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A trifluoromethyl quinazoline inhibits hepatocellular carcinoma proliferation through HDAC1 binding and multi-target mechanisms

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1. scibot 01 Aug 2026
  
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  DOI: 10.1016/j.isci.2026.117037
  
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sciencedirect.com/science/article/pii/S2589004226024156
Jul 2026
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HDAC-driven autophagy repression aids macrophage immune evasion by K. pneumoniae strains displaying classical, MDR, and hypervirulent phenotypes

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1. scibot 11 Jul 2026
  
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  DOI: 10.1016/j.isci.2026.116662
  
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sciencedirect.com/science/article/pii/S2589004226020389
Apr 2026
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RLF/ZFP292 stabilize CoREST-linked LSD1 engagement at bivalent promoters to safeguard pluripotency

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1. scibot 17 Apr 2026
  
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  DOI: 10.1016/j.celrep.2026.117293
  
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sciencedirect.com/science/article/pii/S2211124726003712
Mar 2026
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APOE4 drives widespread changes to the hepatic proteome and alters metabolic function

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1. scibot 10 Mar 2026
  
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  DOI: 10.1016/j.isci.2026.115035
  
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sciencedirect.com/science/article/pii/S2589004226004104
Feb 2026
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MIG-6 Regulates HDAC1-Mediated Angiogenesis and Tumorigenesis in PTEN-Deficient Endometrioid Endometrial Cancer

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1. scibot 27 Feb 2026
  
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  DOI: 10.1158/1541-7786.MCR-25-0544
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12935093/
Jan 2026
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Pregnenolone promotes immune evasion through blocking endogenous retrovirus expression

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1. scibot 27 Jan 2026
  
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  DOI: 10.1016/j.cmet.2025.12.020
  
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sciencedirect.com/science/article/pii/S1550413125005844
Dec 2025
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Respiratory syncytial virus downregulates the airway aryl hydrocarbon receptor pathway: implication for the development of a novel therapeutic target

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1. scibot 23 Dec 2025
  
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  DOI: 10.1152/ajplung.00134.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12716637/
Nov 2025
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Hierarchical regulation of cerebellar neurogenesis by Sin3A-mediated gene repression

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1. scibot 27 Nov 2025
  
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  DOI: 10.1101/2025.10.17.683101
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12632768/
Oct 2025
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Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma

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1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.drup.2025.101312
  
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sciencedirect.com/science/article/pii/S1368764625001153
Jul 2025
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RACK7 senses and fine-tunes enhancer activity

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1. scibot 31 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.113083
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12304917/
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1-s2.0-S2589004225013446-main-html.html

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016
  
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52.53.155.43/3a940a222b37943f01bb89b56d8fe0b40f820eb6/1-s2.0-S2589004225013446-main-html.html
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1-s2.0-S0016508525057324-main-html.html

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1. scibot 08 Jul 2025
  
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  DOI: 10.1053/j.gastro.2025.07.003
  
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52.53.155.43/a363e4ae90be5a0c17cae72bbc9ca19379f34011/1-s2.0-S0016508525057324-main-html.html
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High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.115947
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00718-1
Mar 2025
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Phosphatase PHLPP1 is an alveolar-macrophage-intrinsic transcriptional checkpoint controlling pulmonary fibrosis

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1. scibot 13 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115399
  
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sciencedirect.com/science/article/pii/S2211124725001706
Dec 2024
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BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cells

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1. scibot 05 Dec 2024
  
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  DOI: 10.1038/s44318-024-00276-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11612440/
Nov 2024
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Deciphering the Metabolic Basis and Molecular Circuitry of the Warburg Paradox in Lymphoma

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1. scibot 14 Nov 2024
  
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  DOI: 10.3390/cancers16213606
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11545614/
Sep 2024
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A novel inhibitor of class IIa histone deacetylases attenuates collagen-induced arthritis

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1. scibot 27 Sep 2024
  
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  DOI: 10.1111/bph.17306
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17306
Aug 2024
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Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity

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1. scibot 19 Aug 2024
  
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  DOI: 10.1016/j.immuni.2024.07.010
  
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sciencedirect.com/science/article/pii/S1074761324003595
Jan 2024
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Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression

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1. scibot 11 Jan 2024
  
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  DOI: 10.1016/j.celrep.2023.113575
  
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sciencedirect.com/science/article/pii/S2211124723015875
Dec 2023
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A histone deacetylase network regulates epigenetic reprogramming and viral silencing in HIV-infected cells

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1. scibot 22 Dec 2023
  
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  DOI: 10.1016/j.chembiol.2023.11.009
  
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sciencedirect.com/science/article/pii/S2451945623004245
Aug 2023
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HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation

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1. scibot 12 Aug 2023
  
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  DOI: 10.1016/j.chembiol.2023.07.010
  
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sciencedirect.com/science/article/abs/pii/S2451945623002404
Jun 2023
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Modulation of cellular metabolism by protein crotonylation regulates pancreatic cancer progression

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1. scibot 24 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112666
  
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sciencedirect.com/science/article/pii/S2211124723006770
Sep 2022
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Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity

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1. scibot 13 Sep 2022
  
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  DOI: 10.1016/j.xcrm.2022.100744
  
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sciencedirect.com/science/article/pii/S2666379122002932
Aug 2022
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Histone deacetylase-2 controls IL-1β production through the regulation of NLRP3 expression and activation in tuberculosis infection

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1. scibot 10 Aug 2022
  
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  DOI: 10.1016/j.isci.2022.104799
  
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sciencedirect.com/science/article/pii/S2589004222010719
Jul 2022
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Resolution of R-loops by topoisomerase III-β (TOP3B) in coordination with the DEAD-box helicase DDX5

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1. scibot 13 Jul 2022
  
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  DOI: 10.1016/j.celrep.2022.111067
  
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sciencedirect.com/science/article/pii/S2211124722008658
Jun 2022
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Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses

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1. scibot 08 Jun 2022
  
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  DOI: 10.1016/j.cmet.2022.05.005
  
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sciencedirect.com/science/article/pii/S1550413122001875
May 2022
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Systematic discovery of mutation-directed neo-protein-protein interactions in cancer

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1. scibot 05 May 2022
  
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  DOI: 10.1016/j.cell.2022.04.014
  
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cell.com/cell/fulltext/S0092-8674(22)00461-5
Mar 2022
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PTIP governs NAD+ metabolism by regulating CD38 expression to drive macrophage inflammation

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1. scibot 31 Mar 2022
  
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  DOI: 10.1016/j.celrep.2022.110603
  
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sciencedirect.com/science/article/pii/S2211124722003515
Nov 2021
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An epigenetic mechanism underlying chromosome 17p deletion-driven tumorigenesis

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1. scibot 19 Nov 2021
  
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  DOI: 10.1158/2159-8290.CD-20-0336
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8591992/
Apr 2021
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An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

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1. scibot 24 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.07.001
  
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sciencedirect.com/science/article/pii/S0092867420308230
Sep 2020
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Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex–mediated STAT1 downregulation

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1. scibot 03 Sep 2020
  
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  DOI: 10.1084/jem.20191340
  
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rupress.org/jem/article/217/5/e20191340/151561/Glioma-stem-like-cells-evade-interferon
Jan 2020
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TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.12.017
  
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sciencedirect.com/science/article/pii/S2211124719316675