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Jun 2026
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PKCα-mediated nuclear translocation of cGAS stabilizes β-catenin and drives metastasis

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1. scibot 23 Jun 2026
  
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  DOI: 10.1016/j.molcel.2026.05.023
  
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Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple-Negative Breast Cancer to PD-1 Blockade

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1. scibot 17 Jun 2026
  
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  DOI: 10.1002/advs.202521541
  
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STING-OPTN signaling confers cytoprotection through TBK1-dependent mitophagy

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1. scibot 11 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117515
  
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The modulation of AUF1 regulates the R-loop resolution activating the immune response in DDR

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1. scibot 06 Jun 2026
  
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  DOI: 10.1016/j.isci.2026.115900
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13196424/
May 2026
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It’s Not Rewarding for Mitochondria: Dopamine-Induced Mitochondrial Dysfunction Activates cGAS-STING to Drive IL-6 Secretion in Macrophages

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1. scibot 01 May 2026
  
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  DOI: 10.64898/2026.04.23.719926
  
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biorxiv.org/content/10.64898/2026.04.23.719926v1
Apr 2026
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Identification of an STING inhibitor targeting the allosteric transmembrane domains

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1. scibot 29 Apr 2026
  
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  DOI: 10.1016/j.chembiol.2026.04.001
  
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1-s2.0-S2589004226010862-main-html.html

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1. scibot 11 Apr 2026
  
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54.241.53.176/be028d43344bab6907bc9e771fd88e2dec1a0cd7/1-s2.0-S2589004226010862-main-html.html
Mar 2026
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ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei

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1. scibot 20 Mar 2026
  
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  DOI: 10.1016/j.molcel.2026.02.012
  
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MSH6 regulates cGAS activity in antiviral and antitumor signaling pathways by governing its cytosolic/nuclear distribution

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1. scibot 13 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117059
  
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Feb 2026
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Divergent tumor immunity determined by bacteria-cancer cell engagement

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1. scibot 05 Feb 2026
  
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  DOI: 10.1016/j.cell.2025.12.044
  
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Jan 2026
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Uncovering genetic interactions in the DNA repair network in response to endogenous damage and ionizing radiation

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1. scibot 22 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116850
  
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sciencedirect.com/science/article/pii/S2211124725016225
Dec 2025
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A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement

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1. scibot 09 Dec 2025
  
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  DOI: 10.1016/j.immuni.2025.11.004
  
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Sep 2025
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RSK1 reprograms the ubiquitin pathway to promote immune suppression

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1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116323
  
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Jul 2025
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A fluorescent STING ligand sensor for high-throughput screening of compounds that can enhance tumor immunotherapy

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.crmeth.2025.101106
  
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sciencedirect.com/science/article/pii/S2667237525001420
Jun 2025
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Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS

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1. scibot 03 Jun 2025
  
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  DOI: 10.1016/j.cell.2025.05.008
  
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May 2025
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SIRT2 suppresses aging-associated cGAS activation and protects aged mice from severe COVID-19

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115562
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12074670/
Feb 2025
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PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma

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1. scibot 27 Feb 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0515
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11836641/
Dec 2024
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The N-degron pathway mediates the autophagic degradation of cytosolic mitochondrial DNA during sterile innate immune responses

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1. scibot 24 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115094
  
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RNA sensing induced by chromosome missegregation augments anti-tumor immunity

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.025
  
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MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling

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1. scibot 18 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.026
  
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Oct 2024
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Type I IFN drives unconventional IL-1β secretion in lupus monocytes

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1. scibot 09 Oct 2024
  
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  DOI: 10.1016/j.immuni.2024.09.004
  
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Sep 2024
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Purification of micronuclei from cultured cells by flow cytometry

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.xpro.2021.100378
  
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Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.celrep.2020.108080
  
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Jul 2024
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VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

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1. scibot 27 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110285
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11267025/
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Molecular and Clinical Determinants of Acquired Resistance and Treatment Duration for Targeted Therapies in Colorectal Cancer

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1. scibot 09 Jul 2024
  
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  DOI: 10.1158/1078-0432.CCR-23-4005
  
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aacrjournals.org/clincancerres/article/30/12/2672/745797/Molecular-and-Clinical-Determinants-of-Acquired
Jun 2024
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Setdb1 protects genome integrity in murine muscle stem cells to allow for regenerative myogenesis and inflammation

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1. scibot 07 Jun 2024
  
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  DOI: 10.1016/j.devcel.2024.05.012
  
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May 2024
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ccr-23-4005-html.html

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1. scibot 23 May 2024
  
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  DOI: 10.1158/1078-0432.ccr-23-4005
  
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  DOI: 10.1158/1078-0432.ccr-23-4005
  
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  DOI: 10.1158/1078-0432.ccr-23-4005
  
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52.53.155.43/182d0fc47d4b0787ed5f14ae9d99c52af646547f/ccr-23-4005 (1)-html.html
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TREX1 inactivation unleashes cancer cell STING-interferon signaling and promotes anti-tumor immunity

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1. scibot 23 May 2024
  
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  DOI: 10.1158/2159-8290.CD-23-0700
  
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2. scibot 23 May 2024
  
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  DOI: 10.1158/2159-8290.CD-23-0700
  
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aacrjournals.org/cancerdiscovery/article/14/5/752/745044/TREX1-Inactivation-Unleashes-Cancer-Cell-STING
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Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING

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1. scibot 21 May 2024
  
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  DOI: 10.1016/j.molcel.2024.04.017
  
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Apr 2024
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Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity

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1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.xcrm.2024.101528
  
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SETD2 loss and ATR inhibition synergize to promote cGAS signaling and immunotherapy response in renal cell carcinoma

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1. scibot 03 Apr 2024
  
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  DOI: 10.1158/1078-0432.CCR-23-1003
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10592192/
Feb 2024
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The proteomic landscape of genotoxic stress-induced micronuclei

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1. scibot 29 Feb 2024
  
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  DOI: 10.1016/j.molcel.2024.02.001
  
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  DOI: 10.1016/j.molcel.2024.02.001
  
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SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion

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SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1

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Oct 2023
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Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy

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Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy

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Jun 2023
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Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

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Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging

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May 2023
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Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer

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Apr 2023
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Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING

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The mechanism of STING autoinhibition and activation

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Mar 2023
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Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS

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Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity

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Feb 2023
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Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS

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Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks

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Resurrection of endogenous retroviruses during aging reinforces senescence

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Dec 2022
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Low-dose ganciclovir ameliorates dextran sulfate sodium-induced ulcerative colitis through inhibiting macrophage STING activation in mice

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Nov 2022
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Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1

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Oct 2022
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Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas

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SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA

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MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

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Ku proteins promote DNA binding and condensation of cyclic GMP-AMP synthase

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DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production

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WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC

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Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS

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STING nuclear partners contribute to innate immune signaling responses

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Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion

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SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer

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Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE

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LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

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PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity

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Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

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Protocol for nuclear export signal characterization of cGAS in mammalian cells

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Jun 2021
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Translation stress and collided ribosomes are co-activators of cGAS

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May 2021
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Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion

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cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing

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Purification of micronuclei from cultured cells by flow cytometry

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ER-directed TREX1 limits cGAS activation at micronuclei

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  DOI: 10.1016/j.molcel.2020.12.037
  
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FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

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A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA

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Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres

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PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response

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  DOI: 10.7554/eLife.60637
  
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The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING

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  DOI: 10.1016/j.celrep.2018.11.097
  
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The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

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RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres

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Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity

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Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury

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Untitled document

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Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA

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SLC19A1 Is an Importer of the Immunotransmitter cGAMP

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Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production

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Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

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  DOI: 10.1016/j.molcel.2019.02.038
  
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Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages

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NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation

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Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication

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