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Single-cell and spatial multi-omics reveal a recurrent multicellular niche at the tumor-stroma interface in multidrug resistance

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1. scibot 17 Sep 2026
  
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  DOI: 10.1016/j.xcrm.2026.103052
  
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sciencedirect.com/science/article/pii/S2666379126004696
Jul 2026
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GABA promotes resistance to immunotherapy in patients with TLS-positive tumors

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1. scibot 11 Jul 2026
  
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  DOI: 10.1016/j.ccell.2026.06.006
  
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sciencedirect.com/science/article/pii/S153561082600293X
Jun 2026
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Tumor cells metabolically resist immune-checkpoint therapy by macrophage efferocytosis-mediated fatty acid recycling

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1. scibot 09 Jun 2026
  
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  DOI: 10.1016/j.ccell.2026.05.005
  
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sciencedirect.com/science/article/pii/S1535610826002503
May 2026
onlinelibrary.wiley.com onlinelibrary.wiley.com

Reduced SH3RF3 May Protect Against Alzheimer's Disease by Lowering Microglial Pro-Inflammatory Responses via Modulation of JNK and NFkB Signaling

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1. scibot 28 May 2026
  
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  DOI: 10.1002/glia.70165
  
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onlinelibrary.wiley.com/doi/10.1002/glia.70165
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Secreted GPNMB enhances uptake of fibrillar alpha-synuclein in a non-cell-autonomous process that can be blocked by anti-GPNMB antibodies

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1. scibot 13 May 2026
  
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  DOI: 10.1016/j.neuron.2026.04.033
  
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sciencedirect.com/science/article/pii/S0896627326003284
Apr 2026
www.biorxiv.org www.biorxiv.org

2026.04.09.717238.full-html.html

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1. scibot 17 Apr 2026
  
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  DOI: 10.64898/2026.04.09.717238
  
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biorxiv.org/content/10.64898/2026.04.09.717238v1
Dec 2025
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The Alzheimer’s disease risk genes MS4A4A and MS4A6A cooperate to negatively regulate TREM2 and microglia states

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.neuron.2025.11.022
  
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sciencedirect.com:5037/science/article/pii/S0896627325008955
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A dysregulated hepcidin-iron axis impairs antiviral immunity and induces lethal liver pathology in neonates

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1. scibot 09 Dec 2025
  
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  DOI: 10.1016/j.immuni.2025.11.001
  
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sciencedirect.com:5037/science/article/pii/S1074761325005035
Nov 2025
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Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.cell.2025.10.030
  
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sciencedirect.com/science/article/pii/S0092867425012358
Oct 2025
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The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function

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1. scibot 18 Oct 2025
  
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  DOI: 10.1016/j.neuron.2025.09.032
  
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sciencedirect.com/science/article/pii/S0896627325007457
Jun 2025
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Cytokine-induced reprogramming of human macrophages toward Alzheimer’s disease-relevant molecular and cellular phenotypes in vitro

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115909
  
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sciencedirect.com/science/article/pii/S2211124725006801
Jan 2025
alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com

Roles of blood monocytes carrying TREM2R47H mutation in pathogenesis of Alzheimer's disease and its therapeutic potential in APP/PS1 mice

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1. scibot 05 Jan 2025
  
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  DOI: 10.1002/alz.14402
  
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alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.14402
Oct 2024
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Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

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1. scibot 02 Oct 2024
  
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  AB_2721119
  
  DOI: 10.1016/j.neuron.2024.09.006
  
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sciencedirect.com/science/article/pii/S0896627324006548
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer

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1. scibot 22 Aug 2024
  
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  DOI: 10.1186/s13046-024-03124-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11321020/
Apr 2024
aacrjournals.org aacrjournals.org

Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary

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1. scibot 19 Apr 2024
  
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  DOI: 10.1158/2159-8290.CD-23-0299
  
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aacrjournals.org/cancerdiscovery/article/13/12/2610/731625/Spatial-and-Temporal-Mapping-of-Breast-Cancer-Lung
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SHIP inhibition mediates select TREM2-induced microglial functions

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1. scibot 16 Apr 2024
  
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  RRID:AB_2721119
  
  DOI: 10.1016/j.molimm.2024.04.002
  
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sciencedirect.com/science/article/pii/S0161589024000725
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias

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1. scibot 16 Mar 2024
  
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  DOI: 10.1038/s44319-024-00077-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10933458/
Feb 2024
www.embopress.org www.embopress.org

Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer’s and related dementias

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1. scibot 15 Feb 2024
  
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  RRID:AB_2721119
  
  DOI: 10.1038/s44319-024-00077-x
  
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embopress.org/doi/10.1038/s44319-024-00077-x
Dec 2023
52.53.155.43 52.53.155.43

cd-23-0299-html.html

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1. scibot 01 Dec 2023
  
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  DOI: 10.1158/2159-8290.cd-23-0299
  
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52.53.155.43/2b6c279d82b7a0e0d491057f5790a1189e93077e/cd-23-0299-html.html
Mar 2023
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Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer

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1. scibot 03 Mar 2023
  
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  DOI: 10.1016/j.ccell.2023.02.004
  
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sciencedirect.com/science/article/pii/S1535610823000326
Jan 2023
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Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development

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1. scibot 28 Jan 2023
  
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  DOI: 10.1016/j.immuni.2022.11.013
  
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sciencedirect.com/science/article/pii/S1074761322006033
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Time-dependent and selective microglia-mediated removal of spinal synapses in neuropathic pain

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1. scibot 19 Jan 2023
  
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  DOI: 10.1016/j.celrep.2023.112010
  
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sciencedirect.com/science/article/pii/S2211124723000219
May 2021
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Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages

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1. scibot 21 May 2021
  
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  Rabbit anti-human TREM2, clone D8I4C
  
  DOI: 10.1016/j.cell.2021.04.038
  
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sciencedirect.com/science/article/pii/S0092867421005730
Nov 2018
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APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S0896627318303805
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TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S0896627318300564