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Targeting RNase H2: A dual-mechanism strategy to elevate replication stress, DNA damage, and antitumor immunity in TNBC

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  DOI: 10.1016/j.xcrm.2026.102750
  
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Apr 2026
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Nerves Stimulate Cross-talk Between Gastric Cancer and Group 3 Innate Lymphoid Cells to Enhance Immunosuppression

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1. scibot 17 Apr 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3092
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13080324/
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Targeting leucine-rich repeat kinase 2 overcomes resistance to oncolytic herpes simplex virus-based therapies in glioblastoma

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1. scibot 15 Apr 2026
  
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  DOI: 10.1038/s41467-026-70132-9
  
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Pan-cancer macrophage atlas uncovers that MHC-IIhigh TAMs induce Treg activation through physical interactions

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1. scibot 15 Apr 2026
  
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  DOI: 10.1016/j.celrep.2026.117230
  
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sciencedirect.com/science/article/pii/S2211124726003086
Mar 2026
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A senescent tumor cell-derived nanovesicle directly primes splenic T cells to potentiate cancer radiotherapy

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1. scibot 31 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102709
  
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Immunogenic tumor cell death and T-cell-derived IFN-γ elicit tumoricidal macrophages to potentiate OX40 immunotherapy

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1. scibot 27 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102699
  
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Radiotherapy synergizes with an inducible AAV-based immunotherapy platform to program local and systemic antitumor immunity

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1. scibot 24 Mar 2026
  
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  DOI: 10.1016/j.ccell.2026.02.013
  
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sciencedirect.com/science/article/pii/S153561082600111X
Jan 2026
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Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth

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1. scibot 23 Jan 2026
  
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  DOI: 10.1016/j.ccell.2025.12.021
  
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Fibroblast-derived alarmin promotes oral wound healing by activating regulatory T cells that relay pro-angiogenic and anti-inflammatory responses

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1. scibot 15 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116829
  
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Dec 2025
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1-s2.0-S2589004225025933-main-html.html

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1. scibot 04 Dec 2025
  
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54.241.53.176/f8496056a6f1160458204b618efc50d8bf946be7/1-s2.0-S2589004225025933-main-html.html
Nov 2025
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IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing antitumor efficacy

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.immuni.2025.10.021
  
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Regulatory T cell stability determines the efficiency of bile duct regeneration during cholangitis

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1. scibot 18 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116557
  
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sciencedirect.com/science/article/pii/S2211124725013282
Sep 2025
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SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance

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1. scibot 07 Sep 2025
  
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  DOI: 10.1158/1078-0432.CCR-24-3882
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12402801/
Jul 2025
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PLT012, a humanized CD36-blocking antibody, is effective for unleashing anti-tumor immunity against liver cancer and liver metastasis

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1. scibot 30 Jul 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1409
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617665/
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Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.cell.2025.06.027
  
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AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis

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1. scibot 02 Jul 2025
  
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  DOI: 10.1016/j.jid.2023.12.017
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11193656/
Jun 2025
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The RXR Agonist MSU-42011 Reduces Tumor Burden in a Murine Preclinical NF1-Deficient Model

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1. scibot 13 Jun 2025
  
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  DOI: 10.3390/cancers17121920
  
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mdpi.com/2072-6694/17/12/1920
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Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy

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1. scibot 03 Jun 2025
  
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  DOI: 10.1016/j.immuni.2025.05.006
  
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sciencedirect.com/science/article/pii/S1074761325002274
May 2025
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1. scibot 21 May 2025
  
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  DOI: 10.1158/2159-8290.cd-24-1409
  
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52.53.155.43/449eeec941982dcbbbd18cfe95d7f2b03d57e236/PDF-html.html
Apr 2025
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Constructed transferrin receptor-targeted liposome for the delivery of fluvoxamine to improve prognosis in a traumatic brain injury mouse model

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1. scibot 18 Apr 2025
  
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  DOI: 10.1080/10717544.2025.2486840
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12001850/
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Constructed transferrin receptor-targeted liposome for the delivery of fluvoxamine to improve prognosis in a traumatic brain injury mouse model

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52.53.155.43 52.53.155.43

1-s2.0-S0016508525005426-main-html.html

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1. scibot 05 Apr 2025
  
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52.53.155.43/417f7e11cf34a4a05dabce5f916b0d6ed71a75c4/1-s2.0-S0016508525005426-main-html.html
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SARC028 samples reveal an interplay between TGF-beta, interferon signaling and low HLA class I expression as contributors to Ewing sarcoma checkpoint blockade resistance

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1. scibot 02 Apr 2025
  
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  DOI: 10.1101/2025.03.26.645492
  
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biorxiv.org/content/10.1101/2025.03.26.645492v1
Mar 2025
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ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.xcrm.2025.102038
  
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Feb 2025
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Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy

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1. scibot 07 Feb 2025
  
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  DOI: 10.1016/j.xcrm.2024.101927
  
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Jan 2025
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The Tumor Immune Microenvironment and Therapeutic Efficacy of Trastuzumab Deruxtecan in Gastric Cancer

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1. scibot 16 Jan 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0302
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11729160/
Dec 2024
52.53.155.43 52.53.155.43

crc-24-0302-html.html

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1. scibot 19 Dec 2024
  
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  DOI: 10.1158/2767-9764.crc-24-0302
  
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Sep 2024
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The rebalancing of the immune system at the maternal-fetal interface ameliorates autism-like behavior in adult offspring

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  DOI: 10.1016/j.celrep.2024.114787
  
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Jul 2024
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Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response

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  DOI: 10.1016/j.celrep.2024.114532
  
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Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance

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  DOI: 10.1016/j.cell.2024.06.012
  
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Apr 2024
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Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis

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1. scibot 19 Apr 2024
  
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  DOI: 10.1158/0008-5472.CAN-23-1542
  
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aacrjournals.org/cancerres/article/84/4/527/734130/Mesothelin-Secretion-by-Pancreatic-Cancer-Cells-Co
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CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer

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1. scibot 12 Apr 2024
  
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  DOI: 10.1016/j.xcrm.2024.101479
  
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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

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1. scibot 11 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114088
  
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sciencedirect.com/science/article/pii/S2211124724004169
Mar 2024
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ΔNp63 regulates MDSC survival and metabolism in triple-negative breast cancer

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Multimodal immune phenotyping reveals microbial-T cell interactions that shape pancreatic cancer

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Lethal severe fever with thrombocytopenia syndrome virus infection causes systemic germinal centre failure and massive T cell apoptosis in cats

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Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors

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Multi-omics of the gut microbial ecosystem in patients with microsatellite-instability-high gastrointestinal cancer resistant to immunotherapy

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AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis

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CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions

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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

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A CSF-1R-blocking antibody/IL-10 fusion protein increases anti-tumor immunity by effectuating tumor-resident CD8+ T cells

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Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer

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Interventional hydrogel microsphere vaccine as an immune amplifier for activated antitumour immunity after ablation therapy

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Targeting PCSK9 reduces cancer cell stemness and enhances antitumor immunity in head and neck cancer

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Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling

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Synergistic effects of combined immunotherapy strategies in a model of multifocal hepatocellular carcinoma

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Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer

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Depletion of conventional type-1 dendritic cells in established tumors suppresses immunotherapy efficacy

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Ewing sarcoma and osteosarcoma have distinct immune signatures and intercellular communication networks

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NF-κB-regulated VentX expression mediates tumoricidal effects of chemotherapeutics at noncytotoxic concentrations

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CYP4F2-catalyzed metabolism of arachidonic acid promotes stromal cell-mediated immunosuppression in non-small cell lung cancer

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Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma

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AMP-activated protein kinase alpha1 promotes tumor development via FOXP3 elevation in tumor-infiltrating Treg cells

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Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion

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Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection

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Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis

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Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer

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PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells

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Soluble recombinant human thrombomodulin suppresses inflammation-induced gastrointestinal tumor growth in a murine peritonitis model

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Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer

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