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Pharmacologic reversion of Merkel cell carcinoma via CBP/p300 inhibition

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1. scibot 25 Jun 2026
  
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  DOI: 10.1073/pnas.2516667122
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12772197/
May 2026
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eIF4G2-mediated selective translation of chromatin regulators safeguards adult intestinal stem cell identity and differentiation

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1. scibot 01 May 2026
  
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  DOI: 10.1016/j.stem.2026.04.006
  
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sciencedirect.com/science/article/pii/S1934590926001463
Jul 2025
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High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.115947
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00718-1
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Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells

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1. scibot 01 Jul 2025
  
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  DOI: 10.1158/2767-9764.CRC-25-0058
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12202856/
Jun 2025
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1. scibot 12 Jun 2025
  
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  DOI: 10.1158/2767-9764.crc-25-0058
  
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52.53.155.43/6f95ee3860ed32eb2fc3447b03e264cd8239544f/PDF-html.html
Feb 2025
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Reactive Oxygen species dependent increase in H3K27 acetylation by intermittent hypoxia is regulated by H3S28 phosphorylation

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1. scibot 06 Feb 2025
  
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  DOI: 10.1101/2024.09.09.612097
  
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52.53.155.43/f05ab403f134b3e958e2f7b12bdc7f45adf9ceaf/2024.09.09.612097v1.full-html.html
Nov 2024
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ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion

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1. scibot 24 Nov 2024
  
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  DOI: 10.1016/j.cmet.2024.10.015
  
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sciencedirect.com/science/article/pii/S155041312400411X
Feb 2024
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Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation

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1. scibot 09 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113746
  
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sciencedirect.com/science/article/pii/S2211124724000743
Jul 2023
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Ketolysis drives CD8+ T cell effector function through effects on histone acetylation

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1. scibot 29 Jul 2023
  
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  DOI: 10.1016/j.immuni.2023.07.002
  
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sciencedirect.com/science/article/pii/S107476132300314X
Nov 2022
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Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation

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1. scibot 24 Nov 2022
  
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  DOI: 10.1016/j.molcel.2022.11.002
  
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sciencedirect.com/science/article/abs/pii/S1097276522010644
Sep 2021
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GAGE mediates radio resistance in cervical cancers via the regulation of chromatin accessibility

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1. scibot 01 Sep 2021
  
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  DOI: 10.1016/j.celrep.2021.109621
  
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sciencedirect.com/science/article/pii/S2211124721010597
Apr 2021
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Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor

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1. scibot 28 Apr 2021
  
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  DOI: 10.1016/j.chembiol.2021.04.004
  
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sciencedirect.com/science/article/pii/S2451945621001598