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Cyclin E modulates vulnerability to CDC7 kinase inhibition

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Apr 2026
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2026.04.20.719456.full-html.html

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1. scibot 30 Apr 2026
  
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QW-5-70 targets the colchicine site and demonstrates antitumor activity in P-gp–overexpressing cancer models

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aacrjournals.org/mct/article/doi/10.1158/1535-7163.MCT-25-1013/784192/QW-5-70-Targets-the-Colchicine-Site-and
Feb 2026
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ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression

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pmc.ncbi.nlm.nih.gov/articles/PMC11792891/
Jan 2026
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The FANCD2-FANCI heterodimer coordinates chromatin openness and cell cycle progression throughout DNA double-strand break repair

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  DOI: 10.1016/j.celrep.2025.116830
  
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Dec 2025
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Sappanchalcone Suppresses NSCLC by Oxidative Stress-Driven DNA Damage and ER Stress Activation through PIEZO1 Modulation

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1. scibot 19 Dec 2025
  
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Nov 2025
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Cystine import and oxidative catabolism fuel vascular growth and repair via nutrient-responsive histone acetylation

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Oct 2025
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Dual molecular therapy targeting tumor cell heterogeneity improves therapeutic efficacy in glioblastoma

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pmc.ncbi.nlm.nih.gov/articles/PMC12496224/
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Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocytes and generating quinolinic acid

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Jul 2025
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Retinoic acid-induced 2 deficiency impairs genomic stability in breast cancer

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1. scibot 25 Jul 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12285165/
May 2025
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CDK4/6 activity is required during G2 arrest to prevent stress induced endoreplication

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1. scibot 20 May 2025
  
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  DOI: 10.1126/science.adi2421
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11305671/
Apr 2025
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PDF-html.html

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52.53.155.43/fb744ae1c201e64705cbba4fb67640ca74ff97a4/PDF-html.html
Jan 2025
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CDKN2A/B homozygous deletion sensitizes IDH-mutant glioma to CDK4/6 inhibition

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1. scibot 25 Jan 2025
  
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  DOI: 10.1158/1078-0432.CCR-24-0562
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11250907/
Dec 2024
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Mapping functional elements of the DNA damage response through base editor screens

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1. scibot 12 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115047
  
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Transcriptional and functional regulation of cell cycle and UV response by PPARβ in human skin epidermal cells

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1. scibot 06 Dec 2024
  
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  DOI: 10.1096/fj.202401950R
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11610672/
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Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.neuron.2024.10.029
  
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Sep 2024
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The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug Resistance

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1. scibot 25 Sep 2024
  
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sciencedirect.com/science/article/pii/S2211124720310913
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Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic gene reactivation

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1. scibot 17 Sep 2024
  
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A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib

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Aug 2024
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The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma

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1. scibot 18 Aug 2024
  
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  DOI: 10.1186/s12885-024-12691-y
  
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May 2024
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SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis

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1. scibot 23 May 2024
  
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CDK4/6 activity is required during G2 arrest to prevent stress-induced endoreplication

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Apr 2024
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Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication

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Mar 2024
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Light-mediated intracellular polymerization

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  DOI: 10.1038/s41596-024-00970-8
  
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nature.com/articles/s41596-024-00970-8
Feb 2024
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Dual roles of CCDC102A in governing centrosome duplication and cohesion

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Dec 2023
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Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives

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  DOI: 10.1016/j.isci.2023.108659
  
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Nov 2023
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Unbiased interrogation of functional lysine residues in human proteome

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Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers

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  DOI: 10.1158/1078-0432.CCR-23-0103
  
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Oct 2023
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ccr-23-0103-html.html

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52.53.155.43/05abf3a0903b8473a428373dc7a2f791e1da90bb/ccr-23-0103-html.html
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PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C

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cell.com/cell-reports/fulltext/S2211-1247(23)01052-5
Aug 2023
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L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab

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  DOI: 10.1016/j.xcrm.2023.101142
  
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ccr-23-0103-html.html

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Jul 2023
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ccr-23-0103-html.html

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1. scibot 08 Jul 2023
  
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Jun 2023
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Centromere/kinetochore is assembled through CENP-C oligomerization

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  DOI: 10.1016/j.molcel.2023.05.023
  
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Apr 2023
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Histone H3 phospho-regulation by KimH3 in both interphase and mitosis

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  DOI: 10.1016/j.isci.2023.106372
  
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Jan 2023
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ER-001259851-000, a novel selective inhibitor of AXL, overcomes resistance to antimitotic drugs

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  DOI: 10.1158/1535-7163.MCT-21-0879
  
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aacrjournals.org/mct/article/22/1/12/711996/ER-851-a-Novel-Selective-Inhibitor-of-AXL
Mar 2022
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Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch

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  DOI: 10.1016/j.celrep.2022.110468
  
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CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities

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  DOI: 10.1016/j.celrep.2022.110448
  
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Feb 2022
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Paris polyphylla ethanol extract induces G2/M arrest and suppresses migration and invasion in bladder cancer

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1. scibot 05 Feb 2022
  
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  DOI: 10.21037/tcr-20-1512
  
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Dec 2021
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Low-intensity pulsed ultrasound-generated singlet oxygen induces telomere damage leading to glioma stem cell awakening from quiescence

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1. scibot 18 Dec 2021
  
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Aug 2021
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The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway

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Jul 2021
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An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

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  DOI: 10.1016/j.molcel.2019.10.016
  
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Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation

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Jun 2021
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A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways

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May 2021
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Centrosomal Localization of RXRα Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability

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Jan 2020
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RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres

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CCDC84 Acetylation Oscillation Regulates Centrosome Duplication by Modulating HsSAS-6 Degradation

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