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  1. Last 7 days
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    A TBK1-independent primordial function of STING in lysosomal biogenesis
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S1097276524007032
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    STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
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    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.cell.2019.05.036

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  4. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    InsP 3 R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca 2+ elevation and TBK1 activity
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      RRID:AB_823547

      DOI: 10.1186/s12915-018-0507-6

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    bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0507-6
  5. Sep 2024
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    Targeting APT2 improves MAVS palmitoylation and antiviral innate immunity
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      AB_2773013

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    sciencedirect.com/science/article/pii/S1097276524006683
  7. Jul 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway
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    1. scibot 27 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11267025/
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    Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer
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    sciencedirect.com/science/article/pii/S2666634024002484
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication
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  11. www.cell.com www.cell.com
    GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development
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    cell.com/developmental-cell/abstract/S1534-5807(24)00385-X
  12. Jun 2024
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    STING orchestrates the neuronal inflammatory stress response in multiple sclerosis
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    1. scibot 21 Jun 2024
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    sciencedirect.com/science/article/pii/S0092867424005762
  14. Apr 2024
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    IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling
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    1. scibot 11 Apr 2024
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    sciencedirect.com/science/article/pii/S2211124724004169
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    Galectin-1 mediates chronic STING activation in tumors to promote metastasis through MDSC recruitment
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    1. scibot 03 Apr 2024
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      DOI: 10.1158/0008-5472.CAN-23-0046

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    ncbi.nlm.nih.gov/pmc/articles/PMC10592379/
  17. Mar 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity
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    1. scibot 23 Mar 2024
      RRID:AB_2773013

      DOI: 10.7554/eLife.88122

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    ncbi.nlm.nih.gov/pmc/articles/PMC10945704/
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress-Induced Inflammation
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    1. scibot 17 Mar 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10940857/
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    Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation
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    1. scibot 15 Mar 2024
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    sciencedirect.com/science/article/pii/S2211124724002730
  21. Nov 2023
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    AGC kinase inhibitors regulate STING signaling through SGK-dependent and SGK-independent mechanisms
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.chembiol.2023.10.008

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    sciencedirect.com/science/article/abs/pii/S2451945623003690
  23. Oct 2023
  24. 52.53.155.43 52.53.155.43
    Blocking oligomerization is the most viable strategy to inhibit STING
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    1. scibot 20 Oct 2023
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      DOI: 10.1101/2023.08.11.553045

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    52.53.155.43/b51af3efb3ab194b2ea96b77566b6b4cbbb36c40/2023.08.11.553045v1.full-html.html
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    Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells
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    1. scibot 13 Oct 2023
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    sciencedirect.com/science/article/pii/S2211124723012251
  26. Jul 2023
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    STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages
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    sciencedirect.com/science/article/pii/S2589004223014530
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    Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy
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    sciencedirect.com/science/article/pii/S221112472300863X
  29. Jun 2023
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    A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity
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    sciencedirect.com/science/article/pii/S2211124723006666
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    Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
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    sciencedirect.com/science/article/pii/S1535610823001733
  32. May 2023
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    Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
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    sciencedirect.com/science/article/pii/S1535610823001629
  34. www.pnas.org www.pnas.org
    A genome-wide optical pooled screen reveals regulators of cellular antiviral responses
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      DOI: 10.1073/pnas.2210623120

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    pnas.org/doi/abs/10.1073/pnas.2210623120
  35. Apr 2023
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    Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING
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    sciencedirect.com/science/article/pii/S2211124723004539
  37. Mar 2023
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    4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING
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    sciencedirect.com/science/article/pii/S2211124723001560
  39. Jan 2023
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    A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3
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      DOI: 10.1016/j.isci.2023.105935

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    sciencedirect.com/science/article/pii/S2589004223000123
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    Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner
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    Resurrection of endogenous retroviruses during aging reinforces senescence
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    sciencedirect.com/science/article/pii/S0092867422015306
  43. Oct 2022
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    Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation
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    sciencedirect.com/science/article/pii/S221112472201275X
  45. Sep 2022
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    cGAS-STING Activation by Cytosolic Mitochondrial DNA Contributes to Podocyte Injury in Diabetic Kidney Disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC9513272/
  47. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Activation of cGAS-STING pathway – A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy
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      DOI: 10.1002/jcla.24631

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    onlinelibrary.wiley.com/doi/10.1002/jcla.24631
  48. Aug 2022
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    DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages
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      DOI: 10.1016/j.immuni.2022.06.022

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    sciencedirect.com/science/article/pii/S1074761322002953
  50. Jul 2022
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    LncNSPL facilitates influenza A viral immune escape by restricting TRIM25-mediated K63-linked RIG-I ubiquitination
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      DOI: 10.1016/j.isci.2022.104607

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    sciencedirect.com/science/article/pii/S2589004222008793
  52. May 2022
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    STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program
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    sciencedirect.com/science/article/pii/S2211124722006118
  54. Feb 2022
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    Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1535610822000058
  56. Jan 2022
  57. www.sciencedirect.com www.sciencedirect.com
    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
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      DOI: 10.1016/j.celrep.2022.110302

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    sciencedirect.com/science/article/pii/S2211124722000146
  58. Nov 2021
  59. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      DOI: 10.1111/bph.15673

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15673
  60. Aug 2021
  61. www.sciencedirect.com www.sciencedirect.com
    Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA
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      DOI: 10.1016/j.celrep.2021.109537

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    sciencedirect.com/science/article/pii/S2211124721009712
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    SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer
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      DOI: 10.1158/0008-5472.CAN-20-3738

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  63. www.sciencedirect.com www.sciencedirect.com
    Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death
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  64. www.sciencedirect.com www.sciencedirect.com
    Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair
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  65. Jun 2021
  66. www.cell.com www.cell.com
    Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity
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      DOI: 10.1016/j.molcel.2021.06.004

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  67. May 2021
  68. www.sciencedirect.com www.sciencedirect.com
    The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake
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  69. www.sciencedirect.com www.sciencedirect.com
    BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse
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      DOI: 10.1016/j.stem.2020.06.022

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    sciencedirect.com/science/article/pii/S1934590920302897
  70. Apr 2021
  71. www.sciencedirect.com www.sciencedirect.com
    Mutant p53 suppresses innate immune signaling to promote tumorigenesis
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    sciencedirect.com/science/article/pii/S1535610821000416
  72. Mar 2021
  73. www.sciencedirect.com www.sciencedirect.com
    Endogenous retrovirus expression activates type-I interferon signaling in an experimental mouse model of mesothelioma development
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    sciencedirect.com/science/article/pii/S0304383521001087
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    ER-directed TREX1 limits cGAS activation at micronuclei
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    sciencedirect.com/science/article/pii/S1097276520309588
  75. Feb 2021
  76. www.sciencedirect.com www.sciencedirect.com
    Evasion of type-I interferon by SARS-CoV-2
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    sciencedirect.com/science/article/pii/S2211124720312237
  77. Oct 2020
  78. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
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    Evasion of type-I interferon by SARS-CoV-2
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  80. Sep 2020
  81. www.sciencedirect.com www.sciencedirect.com
    Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP
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  82. www.sciencedirect.com www.sciencedirect.com
    SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages
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      DOI: 10.1016/j.celrep.2020.02.112

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    sciencedirect.com/science/article/pii/S221112472030293X
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    The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling
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      DOI: 10.1016/j.immuni.2020.03.004

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    sciencedirect.com/science/article/pii/S1074761320301175
  84. www.sciencedirect.com www.sciencedirect.com
    mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury
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      DOI: 10.1016/j.immuni.2020.02.002

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  85. Jan 2020
  86. www.sciencedirect.com www.sciencedirect.com
    RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs
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      RRID:AB_2773013

      DOI: 10.1016/j.molcel.2019.07.029

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    sciencedirect.com/science/article/pii/S1097276519305842
  87. www.cell.com www.cell.com
    Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury
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      RRID:AB_2773013

      DOI: 10.1016/j.celrep.2019.09.050

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    cell.com/cell-reports/fulltext/S2211-1247(19)31238-0
  88. www.sciencedirect.com www.sciencedirect.com
    SLC19A1 Is an Importer of the Immunotransmitter cGAMP
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      RRID:AB_2773013

      DOI: 10.1016/j.molcel.2019.05.006

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    sciencedirect.com/science/article/pii/S1097276519303594
  89. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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      RRID:AB_2773013

      DOI: 10.1016/j.celrep.2019.01.030

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    sciencedirect.com/science/article/pii/S2211124719300397