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Bioengineering mini-colons for ex vivo colorectal cancer research

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1. scibot 06 Dec 2025
  
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  DOI: 10.1038/s41596-025-01292-z
  
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nature.com/articles/s41596-025-01292-z
Nov 2025
www.biorxiv.org www.biorxiv.org

The antiviral Interferon pathway drives astrocyte aging and motor decline

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1. scibot 18 Nov 2025
  
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  DOI: 10.1101/2025.11.12.688147
  
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biorxiv.org/content/10.1101/2025.11.12.688147v1
Oct 2025
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BST2 expression at astrocyte borders promotes microglial recruitment via the C3/C3aR signaling

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1. scibot 28 Oct 2025
  
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  DOI: 10.1016/j.neuron.2025.09.038
  
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sciencedirect.com/science/article/pii/S0896627325007512
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional deficits in Down syndrome

1
1. scibot 19 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116300
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12591093/
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Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling

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1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.cell.2025.08.023
  
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sciencedirect.com/science/article/pii/S009286742500978X
Aug 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225015962-main-html.html

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1. scibot 12 Aug 2025
  
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  AB_2728660
  
  DOI: 10.1016/j.isci.2025.113335
  
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52.53.155.43/1929f01baa91ec4dd41d4abcfe59a4f9a16b0a93/1-s2.0-S2589004225015962-main-html.html
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Chemical reprogramming of human blood cells to pluripotent stem cells

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1. scibot 05 Aug 2025
  
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  DOI: 10.1016/j.stem.2025.07.003
  
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cell.com/cell-stem-cell/abstract/S1934-5909(25)00260-7
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Distribution and morphological features of astrocytes and Purkinje cells in the human cerebellum

1
1. scibot 22 Jul 2025
  
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  DOI: 10.3389/fnana.2025.1592671
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12271190/
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CLDN4 palmitoylation promotes hepatic-to-biliary lineage transition and lenvatinib resistance in hepatocellular carcinoma

1
1. scibot 01 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102208
  
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sciencedirect.com/science/article/pii/S2666379125002812
Jun 2025
journals.lww.com journals.lww.com

M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury

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1. scibot 28 Jun 2025
  
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  DOI: 10.4103/1673-5374.324858
  
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journals.lww.com/nrronline/fulltext/2022/05000/m1_type_microglia_can_induce_astrocytes_to_deposit.34.aspx
pubs.acs.org pubs.acs.org

HIF-1α Stabilization Hampers the Chondrogenic Differentiation of Aged Bone Marrow Mesenchymal Stem Cells by Adenosine A2A/A2B Receptors Imbalance

1
1. scibot 28 Jun 2025
  
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  DOI: 10.1021/acsptsci.5c00190
  
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pubs.acs.org/doi/full/10.1021/acsptsci.5c00190
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis

1
1. scibot 23 Jun 2025
  
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  DOI: 10.1186/s13024-025-00864-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12181884/
www.cell.com www.cell.com

Hexokinase 2 interacts with PINK1 to facilitate mitophagy in astrocytes and restrain inflammation-induced neurotoxicity

1
1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115809
  
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cell.com/cell-reports/abstract/S2211-1247(25)00580-7
May 2025
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Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

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1. scibot 20 May 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-1388
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11534540/
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Inflammasome signaling in astrocytes modulates hippocampal plasticity

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.immuni.2025.04.007
  
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sciencedirect.com/science/article/pii/S1074761325001700
Feb 2025
52.53.155.43 52.53.155.43

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis

1
1. scibot 06 Feb 2025
  
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  RRID:AB_2728660
  
  DOI: 10.1101/2024.09.09.611621
  
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52.53.155.43/ccdd8f2b9b0076ccdaf42c273b248e5adbb5da1d/2024.09.09.611621v1.full-html.html
Dec 2024
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Generation of self-organized neuromusculoskeletal tri-tissue organoids from human pluripotent stem cells

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1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.stem.2024.11.005
  
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sciencedirect.com/science/article/pii/S1934590924004041
Nov 2024
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Generation of self-renewing neuromesodermal progenitors with neuronal and skeletal muscle bipotential from human embryonic stem cells

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1. scibot 17 Nov 2024
  
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  DOI: 10.1016/j.crmeth.2024.100897
  
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sciencedirect.com/science/article/pii/S266723752400287X
Oct 2024
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A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration

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1. scibot 02 Oct 2024
  
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  DOI: 10.1016/j.stem.2024.09.001
  
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sciencedirect.com/science/article/pii/S1934590924003151
Sep 2024
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IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.cmet.2024.08.012
  
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sciencedirect.com/science/article/pii/S1550413124003644
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Decoding the pathogenesis of spermatogenic failure in cryptorchidism through single-cell transcriptomic profiling

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1. scibot 04 Sep 2024
  
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  DOI: 10.1016/j.xcrm.2024.101709
  
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sciencedirect.com/science/article/pii/S2666379124004300
Jul 2024
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Very long-chain fatty acids control peroxisome dynamics via a feedback loop in intestinal stem cells during gut regeneration

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1. scibot 24 Jul 2024
  
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  DOI: 10.1016/j.devcel.2024.06.020
  
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sciencedirect.com/science/article/pii/S1534580724003988
May 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer

1
1. scibot 24 May 2024
  
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  DOI: 10.1016/j.ccell.2024.05.003
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11186085/
Apr 2024
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Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids

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1. scibot 02 Apr 2024
  
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  DOI: 10.1016/j.stem.2024.03.007
  
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sciencedirect.com/science/article/pii/S1934590924000894
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SOX2 and SOX9 Expression in Developing Postnatal Opossum (Monodelphis domestica) Cortex

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  DOI: 10.3390/biom14010070
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10813269/
www.nature.com www.nature.com

A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs

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  DOI: 10.1038/s41698-024-00500-5
  
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  DOI: 10.1038/s41698-024-00500-5
  
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nature.com/articles/s41698-024-00500-5
Dec 2023
aacrjournals.org aacrjournals.org

Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma

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1. scibot 30 Dec 2023
  
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  DOI: 10.1158/0008-5472.CAN-22-2108
  
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aacrjournals.org/cancerres/article/82/24/4586/711513/Dormant-SOX9-Positive-Cells-Facilitate-MYC-Driven
Nov 2023
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Mechanical overloading leads to chondrocyte degeneration and senescence via Zmpste24 mediated nuclear membrane instability

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  DOI: 10.1016/j.isci.2023.108119
  
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  DOI: 10.1016/j.isci.2023.108119
  
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sciencedirect.com/science/article/pii/S258900422302196X
Oct 2023
www.cell.com www.cell.com

Single-cell transcriptome profiling reveals immune and stromal cell heterogeneity in primary Sjögren’s syndrome

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1. scibot 06 Oct 2023
  
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  DOI: 10.1016/j.isci.2023.107943
  
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cell.com/iscience/abstract/S2589-0042(23)02020-5
Sep 2023
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Protocol for the purification and transcriptomic analysis of mouse astrocytes using GFAT

1
1. scibot 30 Sep 2023
  
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  DOI: 10.1016/j.xpro.2023.102599
  
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sciencedirect.com/science/article/pii/S266616672300566X
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Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis

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1. scibot 29 Sep 2023
  
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  DOI: 10.1016/j.stem.2023.07.002
  
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sciencedirect.com/science/article/pii/S1934590923002473
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Mitoquinone alleviates osteoarthritis progress by activating the NRF2-Parkin axis

1
1. scibot 07 Sep 2023
  
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  DOI: 10.1016/j.isci.2023.107647
  
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sciencedirect.com/science/article/pii/S2589004223017248
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Rat post-implantation epiblast-derived pluripotent stem cells produce functional germ cells

1
1. scibot 07 Sep 2023
  
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  DOI: 10.1016/j.crmeth.2023.100542
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10475792/
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Novel human pluripotent stem cell-derived hypothalamus organoids demonstrate cellular diversity

1
1. scibot 31 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107525
  
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Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice

1
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  DOI: 10.1016/j.stem.2023.07.016
  
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Bioengineered human tissue regeneration and repair using endogenous stem cells

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Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

1
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MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice

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  DOI: 10.1038/s41536-023-00310-6
  
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Jun 2023
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Photobiomodulation inhibits the expression of chondroitin... : Neural Regeneration Research

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Mettl14-mediated m6A modification ensures the cell-cycle progression of late-born retinal progenitor cells

1
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  DOI: 10.1016/j.celrep.2023.112596
  
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May 2023
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Ex utero monkey embryogenesis from blastocyst to early organogenesis

1
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  DOI: 10.1016/j.cell.2023.04.020
  
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Apr 2023
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Hic1 identifies a specialized mesenchymal progenitor population in the embryonic limb responsible for bone superstructure formation

1
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Mar 2023
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Inhibition of karyopherin β1-mediated nuclear import disrupts oncogenic lineage- defining transcription factor activity in small cell lung cancer

1
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  DOI: 10.1158/0008-5472.CAN-21-3713
  
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Feb 2023
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Lymphatic vessels in bone support regeneration after injury

1
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Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET

1
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ARID1A loss in pancreas leads to islet developmental defect and metabolic disturbance

1
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Dec 2022
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Single-cell RNA sequencing uncovers dynamic roadmap and cell-cell communication during buffalo spermatogenesis

1
1. scibot 30 Dec 2022
  
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  DOI: 10.1016/j.isci.2022.105733
  
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Nov 2022
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Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair

1
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  DOI: 10.1016/j.celrep.2022.111610
  
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Transcription factor Hb9 is expressed in glial cell lineages in the developing mouse spinal cord

1
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  DOI: 10.1523/ENEURO.0214-22.2022
  
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Oct 2022
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KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice

1
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Jul 2022
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can-21-3713-html.html

1
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  DOI: 10.1158/0008-5472.CAN-21-3713
  
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MicroRNA-22-3p ameliorates Alzheimer’s disease by targeting SOX9 through the NF-κB signaling pathway in the hippocampus

1
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  DOI: 10.1186/s12974-022-02548-1
  
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Lymphatics act as a signaling hub to regulate intestinal stem cell activity

1
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Single-cell analysis of human testis aging and correlation with elevated body mass index

1
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  DOI: 10.1016/j.devcel.2022.04.004
  
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Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer’s disease

1
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  DOI: 10.1016/j.neuron.2022.03.008
  
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Mar 2022
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Stem cell differentiation with consistent lineage commitment induced by a flash of ultrafast-laser activation in vitro and in vivo

1
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  DOI: 10.1016/j.celrep.2022.110486
  
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Feb 2022
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Hypermethylation of miR-145 promoter-mediated SOX9-CLDN8 pathway regulates intestinal mucosal barrier in Crohn's disease

2
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  DOI: 10.1016/j.ebiom.2022.103846
  
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  DOI: 10.1016/j.ebiom.2022.103846
  
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Dec 2021
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SDF-1 inhibits the dedifferentiation of islet β cells in hyperglycaemia by up-regulating FoxO1 via binding to CXCR4

1
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  DOI: 10.1111/jcmm.17110
  
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Oct 2021
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Renal Subcapsular Delivery of PGE2 Promotes Kidney Repair by Activating Endogenous Sox9+ Stem Cells

1
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  DOI: 10.1016/j.isci.2021.103243
  
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Activity-dependent modulation of synapse-regulating genes in astrocytes

1
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  DOI: 10.7554/eLife.70514
  
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Sep 2021
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Generation and differentiation of chemically derived hepatic progenitors from mouse primary hepatocytes

1
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  DOI: 10.1016/j.xpro.2021.100840
  
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Aug 2021
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Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads

1
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  DOI: 10.1083/jcb.202103003
  
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Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

1
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  DOI: 10.7554/eLife.68603
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8318592/
May 2021
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Kindlin-3 Mutation in Mesenchymal Stem Cells Results in Enhanced Chondrogenesis

1
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  DOI: 10.1016/j.yexcr.2020.112456
  
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Adenine base editing and prime editing of chemically derived hepatic progenitors rescue genetic liver disease

1
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  DOI: 10.1016/j.stem.2021.04.010
  
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Apr 2021
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Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

1
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  DOI: 10.1016/j.ccell.2021.02.007
  
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Sep 2020
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Smooth Muscle Cell Reprogramming in Aortic Aneurysms

1
1. scibot 16 Sep 2020
  
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  DOI: 10.1016/j.stem.2020.02.013
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7182079/
Jan 2020
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The Dynamic Transcriptional Cell Atlas of Testis Development during Human Puberty

1
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  DOI: 10.1016/j.stem.2019.12.005
  
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Untitled document

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  DOI: 10.1016/j.celrep.2019.01.079
  
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sciencedirect.com/science/article/pii/S2211124719301081
Nov 2018
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Stage-Specific Transcription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes

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1. scibot 05 Nov 2018
  
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  (Abcam Cat# ab185966, RRID:AB_2728660)
  
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academic.oup.com/endo/article/159/9/3287/5060806

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