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Aug 2025
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Type I interferon signaling promotes kainic acid-induced seizures through mTOR activation

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1. scibot 19 Aug 2025
  
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  DOI: 10.1016/j.neuropharm.2025.110634
  
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sciencedirect.com/science/article/pii/S0028390825003429
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Overcoming ovarian cancer resistance and evasion to CAR-T cell therapy by harnessing allogeneic CAR-NKT cells

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.medj.2025.100804
  
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sciencedirect.com/science/article/pii/S2666634025002314
Jul 2025
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Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102251
  
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sciencedirect.com/science/article/pii/S2666379125003246
Jun 2025
52.53.155.43 52.53.155.43

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1. scibot 12 Jun 2025
  
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  DOI: 10.1158/2326-6066.cir-24-1298
  
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52.53.155.43/3713636d600e62e8db399e96c9a07021d0812f3a/PDF-html.html
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LEADR, a p63 target, dampens interferon signalling in bladder cancer

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1. scibot 11 Jun 2025
  
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  DOI: 10.1038/s41420-025-02546-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12134291/
May 2025
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Phase transition of WTAP regulates m6A modification of interferon-stimulated genes

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1. scibot 31 May 2025
  
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  DOI: 10.7554/eLife.100601
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12113268/
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Inhibition of IRE1α Alleviates Renal Fibrosis and Downregulates M1 Macrophage Activation via the p38 MAPK Pathway

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1. scibot 29 May 2025
  
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  DOI: 10.1111/imm.13949
  
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onlinelibrary.wiley.com/doi/10.1111/imm.13949
Apr 2025
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1-s2.0-S0016508525005426-main-html.html

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1. scibot 05 Apr 2025
  
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  DOI: 10.1053/j.gastro.2025.03.019
  
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52.53.155.43/417f7e11cf34a4a05dabce5f916b0d6ed71a75c4/1-s2.0-S0016508525005426-main-html.html
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O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles

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1. scibot 03 Apr 2025
  
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  DOI: 10.1016/j.cmet.2025.03.006
  
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sciencedirect.com/science/article/pii/S1550413125001093
Mar 2025
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Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome

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1. scibot 27 Mar 2025
  
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  DOI: 10.1126/sciadv.adi9885
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11927619/
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Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome

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1. scibot 24 Mar 2025
  
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  DOI: 10.1126/sciadv.adi9885
  
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science.org/doi/10.1126/sciadv.adi9885
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AGO2 mediates immunotherapy failure via suppressing tumor IFN-gamma response-dependent CD8+ T cell immunity

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1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115445
  
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sciencedirect.com/science/article/pii/S2211124725002165
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Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy

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1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.ccell.2025.02.014
  
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sciencedirect.com/science/article/pii/S1535610825000662
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CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

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1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.ccell.2025.02.006
  
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sciencedirect.com/science/article/pii/S1535610825000583
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DA-DRD5 signaling reprograms B cells to promote CD8+ T cell-mediated antitumor immunity

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1. scibot 04 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115364
  
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sciencedirect.com/science/article/pii/S2211124725001354
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Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response

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1. scibot 04 Mar 2025
  
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  DOI: 10.1016/j.cell.2025.01.043
  
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cell.com/cell/abstract/S0092-8674(25)00145-X
Feb 2025
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TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-22-3009
  
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aacrjournals.org/cancerres/article/83/13/2262/727433/TGF-Antagonizes-IFN-Mediated-Adaptive-Immune
Jan 2025
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Acquired resistance to PD-L1 inhibition enhances a type I IFN-regulated secretory program in tumors

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1. scibot 30 Jan 2025
  
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  DOI: 10.1038/s44319-024-00333-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11772817/
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Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity

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1. scibot 15 Jan 2025
  
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  DOI: 10.1038/s41467-024-55667-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11711318/
Dec 2024
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Pressure to evade cell-autonomous innate sensing reveals interplay between mitophagy, IFN signaling, and SARS-CoV-2 evolution

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115115
  
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sciencedirect.com/science/article/pii/S2211124724014669
Nov 2024
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Deciphering the Metabolic Basis and Molecular Circuitry of the Warburg Paradox in Lymphoma

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1. scibot 14 Nov 2024
  
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  DOI: 10.3390/cancers16213606
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11545614/
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Deciphering the composition and key driver genes of breast invasive micropapillary carcinoma by multi-omics analysis

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1. scibot 14 Nov 2024
  
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  DOI: 10.1016/j.isci.2024.111178
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11549989/
Sep 2024
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PDIA3 orchestrates effector T cell program by serving as a chaperone to facilitate the non-canonical nuclear import of STAT1 and PKM2

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.ymthe.2024.05.038
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11405166/
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Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.chom.2024.08.013
  
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sciencedirect.com/science/article/pii/S1931312824003202
Aug 2024
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Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression

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1. scibot 28 Aug 2024
  
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  DOI: 10.1016/j.devcel.2024.08.003
  
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sciencedirect.com/science/article/pii/S1534580724004866
Jul 2024
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Citrate metabolism controls the senescent microenvironment via the remodeling of pro-inflammatory enhancers

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1. scibot 25 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114496
  
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sciencedirect.com/science/article/pii/S2211124724008258
Jun 2024
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The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity

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1. scibot 08 Jun 2024
  
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  DOI: 10.1158/2326-6066.CIR-23-1078
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11148535/
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Interferon-γ induces combined pyroptotic angiopathy and APOL1 expression in human kidney disease

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1. scibot 07 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114310
  
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sciencedirect.com/science/article/pii/S2211124724006387
May 2024
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cir-23-1078-html.html

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  DOI: 10.1158/2326-6066.cir-23-1078
  
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52.53.155.43/ee0bd7762d373e957152429ed1d9032329c895e5/cir-23-1078-html.html
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Development of nitroalkene-based inhibitors to target STING-dependent inflammation

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1. scibot 23 May 2024
  
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  DOI: 10.1016/j.redox.2024.103202
  
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sciencedirect.com/science/article/pii/S2213231724001800
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PABPC1L induces IDO1 to promote tryptophan metabolism and immune suppression in renal cell carcinoma

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1. scibot 17 May 2024
  
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  DOI: 10.1158/0008-5472.CAN-23-2521
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11094425/
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The Janus kinase 1 is critical for pancreatic cancer initiation and progression

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1. scibot 14 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114202
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11194014/
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Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation

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1. scibot 14 May 2024
  
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  DOI: 10.1016/j.stem.2024.04.015
  
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sciencedirect.com/science/article/pii/S1934590924001425
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Hepatokine ITIH3 Protects Against Hepatic Steatosis by Downregulating Mitochondrial Bioenergetics and De Novo Lipogenesis

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1. scibot 03 May 2024
  
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  DOI: 10.1016/j.isci.2024.109709
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11059128/
Apr 2024
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Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity

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1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.xcrm.2024.101528
  
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Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21

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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

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ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-Catenin/PD-L1 axis

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Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation

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Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon

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Gut-Brain Axis Interplay via STAT3 pathway: Implications of Helicobacter pylori derived secretome on inflammation and Alzheimer's disease

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Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5

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IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects

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Aedes aegypti saliva modulates inflammasome activation and facilitates flavivirus infection in vitro

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The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer

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Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity

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Serotonin reduction in post-acute sequelae of viral infection

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MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling

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High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma

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Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer

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Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation

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New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation

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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

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Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses

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Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination

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Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity

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SECTM1 is upregulated in immuno-hot tumors and predicts immunotherapeutic efficacy in multiple cancers

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Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity

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Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner

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Immunoediting instructs tumor metabolic reprogramming to support immune evasion

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Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer

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Antiviral function and viral antagonism of the rapidly evolving dynein activating adaptor NINL

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AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity

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Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

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Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis

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OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis

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Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation

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SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA

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The redox cycling of STAT2 maintains innate immune homeostasis

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Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-low Induction of Therapy Resistance

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cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model

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May 2022
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WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC

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Extracellular Nicotinamide Phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4

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Ruxolitinib attenuates secondary injury after traumatic spinal cord injury

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JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction

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Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling

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Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility

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Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription

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Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells

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Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance

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ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

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In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target

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Activating a collaborative innate-adaptive immune response to control metastasis

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IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners

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Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

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PML-NB-dependent type I interferon memory results in a restricted form of HSV latency

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embopress.org/doi/abs/10.15252/embr.202152547
Jun 2021
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Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition

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Promotion of Bone Lesions Through the Myeloma Integrin α6-Mediated Osteolytic Signaling

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May 2021
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Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus

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Apr 2021
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NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion

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Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication

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Feb 2021
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microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP

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Evasion of type-I interferon by SARS-CoV-2

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Disruption of DNA polymerase ζ engages an innate immune response

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MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

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Evasion of type-I interferon by SARS-CoV-2

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Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex–mediated STAT1 downregulation

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  DOI: 10.1084/jem.20191340
  
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BPS Publications

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Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

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sciencedirect.com/science/article/pii/S0092867420303330
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Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

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Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and III Interferons

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STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production

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Activation of peroxisome proliferator‐activated receptor delta suppresses BACE1 expression by up‐regulating SOCS1 in a JAK2/STAT1‐dependent manner

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onlinelibrary.wiley.com/doi/full/10.1111/jnc.14715
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A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

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1. scibot 13 Jan 2020
  
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  RRID:AB_2737027
  
  DOI: 10.1016/j.ccell.2019.10.002
  
  Resource: (Cell Signaling Technology Cat# 14994, RRID:AB_2737027)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2737027
  
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  RRID:AB_2737027 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610819304763
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Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

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1. scibot 13 Jan 2020
  
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  RRID:AB_2737027
  
  DOI: 10.1016/j.celrep.2019.10.020
  
  Resource: (Cell Signaling Technology Cat# 14994, RRID:AB_2737027)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2737027
  
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  RRID:AB_2737027 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124719313208
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Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility

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1. scibot 12 Jan 2020
  
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  RRID:AB_2737027
  
  DOI: 10.1016/j.cell.2019.01.039
  
  Resource: (Cell Signaling Technology Cat# 14994, RRID:AB_2737027)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2737027
  
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  RRID:AB_2737027 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0092867419301023

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