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Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptopathy in encephalitis

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1. scibot 25 Dec 2025
  
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  DOI: 10.1016/j.neuron.2025.11.006
  
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Nov 2025
54.241.53.176 54.241.53.176

jaeckstein-et-al-2025-purinergic-adipocyte-macrophage-crosstalk-promotes-degeneration-of-thermogenic-brown-adipose-html.html

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  DOI: 10.1038/s44319-025-00642-y
  
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54.241.53.176/f747cb2da22a4018614419251bb372fb2280d9d1/jaeckstein-et-al-2025-purinergic-adipocyte-macrophage-crosstalk-promotes-degeneration-of-thermogenic-brown-adipose-html.html
Oct 2025
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The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8+ T cells

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1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.immuni.2025.09.008
  
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Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas

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  DOI: 10.1016/j.ccell.2025.09.005
  
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sciencedirect.com/science/article/pii/S1535610825003976
Sep 2025
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Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines

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Lactate Blocks Tertiary Lymphoid Structure Formation by Inhibiting B Cell Chemotaxis

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1. scibot 10 Sep 2025
  
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  DOI: 10.1101/2025.08.30.673054
  
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biorxiv.org/content/10.1101/2025.08.30.673054v1
Aug 2025
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Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

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  DOI: 10.1016/j.celrep.2025.116150
  
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Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control

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  DOI: 10.1016/j.cmet.2025.07.006
  
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Jul 2025
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Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

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TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice

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  DOI: 10.1016/j.stem.2025.06.006
  
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cell.com/cell-stem-cell/fulltext/S1934-5909(25)00228-0
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PARP1-NFATc1-PD1 pathway of maturation and stability of CD8+T cells is beneficial against chronic Trypanosoma cruzi infection

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  DOI: 10.1016/j.isci.2025.112926
  
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APOE protects against severe infection with Mycobacterium tuberculosis by restraining production of neutrophil extracellular traps

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  DOI: 10.1371/journal.ppat.1013267
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12201663/
Jun 2025
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Single-cell analysis of temporal immune cell dynamics in alopecia areata reveals a causal role for clonally expanded CD8+ T cells in disease

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115798
  
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Mucosal boosting increases protective efficacy of an influenza vaccine in mice

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  DOI: 10.1016/j.isci.2025.112721
  
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Distinct TAM subset with cross-dressing capability determines the bifurcation of tumor immunity

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  DOI: 10.1016/j.celrep.2025.115800
  
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May 2025
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PDF-html.html

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  DOI: 10.1101/2025.04.23.649615
  
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52.53.155.43/940b43b532f27c10fd5855c1e3772edb393b5559/PDF-html.html
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Selective requirement of glycosphingolipid synthesis for natural killer and cytotoxic T cells

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.cell.2025.04.007
  
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Mar 2025
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Collaboration between interleukin-7 and -15 enables adaptation of tissue-resident and circulating memory CD8+ T cells to cytokine deficiency

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1. scibot 04 Mar 2025
  
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  DOI: 10.1016/j.immuni.2025.02.009
  
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Feb 2025
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Recirculating regulatory T cells mediate thymic regeneration through amphiregulin following damage

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Nov 2024
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The BNT162b2 mRNA vaccine demonstrates reduced age-associated TH1 support in vitro and in vivo

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pmc.ncbi.nlm.nih.gov/articles/PMC11576392/
Sep 2024
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A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies

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Jul 2024
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The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses

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Transcriptional programming mediated by the histone demethylase KDM5C regulates dendritic cell population heterogeneity and function

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Table 2 Primary antibodies used in ChipCytometry

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  DOI: 10.1038/s41596-024-01001-2
  
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nature.com/articles/s41596-024-01001-2/tables/2
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Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE2 production

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  DOI: 10.1016/j.celrep.2024.114469
  
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Jun 2024
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Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule

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Quantitative trait loci mapping provides insights into the genetic regulation of dendritic cell numbers in mouse tissues

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  DOI: 10.1016/j.celrep.2024.114296
  
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May 2024
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A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

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  DOI: 10.1016/j.immuni.2024.04.025
  
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The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects

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ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity

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Apr 2024
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Cbl-b mitigates the responsiveness of naive CD8+ T cells that experience extensive tonic T cell receptor signaling

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  DOI: 10.1126/scisignal.adh0439
  
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science.org/doi/10.1126/scisignal.adh0439
Mar 2024
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Acod1 expression in cancer cells promotes immune evasion through the generation of inhibitory peptides

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  DOI: 10.1016/j.celrep.2024.113984
  
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IKK2 controls the inflammatory potential of tissue-resident regulatory T cells in a murine gain of function model

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  DOI: 10.1038/s41467-024-45870-3
  
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nature.com/articles/s41467-024-45870-3
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Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis

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  DOI: 10.1016/j.celrep.2024.113934
  
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  DOI: 10.1016/j.celrep.2024.113934
  
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Reversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision

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MHC class II regulation of CD8+ T cell tolerance and implications in autoimmunity and cancer immunotherapy

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The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

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CTLA-4 blockade induces CD4+ T cell IFNγ-driven microglial phagocytosis and anti-tumor function in glioblastoma

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Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity

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Attenuated Mycobacterium tuberculosis vaccine protection in a low-dose murine challenge model

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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

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PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion

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Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma

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BATF2 promotes HSC myeloid differentiation by amplifying IFN response mediators during chronic infection

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OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum

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Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells

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P2RX7 enhances tumor control by CD8+ T cells in adoptive cell therapy

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Dec 2022
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Nur77-Tempo mice reveal T cell steady state antigen recognition

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IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer

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Maternal fiber deprivation alters microbiota in offspring, resulting in low-grade inflammation and predisposition to obesity

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STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation

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IFN-γ–dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis

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CD8 memory precursor cell generation is a continuous process

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Using Full-Spectrum Flow Cytometry to Phenotype Memory T and NKT Cell Subsets with Optimized Tissue-Specific Preparation Protocols

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T-cell dysfunction upon expression of MYC with altered phosphorylation at Threonine 58 and Serine 62

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IFN-γ–dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis

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A humanized β2 integrin knockin mouse reveals localized intra- and extravascular neutrophil integrin activation in vivo

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Loss of T cell tolerance in the skin following immunopathology is linked to failed restoration of the dermal niche by recruited macrophages

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Tnfrsf4-expressing regulatory T cells promote immune escape of chronic myeloid leukemia stem cells

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Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells

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The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota

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Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses

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CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection

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Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

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MicroRNA-29 specifies age-related differences in the CD8+ T cell immune response

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Cold exposure protects from neuroinflammation through immunologic reprogramming

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Sep 2021
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Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors

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Conventional type I dendric cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes

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Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strength

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Flow cytometric characterization of tissue-resident lymphocytes after murine liver and heart transplantation

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The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life

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The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer

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MYC deficiency impairs the development of effector/memory T lymphocytes

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Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

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Dynamic changes to tissue-resident immunity after MHC-matched and MHC-mismatched solid organ transplantation

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An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development

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Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β

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UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability

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Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade

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Application of dual Nr4a1-GFP Nr4a3-Tocky reporter mice to study T cell receptor signaling by flow cytometry

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Nr4a1 and Nr4a3 Reporter Mice Are Differentially Sensitive to T Cell Receptor Signal Strength and Duration

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Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

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Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB

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Impaired phagocytic function in CX3CR1+ tissue‐resident skeletal muscle macrophages prevents muscle recovery after influenza A virus‐induced pneumonia in old mice

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RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity

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Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

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PD-1 Signaling Promotes Control of Chronic Viral Infection by Restricting Type-I-Interferon-Mediated Tissue Damage

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Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation

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Untitled document

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Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8+ T Cells

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Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting

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Untitled document

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