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25 Matching Annotations

Apr 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

α4 Integrin blockade impairs CD8+ T cell neuroimmune surveillance following SIV infection

1
1. scibot 23 Apr 2026
  
  in Public
  
  AB_2716326
  
  DOI: 10.1172/JCI198730
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2716326
  
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  RRID:AB_2716326
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pmc.ncbi.nlm.nih.gov/articles/PMC13078879/
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

IL-21 and anti-α4β7 dual therapy during ART promotes immunological and microbiome responses in SIV-infected macaques

1
1. scibot 09 Apr 2025
  
  in Public
  
  anti-α4β7 mAb
  
  DOI: 10.1172/jci.insight.184491
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @giovanni.decastro
  
  SciCrunch record: RRID:AB_2716326
  
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  RRID:AB_2716326
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pmc.ncbi.nlm.nih.gov/articles/PMC11949015/
Nov 2023
www.science.org www.science.org

Evaluation of an antibody to α4β7 in the control of SIVmac239-nef-stop infection

1
1. scibot 03 Nov 2023
  
  in Public
  
  Summary
  
  DOI: 10.1126/science.aav6695
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
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  RRID:AB_2716326
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scibot

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science.org/doi/10.1126/science.aav6695
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Lack of Therapeutic Efficacy of an Anti-α4β7 Antibody in SIVmac251-Infected Rhesus Macaques

1
1. scibot 03 Nov 2023
  
  in Public
  
  anti-α4β7 antibody (8) (Clone #A4B7, primatized ACT1
  
  DOI: 10.1126/science.aaw8562
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
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  RRID:AB_2716326
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ncbi.nlm.nih.gov/pmc/articles/PMC6768629/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Blocking of α4β7 Gut-Homing Integrin during Acute Infection Leads to Decreased Plasma and Gastrointestinal Tissue Viral Loads in Simian Immunodeficiency Virus-Infected Rhesus Macaques

1
1. scibot 03 Nov 2023
  
  in Public
  
  anti-α4β7
  
  DOI: 10.4049/jimmunol.1003052
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
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  RRID:AB_2716326
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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC3691699/
Oct 2023
www.science.org www.science.org

Evaluation of an antibody to α4β7 in the control of SIVmac239-nef-stop infection

1
1. scibot 25 Oct 2023
  
  in Public
  
  Supplementary
  
  DOI: 10.1126/science.aav6695
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1117, RRID:AB_2716330)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716330
  
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  RRID:AB_2716330 RRID:AB_2819257 RRID:AB_2716326
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RRID:AB_2819257

RRID:AB_2716326

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scibot

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science.org/doi/10.1126/science.aav6695
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Safety and Immunological Evaluation of Interleukin-21 Plus Anti-α4β7 mAb Combination Therapy in Rhesus Macaques

1
1. scibot 25 Oct 2023
  
  in Public
  
  anti-α4β7
  
  DOI: 10.3389/fimmu.2020.01275
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
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  RRID:AB_2716326
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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC7379916/
www.nature.com www.nature.com

Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

1
1. scibot 25 Oct 2023
  
  in Public
  
  anti-α4β7 mAb
  
  DOI: 10.1038/nm.3715
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
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  RRID:AB_2716326
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scibot

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nature.com/articles/nm.3715
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Blocking α4β7 integrin binding to SIV does not improve virologic control

1
1. scibot 25 Oct 2023
  
  in Public
  
  anti-α4β7
  
  DOI: 10.1126/science.aaw7765
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
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  RRID:AB_2716326
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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC9513815/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Preferential Small Intestine Homing and Persistence of CD8 T Cells in Rhesus Macaques Achieved by Molecularly Engineered Expression of CCR9 and Reduced Ex Vivo Manipulation

1
1. scibot 25 Oct 2023
  
  in Public
  
  α4β7 antibody, number PR-1427
  
  DOI: 10.1128/JVI.00896-19
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
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  RRID:AB_2716326
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ncbi.nlm.nih.gov/pmc/articles/PMC6803279/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Rectal Microbiome Composition Correlates with Humoral Immunity to HIV-1 in Vaccinated Rhesus Macaques

1
1. scibot 25 Oct 2023
  
  in Public
  
  anti-α4β7 (Act-1
  
  DOI: 10.1128/mSphere.00824-19
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
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  RRID:AB_2716326
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ncbi.nlm.nih.gov/pmc/articles/PMC6908426/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Oral Coadministration of an Intramuscular DNA/Modified Vaccinia Ankara Vaccine for Simian Immunodeficiency Virus Is Associated with Better Control of Infection in Orally Exposed Infant Macaques

1
1. scibot 25 Oct 2023
  
  in Public
  
  α4β7
  
  DOI: 10.1089/aid.2018.0180
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
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  RRID:AB_2716326
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ncbi.nlm.nih.gov/pmc/articles/PMC6434602/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Experimental Infection of Cynomolgus Macaques (Macaca fascicularis) with Human Varicella-Zoster Virus

1
1. scibot 25 Oct 2023
  
  in Public
  
  α4β7
  
  DOI: 10.1128/JVI.06264-11
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
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  RRID:AB_2716326
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ncbi.nlm.nih.gov/pmc/articles/PMC3302534/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Early treatment with anti-α4β7 antibody facilitates increased gut macrophage maturity in SIV-infected rhesus macaques

1
1. scibot 24 Oct 2023
  
  in Public
  
  anti-α4β7 mAb
  
  DOI: 10.3389/fimmu.2022.1001727
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
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  RRID:AB_2716326
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ncbi.nlm.nih.gov/pmc/articles/PMC9664000/
Jun 2023
insight.jci.org insight.jci.org

IL-21 enhances influenza vaccine responses in aged macaques with suppressed SIV infection

1
1. scibot 15 Jun 2023
  
  in Public
  
  α4β7
  
  DOI: 10.1172/jci.insight.150888
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
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  RRIDCUR:Missing RRID:AB_2716326
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RRID:AB_2716326

RRIDCUR:Missing

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scibot

URL

insight.jci.org/articles/view/150888
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Blocking α4β7 integrin delays viral rebound in SHIVSF162P3-infected macaques treated with anti-HIV broadly neutralizing antibodies

1
1. scibot 15 Jun 2023
  
  in Public
  
  Rh-α4β7
  
  DOI: 10.1126/scitranslmed.abf7201
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
  What is this?
  
  RRIDCUR:Missing RRID:AB_2716326
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RRID:AB_2716326

RRIDCUR:Missing

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8977869/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7

1
1. scibot 14 Jun 2023
  
  in Public
  
  Anti-α4β7
  
  DOI: 10.1371/journal.ppat.1007278
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
  What is this?
  
  RRID:AB_2716326 RRIDCUR:Missing
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RRID:AB_2716326

RRIDCUR:Missing

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6130882/
Apr 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Integrin α4β7 blockade preferentially impacts CCR6+ lymphocyte subsets in blood and mucosal tissues of naive rhesus macaques

1
1. scibot 22 Apr 2023
  
  in Public
  
  Rh-α4β7 antibody (clone Act-1; NIH Nonhuman Primate Reagents Resource center
  
  DOI: 10.4049/jimmunol.1701150
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1422, RRID:AB_2819258)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2819258
  
  What is this?
  
  RRID:AB_2819258 RRID:AB_2716326 RRIDCUR:Missing
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RRID:AB_2819258

RRID:AB_2716326

RRIDCUR:Missing

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URL

ncbi.nlm.nih.gov/pmc/articles/PMC5760460/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3

1
1. scibot 20 Apr 2023
  
  in Public
  
  α4β7 (Act-1, NHP-repository
  
  DOI: 10.1371/journal.ppat.1005720
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
  What is this?
  
  RRIDCUR:Missing RRID:AB_2716326
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RRID:AB_2716326

RRIDCUR:Missing

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC4922556/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Induction of Th1 biased Tfh (Tfh1 cells) in lymphoid tissues during chronic SIV infection defines functionally distinct germinal center Tfh cells

1
1. scibot 20 Apr 2023
  
  in Public
  
  α4β7 (Act1, NHP reagent resource)
  
  DOI: 10.4049/jimmunol.1600143
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
  What is this?
  
  RRIDCUR:Missing RRID:AB_2716326
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RRIDCUR:Missing

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC4992610/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Early Treatment of SIV+ macaques with an α4β7 mAb alters virus distribution and preserves CD4+ T cells in later stages of infection

1
1. scibot 19 Apr 2023
  
  in Public
  
  Anti α4β7 mAb, rhesus IgG mAb and anti-CD4 (Fab)2 provided by the NIH Nonhuman Primate Reagents Resource
  
  DOI: 10.1038/mi.2017.112
  
  Resource: AB_2716330
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716330
  
  What is this?
  
  RRIDCUR:Missing RRID:AB_2716330 RRID:AB_2819255 RRID:AB_2716326
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RRID:AB_2716330

RRID:AB_2716326

RRIDCUR:Missing

RRID:AB_2819255

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC5976508/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Functional MAIT Cells Are Associated With Reduced Simian–Human Immunodeficiency Virus Infection

1
1. scibot 19 Apr 2023
  
  in Public
  
  α4β7 (Act1, NHP reagent resource
  
  DOI: 10.3389/fimmu.2019.03053
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
  What is this?
  
  RRIDCUR:Missing RRID:AB_2716326
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RRID:AB_2716326

RRIDCUR:Missing

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC6978843/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mucosal integrin α4β7 blockade fails to reduce the seeding and size of viral reservoirs in SIV‐infected rhesus macaques

1
1. scibot 18 Apr 2023
  
  in Public
  
  anti‐α4β7 Ab (NHP reagents)
  
  DOI: 10.1096/fj.202002235R
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
  What is this?
  
  RRID:AB_2716326 RRIDCUR:Missing
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RRID:AB_2716326

RRIDCUR:Missing

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7839271/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Blocking α4β7 integrin delays viral rebound in SHIVSF162P3-infected macaques treated with anti-HIV broadly neutralizing antibodies

1
1. scibot 18 Apr 2023
  
  in Public
  
  Rh-α4β7 antibody can be purchased from the Nonhuman Primate Reagent Resource of MassBiologics at www.nhpreagents.org/
  
  DOI: 10.1126/scitranslmed.abf7201
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
  What is this?
  
  RRID:AB_2716326 RRIDCUR:Missing
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RRID:AB_2716326

RRIDCUR:Missing

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8977869/
insight.jci.org insight.jci.org

IL-21 enhances influenza vaccine responses in aged macaques with suppressed SIV infection

1
1. scibot 18 Apr 2023
  
  in Public
  
  α4β7 (A4B7, NHP Reagent Resource
  
  DOI: 10.1172/jci.insight.150888
  
  Resource: (NIH Nonhuman Primate Reagent Resource Cat# PR-1427, RRID:AB_2716326)
  
  Curator: @Apiekniewska
  
  SciCrunch record: RRID:AB_2716326
  
  What is this?
  
  RRID:AB_2716326 RRIDCUR:Missing
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RRID:AB_2716326

RRIDCUR:Missing

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scibot

URL

insight.jci.org/articles/view/150888