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Pre-clinical Modeling of Navtemadlin Pharmacokinetics, Pharmacodynamics, and Efficacy in IDH-wildtype Glioblastoma

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1. scibot 07 Sep 2025
  
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  DOI: 10.1158/1078-0432.CCR-25-0244
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12402800/
Aug 2025
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19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism

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1. scibot 01 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116041
  
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cell.com/cell-reports/abstract/S2211-1247(25)00812-5
Jul 2025
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19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism

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1. scibot 24 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116041
  
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cell.com/cell-reports/abstract/S2211-1247(25)00812-5
Jun 2025
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Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator

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1. scibot 12 Jun 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1421
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12130801/
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Mdm2 targeting via PROteolysis TArgeting Chimeras (PROTAC) is efficient in p53 wildtype, p53-mutated, and abemaciclib-resistant estrogen receptor-positive cell lines and superior to mdm2 inhibition

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1. scibot 04 Jun 2025
  
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  DOI: 10.1186/s12885-025-14361-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12128487/
Feb 2025
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Designer polyQ fusion proteins sequester USP7/HDM2 for modulating P53 functionality

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1. scibot 28 Feb 2025
  
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  DOI: 10.1016/j.isci.2025.112025
  
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sciencedirect.com/science/article/pii/S2589004225002858
Dec 2024
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Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer

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1. scibot 03 Dec 2024
  
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  DOI: 10.1126/scisignal.adp1375
  
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science.org/doi/10.1126/scisignal.adp1375
Nov 2024
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Plausible, robust biological oscillations through allelic buffering

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1. scibot 15 Nov 2024
  
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  DOI: 10.1016/j.cels.2024.10.002
  
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sciencedirect.com/science/article/pii/S2405471224002990
Aug 2024
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Patient-derived tumor organoids mimic treatment-induced DNA damage response in glioblastoma

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.isci.2024.110604
  
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sciencedirect.com/science/article/pii/S2589004224018297
Jul 2024
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Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication

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1. scibot 14 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110144
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11233922/
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HER4 Affects Sensitivity to Tamoxifen and Abemaciclib in Luminal Breast Cancer Cells and Restricts Tumor Growth in MCF-7-Based Humanized Tumor Mice

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1. scibot 12 Jul 2024
  
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  DOI: 10.3390/ijms25137475
  
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  RRID:AB_2784534 DOI:10.3390/ijms25137475
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mdpi.com/1422-0067/25/13/7475
Jun 2024
52.53.155.43 52.53.155.43

Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency

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1. scibot 06 Jun 2024
  
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  DOI: 10.1101/2024.02.09.579580
  
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2. scibot 06 Jun 2024
  
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  RRID:AB_2784534
  
  DOI: 10.1101/2024.02.09.579580
  
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52.53.155.43/be49547c4f9e1293474726024249294abe2db848/2024.02.09.579580v1.full-html.html
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Fatal COVID-19 pulmonary disease involves ferroptosis

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1. scibot 23 May 2024
  
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  DOI: 10.1038/s41467-024-48055-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11106344/
52.53.155.43 52.53.155.43

2024.02.09.579580v1.full-html.html

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1. scibot 10 May 2024
  
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  DOI: 10.1038/nature05972
  
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2. scibot 10 May 2024
  
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  DOI: 10.1038/nature05972
  
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52.53.155.43/32c668e9e171a0d93bacd7fd25061d69f59c1b8d/2024.02.09.579580v1.full-html.html
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Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity

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1. scibot 03 May 2024
  
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  DOI: 10.1016/j.isci.2024.109693
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11059122/
Mar 2024
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Comparison of three-dimensional cell culture techniques of dedifferentiated liposarcoma and their integration with future research

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1. scibot 22 Mar 2024
  
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  DOI: 10.3389/fcell.2024.1362696
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10945377/
Feb 2024
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Alternative polyadenylation determines the functional landscape of inverted Alu repeats

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1. scibot 06 Feb 2024
  
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  DOI: 10.1016/j.molcel.2024.01.008
  
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sciencedirect.com/science/article/pii/S1097276524000091
Nov 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia

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1. scibot 03 Nov 2023
  
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  DOI: 10.1172/jci.insight.170065
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10619439/
Aug 2023
52.53.155.43 52.53.155.43

Nuclear transport surveillance of p53 by nuclear pores in glioblastoma

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1. scibot 12 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112882
  
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2. scibot 10 Aug 2023
  
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  RRID:AB_2784534
  
  DOI: 10.1016/j.celrep.2023.112882
  
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52.53.155.43/64ae675a86b73874b1bb5c50aa8d9678e93e36d6/PIIS2211124723008938-html.html
Jun 2023
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Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2

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1. scibot 28 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112693
  
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sciencedirect.com/science/article/pii/S2211124723007040
Mar 2023
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Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells

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1. scibot 10 Mar 2023
  
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  DOI: 10.1016/j.ccell.2023.02.010
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10466730/
Feb 2023
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Three dimensional models of dedifferentiated liposarcoma cell lines: scaffold-based and scaffold-free approaches

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1. scibot 11 Feb 2023
  
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  DOI: 10.1007/s13577-023-00865-y
  
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link.springer.com/article/10.1007/s13577-023-00865-y
Jun 2022
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Poroptosis: a form of cell death depending on plasma membrane nanopores formation

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1. scibot 15 Jun 2022
  
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  DOI: 10.1016/j.isci.2022.104481
  
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sciencedirect.com/science/article/pii/S2589004222007520
May 2022
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Mutations in DNA binding domain of p53 impede RSL1D1-p53 interaction to escape from degradation in human colorectal cancer cells

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1. scibot 19 May 2022
  
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  DOI: 10.1016/j.yexcr.2022.113211
  
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sciencedirect.com/science/article/pii/S001448272200204X
Oct 2021
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Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma

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1. scibot 20 Oct 2021
  
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  DOI: 10.1016/j.xcrm.2021.100411
  
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sciencedirect.com/science/article/pii/S266637912100269X
Aug 2021
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Ribosomal L1 domain-containing protein 1 coordinates with HDM2 to negatively regulate p53 in human colorectal Cancer cells

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1. scibot 15 Aug 2021
  
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  DOI: 10.1186/s13046-021-02057-8
  
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link.springer.com/article/10.1186/s13046-021-02057-8
Sep 2020
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Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage

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1. scibot 09 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.108077
  
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sciencedirect.com/science/article/pii/S2211124720310627
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FBXW7 Confers Radiation Survival by Targeting p53 for Degradation

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1. scibot 09 Sep 2020
  
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  DOI: 10.1016/j.celrep.2019.12.032
  
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sciencedirect.com/science/article/pii/S2211124719316821
Jan 2020
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GRWD1 promotes cell proliferation and migration in non-small cell lung cancer by activating the Notch pathway

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.yexcr.2019.111806
  
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sciencedirect.com/science/article/pii/S0014482719306949