34 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12900515/
  3. Feb 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The molecular and functional landscape of resistance to FOLFIRI chemotherapy in metastatic colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12877753/
  5. Nov 2025
  6. www.sciencedirect.com www.sciencedirect.com
    CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability
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    sciencedirect.com/science/article/pii/S2211124725012665
  7. Sep 2025
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CF10 Displayed Improved Activity Relative to 5-FU in a Mouse CRLM Model Under Conditions of Physiological Folate
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    pmc.ncbi.nlm.nih.gov/articles/PMC12427396/
  9. Aug 2025
  10. www.sciencedirect.com www.sciencedirect.com
    Combined MEK and PARP inhibition enhances radiation response in rectal cancer
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    sciencedirect.com/science/article/pii/S266637912500357X
  11. Mar 2025
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair
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    pmc.ncbi.nlm.nih.gov/articles/PMC11900879/
  13. Feb 2025
  14. www.sciencedirect.com www.sciencedirect.com
    Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors
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    sciencedirect.com/science/article/pii/S109727652500098X
  15. Dec 2024
  16. www.sciencedirect.com www.sciencedirect.com
    Mapping functional elements of the DNA damage response through base editor screens
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    sciencedirect.com/science/article/pii/S2211124724013986
  17. Nov 2024
  18. www.sciencedirect.com www.sciencedirect.com
    Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer
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    sciencedirect.com/science/article/pii/S2589004224025082
  19. Sep 2024
  20. www.sciencedirect.com www.sciencedirect.com
    A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib
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    sciencedirect.com/science/article/pii/S2666379124004245
  21. Aug 2024
  22. www.sciencedirect.com www.sciencedirect.com
    RAD51 protects abasic sites to prevent replication fork breakage
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    sciencedirect.com/science/article/pii/S109727652400580X
  23. Jul 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11238136/
  25. May 2024
  26. 52.53.155.43 52.53.155.43
    Mechanisms Driving Fasting-Induced Protection from Genotoxic Injury in the Small Intestine
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    52.53.155.43/930a5a5a8b2489c0ec72d025108e06cc5c87d2d2/deans-fielder-et-al-2024-mechanisms-driving-fasting-induced-protection-from-genotoxic-injury-in-the-small-intestine-html.html
  27. www.sciencedirect.com www.sciencedirect.com
    Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations
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    sciencedirect.com/science/article/pii/S2666379124002702
  28. Apr 2024
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC10993188/
  30. Feb 2024
  31. www.sciencedirect.com www.sciencedirect.com
    Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection
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    sciencedirect.com/science/article/pii/S2211124724001736
  32. Oct 2023
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DNA2 nuclease inhibition confers synthetic lethality in cancers with mutant p53 and synergizes with PARP inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10578204/
  34. www.sciencedirect.com www.sciencedirect.com
    Crucial roles of the BRCA1-BARD1 E3 ubiquitin ligase activity in homology-directed DNA repair
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    sciencedirect.com/science/article/abs/pii/S1097276523007347
  35. Aug 2023
  36. 52.53.155.43 52.53.155.43
    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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    52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
  37. Apr 2023
  38. aacrjournals.org aacrjournals.org
    Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
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    aacrjournals.org/cancerimmunolres/article/11/3/381/716712/Cancer-Cell-Resistance-to-IFN-Can-Occur-via
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
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    ncbi.nlm.nih.gov/pmc/articles/PMC10102842/
  40. Dec 2022
  41. www.sciencedirect.com www.sciencedirect.com
    The ADP-ribose hydrolase NUDT5 is important for DNA repair
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    sciencedirect.com/science/article/pii/S2211124722017624
  42. Nov 2022
  43. www.sciencedirect.com www.sciencedirect.com
    NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step
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    sciencedirect.com/science/article/pii/S2211124722014656
  44. May 2022
  45. www.sciencedirect.com www.sciencedirect.com
    AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma
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    sciencedirect.com/science/article/pii/S2589004222006691
  46. Jan 2022
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC8773906/
  48. Jul 2021
  49. www.sciencedirect.com www.sciencedirect.com
    Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer
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    sciencedirect.com/science/article/pii/S2211124721007920
  50. Sep 2020
  51. www.sciencedirect.com www.sciencedirect.com
    Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection
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    sciencedirect.com/science/article/pii/S2211124720300772
  52. cancerres.aacrjournals.org cancerres.aacrjournals.org
    CoA Synthase (COASY) mediates radiation resistance via PI3K signaling in rectal cancer
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    cancerres.aacrjournals.org/content/80/2/334
  53. Jan 2020
  54. www.sciencedirect.com www.sciencedirect.com
    Stress hormone-mediated acceleration of breast cancer metastasis is halted by inhibition of nitric oxide synthase
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    sciencedirect.com/science/article/pii/S0304383519303222
  55. Nov 2018
  56. www.cell.com www.cell.com
    EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma
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    cell.com/cancer-cell/fulltext/S1535-6108(17)30561-5
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Systematic Functional Annotation of Somatic Mutations in Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC5926201/