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  1. Last 7 days
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    TRIM65 regulates innate immune signaling by enhancing K6-linked ubiquitination of IRF3 and its chromatin recruitment
    7
    1. scibot 22 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    2. scibot 21 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    3. scibot 20 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    4. scibot 19 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    5. scibot 18 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    6. scibot 17 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    7. scibot 16 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
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  3. Dec 2024
  4. www.sciencedirect.com www.sciencedirect.com
    TRIM65 regulates innate immune signaling by enhancing K6-linked ubiquitination of IRF3 and its chromatin recruitment
    15
    1. scibot 15 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    2. scibot 14 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    3. scibot 13 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    4. scibot 12 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    5. scibot 11 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    6. scibot 10 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    7. scibot 09 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    8. scibot 08 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    9. scibot 07 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    10. scibot 06 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    11. scibot 05 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    12. scibot 04 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    13. scibot 03 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    14. scibot 02 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    15. scibot 01 Dec 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

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    Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening
    1
    1. scibot 10 Dec 2024
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      DOI: 10.1016/j.cels.2024.11.004

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    sciencedirect.com/science/article/pii/S2405471224003375
  6. Nov 2024
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    TRIM65 regulates innate immune signaling by enhancing K6-linked ubiquitination of IRF3 and its chromatin recruitment
    2
    1. scibot 29 Nov 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

      RRID:AB_2732796
    2. scibot 28 Nov 2024
      RRID:AB_2732796

      Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

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  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma
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      DOI: 10.1158/0008-5472.CAN-24-0134

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    Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy
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  10. Oct 2024
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    Type I IFN drives unconventional IL-1β secretion in lupus monocytes
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      AB_2732796

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    Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
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      AB_2732796

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    Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
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  14. Sep 2024
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    IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1
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    Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses
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      DOI: 10.1016/j.celrep.2020.108080

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    Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response
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  18. Aug 2024
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    Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence
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    Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases
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      Rabbit anti-STING

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    The V-ATPase/ATG16L1 axis is controlled by the V1H subunit
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  22. Jul 2024
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    VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway
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      DOI: 10.1016/j.isci.2024.110285

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    Mitochondrial DNA-boosted dendritic cell-based nanovaccination triggers antitumor immunity in lung and pancreatic cancers
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      DOI: 10.1016/j.xcrm.2024.101648

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  25. Jun 2024
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    STING orchestrates the neuronal inflammatory stress response in multiple sclerosis
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      DOI: 10.1016/j.cell.2024.05.031

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    The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity
    1
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      DOI: 10.1158/2326-6066.CIR-23-1078

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    Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice
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      RRID:AB_2732796

      DOI: 10.1016/j.celrep.2024.114284

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    sciencedirect.com/science/article/pii/S2211124724006120
  29. May 2024
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      DOI: 10.1158/2326-6066.cir-23-1078

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    Development of nitroalkene-based inhibitors to target STING-dependent inflammation
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      RRID:AB_2732796

      DOI: 10.1016/j.redox.2024.103202

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    Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING
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      RRID:AB_2732796

      DOI: 10.1016/j.molcel.2024.04.017

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    ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity
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      RRID:AB_2732796

      DOI: 10.1016/j.cell.2024.04.025

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    sciencedirect.com/science/article/pii/S0092867424004513
  34. www.biorxiv.org www.biorxiv.org
    Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
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      RRID:AB_2732796

      DOI: 10.1101/2024.01.24.577107

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    biorxiv.org/content/10.1101/2024.01.24.577107v1
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    Intratumoral delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR, and CD8+ T cell-dependent anti-tumor immunity
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      DOI: 10.1016/j.xcrm.2024.101560

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    sciencedirect.com/science/article/pii/S2666379124002520
  36. Apr 2024
  37. www.sciencedirect.com www.sciencedirect.com
    Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
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    Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration
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  39. Mar 2024
  40. www.sciencedirect.com www.sciencedirect.com
    HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
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  41. Feb 2024
  42. www.sciencedirect.com www.sciencedirect.com
    The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation
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  43. Jan 2024
  44. www.sciencedirect.com www.sciencedirect.com
    DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells
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  45. www.sciencedirect.com www.sciencedirect.com
    Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.
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  46. www.sciencedirect.com www.sciencedirect.com
    Interferon-stimulated neutrophils as a predictor of immunotherapy response
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    sciencedirect.com/science/article/pii/S1535610823004336
  47. Dec 2023
  48. www.sciencedirect.com www.sciencedirect.com
    Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
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  49. Nov 2023
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression
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  51. www.sciencedirect.com www.sciencedirect.com
    Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis
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  52. www.sciencedirect.com www.sciencedirect.com
    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
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  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
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  54. Oct 2023
  55. www.sciencedirect.com www.sciencedirect.com
    Regulation of STING activity in DNA sensing by ISG15 modification
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  56. 52.53.155.43 52.53.155.43
    Blocking oligomerization is the most viable strategy to inhibit STING
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  57. www.sciencedirect.com www.sciencedirect.com
    Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells
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    Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells
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  59. 52.53.155.43 52.53.155.43
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  60. Sep 2023
  61. www.sciencedirect.com www.sciencedirect.com
    Spinal TAOK2 contributes to neuropathic pain via cGAS-STING activation in rats
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  62. www.sciencedirect.com www.sciencedirect.com
    STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells
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  63. Aug 2023
  64. 52.53.155.43 52.53.155.43
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  65. Jul 2023
  66. www.sciencedirect.com www.sciencedirect.com
    STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages
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  67. 52.53.155.43 52.53.155.43
    Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
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  68. 52.53.155.43 52.53.155.43
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.
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  70. Jun 2023
  71. www.sciencedirect.com www.sciencedirect.com
    The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity
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    Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
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    sciencedirect.com/science/article/pii/S1535610823001733
  73. www.sciencedirect.com www.sciencedirect.com
    Cancer cell-autonomous cGAS-STING response confers drug resistance
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    sciencedirect.com/science/article/pii/S2451945623001411
  74. May 2023
  75. www.sciencedirect.com www.sciencedirect.com
    Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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    Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
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    sciencedirect.com/science/article/pii/S1535610823001629
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    Human papillomavirus E5 suppresses immunity via inhibition of the immunoproteasome and STING pathway
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    sciencedirect.com/science/article/pii/S2211124723005193
  78. Apr 2023
  79. www.sciencedirect.com www.sciencedirect.com
    Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses
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    sciencedirect.com/science/article/pii/S2666379123001349
  80. www.sciencedirect.com www.sciencedirect.com
    Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING
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    sciencedirect.com/science/article/pii/S2211124723004539
  81. www.sciencedirect.com www.sciencedirect.com
    The mechanism of STING autoinhibition and activation
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  82. www.sciencedirect.com www.sciencedirect.com
    ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer
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    sciencedirect.com/science/article/pii/S1534580723001314
  83. Mar 2023
  84. www.sciencedirect.com www.sciencedirect.com
    STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion
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  85. europepmc.org europepmc.org
    Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING
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    europepmc.org/article/med/36952341
  86. www.sciencedirect.com www.sciencedirect.com
    Leaked genomic and mitochondrial DNA contribute to the host response to noroviruses in a STING-dependent manner
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    sciencedirect.com/science/article/pii/S2211124723001900
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    The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus
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    sciencedirect.com/science/article/pii/S2211124723003170
  88. www.sciencedirect.com www.sciencedirect.com
    NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking
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  89. Feb 2023
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model
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  91. Jan 2023
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    Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks
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  93. Dec 2022
  94. www.embopress.org www.embopress.org
    DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma
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    The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER
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    Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling
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    Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer
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  98. Nov 2022
  99. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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  100. www.sciencedirect.com www.sciencedirect.com
    Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis
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    Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1
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  102. Sep 2022
  103. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Activation of cGAS-STING pathway – A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy
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    ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP
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  105. Jul 2022
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    Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS
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  107. Jun 2022
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    Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD
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  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model
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  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SETDB1–TRIM28 complex suppresses antitumor immunity
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    LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity
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  112. May 2022
  113. www.sciencedirect.com www.sciencedirect.com
    DDX41 is required for cGAS-STING activation against DNA virus infection
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    STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program
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    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
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    WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC
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    Protocol to induce and assess cGAS-STING pathway activation in vitro
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    The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis
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  119. Feb 2022
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    The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation
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  121. Jan 2022
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    MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells
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    Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells
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    STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses
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  125. Dec 2021
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    IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer
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  127. Nov 2021
  128. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis
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    APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis
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  131. Oct 2021
  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CX-5461 Treatment Leads to Cytosolic DNA-Mediated STING Activation in Ovarian Cancer
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  133. Sep 2021
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    PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis
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    STING nuclear partners contribute to innate immune signaling responses
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  136. Aug 2021
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    Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity
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    Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy
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    SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer
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    Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm
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    Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair
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    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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    ncbi.nlm.nih.govhttp://europepmc.org/articles/PMC6127031/
  143. Jul 2021
  144. www.nature.com www.nature.com
    Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C
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      13647

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  145. www.sciencedirect.com www.sciencedirect.com
    LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade
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  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  147. www.sciencedirect.com www.sciencedirect.com
    Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING
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    PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity
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  149. Jun 2021
  150. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment.
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    DHX15 is required to control RNA virus-induced intestinal inflammation
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    C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation
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  153. www.sciencedirect.com www.sciencedirect.com
    Translation stress and collided ribosomes are co-activators of cGAS
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  154. May 2021
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    Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells
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    The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake
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    BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse
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    Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress
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    SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function
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    LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP
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  161. Apr 2021
  162. www.sciencedirect.com www.sciencedirect.com
    Mutant p53 suppresses innate immune signaling to promote tumorigenesis
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    MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
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    A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology
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      anti‐STING

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    sciencedirect.com/science/article/pii/S2352396421001079
  165. Feb 2021
  166. www.sciencedirect.com www.sciencedirect.com
    DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity
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    sciencedirect.com/science/article/pii/S1535610820305985
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    FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells
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      RRID:AB_2732796

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    sciencedirect.com/science/article/pii/S0092867420316147
  168. www.mdpi.com www.mdpi.com
    Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes
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      DOI: 10.3390/antiox10020334

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    mdpi.com/2076-3921/10/2/334
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    Disruption of DNA polymerase ζ engages an innate immune response
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    sciencedirect.com/science/article/pii/S2211124721000887
  170. Dec 2020
  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
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    ncbi.nlm.nih.gov/pmc/articles/PMC7733315/
  172. Oct 2020
  173. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
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  174. Sep 2020
  175. www.sciencedirect.com www.sciencedirect.com
    mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury
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      RRID:AB_2732796

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  176. www.sciencedirect.com www.sciencedirect.com
    TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
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    Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity
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    Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP
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      RRID:AB_2732796

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    Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma
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  180. www.cell.com www.cell.com
    The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
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    cell.com/cell-reports/fulltext/S2211-1247(18)31888-6
  181. www.nature.com www.nature.com
    C9orf72 in myeloid cells suppresses STING-induced inflammation
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      STING

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    Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer
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  183. Jan 2020
  184. www.cell.com www.cell.com
    Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury
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    cell.com/cell-reports/fulltext/S2211-1247(19)31238-0
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    IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation
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    The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death
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    STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
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    Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles
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    sciencedirect.com/science/article/pii/S2211124719306199
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    CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
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    STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production
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    Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity
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    1. scibot 13 Jan 2020
      RRID:AB_2732796

      DOI: 10.1016/j.celrep.2019.09.065

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    sciencedirect.com/science/article/pii/S2211124719312628
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      RRID:AB_2732796

      DOI: 10.1016/j.celrep.2018.11.097

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    sciencedirect.com/science/article/pii/S2211124718318886
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    SLC19A1 Is an Importer of the Immunotransmitter cGAMP
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      DOI: 10.1016/j.molcel.2019.05.006

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    sciencedirect.com/science/article/pii/S1097276519303594
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      RRID:AB_2732796

      DOI: 10.1016/j.celrep.2019.03.098

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    sciencedirect.com/science/article/pii/S2211124719304371
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.celrep.2019.01.105

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    sciencedirect.com/science/article/pii/S2211124719301421
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    1. scibot 13 Jan 2020
      RRID:AB_2732796

      DOI: 10.1016/j.celrep.2018.11.094

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    sciencedirect.com/science/article/pii/S2211124718318850
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    Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING
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    1. scibot 12 Jan 2020
      RRID:AB_2732796

      DOI: 10.1016/j.molcel.2019.02.038

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  198. Nov 2018
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    Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages
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    NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation
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    sciencedirect.com/science/article/pii/S0092867418311632
  201. www.ncbi.nlm.nih.govhttp: www.ncbi.nlm.nih.govhttp:
    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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    ncbi.nlm.nih.govhttp://europepmc.org/articles/PMC6127031/
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    Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis
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    sciencedirect.com/science/article/pii/S1074761318303261
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      RRID:AB_2732796

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    sciencedirect.com/science/article/pii/S0092867418308560