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Nuclear localization of the glutaminyl-tRNA synthetase QARS reveals its role in DNA damage response in ovarian cancer

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  DOI: 10.1038/s41467-026-76046-w
  
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Sep 2026
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5-Azacytosine induces cytotoxicity via 5-methylcytosine depletion on chromatin-associated RNA in leukemia

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sciencedirect.com/science/article/pii/S1097276526005873
Aug 2026
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Magnesium Attenuates Renal Senescence and Fibrosis With Reduced <fc>DNA</fc> Damage Response and <fc>H</fc>3<fc>K</fc>4me3 Enrichment at the <fi>p16<sup>INK4a</sup></fi> Promoter

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  DOI: 10.1096/fj.202504665RR
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202504665RR
Jul 2026
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ABL kinase inactivation induces transcription-replication conflicts and impairs replication fork progression in metastatic small cell lung cancer

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Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Anti-tumor Immunity

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aacrjournals.org/cancerres/article/86/5/1252/774876/Antibody-Mediated-Targeting-of-Secretory-Protein
May 2026
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BMAL2 is a druggable target for ovarian clear cell carcinoma (OCCC)

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pmc.ncbi.nlm.nih.gov/articles/PMC13179388/
Apr 2026
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2026.04.20.719456.full-html.html

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54.241.53.176/6790efd246ed84de929dd028ff8d6465bfa7b2e6/2026.04.20.719456.full-html.html
Mar 2026
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PRMT5 is Frequently Upregulated and a Potential Therapeutic Target in MTAP-deficient Malignant Peripheral Nerve Sheath Tumors

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biorxiv.org/content/10.64898/2026.03.09.710638v1
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miR-181d coordinates homologous recombination and anti-tumor immune responses in glioblastoma

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Feb 2026
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Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition

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pmc.ncbi.nlm.nih.gov/articles/PMC12900515/
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The molecular and functional landscape of resistance to FOLFIRI chemotherapy in metastatic colorectal cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12877753/
Nov 2025
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CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability

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  DOI: 10.1016/j.celrep.2025.116495
  
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sciencedirect.com/science/article/pii/S2211124725012665
Sep 2025
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CF10 Displayed Improved Activity Relative to 5-FU in a Mouse CRLM Model Under Conditions of Physiological Folate

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  DOI: 10.3390/cancers17172739
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12427396/
Aug 2025
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Combined MEK and PARP inhibition enhances radiation response in rectal cancer

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  DOI: 10.1016/j.xcrm.2025.102284
  
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sciencedirect.com/science/article/pii/S266637912500357X
Mar 2025
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Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair

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  DOI: 10.1126/sciadv.adt1241
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11900879/
Feb 2025
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Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors

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sciencedirect.com/science/article/pii/S109727652500098X
Dec 2024
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Mapping functional elements of the DNA damage response through base editor screens

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  DOI: 10.1016/j.celrep.2024.115047
  
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sciencedirect.com/science/article/pii/S2211124724013986
Nov 2024
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Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer

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  DOI: 10.1016/j.isci.2024.111283
  
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sciencedirect.com/science/article/pii/S2589004224025082
Sep 2024
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A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib

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sciencedirect.com/science/article/pii/S2666379124004245
Aug 2024
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RAD51 protects abasic sites to prevent replication fork breakage

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Jul 2024
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A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity

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ncbi.nlm.nih.gov/pmc/articles/PMC11238136/
May 2024
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Mechanisms Driving Fasting-Induced Protection from Genotoxic Injury in the Small Intestine

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  DOI: 10.1152/ajpgi.00126.2023
  
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52.53.155.43/930a5a5a8b2489c0ec72d025108e06cc5c87d2d2/deans-fielder-et-al-2024-mechanisms-driving-fasting-induced-protection-from-genotoxic-injury-in-the-small-intestine-html.html
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Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations

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  DOI: 10.1016/j.xcrm.2024.101578
  
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Apr 2024
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RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair

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ncbi.nlm.nih.gov/pmc/articles/PMC10993188/
Feb 2024
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Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection

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sciencedirect.com/science/article/pii/S2211124724001736
Oct 2023
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DNA2 nuclease inhibition confers synthetic lethality in cancers with mutant p53 and synergizes with PARP inhibitors

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  DOI: 10.1158/2767-9764.CRC-23-0166
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10578204/
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Crucial roles of the BRCA1-BARD1 E3 ubiquitin ligase activity in homology-directed DNA repair

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Aug 2023
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L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab

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52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
Apr 2023
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Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity

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  DOI: 10.1158/2326-6066.CIR-22-0056
  
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aacrjournals.org/cancerimmunolres/article/11/3/381/716712/Cancer-Cell-Resistance-to-IFN-Can-Occur-via
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Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models

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1. scibot 21 Apr 2023
  
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  DOI: 10.1158/1078-0432.CCR-22-2977
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10102842/
Dec 2022
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The ADP-ribose hydrolase NUDT5 is important for DNA repair

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  DOI: 10.1016/j.celrep.2022.111866
  
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sciencedirect.com/science/article/pii/S2211124722017624
Nov 2022
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NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step

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  DOI: 10.1016/j.celrep.2022.111600
  
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sciencedirect.com/science/article/pii/S2211124722014656
May 2022
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AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma

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  DOI: 10.1016/j.isci.2022.104398
  
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sciencedirect.com/science/article/pii/S2589004222006691
Jan 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer

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1. scibot 22 Jan 2022
  
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  RRID:AB_2721109
  
  DOI: 10.3390/cancers14020326
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8773906/
Jul 2021
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Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer

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1. scibot 22 Jul 2021
  
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  RRID:AB_2721109
  
  DOI: 10.1016/j.celrep.2021.109394
  
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sciencedirect.com/science/article/pii/S2211124721007920
Sep 2020
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Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection

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1. scibot 23 Sep 2020
  
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  RRID:AB_2721109
  
  DOI: 10.1016/j.celrep.2020.01.052
  
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sciencedirect.com/science/article/pii/S2211124720300772
cancerres.aacrjournals.org cancerres.aacrjournals.org

CoA Synthase (COASY) mediates radiation resistance via PI3K signaling in rectal cancer

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1. scibot 04 Sep 2020
  
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  RRID:AB_2721109
  
  DOI: 10.1158/0008-5472.CAN-19-1161
  
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cancerres.aacrjournals.org/content/80/2/334
Jan 2020
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Stress hormone-mediated acceleration of breast cancer metastasis is halted by inhibition of nitric oxide synthase

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1. scibot 13 Jan 2020
  
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  RRID:AB_2721109
  
  DOI: 10.1016/j.canlet.2019.05.027
  
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Nov 2018
www.cell.com www.cell.com

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

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1. scibot 05 Nov 2018
  
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cell.com/cancer-cell/fulltext/S1535-6108(17)30561-5
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Systematic Functional Annotation of Somatic Mutations in Cancer

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1. scibot 05 Nov 2018
  
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  RRID:AB_2721109
  
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sciencedirect.com/science/article/pii/S1535610818300217