104 Matching Annotations
  1. Nov 2025
  2. www.sciencedirect.com www.sciencedirect.com
    Circulating FABP5 released by dying macrophages function as a DAMP to exacerbate septic inflammation
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    sciencedirect.com/science/article/pii/S2211124725012689
  3. Sep 2025
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    A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation
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    sciencedirect.com/science/article/pii/S2451945625002594
  5. 52.53.155.43 52.53.155.43
    2025.08.28.672784v1.full-html.html
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    52.53.155.43/ac7f1767c23c6666ccfc705d09859fa9a6162a49/2025.08.28.672784v1.full-html.html
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    FABP5 in skin macrophages mediates saturated fat-induced IL-1β signaling in psoriatic inflammation
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    sciencedirect.com/science/article/pii/S2211124725010253
  7. Jul 2025
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    The Hippo pathway kinase MST1 mediates a feedback loop to maintain NLRP3 inflammasome homeostasis
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    sciencedirect.com/science/article/pii/S2211124725008472
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    Gasdermin-D-mediated epithelial-immune circuit synchronizes nutrient absorption and host defense in the small intestine
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    sciencedirect.com/science/article/pii/S1074761325003097
  10. onlinelibrary.wiley.com onlinelibrary.wiley.com
    S100a9 Aggravates Ischemia Brain Injury via Pyroptosis Pathway: A Potential Prognostic Biomarker and Therapeutic Target for Ischemic Stroke
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    onlinelibrary.wiley.com/doi/10.1111/jnc.70159
  11. www.sciencedirect.com www.sciencedirect.com
    Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity
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    sciencedirect.com/science/article/pii/S1074761325002870
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    Bacterial ADP-heptose triggers stem cell regeneration in the intestinal epithelium following injury
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    sciencedirect.com/science/article/pii/S1934590925002310
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Potent Inhibitor of Caspase-8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases
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    pmc.ncbi.nlm.nih.gov/articles/PMC12371506/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of the pyroptosis, apoptosis, and necroptosis (PANoptosis) involved in osteogenic differentiation inhibition impaired by tumor necrosis factor-α
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    pmc.ncbi.nlm.nih.gov/articles/PMC12211273/
  15. Jun 2025
  16. www.sciencedirect.com www.sciencedirect.com
    Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection
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    sciencedirect.com/science/article/pii/S2589004222003200
  17. www.sciencedirect.com www.sciencedirect.com
    PGK1 phosphorylates NLRP3 and mediates inflammasome activation independent of its glycolytic activity
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    sciencedirect.com/science/article/pii/S221112472500556X
  18. May 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC12048508/
  20. www.sciencedirect.com www.sciencedirect.com
    Inflammasome signaling in astrocytes modulates hippocampal plasticity
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    sciencedirect.com/science/article/pii/S1074761325001700
  21. Apr 2025
  22. 52.53.155.43 52.53.155.43
    Lysosome positioning affects NLRP3 inflammasome activation
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    52.53.155.43/5e725b42faf6f4894ebfb1897ac6165b04d7cac3/PDF-html.html
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    Type I interferons induce guanylate-binding proteins and lysosomal defense in hepatocytes to control malaria
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    sciencedirect.com/science/article/pii/S1931312825000915
  24. Feb 2025
  25. www.sciencedirect.com www.sciencedirect.com
    Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP
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    sciencedirect.com/science/article/pii/S2211124725001111
  26. Jan 2025
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    Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection
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    sciencedirect.com/science/article/pii/S2211124724015675
  28. www.sciencedirect.com www.sciencedirect.com
    Litomosoides sigmodontis microfilariae-induced eosinophil ETosis is dependent on the canonical inflammasome pathway
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    sciencedirect.com/science/article/pii/S2211124724015158
  29. www.sciencedirect.com www.sciencedirect.com
    Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells
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    sciencedirect.com/science/article/pii/S0092867424013345
  30. Dec 2024
  31. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004224028086-main-html.html
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  32. www.sciencedirect.com www.sciencedirect.com
    A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control
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    sciencedirect.com/science/article/pii/S1074761324004904
  33. Nov 2024
  34. www.sciencedirect.com www.sciencedirect.com
    Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair
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    sciencedirect.com/science/article/pii/S0092867424011589
  35. Sep 2024
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11398858/
  37. www.nature.com www.nature.com
    Activation of the NLRP1B inflammasome by caspase-8
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    nature.com/articles/s42003-024-06882-3
  38. www.sciencedirect.com www.sciencedirect.com
    Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis
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    sciencedirect.com/science/article/pii/S2211124724010799
  39. www.sciencedirect.com www.sciencedirect.com
    Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity
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    sciencedirect.com/science/article/pii/S0092867424008985
  40. www.sciencedirect.com www.sciencedirect.com
    CD14 is a decision-maker between Fas-mediated death and inflammation
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    sciencedirect.com/science/article/pii/S2211124724010362
  41. Aug 2024
  42. www.sciencedirect.com www.sciencedirect.com
    Non-canonical autophosphorylation of RIPK1 drives timely pyroptosis to control Yersinia infection
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    sciencedirect.com/science/article/pii/S2211124724009914
  43. Jul 2024
  44. www.sciencedirect.com www.sciencedirect.com
    Lyssavirus matrix protein inhibits NLRP3 inflammasome assembly by binding to NLRP3
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    sciencedirect.com/science/article/pii/S2211124724008076
  45. www.cell.com www.cell.com
    Extracellular vesicles from alveolar macrophages harboring phagocytosed methicillin-resistant Staphylococcus aureus induce necroptosis
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    cell.com/cell-reports/fulltext/S2211-1247(24)00782-4
  46. Jun 2024
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11283362/
  48. www.sciencedirect.com www.sciencedirect.com
    Tmem30a Protects Against Podocyte Injury Through Suppression of Pyroptosis
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    sciencedirect.com/science/article/pii/S2589004224011982
  49. May 2024
  50. www.sciencedirect.com www.sciencedirect.com
    Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes
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    sciencedirect.com/science/article/pii/S2211124721002011
  51. 52.53.155.43 52.53.155.43
    Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke
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    52.53.155.43/23904a6df569543355b93537b87aff6dc46e4387/mmc2-html.html
  52. Apr 2024
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11130711/
  54. Mar 2024
  55. www.sciencedirect.com www.sciencedirect.com
    Subventricular zone stem cell niche injury is associated with intestinal perforation in preterm infants and predicts future motor impairment
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    sciencedirect.com/science/article/pii/S1934590924000821
  56. www.sciencedirect.com www.sciencedirect.com
    A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages
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    sciencedirect.com/science/article/pii/S2211124724003097
  57. www.sciencedirect.com www.sciencedirect.com
    A bacterial toxin co-opts caspase-3 to disable active gasdermin D and limit macrophage pyroptosis
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    sciencedirect.com/science/article/pii/S2211124724003322
  58. link.springer.com link.springer.com
    Effects of the Glucocorticoid-Mediated Mitochondrial Translocation of Glucocorticoid Receptors on Oxidative Stress and Pyroptosis in BV-2 Microglia
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    link.springer.com/article/10.1007/s12031-024-02192-9
  59. www.sciencedirect.com www.sciencedirect.com
    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
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    sciencedirect.com/science/article/pii/S2211124724002638
  60. Feb 2024
  61. www.sciencedirect.com www.sciencedirect.com
    SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination
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    sciencedirect.com/science/article/pii/S2211124724000809
  62. Dec 2023
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10749599/
  64. www.sciencedirect.com www.sciencedirect.com
    The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
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    sciencedirect.com/science/article/pii/S2211124723015930
  65. www.sciencedirect.com www.sciencedirect.com
    Emulsion and liposome-based adjuvanted R21 vaccine formulations mediate protection against malaria through distinct immune mechanisms
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    sciencedirect.com/science/article/pii/S2666379123004226
  66. Nov 2023
  67. www.sciencedirect.com www.sciencedirect.com
    Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis
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    sciencedirect.com/science/article/pii/S1074761323004442
  68. www.nature.com www.nature.com
    Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization
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    nature.com/articles/s41467-023-43180-8
  69. Jul 2023
  70. www.sciencedirect.com www.sciencedirect.com
    Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia
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    sciencedirect.com/science/article/pii/S221112472300880X
  71. Jun 2023
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induced Neural Stem Cells Suppressed Neuroinflammation by Inhibiting the Microglial Pyroptotic Pathway in Intracerebral Hemorrhage Rats
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    ncbi.nlm.nih.gov/pmc/articles/PMC10285565/
  73. www.sciencedirect.com www.sciencedirect.com
    Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine
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    sciencedirect.com/science/article/pii/S0092867423005779
  74. www.sciencedirect.com www.sciencedirect.com
    Whole-genome CRISPR screen identifies RAVER1 regulates RIPK1-mediated inflammatory cell death, PANoptosis
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    sciencedirect.com/science/article/pii/S2589004223010155
  75. www.sciencedirect.com www.sciencedirect.com
    NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs
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    sciencedirect.com/science/article/pii/S009286742300524X
  76. May 2023
  77. www.sciencedirect.com www.sciencedirect.com
    Candida auris uses metabolic strategies to escape and kill macrophages while avoiding robust activation of the NLRP3 inflammasome response
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    sciencedirect.com/science/article/pii/S2211124723005338
  78. www.sciencedirect.com www.sciencedirect.com
    Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome
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    sciencedirect.com/science/article/pii/S2589004223008350
  79. www.sciencedirect.com www.sciencedirect.com
    Engineer a double team of short-lived and glucose-sensing bacteria for cancer eradication
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    sciencedirect.com/science/article/pii/S266637912300157X
  80. Mar 2023
  81. www.sciencedirect.com www.sciencedirect.com
    Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity
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    sciencedirect.com/science/article/pii/S1074761323000882
  82. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    CARD-only proteins regulate in vivo inflammasome responses and ameliorate gout
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    pubmed.ncbi.nlm.nih.gov/36930645/
  83. www.sciencedirect.com www.sciencedirect.com
    Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration
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    sciencedirect.com/science/article/pii/S089662732300123X
  84. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16036
  85. Feb 2023
  86. www.sciencedirect.com www.sciencedirect.com
    Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation
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    sciencedirect.com/science/article/pii/S1074761323000250
  87. Jan 2023
  88. www.science.org www.science.org
    Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis
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    science.org/doi/10.1126/scisignal.abh1083
  89. www.sciencedirect.com www.sciencedirect.com
    Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
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    sciencedirect.com/science/article/pii/S2211124722018691
  90. www.sciencedirect.com www.sciencedirect.com
    Gasdermin D pore-forming activity is redox-sensitive
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    sciencedirect.com/science/article/pii/S2211124723000190
  91. www.sciencedirect.com www.sciencedirect.com
    The NLRP1 and CARD8 inflammasomes detect reductive stress
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    sciencedirect.com/science/article/pii/S2211124722018708
  92. Dec 2022
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death
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    ncbi.nlm.nih.gov/pmc/articles/PMC9754625/
  94. Nov 2022
  95. www.sciencedirect.com www.sciencedirect.com
    Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins
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    sciencedirect.com/science/article/pii/S2211124722015625
  96. www.science.org www.science.org
    Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells
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    science.org/doi/10.1126/sciadv.abn9912
  97. Oct 2022
  98. www.sciencedirect.com www.sciencedirect.com
    Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade
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    sciencedirect.com/science/article/pii/S2211124722014097
  99. www.sciencedirect.com www.sciencedirect.com
    Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation
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    sciencedirect.com/science/article/pii/S221112472201275X
  100. Sep 2022
  101. www.sciencedirect.com www.sciencedirect.com
    The escape of Candida albicans from macrophages is enabled by the fungal toxin candidalysin and two host cell death pathways
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    sciencedirect.com/science/article/pii/S2211124722012062
  102. Aug 2022
  103. onlinelibrary.wiley.com onlinelibrary.wiley.com
    STING mediates neuroinflammatory response by activating NLRP3-related pyroptosis in severe traumatic brain injury
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15678
  104. May 2022
  105. www.sciencedirect.com www.sciencedirect.com
    A TLR4-independent critical role for CD14 in intracellular LPS sensing
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    sciencedirect.com/science/article/pii/S2211124722005198
  106. Mar 2022
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon
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    ncbi.nlm.nih.gov/pmc/articles/PMC8896827/
  108. Feb 2022
  109. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
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    pubmed.ncbi.nlm.nih.gov/35139355/
  110. Nov 2021
  111. www.sciencedirect.com www.sciencedirect.com
    APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis
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    sciencedirect.com/science/article/pii/S1074761321004106
  112. Oct 2021
  113. www.sciencedirect.com www.sciencedirect.com
    ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis
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    sciencedirect.com/science/article/pii/S2211124721013255
  114. Sep 2021
  115. www.sciencedirect.com www.sciencedirect.com
    Inappropriate use of antibiotics exacerbates inflammation through OMV-induced pyroptosis in MDR Klebsiella pneumoniae infection
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    sciencedirect.com/science/article/pii/S2211124721012043
  116. Aug 2021
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Shigella OspC3 suppresses murine cytosolic LPS sensing
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    ncbi.nlm.nih.gov/pmc/articles/PMC8361271/
  118. May 2021
  119. www.sciencedirect.com www.sciencedirect.com
    Heparin prevents caspase-11-dependent septic lethality independent of anticoagulant properties
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    sciencedirect.com/science/article/pii/S1074761321000303
  120. Apr 2021
  121. www.sciencedirect.com www.sciencedirect.com
    Hierarchical cell-type-specific functions of caspase-11 in LPS shock and antibacterial host defense
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    sciencedirect.com/science/article/pii/S2211124721003260
  122. www.sciencedirect.com www.sciencedirect.com
    Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases
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    sciencedirect.com/science/article/pii/S2211124721003120
  123. Mar 2021
  124. www.sciencedirect.com www.sciencedirect.com
    Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes
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    sciencedirect.com/science/article/pii/S2211124721002011
  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock
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    ncbi.nlm.nih.gov/pmc/articles/PMC7947244/
  126. www.sciencedirect.com www.sciencedirect.com
    Itaconate confers tolerance to late NLRP3 inflammasome activation
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    sciencedirect.com/science/article/pii/S2211124721000693
  127. Feb 2021
  128. www.nature.com www.nature.com
    A comprehensive guide to studying inflammasome activation and cell death
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    nature.com/articles/s41596-020-0374-9
  129. Dec 2020
  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes
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    ncbi.nlm.nih.gov/pmc/articles/PMC7674074/
  131. Nov 2020
  132. elifesciences.org elifesciences.org
    LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation
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    elifesciences.org/articles/59704
  133. www.sciencedirect.com www.sciencedirect.com
    RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly
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    sciencedirect.com/science/article/pii/S2211124720313942
  134. Oct 2020
  135. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Activation of the CARD8 Inflammasome Requires a Disordered Region
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    pubmed.ncbi.nlm.nih.gov/33053349/
  136. Sep 2020
  137. www.sciencedirect.com www.sciencedirect.com
    A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling
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    sciencedirect.com/science/article/pii/S2211124720303442
  138. www.sciencedirect.com www.sciencedirect.com
    Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
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    sciencedirect.com/science/article/pii/S0092867420303330
  139. www.sciencedirect.com www.sciencedirect.com
    Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection
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    sciencedirect.com/science/article/pii/S1074761320302843
  140. www.sciencedirect.com www.sciencedirect.com
    β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia
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    sciencedirect.com/science/article/pii/S2211124720301868
  141. www.sciencedirect.com www.sciencedirect.com
    Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium
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    sciencedirect.com/science/article/pii/S2211124720309487
  142. www.sciencedirect.com www.sciencedirect.com
    mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury
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    sciencedirect.com/science/article/pii/S107476132030073X
  143. Jan 2020
  144. iovs.arvojournals.org iovs.arvojournals.org
    Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-trans Retinal
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    iovs.arvojournals.org/article.aspx
  145. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S1074761319301979