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SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism

1
1. scibot 13 Jun 2026
  
  in Public
  
  RRID:AB_2734695
  
  DOI: 10.1016/j.celrep.2026.117544
  
  Resource: (Abcam Cat# ab134113, RRID:AB_2734695)
  
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sciencedirect.com/science/article/pii/S2211124726006224
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Heterogeneity of late endosome/lysosomes shown by multiplexed DNA-PAINT imaging

1
1. scibot 19 May 2025
  
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  RRID:AB_2734695
  
  DOI: 10.1083/jcb.202403116
  
  Resource: (Abcam Cat# ab134113, RRID:AB_2734695)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11533445/
Aug 2024
www.cell.com www.cell.com

Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake

1
1. scibot 29 Aug 2024
  
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  RRID:AB_2734695
  
  DOI: 10.1016/j.cell.2024.08.004
  
  Resource: (Abcam Cat# ab134113, RRID:AB_2734695)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2734695
  
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cell.com/cell/fulltext/S0092-8674(24)00895-X
Jun 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The Aging Lacrimal Gland of Female C57BL/6J Mice Exhibits Multinucleate Macrophage Infiltration Associated With Lipid Dysregulation

1
1. scibot 09 Jun 2024
  
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  AB_2734695
  
  DOI: 10.1167/iovs.65.6.1
  
  Resource: (Abcam Cat# ab134113, RRID:AB_2734695)
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11156205/
Aug 2022
www.sciencedirect.com www.sciencedirect.com

Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction

1
1. scibot 30 Aug 2022
  
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  RRID:AB_2734695
  
  DOI: 10.1016/j.isci.2022.104941
  
  Resource: (Abcam Cat# ab134113, RRID:AB_2734695)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2589004222012135
May 2022
www.sciencedirect.com www.sciencedirect.com

MiR-25 blunts autophagy and promotes the survival of Mycobacterium tuberculosis by regulating NPC1

1
1. scibot 13 May 2022
  
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  RRID:AB_2734695
  
  DOI: 10.1016/j.isci.2022.104279
  
  Resource: (Abcam Cat# ab134113, RRID:AB_2734695)
  
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sciencedirect.com/science/article/pii/S2589004222005491
www.sciencedirect.com www.sciencedirect.com

Cholesterol determines the cytosolic entry and seeded aggregation of tau

1
1. scibot 13 May 2022
  
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  RRID:AB_2734695
  
  DOI: 10.1016/j.celrep.2022.110776
  
  Resource: (Abcam Cat# ab134113, RRID:AB_2734695)
  
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sciencedirect.com/science/article/pii/S221112472200540X
Oct 2021
elifesciences.org elifesciences.org

Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy

1
1. scibot 23 Oct 2021
  
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  RRID:AB_2734695
  
  DOI: 10.7554/eLife.72328
  
  Resource: (Abcam Cat# ab134113, RRID:AB_2734695)
  
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  SciCrunch record: RRID:AB_2734695
  
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elifesciences.org/articles/72328
Jul 2021
www.nature.com www.nature.com

Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C

1
1. scibot 31 Jul 2021
  
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  ab134113
  
  DOI: 10.1038/s41586-021-03762-2
  
  Resource: (Abcam Cat# ab134113, RRID:AB_2734695)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2734695
  
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  RRID:AB_2734695 RRIDCUR:Missing
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nature.com/articles/s41586-021-03762-2
May 2021
www.sciencedirect.com www.sciencedirect.com

NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

1
1. scibot 06 May 2021
  
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  RRID:AB_2734695
  
  DOI: 10.1016/j.devcel.2020.11.016
  
  Resource: (Abcam Cat# ab134113, RRID:AB_2734695)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2734695
  
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sciencedirect.com/science/article/pii/S1534580720309254
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C

1
1. scibot 20 Apr 2021
  
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  RRID:AB_2734695
  
  DOI: 10.1016/j.devcel.2021.03.032
  
  Resource: (Abcam Cat# ab134113, RRID:AB_2734695)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2734695
  
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  RRIDCUR:Validated RRID:AB_2734695
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RRIDCUR:Validated

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sciencedirect.com/science/article/pii/S1534580721003075
Feb 2021
onlinelibrary.wiley.com onlinelibrary.wiley.com

High‐content imaging and structure‐based predictions reveal functional differences between Niemann‐Pick C1 variants

1
1. scibot 25 Feb 2021
  
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  RRID:AB_2734695
  
  DOI: 10.1111/tra.12727
  
  Resource: (Abcam Cat# ab134113, RRID:AB_2734695)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2734695
  
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onlinelibrary.wiley.com/doi/10.1111/tra.12727
Sep 2020
www.sciencedirect.com www.sciencedirect.com

Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism

1
1. scibot 13 Sep 2020
  
  in Public
  
  RRID:AB_2734695
  
  DOI: 10.1016/j.celrep.2019.12.042
  
  Resource: (Abcam Cat# ab134113, RRID:AB_2734695)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2734695
  
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  RRIDCUR:Validated RRID:AB_2734695
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RRIDCUR:Validated

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sciencedirect.com/science/article/pii/S2211124719316997
www.sciencedirect.com www.sciencedirect.com

ZIGIR, a Granule-Specific Zn2+ Indicator, Reveals Human Islet α Cell Heterogeneity

1
1. scibot 09 Sep 2020
  
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  RRID:AB_2734695
  
  DOI: 10.1016/j.celrep.2020.107904
  
  Resource: (Abcam Cat# ab134113, RRID:AB_2734695)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2734695
  
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  RRIDCUR:Validated RRID:AB_2734695
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RRIDCUR:Validated

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sciencedirect.com/science/article/pii/S2211124720308858
Jan 2020
elifesciences.org elifesciences.org

Intracellular cholesterol trafficking is dependent upon NPC2 interaction with Lysobisphosphatidic Acid

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2734695
  
  DOI: 10.7554/eLife.50832
  
  Resource: (Abcam Cat# ab134113, RRID:AB_2734695)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2734695
  
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  RRID:AB_2734695 RRIDCUR:Validated
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elifesciences.org/articles/50832
www.sciencedirect.com www.sciencedirect.com

Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2734695
  
  DOI: 10.1016/j.celrep.2019.04.099
  
  Resource: (Abcam Cat# ab134113, RRID:AB_2734695)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2734695
  
  What is this?
  
  RRID:AB_2734695 RRIDCUR:Validated
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RRIDCUR:Validated

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sciencedirect.com/science/article/pii/S2211124719305790