)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2715688
  
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  RRIDCUR:Validated RRID:AB_2715688
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sciencedirect.com/science/article/pii/S2451945620300672
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation

1
1. scibot 16 Sep 2020
  
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  RRID:AB_2715688
  
  DOI: 10.7554/eLife.59994
  
  Resource: (Cell Signaling Technology Cat# 11973, RRID:AB_2715688)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2715688
  
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  RRIDCUR:Validated RRID:AB_2715688
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ncbi.nlm.nih.gov/pmc/articles/PMC7462607/
Jan 2020
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Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2715688
  
  DOI: 10.1016/j.chembiol.2017.11.007
  
  Resource: (Cell Signaling Technology Cat# 11973, RRID:AB_2715688)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2715688
  
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  RRID:AB_2715688 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2451945617304245
Nov 2018
www.cell.com www.cell.com

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

1
1. scibot 05 Nov 2018
  
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  RRID:AB_2715688
  
  Resource used:
  
  (Cell Signaling Technology Cat# 11973, RRID:AB_2715688)
  
  SciCrunch record: RRID:AB_2715688
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_2715688
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cell.com/cancer-cell/fulltext/S1535-6108(17)30561-5
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Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_2715688
  
  Resource used:
  
  (Cell Signaling Technology Cat# 11973, RRID:AB_2715688)
  
  SciCrunch record: RRID:AB_2715688
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_2715688
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RRID:AB_2715688

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sciencedirect.com/science/article/pii/S0092867418305658