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Linked-domain inhibitors designed to block UBE2D induce the unfolded protein response

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  DOI: 10.1016/j.chembiol.2025.11.007
  
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sciencedirect.com:5037/science/article/pii/S2451945625003770
Oct 2025
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arroyo-gomez-et-al-2025-functional-landscape-of-ubiquitin-linkages-couples-k29-linked-ubiquitylation-to-epigenome-html.html

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54.241.53.176/9315414eccf1e15b040c95d437c7e801ecba4152/arroyo-gomez-et-al-2025-functional-landscape-of-ubiquitin-linkages-couples-k29-linked-ubiquitylation-to-epigenome-html.html
Mar 2025
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TDP-43 seeding induces cytoplasmic aggregation heterogeneity and nuclear loss of function of TDP-43

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.neuron.2025.03.004
  
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sciencedirect.com/science/article/pii/S089662732500176X
Sep 2024
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TRIM67 regulates exocytic mode and neuronal morphogenesis via SNAP47

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  DOI: 10.1016/j.celrep.2021.108743
  
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sciencedirect.com/science/article/pii/S2211124721000565
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The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway

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sciencedirect.com/science/article/pii/S221112472031648X
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The ubiquitin ligase RFWD3 is required for translesion DNA synthesis

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sciencedirect.com/science/article/pii/S1097276520308297
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BPS Publications

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1. scibot 25 Sep 2024
  
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  DOI: 10.1111/bph.15060
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15060
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Noise Exposures Causing Hearing Loss Generate Proteotoxic Stress and Activate the Proteostasis Network

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.celrep.2020.108431
  
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sciencedirect.com/science/article/pii/S2211124720314200
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The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis

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sciencedirect.com/science/article/pii/S2211124720311517
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The Cdc48 Complex Alleviates the Cytotoxicity of Misfolded Proteins by Regulating Ubiquitin Homeostasis

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.celrep.2020.107898
  
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sciencedirect.com/science/article/pii/S2211124720308792
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MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells

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1. scibot 25 Sep 2024
  
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  RRID:AB_2315523
  
  DOI: 10.1016/j.celrep.2019.09.040
  
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sciencedirect.com/science/article/pii/S2211124719312288
Aug 2024
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Structural requirements for activity of Mind bomb1 in Notch signaling

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1. scibot 20 Aug 2024
  
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  DOI: 10.1016/j.str.2024.07.011
  
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sciencedirect.com/science/article/pii/S0969212624002740
Apr 2024
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Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation

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1. scibot 24 Apr 2024
  
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  DOI: 10.1038/s41594-024-01294-7
  
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link.springer.com/article/10.1038/s41594-024-01294-7
Feb 2024
www.biorxiv.org www.biorxiv.org

Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation

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1. scibot 15 Feb 2024
  
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  DOI: 10.1101/2023.12.20.572718
  
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biorxiv.org/content/10.1101/2023.12.20.572718v1
Dec 2023
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FLOT2 promotes nasopharyngeal carcinoma progression through suppression of TGF-β pathway via facilitating CD109 expression

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1. scibot 21 Dec 2023
  
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  RRID:AB_2762364
  
  DOI: 10.1016/j.isci.2023.108580
  
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sciencedirect.com/science/article/pii/S2589004223026573
Aug 2023
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MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy

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1. scibot 27 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.113045
  
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sciencedirect.com/science/article/pii/S2211124723010562
May 2023
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KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells

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1. scibot 05 May 2023
  
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  DOI: 10.1016/j.celrep.2022.111077
  
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sciencedirect.com/science/article/pii/S2211124722008750
Mar 2023
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TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy

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1. scibot 22 Mar 2023
  
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  DOI: 10.1016/j.jbc.2023.104621
  
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sciencedirect.com/science/article/pii/S0021925823002636
Jul 2022
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Membrane Targeting and GTPase Activity of Rab7 Are Required for Its Ubiquitination by RNF167

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1. scibot 31 Jul 2022
  
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  DOI: 10.3390/ijms23147847
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9319455/
Apr 2022
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Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways

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1. scibot 27 Apr 2022
  
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  DOI: 10.1016/j.celrep.2022.110736
  
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sciencedirect.com/science/article/pii/S2211124722004971
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Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques

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  DOI: 10.1016/j.immuni.2022.03.018
  
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sciencedirect.com/science/article/pii/S1074761322001418
Mar 2022
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K27-linked ubiquitylation promotes p97 substrate processing and is essential for cell proliferation

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1. scibot 31 Mar 2022
  
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  RRID:AB_2762364
  
  DOI: 10.15252/embj.2021110145
  
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embopress.org/doi/abs/10.15252/embj.2021110145
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BMI-1 regulates DNA end resection and homologous recombination repair

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  DOI: 10.1016/j.celrep.2022.110536
  
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sciencedirect.com/science/article/pii/S2211124722002777
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Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination

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  DOI: 10.1016/j.molcel.2022.01.021
  
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Regulation of canonical Wnt signalling by the ciliopathy protein MKS1 and the E2 ubiquitin-conjugating enzyme UBE2E1

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1. scibot 04 Mar 2022
  
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  DOI: 10.7554/eLife.57593
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8880992/
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BPS Publications

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1. scibot 02 Mar 2022
  
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  RRID:AB_2762364
  
  DOI: 10.1111/bph.15758
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15758
Feb 2022
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Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis

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  DOI: 10.1016/j.cmet.2021.12.019
  
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sciencedirect.com/science/article/pii/S1550413121006380
Jan 2022
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Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216

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1. scibot 22 Jan 2022
  
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  DOI: 10.1016/j.molcel.2021.12.005
  
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sciencedirect.com/science/article/pii/S1097276521010674
Dec 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation

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1. scibot 17 Dec 2021
  
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  DOI: 10.3389/fphys.2021.779547
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8669767/
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Cell adhesion molecule L1 interacts with the chromo shadow domain of heterochromatin protein 1 isoforms α, β, and ɣ via its intracellular domain

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1. scibot 04 Dec 2021
  
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  DOI: 10.1096/fj.202100816R
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202100816R
Nov 2021
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Integrated genomic and proteomic analyses identify stimulus-dependent molecular changes associated with distinct modes of skeletal muscle atrophy

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1. scibot 10 Nov 2021
  
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  RRID:AB_2762364
  
  DOI: 10.1016/j.celrep.2021.109971
  
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sciencedirect.com/science/article/pii/S2211124721014509
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MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal

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1. scibot 03 Nov 2021
  
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  AB_2762364
  
  DOI: 10.1016/j.celrep.2021.109949
  
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sciencedirect.com/science/article/pii/S2211124721014261
Oct 2021
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Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination

1
1. scibot 30 Oct 2021
  
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  DOI: 10.1016/j.celrep.2021.109904
  
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Aberrant RNA methylation triggers recruitment of an alkylation repair complex

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PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis

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DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation

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Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism

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Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense

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The optineurin/TIA1 pathway inhibits aberrant stress granule formation and reduces ubiquitinated TDP-43

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Pumilio2 and Staufen2 selectively balance the synaptic proteome

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Partial Rescue of F508del-CFTR Stability and Trafficking Defects by Double Corrector Treatment

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  DOI: 10.3390/ijms22105262
  
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Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells

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UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling

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CSN5 promotes carcinogenesis of thyroid carcinoma cells through ANGPTL2

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Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain

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Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging

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In-depth characterization of ubiquitin turnover in mammalian cells by fluorescence tracking

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Proteomics of broad deubiquitylase inhibition unmasks redundant enzyme function to reveal substrates and assess enzyme specificity

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Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response

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GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer

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  DOI: 10.1126/sciadv.abe2470
  
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Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles

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RON Expression Mediates Lipopolysaccharide-Mediated Dendritic Cell Maturation via March-I

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Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss

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Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair

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Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning

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Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor

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  DOI: 10.7554/eLife.44502
  
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Lipocalin-2 Regulates Epidermal Growth Factor Receptor Intracellular Trafficking

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Untitled document

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  DOI: 10.1016/j.neuron.2019.01.048
  
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CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1

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  DOI: 10.1016/j.celrep.2019.04.036
  
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