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79 Matching Annotations

Nov 2025
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Herpes simplex virus type 1 disseminates from the cornea to the CNS in mice by thwarting type III interferon immune defenses

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116581
  
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sciencedirect.com/science/article/pii/S2211124725013531
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An immunometabolic prodrug strategy overcomes DHODH inhibitor resistance in refractory melanoma

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1. scibot 18 Nov 2025
  
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  DOI: 10.1186/s13046-025-03566-6
  
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link.springer.com/article/10.1186/s13046-025-03566-6
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UDP-GlcUA triggers PKR kinase activity to promote liquid-liquid phase separation of TOP2A and enhances radioimmunotherapy resistance

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1. scibot 18 Nov 2025
  
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  DOI: 10.1016/j.molcel.2025.10.011
  
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sciencedirect.com/science/article/pii/S1097276525008287
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ID1 boosts antiviral immunity by countering PRMT5-mediated STING methylation

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1. scibot 13 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116547
  
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sciencedirect.com/science/article/pii/S221112472501318X
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Trilaciclib triggers a neutrophil-related immune response and sensitizes non-small cell lung cancer to anti-PD-1 therapy

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1. scibot 06 Nov 2025
  
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  DOI: 10.1016/j.xcrm.2025.102434
  
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sciencedirect.com/science/article/pii/S2666379125005075
Oct 2025
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Nuclear U1 snRNA facilitates the dimerization of hnRNPA2B1 to enhance anti-DNA viral innate immunity

1
1. scibot 23 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116462
  
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sciencedirect.com/science/article/pii/S2211124725012331
Sep 2025
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Adoptive macrophages suppress glioblastoma growth by reversing immunosuppressive microenvironment through programmed phenotype repolarization

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1. scibot 27 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116350
  
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sciencedirect.com/science/article/pii/S2211124725011210
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RSK1 reprograms the ubiquitin pathway to promote immune suppression

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1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116323
  
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sciencedirect.com/science/article/pii/S2211124725010940
Aug 2025
www.biorxiv.org www.biorxiv.org

IRE1α-XBP1s axis is required for BCG-induced trained immunity against viral infection by inhibiting AHR signaling

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1. scibot 30 Aug 2025
  
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  RRID:AB_2773013
  
  DOI: 10.1101/2025.08.21.671435
  
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biorxiv.org/content/10.1101/2025.08.21.671435v1
jeccr.biomedcentral.com jeccr.biomedcentral.com

TRIM6 ablation reverses ICB resistance in MSS gastric cancer by unleashing cGAS-STING-dependent antitumor immunity

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1. scibot 19 Aug 2025
  
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  RRID:AB_2773013
  
  DOI: 10.1186/s13046-025-03513-5
  
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jeccr.biomedcentral.com/articles/10.1186/s13046-025-03513-5
Jun 2025
www.cell.com www.cell.com

Systematic profiling reveals betaine as an exercise mimetic for geroprotection

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.cell.2025.06.001
  
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cell.com/cell/fulltext/S0092-8674(25)00635-X
May 2025
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GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration

1
1. scibot 29 May 2025
  
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  DOI: 10.1016/j.neuron.2025.04.033
  
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sciencedirect.com/science/article/pii/S0896627325003459
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Reducing Dietary Protein Enhances the Antitumor Effects of Chemotherapy through Immune-Mediated Mechanisms

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1. scibot 20 May 2025
  
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  RRID:AB_2773013
  
  DOI: 10.1158/1535-7163.MCT-24-0545
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617599/
Apr 2025
52.53.155.43 52.53.155.43

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1. scibot 04 Apr 2025
  
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  RRID:AB_2773013
  
  DOI: 10.1158/2326-6066.cir-24-0834
  
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52.53.155.43/b8eb1cd1446295bdd52d11650093cdf439d34361/PDF-html.html
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

ORMDL3 restrains type I interferon signaling and anti-tumor immunity by promoting RIG-I degradation

1
1. scibot 27 Mar 2025
  
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  RRID:AB_2773013
  
  DOI: 10.7554/eLife.101973
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11932694/
52.53.155.43 52.53.155.43

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1. scibot 24 Mar 2025
  
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  DOI: 10.1158/1535-7163.mct-24-0545
  
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52.53.155.43/089c935c8b8375c73eca3bfe64a1d2170a0cdb88/PDF-html.html
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Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy

1
1. scibot 11 Mar 2025
  
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  RRID:AB_2773013
  
  DOI: 10.1016/j.ccell.2025.02.014
  
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sciencedirect.com/science/article/pii/S1535610825000662
Feb 2025
52.53.155.43 52.53.155.43

Toxicity of extracellular cGAMP and its analogs to T cells is due to SLC7A1-mediated import

1
1. scibot 06 Feb 2025
  
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  AB_2773013
  
  DOI: 10.1101/2024.09.21.614248
  
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52.53.155.43/5ae47209b7006eb85d3adbe5cd2f83306ecd19fd/2024.09.21.614248.full-html.html
Jan 2025
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Nuclear adenine activates hnRNPA2B1 to enhance antibacterial innate immunity

1
1. scibot 16 Jan 2025
  
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  RRID:AB_2773013
  
  DOI: 10.1016/j.cmet.2024.11.014
  
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sciencedirect.com/science/article/pii/S1550413124004820
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Anatomical, subset, and HIV-dependent expression of viral sensors and restriction factors

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1. scibot 16 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115202
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11829653/
Dec 2024
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Lurbinectedin sensitizes PD-L1 blockade therapy by activating STING-IFN signaling in small-cell lung cancer

1
1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.xcrm.2024.101852
  
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sciencedirect.com/science/article/pii/S2666379124006232
Sep 2024
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A TBK1-independent primordial function of STING in lysosomal biogenesis

1
1. scibot 25 Sep 2024
  
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  AB_2773013
  
  DOI: 10.1016/j.molcel.2024.08.026
  
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sciencedirect.com/science/article/pii/S1097276524007032
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STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition

1
1. scibot 25 Sep 2024
  
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  AB_2773013
  
  DOI: 10.1016/j.cell.2019.05.036
  
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  Curator comments: Phospho-IRF-3 (Ser396) (D6O1M) Rabbit MAb (Alexa Fluor®647 Conjugate) Antibody Cell Signaling Technology Cat# 10327
  
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sciencedirect.com/science/article/pii/S0092867419305641
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InsP 3 R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca 2+ elevation and TBK1 activity

1
1. scibot 25 Sep 2024
  
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  RRID:AB_823547
  
  DOI: 10.1186/s12915-018-0507-6
  
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  Curator: @evieth
  
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  Curator comments: Cell Signaling Technology Cat# 29047, Phospho-IRF-3 (Ser396) (D6O1M) antibody
  
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bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0507-6
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Targeting APT2 improves MAVS palmitoylation and antiviral innate immunity

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1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.molcel.2024.08.014
  
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sciencedirect.com/science/article/pii/S1097276524006683
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

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1. scibot 27 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110285
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11267025/
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Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer

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1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.medj.2024.06.002
  
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sciencedirect.com/science/article/pii/S2666634024002484
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication

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1. scibot 14 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110144
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11233922/
www.cell.com www.cell.com

GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development

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1. scibot 11 Jul 2024
  
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  DOI: 10.1016/j.devcel.2024.06.007
  
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cell.com/developmental-cell/abstract/S1534-5807(24)00385-X
Jun 2024
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STING orchestrates the neuronal inflammatory stress response in multiple sclerosis

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.cell.2024.05.031
  
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sciencedirect.com/science/article/pii/S0092867424005762
Apr 2024
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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

1
1. scibot 11 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114088
  
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sciencedirect.com/science/article/pii/S2211124724004169
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Galectin-1 mediates chronic STING activation in tumors to promote metastasis through MDSC recruitment

1
1. scibot 03 Apr 2024
  
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  AB_2773013
  
  DOI: 10.1158/0008-5472.CAN-23-0046
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10592379/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity

1
1. scibot 23 Mar 2024
  
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  RRID:AB_2773013
  
  DOI: 10.7554/eLife.88122
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10945704/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress-Induced Inflammation

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1. scibot 17 Mar 2024
  
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  RRID:AB_2773013
  
  DOI: 10.1158/0008-5472.CAN-23-1237
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10940857/
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Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation

1
1. scibot 15 Mar 2024
  
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  RRID:AB_2773013
  
  DOI: 10.1016/j.celrep.2024.113945
  
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AGC kinase inhibitors regulate STING signaling through SGK-dependent and SGK-independent mechanisms

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Oct 2023
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Blocking oligomerization is the most viable strategy to inhibit STING

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Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells

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STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages

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Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy

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A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity

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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

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A genome-wide optical pooled screen reveals regulators of cellular antiviral responses

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Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING

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Mar 2023
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4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

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A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3

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Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner

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Resurrection of endogenous retroviruses during aging reinforces senescence

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Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation

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cGAS-STING Activation by Cytosolic Mitochondrial DNA Contributes to Podocyte Injury in Diabetic Kidney Disease

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Activation of cGAS-STING pathway – A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy

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Aug 2022
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DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages

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LncNSPL facilitates influenza A viral immune escape by restricting TRIM25-mediated K63-linked RIG-I ubiquitination

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STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program

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Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer

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Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription

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BPS Publications

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Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA

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SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer

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Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death

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Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair

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Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity

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May 2021
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The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

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BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse

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Apr 2021
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Mutant p53 suppresses innate immune signaling to promote tumorigenesis

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Mar 2021
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Endogenous retrovirus expression activates type-I interferon signaling in an experimental mouse model of mesothelioma development

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ER-directed TREX1 limits cGAS activation at micronuclei

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Feb 2021
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Evasion of type-I interferon by SARS-CoV-2

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Oct 2020
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TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

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Evasion of type-I interferon by SARS-CoV-2

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  DOI: 10.1016/j.celrep.2020.108234
  
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Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

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  DOI: 10.1016/j.immuni.2020.01.014
  
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SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages

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  DOI: 10.1016/j.celrep.2020.02.112
  
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The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

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  DOI: 10.1016/j.immuni.2020.03.004
  
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mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

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  DOI: 10.1016/j.immuni.2020.02.002
  
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RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs

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  DOI: 10.1016/j.molcel.2019.07.029
  
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Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury

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  DOI: 10.1016/j.celrep.2019.09.050
  
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cell.com/cell-reports/fulltext/S2211-1247(19)31238-0
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SLC19A1 Is an Importer of the Immunotransmitter cGAMP

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  DOI: 10.1016/j.molcel.2019.05.006
  
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Untitled document

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  DOI: 10.1016/j.celrep.2019.01.030
  
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sciencedirect.com/science/article/pii/S2211124719300397

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