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Jun 2026
aacrjournals.org aacrjournals.org

PI3Kα inhibitor and degrader inavolisib can co-opt FGFR2 to enhance responses in patients with PIK3CA-mutated solid tumors and in preclinical models

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1. scibot 19 Jun 2026
  
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  AB_2728690
  
  DOI: 10.1158/1078-0432.CCR-25-1459
  
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aacrjournals.org/clincancerres/article/32/1/56/771272/PI3K-Inhibitor-and-Degrader-Inavolisib-Can-Co-opt
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Unconventional activation of the proto-oncogene FGFR1 by extracellular phosphate via H2O2-mediated kinase oxidation

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1. scibot 05 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117504
  
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sciencedirect.com/science/article/pii/S2211124726005826
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Optogenetic control of PLC-γ1 activity directs cell motility

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1. scibot 03 Jun 2026
  
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  DOI: 10.1083/jcb.202507177
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13225428/
May 2026
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PrPC-facilitated cell signaling activates phospholipase Cɣ1 and triggers an Arc/Arg3.1 response in mouse and iPSC-derived human neurons

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1. scibot 15 May 2026
  
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  DOI: 10.1016/j.stemcr.2026.102924
  
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sciencedirect.com/science/article/pii/S2213671126001359
Mar 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Collagen-bearing exosomes from breast cancer-associated fibroblasts promote T cell dysfunction

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1. scibot 26 Mar 2026
  
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  DOI: 10.1158/2767-9764.CRC-25-0259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13012019/
Jan 2026
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DNA-PKcs controls the cytotoxic T cell response to cancer and transplant allograft through regulating LAT-dependent signaling

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116796
  
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sciencedirect.com/science/article/pii/S2211124725015682
Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Sensitized mast cells for targeted drug delivery and augmented cancer immunotherapy

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1. scibot 10 Dec 2025
  
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  DOI: 10.1016/j.cell.2025.11.015
  
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sciencedirect.com:5037/science/article/pii/S009286742501311X
Nov 2025
54.241.53.176 54.241.53.176

ssrn-5691051-html.html

1
1. scibot 11 Nov 2025
  
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  RRID:AB_2728690
  
  DOI: 10.1016/j.molmed.2018.11.005
  
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54.241.53.176/64713c65fcc1216b83fddb214e5f4f3dbce54cd7/ssrn-5691051-html.html
Aug 2025
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Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control

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1. scibot 06 Aug 2025
  
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  DOI: 10.1016/j.cmet.2025.07.006
  
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sciencedirect.com/science/article/pii/S155041312500333X
Jul 2025
www.cell.com www.cell.com

FGF-induced phospholipase Cγ signaling regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolism

1
1. scibot 30 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116046
  
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cell.com/cell-reports/abstract/S2211-1247(25)00817-4
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells

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1. scibot 20 May 2025
  
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  DOI: 10.1111/tra.70005
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12052438/
Apr 2025
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Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity

1
1. scibot 15 Apr 2025
  
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  DOI: 10.1016/j.cell.2025.03.017
  
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sciencedirect.com/science/article/pii/S0092867425002909
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Placenta-derived SOD3 deletion impairs maternal behavior via alterations in FGF/FGFR-prolactin signaling axis

1
1. scibot 21 Dec 2024
  
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  RRID:AB_2728690
  
  DOI: 10.1016/j.celrep.2024.114789
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11639441/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8+ T cell exhaustion and anti-PD-1 resistance

1
1. scibot 25 Aug 2024
  
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  RRID:AB_2728690
  
  DOI: 10.1016/j.xcrm.2024.101686
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11384939/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias

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1. scibot 16 Mar 2024
  
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  DOI: 10.1038/s44319-024-00077-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10933458/
Feb 2024
www.embopress.org www.embopress.org

Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer’s and related dementias

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1. scibot 15 Feb 2024
  
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  DOI: 10.1038/s44319-024-00077-x
  
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embopress.org/doi/10.1038/s44319-024-00077-x
Oct 2023
link.springer.com link.springer.com

Serotonin 2C receptors are also important in head-twitch responses in male mice

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1. scibot 27 Oct 2023
  
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  RRID:AB_2728690
  
  DOI: 10.1007/s00213-023-06482-9
  
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link.springer.com/article/10.1007/s00213-023-06482-9
Jul 2023
dx.doi.org dx.doi.org

Heterogeneity of Signaling Complex Nanostructure in T Cells Activated Via the T Cell Antigen Receptor

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1. scibot 22 Jul 2023
  
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  RRID:AB_2728690
  
  DOI: 10.1093/micmic/ozad072
  
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dx.doi.org/10.1093/micmic/ozad072
May 2023
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Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity

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1. scibot 25 May 2023
  
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  RRID:AB_2728690
  
  DOI: 10.1016/j.cmet.2023.05.001
  
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sciencedirect.com/science/article/pii/S155041312300178X
Aug 2022
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Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

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1. scibot 26 Aug 2022
  
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  DOI: 10.1016/j.medj.2022.07.008
  
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sciencedirect.com/science/article/pii/S266663402200318X
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Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healing

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1. scibot 17 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111192
  
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sciencedirect.com/science/article/pii/S2211124722010099
Mar 2022
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3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells

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1. scibot 15 Mar 2022
  
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  DOI: 10.1016/j.stem.2022.02.009
  
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sciencedirect.com/science/article/pii/S1934590922000601
May 2021
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PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR

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1. scibot 26 May 2021
  
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  DOI: 10.1016/j.celrep.2021.109181
  
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sciencedirect.com/science/article/pii/S221112472100526X
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Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy

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1. scibot 07 May 2021
  
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  DOI: 10.1016/j.immuni.2020.09.006
  
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sciencedirect.com/science/article/pii/S1074761320304003
Apr 2021
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An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

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1. scibot 24 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.07.001
  
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sciencedirect.com/science/article/pii/S0092867420308230
Sep 2020
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Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy

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1. scibot 26 Sep 2020
  
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  DOI: 10.1016/j.cell.2020.07.018
  
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sciencedirect.com/science/article/pii/S0092867420308837
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Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis

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1. scibot 26 Sep 2020
  
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  DOI: 10.1016/j.stem.2020.04.001
  
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sciencedirect.com/science/article/pii/S1934590920301405
Nov 2018
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Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1931312818302634
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Th9 Cells Represent a Unique Subset of CD4+ T Cells Endowed with the Ability to Eradicate Advanced Tumors

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1535610818302186