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P21-positive senescent stromal cells promote prostate cancer immune suppression and progression that can be reversed by senolytic therapy

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  DOI: 10.1158/2159-8290.CD-25-1212
  
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aacrjournals.org/cancerdiscovery/article/16/3/571/774737/p21-Positive-Senescent-Stromal-Cells-Promote
Apr 2026
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A pig model of human radiation-induced veno-occlusive liver disease reveals ferroptosis as a therapeutic target

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  DOI: 10.1016/j.xcrm.2026.102745
  
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sciencedirect.com/science/article/pii/S266637912600162X
Mar 2026
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Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates

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  DOI: 10.1016/j.cmet.2026.02.010
  
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sciencedirect.com/science/article/pii/S1550413126000537
Jan 2026
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NNMT inhibition counteracts tubular senescence and fibrosis in early stages of chronic kidney disease

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  DOI: 10.1016/j.celrep.2025.116823
  
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sciencedirect.com/science/article/pii/S2211124725015955
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Targeting senescent EGR1+ B cells enhances immunotherapy efficacy in esophageal squamous cell carcinoma

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  DOI: 10.1016/j.xcrm.2025.102532
  
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sciencedirect.com/science/article/pii/S2666379125006056
Nov 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Protein kinase Cι dictates tumor trajectory, cell plasticity, and immune surveillance in lung adenocarcinoma

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116606
  
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sciencedirect.com:5037/science/article/pii/S2211124725013786
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Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution

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1. scibot 15 Nov 2025
  
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  DOI: 10.1016/j.neuron.2025.10.018
  
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sciencedirect.com/science/article/abs/pii/S0896627325007998
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Impaired macroautophagy in oligodendrocyte precursor cells suppresses neuronal plasticity via a senescence-associated signaling

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  DOI: 10.1126/sciadv.adq7665
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12459396/
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Nucleolar stress facilitates islet β cell senescence via hijacking the DNA damage response pathways

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1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.isci.2025.113508
  
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sciencedirect.com/science/article/pii/S2589004225017699
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Cyclin-dependent kinase inhibitor 1A mediates mouse line- and fate-dependent cellular responses in Cx3cr1-Cre genetic tools

1
1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116267
  
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sciencedirect.com/science/article/pii/S2211124725010381
Aug 2025
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Protein arginine methylation regulates anti-inflammatory programming in response to aging stress

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1. scibot 05 Aug 2025
  
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  DOI: 10.1016/j.isci.2025.113095
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12312054/
Jul 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225013562-main-html.html

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016
  
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52.53.155.43/365e43ac25972b4e957d9092af0f2f1fb9101478/1-s2.0-S2589004225013562-main-html.html
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Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps

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1. scibot 03 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.06.007
  
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sciencedirect.com/science/article/pii/S1535610825002570
Jun 2025
www.cell.com www.cell.com

Systematic profiling reveals betaine as an exercise mimetic for geroprotection

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.cell.2025.06.001
  
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cell.com/cell/fulltext/S0092-8674(25)00635-X
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Inhibition of caspase-1 by ginsenoside Rg1 ameliorates d-gal-induced renal aging and injury through suppression of oxidative stress and inflammation

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1. scibot 21 May 2025
  
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  DOI: 10.1080/0886022X.2025.2504634
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12086920/
Apr 2025
faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

Targeting MLL1/WDR5-Mediated Epigenetic Regulation Mitigates Peritoneal Fibrosis by Reducing p16INK4a

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1. scibot 17 Apr 2025
  
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  DOI: 10.1096/fj.202402382R
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202402382R
Feb 2025
52.53.155.43 52.53.155.43

ER stress relief drives ß-cell proliferation

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1. scibot 06 Feb 2025
  
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  AB_2734729
  
  DOI: 10.1101/2024.09.06.611615
  
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52.53.155.43/b13b156e364661559b264098671a0939c200ccb5/2024.09.06.611615v1.full-html.html
Dec 2024
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Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence

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1. scibot 11 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111311
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11617384/
Nov 2024
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Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging

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1. scibot 16 Nov 2024
  
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  DOI: 10.1016/j.cell.2024.10.019
  
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sciencedirect.com/science/article/pii/S0092867424012017
Oct 2024
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Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

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1. scibot 02 Oct 2024
  
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  DOI: 10.1016/j.neuron.2024.09.006
  
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sciencedirect.com/science/article/pii/S0896627324006548
Sep 2024
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Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation

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  DOI: 10.1016/j.immuni.2024.08.015
  
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sciencedirect.com/science/article/pii/S1074761324004151
Jul 2024
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Autophagy regulates age-related delayed jawbone regeneration and decreased osteoblast osteogenesis by degrading FABP3

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1. scibot 23 Jul 2024
  
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  DOI: 10.1096/fj.202400549RR
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202400549RR
May 2024
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A cocktail of rapamycin, acarbose, and phenylbutyrate prevents age-related cognitive decline in mice by targeting multiple aging pathways

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1. scibot 30 May 2024
  
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  DOI: 10.1007/s11357-024-01198-w
  
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link.springer.com/article/10.1007/s11357-024-01198-w
www.biorxiv.org www.biorxiv.org

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

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1. scibot 10 May 2024
  
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  DOI: 10.1101/2024.01.24.577107
  
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biorxiv.org/content/10.1101/2024.01.24.577107v1
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Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor

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1. scibot 07 May 2024
  
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  DOI: 10.1016/j.stem.2024.04.011
  
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  DOI: 10.1016/j.stem.2024.04.011
  
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sciencedirect.com/science/article/pii/S1934590924001383
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Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size

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1. scibot 02 May 2024
  
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  DOI: 10.1016/j.neuron.2024.04.006
  
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sciencedirect.com/science/article/pii/S0896627324002447
Apr 2024
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Tracing the origin of alveolar stem cells in lung repair and regeneration

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  DOI: 10.1016/j.cell.2024.03.010
  
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sciencedirect.com/science/article/pii/S0092867424003027
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Telomere dysfunction alters intestinal stem cell dynamics to promote cancer

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1. scibot 04 Apr 2024
  
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  DOI: 10.1016/j.devcel.2024.03.020
  
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sciencedirect.com/science/article/pii/S1534580724001886
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks

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  DOI: 10.1016/j.celrep.2024.114006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11272184/
Dec 2023
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VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis

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1. scibot 02 Dec 2023
  
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  DOI: 10.1016/j.stem.2023.10.008
  
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sciencedirect.com/science/article/pii/S1934590923003922
Nov 2023
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Age-related decline in spermatogenic activity accompanied with endothelial cell senescence in male mice

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.isci.2023.108456
  
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sciencedirect.com/science/article/pii/S2589004223025336
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Stress-induced β cell early senescence confers protection against type 1 diabetes

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1. scibot 17 Nov 2023
  
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  DOI: 10.1016/j.cmet.2023.10.014
  
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sciencedirect.com/science/article/pii/S1550413123003832
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Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors

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1. scibot 04 Nov 2023
  
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  RRID:AB_2734729
  
  DOI: 10.1016/j.isci.2023.108169
  
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sciencedirect.com/science/article/pii/S2589004223022460
Oct 2023
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A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells

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1. scibot 13 Oct 2023
  
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  RRID:AB_2734729
  
  DOI: 10.1016/j.molcel.2023.09.006
  
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Death-seq identifies regulators of cell death and senolytic therapies

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  DOI: 10.1016/j.cmet.2023.08.008
  
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Aug 2023
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Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer

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Jun 2023
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Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response

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Mettl14-mediated m6A modification ensures the cell-cycle progression of late-born retinal progenitor cells

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Reversal of liver failure using a bioartificial liver device implanted with clinical-grade human-induced hepatocytes

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In vivo RNA-seq and ChIP-seq analyses show an obligatory role for the C terminus of p53 in conferring tissue-specific radiation sensitivity

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TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state

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Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis

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Jan 2023
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Resurrection of endogenous retroviruses during aging reinforces senescence

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Immunoediting instructs tumor metabolic reprogramming to support immune evasion

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Dec 2022
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Cystatin B deficiency results in sustained histone H3 tail cleavage in postnatal mouse brain mediated by increased chromatin-associated cathepsin L activity

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GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment

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hsa-miR-195-5p inhibits cell proliferation of human thyroid carcinoma cells via modulation of p21/cyclin D1 axis

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Oct 2021
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Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress

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Sep 2020
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Sirt1-inducible deacetylation of p21 promotes cardiomyocyte proliferation

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Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation

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Immp2l mutation causes ovarian aging through ROS-Wnt/β-catenin-estrogen pathway: preventive effect of melatonin

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  DOI: 10.1210/endocr/bqaa119
  
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Jan 2020
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Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons

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Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma

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Untitled document

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  DOI: 10.1016/j.ccell.2018.12.013
  
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Nov 2018
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Untitled document

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