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Small-molecule enhancement of METTL3 S-palmitoylation as a therapeutic strategy for osteoarthritis

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1. scibot 20 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.116993
  
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sciencedirect.com/science/article/pii/S2211124726000719
Jan 2026
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N(6)-methyladenosine modification of RNA is regulated by senataxin and E6 to control HPV replication

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1. scibot 13 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116828
  
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sciencedirect.com/science/article/pii/S2211124725016006
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

METTL3 inhibits osteoporosis by promoting osteoblast differentiation through m6A-mediated activation of the FZD3/RUNX1 signaling axis

1
1. scibot 20 Nov 2025
  
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  DOI: 10.1186/s40001-025-03392-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12625130/
Oct 2025
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N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells

1
1. scibot 30 Oct 2025
  
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  DOI: 10.1016/j.stem.2025.10.003
  
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sciencedirect.com/science/article/pii/S1934590925003716
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Arsenic regulates ALKBH1 abundance and substrate specificity to promote translation and tumorigenicity

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1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116311
  
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sciencedirect.com/science/article/pii/S2211124725010824
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia

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1. scibot 04 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.115618
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12219090/
Jun 2025
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SSB cooperates with METTL16-mediated m6A RNA methylation to promote chemoresistance in colorectal cancer cells

1
1. scibot 28 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115926
  
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sciencedirect.com/science/article/pii/S2211124725006977
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Hyperacute response proteins synthesized on γ-tubulin-FTO-MARK4 translation microdomains regulate cancer’s acute stress response

1
1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115871
  
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sciencedirect.com/science/article/pii/S2211124725006424
Mar 2025
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Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin

1
1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.molcel.2025.02.016
  
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sciencedirect.com/science/article/pii/S1097276525001479
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

METTL3/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma

1
1. scibot 21 Dec 2024
  
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  DOI: 10.1038/s44318-024-00299-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11649786/
Oct 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

1
1. scibot 02 Oct 2024
  
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  DOI: 10.4103/NRR.NRR-D-23-01592
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11433901/
Sep 2024
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m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.08.040
  
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sciencedirect.com/science/article/pii/S0092867424009693
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C2H2-zinc-finger transcription factors bind RNA and function in diverse post-transcriptional regulatory processes

1
1. scibot 25 Sep 2024
  
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  AB_2721254
  
  DOI: 10.1016/j.molcel.2024.08.037
  
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sciencedirect.com/science/article/pii/S1097276524007330
Aug 2024
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Epitranscriptomic reader YTHDF2 regulates SEK1(MAP2K4)-JNK-cJUN inflammatory signaling in astrocytes during neurotoxic stress

1
1. scibot 23 Aug 2024
  
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  DOI: 10.1016/j.isci.2024.110619
  
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sciencedirect.com/science/article/pii/S2589004224018443
www.cell.com www.cell.com

Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11

1
1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.cmet.2024.07.014
  
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cell.com/cell-metabolism/fulltext/S1550-4131(24)00285-7
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Anticancer effects of Erzhimaoling decoction in high-grade serous ovarian cancer in vitro and in vivo

1
1. scibot 19 Aug 2024
  
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  DOI: 10.1186/s40001-024-01968-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11299366/
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METTL3 regulates cartilage development and homeostasis by affecting Lats1 mRNA stability in an m6A-YTHDF2-dependent manner

1
1. scibot 18 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114535
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00864-7
Jul 2024
www.cell.com www.cell.com

m6A modification inhibits miRNAs’ intracellular function, favoring their extracellular export for intercellular communication

1
1. scibot 18 Jul 2024
  
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  RRID:AB_2721254
  
  DOI: 10.1016/j.celrep.2024.114369
  
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cell.com/cell-reports/abstract/S2211-1247(24)00697-1
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration

1
1. scibot 07 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.113999
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11216409/
May 2024
www.cell.com www.cell.com

Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation

2
1. scibot 03 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114165
  
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2. scibot 03 May 2024
  
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  AB_2721254
  
  DOI: 10.1016/j.celrep.2024.114165
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00493-5
Apr 2024
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DDX21 mediates co-transcriptional RNA m6A modification to promote transcription termination and genome stability

2
1. scibot 04 Apr 2024
  
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  DOI: 10.1016/j.molcel.2024.03.006
  
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2. scibot 04 Apr 2024
  
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  DOI: 10.1016/j.molcel.2024.03.006
  
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sciencedirect.com/science/article/pii/S1097276524001886
Mar 2024
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YTHDF1-CLOCK axis contributes to pathogenesis of allergic airway inflammation through LLPS

1
1. scibot 19 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113947
  
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sciencedirect.com/science/article/pii/S2211124724002754
Sep 2023
journals.physiology.org journals.physiology.org

Methyltransferase-like 3 facilitates the stem cell properties of esophageal cancer by upregulating patched homolog 1 via N6-methyladenosine methylation

1
1. scibot 14 Sep 2023
  
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  DOI: 10.1152/ajpcell.00136.2023
  
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journals.physiology.org/doi/10.1152/ajpcell.00136.2023
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Reinvestigating the clinical relevance of the m6A writer METTL3 in urothelial carcinoma of the bladder

1
1. scibot 09 Aug 2023
  
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  RRID:AB_2721254
  
  DOI: 10.1016/j.isci.2023.107300
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10405067/
Jul 2023
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ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway

1
1. scibot 13 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112779
  
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sciencedirect.com/science/article/pii/S2211124723007908
Jun 2023
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QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism

1
1. scibot 28 Jun 2023
  
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  DOI: 10.1016/j.cell.2023.05.047
  
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sciencedirect.com/science/article/pii/S0092867423005986
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Loss of Mettl3 enhances liver tumorigenesis by inducing hepatocyte dedifferentiation and hyperproliferation

1
1. scibot 28 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112704
  
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sciencedirect.com/science/article/pii/S2211124723007155
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METTL3-mediated m6A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis

1
1. scibot 07 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112589
  
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sciencedirect.com/science/article/pii/S2211124723006009
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Mettl3-m6A-Creb1 forms an intrinsic regulatory axis in maintaining iNKT cell pool and functional differentiation

1
1. scibot 03 Jun 2023
  
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  RRID: AB_2721254
  
  DOI: 10.1016/j.celrep.2023.112584
  
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sciencedirect.com/science/article/pii/S2211124723005958
Dec 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

m6A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina

1
1. scibot 06 Dec 2022
  
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  DOI: 10.7554/eLife.79994
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9718531/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TWIK-related acid-sensitive K+ channel 2 promotes renal fibrosis by inducing cell cycle arrest

1
1. scibot 03 Dec 2022
  
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  DOI: 10.1016/j.isci.2022.105620
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9712759/
Oct 2022
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METTL3 regulates m6A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma

1
1. scibot 26 Oct 2022
  
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  AB_2721254
  
  DOI: 10.1016/j.celrep.2022.111530
  
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sciencedirect.com/science/article/pii/S2211124722013869
May 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Methyltransferase-Like 3 Rescues the Amyloid-beta protein-Induced Reduction of Activity-Regulated Cytoskeleton Associated Protein Expression via YTHDF1-Dependent N6-Methyladenosine Modification

1
1. scibot 11 May 2022
  
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  RRID:AB_2721254
  
  DOI: 10.3389/fnagi.2022.890134
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9084913/
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The Mettl3 epitranscriptomic writer amplifies p53 stress responses

1
1. scibot 05 May 2022
  
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  RRID:AB_2721254
  
  DOI: 10.1016/j.molcel.2022.04.010
  
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sciencedirect.com/science/article/pii/S1097276522003215
Mar 2022
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Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

1
1. scibot 26 Mar 2022
  
  in Public
  
  RRID:AB_2721254
  
  DOI: 10.1016/j.molcel.2022.02.033
  
  Resource: (Abcam Cat# ab195352, RRID:AB_2721254)
  
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sciencedirect.com/science/article/pii/S1097276522002076
Nov 2021
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HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease

1
1. scibot 30 Nov 2021
  
  in Public
  
  RRID:AB_2721254
  
  DOI: 10.1016/j.molcel.2021.10.028
  
  Resource: (Abcam Cat# ab195352, RRID:AB_2721254)
  
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sciencedirect.com/science/article/pii/S1097276521009485
Jun 2021
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

1
1. scibot 15 Jun 2021
  
  in Public
  
  ab195352
  
  DOI: 10.1002/2211-5463.13165
  
  Resource: (Abcam Cat# ab195352, RRID:AB_2721254)
  
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febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.13165
May 2021
www.cell.com www.cell.com

The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth

1
1. scibot 21 May 2021
  
  in Public
  
  RRID:AB_2721254
  
  DOI: 10.1016/j.ccell.2021.04.016
  
  Resource: (Abcam Cat# ab195352, RRID:AB_2721254)
  
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cell.com/cancer-cell/fulltext/S1535-6108(21)00224-5
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A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting

1
1. scibot 09 May 2021
  
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  RRID:AB_2721254
  
  DOI: 10.1016/j.stem.2021.01.007
  
  Resource: (Abcam Cat# ab195352, RRID:AB_2721254)
  
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sciencedirect.com/science/article/pii/S1934590921000072
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Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation

1
1. scibot 08 May 2021
  
  in Public
  
  RRID:AB_2721254
  
  DOI: 10.1016/j.molcel.2020.10.026
  
  Resource: (Abcam Cat# ab195352, RRID:AB_2721254)
  
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sciencedirect.com/science/article/pii/S1097276520307334
Apr 2021
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A methionine-Mettl3-N6-methyladenosine axis promotes polycystic kidney disease

1
1. scibot 14 Apr 2021
  
  in Public
  
  RRID:AB_2721254
  
  DOI: 10.1016/j.cmet.2021.03.024
  
  Resource: (Abcam Cat# ab195352, RRID:AB_2721254)
  
  Curator: @Naa003
  
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  RRID:AB_2721254 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1550413121001315
Dec 2020
onlinelibrary.wiley.com onlinelibrary.wiley.com

Epitranscriptomic m6A regulation following spinal cord injury

1
1. scibot 08 Dec 2020
  
  in Public
  
  RRID:AB_2721254
  
  DOI: 10.1002/jnr.24763
  
  Resource: (Abcam Cat# ab195352, RRID:AB_2721254)
  
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  RRIDCUR:Validated RRID:AB_2721254
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onlinelibrary.wiley.com/doi/10.1002/jnr.24763
Oct 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

m6A RNA methylation impacts fate choices during skin morphogenesis

1
1. scibot 13 Oct 2020
  
  in Public
  
  RRID:AB_2721254
  
  DOI: 10.7554/eLife.56980
  
  Resource: (Abcam Cat# ab195352, RRID:AB_2721254)
  
  Curator: @evieth
  
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  RRID:AB_2721254 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC7535931/
Sep 2020
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Modulation of circRNA Metabolism by m6A Modification

1
1. scibot 16 Sep 2020
  
  in Public
  
  RRID:AB_2721254
  
  DOI: 10.1016/j.celrep.2020.107641
  
  Resource: (Abcam Cat# ab195352, RRID:AB_2721254)
  
  Curator: @ethanbadger
  
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  RRID:AB_2721254 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720305945
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METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation

1
1. scibot 10 Sep 2020
  
  in Public
  
  RRID:AB_2721254
  
  DOI: 10.1016/j.molcel.2020.06.017
  
  Resource: (Abcam Cat# ab195352, RRID:AB_2721254)
  
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sciencedirect.com/science/article/pii/S1097276520304020
Jan 2020
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Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2721254
  
  DOI: 10.1016/j.molcel.2019.06.001
  
  Resource: (Abcam Cat# ab195352, RRID:AB_2721254)
  
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sciencedirect.com/science/article/pii/S1097276519304344
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N6-Methyladenosine Modification Controls Circular RNA Immunity

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2721254
  
  DOI: 10.1016/j.molcel.2019.07.016
  
  Resource: (Abcam Cat# ab195352, RRID:AB_2721254)
  
  Curator: @ethanbadger
  
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  RRID:AB_2721254 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276519305465
Nov 2018
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Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_2721254
  
  Curator: @Jmenke
  
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  (Abcam Cat# ab195352, RRID:AB_2721254)
  
  SciCrunch record: RRID:AB_2721254
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
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  RRID:AB_2721254 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276518301345