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  1. Last 7 days
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    MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics
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    1. scibot 21 Dec 2024
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    sciencedirect.com/science/article/pii/S2211124724014554
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    MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling
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    The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance
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  5. Dec 2024
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    Lurbinectedin sensitizes PD-L1 blockade therapy by activating STING-IFN signaling in small-cell lung cancer
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    Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening
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    1. scibot 10 Dec 2024
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    sciencedirect.com/science/article/pii/S2405471224003375
  8. Nov 2024
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy
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    1. scibot 07 Nov 2024
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      DOI: 10.3389/fonc.2024.1441935

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    pmc.ncbi.nlm.nih.gov/articles/PMC11513249/
  10. Sep 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1
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    1. scibot 26 Sep 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387596/
  12. Aug 2024
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    The V-ATPase/ATG16L1 axis is controlled by the V1H subunit
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    sciencedirect.com/science/article/pii/S1097276524005793
  14. Jul 2024
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway
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    1. scibot 27 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11267025/
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    PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection
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    1. scibot 24 Jul 2024
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  17. May 2024
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    Development of nitroalkene-based inhibitors to target STING-dependent inflammation
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    1. scibot 23 May 2024
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    sciencedirect.com/science/article/pii/S2213231724001800
  19. Apr 2024
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    Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
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    Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening
    1
    1. scibot 28 Apr 2024
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      DOI: 10.1101/2024.04.07.588166

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    Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
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    IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling
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    1. scibot 11 Apr 2024
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    sciencedirect.com/science/article/pii/S2211124724004169
  24. Mar 2024
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses
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      DOI: 10.1016/j.celrep.2024.113886

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    HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
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    sciencedirect.com/science/article/pii/S2211124724001980
  27. Nov 2023
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    Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis
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    1. scibot 28 Nov 2023
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    sciencedirect.com/science/article/abs/pii/S1074761323004582
  29. Oct 2023
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    Regulation of STING activity in DNA sensing by ISG15 modification
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      DOI: 10.1016/j.celrep.2023.113277

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    sciencedirect.com/science/article/pii/S2211124723012895
  31. Jul 2023
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    MEF2A suppresses stress responses that trigger DDX41-dependent IFN production
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    sciencedirect.com/science/article/pii/S2211124723008161
  33. May 2023
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    Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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    1. scibot 27 May 2023
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      DOI: 10.1016/j.ccell.2023.04.016

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    sciencedirect.com/science/article/pii/S1535610823001423
  35. Apr 2023
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    Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses
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    sciencedirect.com/science/article/pii/S2666379123001349
  37. Mar 2023
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    The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus
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    sciencedirect.com/science/article/pii/S2211124723003170
  39. Dec 2022
  40. www.embopress.org www.embopress.org
    DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma
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      DOI: 10.15252/embj.2022111961

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    embopress.org/doi/10.15252/embj.2022111961
  41. Nov 2022
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9619380/
  43. Sep 2022
  44. www.sciencedirect.com www.sciencedirect.com
    Ku proteins promote DNA binding and condensation of cyclic GMP-AMP synthase
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      RRID:AB_2920552

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    sciencedirect.com/science/article/pii/S2211124722011342
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    ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP
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    sciencedirect.com/science/article/pii/S1074761322003995
  46. Jun 2022
  47. rupress.org rupress.org
    ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
    1
    1. scibot 09 Jun 2022
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      DOI: 10.1083/jcb.202106046

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    rupress.org/jcb/article/221/7/e202106046/213259/ER-lysosome-lipid-transfer-protein-VPS13C-PARK23
  48. May 2022
  49. www.sciencedirect.com www.sciencedirect.com
    DDX41 is required for cGAS-STING activation against DNA virus infection
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    sciencedirect.com/science/article/pii/S2211124722006295
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    WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC
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    sciencedirect.com/science/article/pii/S221112472200585X
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    Protocol to induce and assess cGAS-STING pathway activation in vitro
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      RRID:AB_2737062

      DOI: 10.1016/j.xpro.2022.101384

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    sciencedirect.com/science/article/pii/S2666166722002647
  52. Nov 2021
  53. www.sciencedirect.com www.sciencedirect.com
    APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis
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      RRID:AB_2737062

      DOI: 10.1016/j.immuni.2021.10.004

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    sciencedirect.com/science/article/pii/S1074761321004106
  54. May 2021
  55. www.sciencedirect.com www.sciencedirect.com
    BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse
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    1. scibot 09 May 2021
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      DOI: 10.1016/j.stem.2020.06.022

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    sciencedirect.com/science/article/pii/S1934590920302897
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    Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress
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      DOI: 10.1016/j.molcel.2021.02.038

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    sciencedirect.com/science/article/pii/S1097276521001684
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    SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function
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      DOI: 10.1016/j.molcel.2020.12.024

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    sciencedirect.com/science/article/pii/S109727652030945X
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    LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP
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      RRID:AB_2737062

      DOI: 10.1016/j.molcel.2020.10.021

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    sciencedirect.com/science/article/pii/S1097276520307280
  59. Apr 2021
  60. www.sciencedirect.com www.sciencedirect.com
    Mutant p53 suppresses innate immune signaling to promote tumorigenesis
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      RRID:AB_2737062

      DOI: 10.1016/j.ccell.2021.01.003

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    sciencedirect.com/science/article/pii/S1535610821000416
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    Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity
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      DOI: 10.1016/j.ccell.2020.05.020

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    sciencedirect.com/science/article/pii/S1535610820302701
  62. Sep 2020
  63. www.sciencedirect.com www.sciencedirect.com
    TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
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    1. scibot 17 Sep 2020
      RRID:AB_2737062

      DOI: 10.1016/j.celrep.2020.03.056

      Resource: (Cell Signaling Technology Cat# 19781, RRID:AB_2737062)

      Curator: @ethanbadger

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      RRIDCUR:Validated RRID:AB_2737062
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    sciencedirect.com/science/article/pii/S2211124720303703
  64. www.cell.com www.cell.com
    The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
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    1. scibot 04 Sep 2020
      RRID: AB_2737062

      DOI: 10.1016/j.celrep.2018.11.097

      Resource: (Cell Signaling Technology Cat# 19781, RRID:AB_2737062)

      Curator: @evieth

      SciCrunch record: RRID:AB_2737062

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      RRID:AB_2737062
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    cell.com/cell-reports/fulltext/S2211-1247(18)31888-6
  65. Jan 2020
  66. www.sciencedirect.com www.sciencedirect.com
    Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING
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    1. scibot 12 Jan 2020
      RRID:AB_2737062

      DOI: 10.1016/j.molcel.2019.02.038

      Resource: (Cell Signaling Technology Cat# 19781, RRID:AB_2737062)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_2737062

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      RRID:AB_2737062 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1097276519301492