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CRISPR-Cas9 screening reveals G2E3 as a novel ubiquitin-linked factor controlling autophagosome-lysosome fusion and cancer cell progression

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1. scibot 14 Oct 2025
  
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  DOI: 10.1038/s41420-025-02717-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12511632/
Oct 2025
www.science.org www.science.org

Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer

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1. scibot 04 Oct 2025
  
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  DOI: 10.1126/scisignal.adu7145
  
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science.org/doi/10.1126/scisignal.adu7145
Aug 2025
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Harmine suppresses pancreatic cancer through DYRK1A-mediated hyper-activated RAS/MAPK inhibition

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1. scibot 30 Aug 2025
  
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  RRID:AB_2728748
  
  DOI: 10.1016/j.bcp.2025.117291
  
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sciencedirect.com/science/article/pii/S0006295225005568
Jun 2025
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GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRASG12D-mutant cancer

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1. scibot 11 Jun 2025
  
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  AB_2728748
  
  DOI: 10.1016/j.celrep.2025.115774
  
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sciencedirect.com/science/article/pii/S2211124725005455
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115444
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12091147/
Apr 2025
www.nature.com www.nature.com

Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways

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1. scibot 04 Apr 2025
  
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  DOI: 10.1038/s41598-025-95766-5
  
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nature.com/articles/s41598-025-95766-5
Mar 2025
www.biorxiv.org www.biorxiv.org

In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer

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1. scibot 26 Mar 2025
  
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  DOI: 10.1101/2025.03.20.644389
  
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biorxiv.org/content/10.1101/2025.03.20.644389v1
Feb 2025
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Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation

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1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.stem.2025.01.011
  
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sciencedirect.com/science/article/pii/S1934590925000116
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KRAS4B oncogenic mutants promote non-small cell lung cancer progression via the interaction of deubiquitinase USP25 with RNF31

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1. scibot 14 Feb 2025
  
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  DOI: 10.1016/j.devcel.2025.01.015
  
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sciencedirect.com/science/article/pii/S1534580725000358
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer

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1. scibot 03 Mar 2024
  
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  DOI: 10.1101/gad.351037.123
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10621596/
Nov 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Acid-base homeostasis orchestrated by NHE1 defines the pancreatic stellate cell phenotype in pancreatic cancer

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1. scibot 03 Nov 2023
  
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  DOI: 10.1172/jci.insight.170928
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10619433/
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Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers

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1. scibot 02 Nov 2023
  
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  DOI: 10.1016/j.immuni.2023.09.013
  
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sciencedirect.com/science/article/pii/S1074761323004181
Jul 2023
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Oncogenic K-Ras suppresses global miRNA function

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1. scibot 06 Jul 2023
  
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  RRID:AB_2728748
  
  DOI: 10.1016/j.molcel.2023.06.008
  
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sciencedirect.com/science/article/pii/S109727652300429X
Feb 2023
www.embopress.org www.embopress.org

Pericyte stem cells induce Ly6G+ cell accumulation and immunotherapy resistance in pancreatic cancer

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1. scibot 23 Feb 2023
  
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  RRID:AB_2728748
  
  DOI: 10.15252/embr.202256524
  
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embopress.org/doi/10.15252/embr.202256524
Aug 2022
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Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells

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1. scibot 17 Aug 2022
  
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  RRID:AB_2728748
  
  DOI: 10.1016/j.celrep.2022.111182
  
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sciencedirect.com/science/article/pii/S2211124722009950
Aug 2021
www.mdpi.com www.mdpi.com

CRISPR/Cas9-Mediated Knock-Out of KrasG12D Mutated Pancreatic Cancer Cell Lines

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1. scibot 02 Aug 2021
  
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  RRID:AB_2728748
  
  DOI: 10.3390/ijms20225706
  
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mdpi.com/1422-0067/20/22/5706
Jun 2021
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NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma

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1. scibot 16 Jun 2021
  
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  RRID:AB_2728748
  
  DOI: 10.1016/j.celrep.2021.109238
  
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sciencedirect.com/science/article/pii/S2211124721005970
Apr 2021
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Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer

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1. scibot 17 Apr 2021
  
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  RRID:AB_2728748
  
  DOI: 10.1016/j.ccell.2020.05.010
  
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  RRIDCUR:Validated RRID:AB_2728748
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sciencedirect.com/science/article/pii/S1535610820302609
Sep 2020
elifesciences.org elifesciences.org

HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

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1. scibot 04 Sep 2020
  
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  RRID:AB_2728748
  
  DOI: 10.7554/eLife.33947
  
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  Curator: @evieth
  
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elifesciences.org/articles/33947
Nov 2018
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 05 Nov 2018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6122955/