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Pharmacologic reversion of Merkel cell carcinoma via CBP/p300 inhibition

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pmc.ncbi.nlm.nih.gov/articles/PMC12772197/
May 2026
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A reabsorption mechanism in Drosophila renal tubules maintains amino acid homeostasis

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biorxiv.org/content/10.64898/2026.05.07.723391v1
Jan 2026
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Protocol for identification of protein citrullination by immunoprecipitation followed by mass spectrometry

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Innate Immune Tolerance Regulates Microglia Response to Aβ Oligomers

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onlinelibrary.wiley.com/doi/10.1111/jnc.70341
Dec 2025
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NAT10 promotes cancer metastasis by modulating p300/CBP activity through chromatin-associated tRNA

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pmc.ncbi.nlm.nih.gov/articles/PMC12709618/
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Recruitment of FBXO22 for targeted degradation of NSD2

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pmc.ncbi.nlm.nih.gov/articles/PMC11581931/
Oct 2025
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SMARCA1 regulates PARP1-dependent ABC transporters expression and mediates doxorubicin resistance in triple-negative breast cancer

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Targeted citrullination enables p53 binding to non-canonical sites

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Sep 2025
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Hepatic acetyl-CoA metabolism modulates neuroinflammation and depression susceptibility via acetate

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Aurora kinase A promotes trained immunity via regulation of endogenous S-adenosylmethionine metabolism

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pmc.ncbi.nlm.nih.gov/articles/PMC12416886/
May 2025
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Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV

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Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control

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Dec 2024
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A nonsecretory antimicrobial peptide mediates inflammatory organ damage in Drosophila renal tubules

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The C-terminal PHDVC5HCH tandem domain of NSD2 is a combinatorial reader of unmodified H3K4 and tri-methylated H3K27 that regulates transcription of cell adhesion genes in multiple myeloma

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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1121/7917111
Jul 2024
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ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer

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1-s2.0-S2589004224017851-main-html.html

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BPS Publications

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  DOI: 10.1111/bph.16439
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16439
Jun 2024
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Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice

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ncbi.nlm.nih.gov/pmc/articles/PMC11154205/
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Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS-dependent apoptosis in ovarian cancer cells by targeting PAR-1

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sciencedirect.com/science/article/pii/S2589004224010502
Feb 2024
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EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis

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Nov 2023
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A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression

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I-CBP112 declines overexpression of ATP-binding cassette transporters and sensitized drug-resistant MDA-MB-231 and A549 cell lines to chemotherapy drugs

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Recruitment of FBXO22 for Targeted Degradation of NSD2

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Aug 2023
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ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer

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Nuclear transport surveillance of p53 by nuclear pores in glioblastoma

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52.53.155.43/64ae675a86b73874b1bb5c50aa8d9678e93e36d6/PIIS2211124723008938-html.html
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Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2

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nature.com/articles/s41594-023-01044-1
Jun 2023
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Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss

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ncbi.nlm.nih.gov/pmc/articles/PMC10285549/
May 2023
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Transcriptional and metabolic programs promote the expansion of follicular helper T cells in lupus-prone mice

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sciencedirect.com/science/article/pii/S2589004223008519
Apr 2023
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Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis

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Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting

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sciencedirect.com/science/article/pii/S1097276523001028
Jan 2023
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Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation

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cell.com/cell/fulltext/S0092-8674(22)01517-3
Dec 2022
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BAF complex maintains glioma stem cells in pediatric H3K27M-glioma

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aacrjournals.org/cancerdiscovery/article/12/12/2880/711164/BAF-Complex-Maintains-Glioma-Stem-Cells-in
Oct 2022
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Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomas

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sciencedirect.com/science/article/pii/S1097276522009340
Mar 2022
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Indirubin-3’-monoxime acts as proteasome inhibitor: Therapeutic application in multiple myeloma

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  DOI: 10.1016/j.ebiom.2022.103950
  
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Jan 2022
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Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation

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Sep 2021
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ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance

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  DOI: 10.1016/j.cell.2021.08.036
  
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Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation

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  DOI: 10.1016/j.devcel.2021.08.018
  
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Aug 2021
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Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis

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A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

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May 2021
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Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas

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  DOI: 10.1016/j.immuni.2020.11.002
  
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Mar 2021
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Targeting the mitochondrial permeability transition pore for neuroprotection in a piglet model of neonatal hypoxic‐ischemic encephalopathy

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  DOI: 10.1002/jnr.24821
  
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Sep 2020
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BPS Publications

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  DOI: 10.1111/bph.14806
  
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Jan 2020
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EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex

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Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1

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  DOI: 10.1016/j.molcel.2019.12.003
  
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Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy

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  DOI: 10.1016/j.celrep.2019.08.105
  
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Untitled document

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