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Sep 2026
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A dual-module ECAS complex couples transcription elongation and RNA processing

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  DOI: 10.1016/j.molcel.2026.08.019
  
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sciencedirect.com/science/article/pii/S1097276526005885
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Genome-wide chromatin recording resolves dynamic cell state changes

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1. scibot 10 Sep 2026
  
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  DOI: 10.1016/j.cels.2026.101717
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13540299/
Jul 2026
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Condensates of the chromatin regulator ANKRD11 restrict hypertranscribed genes to safeguard development

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1. scibot 23 Jul 2026
  
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  DOI: 10.1016/j.cell.2026.07.006
  
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sciencedirect.com/science/article/pii/S0092867426008044
Jun 2026
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Cyclin-dependent kinase-9 and oxidative phosphorylation inhibition overcome ibrutinib resistance in mantle cell lymphoma

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1. scibot 24 Jun 2026
  
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  DOI: 10.1158/2767-9764.CRC-25-0818
  
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aacrjournals.org/cancerrescommun/article/6/5/1192/785363/Cyclin-Dependent-Kinase-9-and-Oxidative
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SETDB1 and HUSH modulate Xist RNA levels during establishment of X chromosome inactivation

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1. scibot 10 Jun 2026
  
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  DOI: 10.1038/s41467-026-71569-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13243529/
Feb 2026
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Cytoplasmic mRNA decay by the antiviral nuclease RNase L promotes transcriptional repression

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1. scibot 27 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.117028
  
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sciencedirect.com/science/article/pii/S2211124726001063
Jan 2026
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Sequential RNA polymerase II activation drives human hematopoiesis

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1. scibot 13 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116802
  
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sciencedirect.com/science/article/pii/S2211124725015748
Nov 2025
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CDK7 is a novel therapeutic target in fibrolamellar carcinoma

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.isci.2025.113925
  
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sciencedirect.com/science/article/pii/S2589004225021868
Aug 2025
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RNA Pol II inhibition activates cell death independently from the loss of transcription

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1. scibot 19 Aug 2025
  
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  DOI: 10.1016/j.cell.2025.07.034
  
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cell.com/cell/abstract/S0092-8674(25)00856-6
Jun 2025
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PRPS activity tunes redox homeostasis in Myc-driven lymphoma

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.redox.2025.103649
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12166406/
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Targeting CDK7/12/13 functional synergism reverses myofibroblast activation and ameliorates lung fibrosis

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.isci.2025.112778
  
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sciencedirect.com/science/article/pii/S2589004225010399
May 2025
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Chromatin-bound U2AF2 splicing factor ensures exon inclusion

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.molcel.2025.04.013
  
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sciencedirect.com/science/article/pii/S1097276525003168
Mar 2025
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Targeted degradation of CDK9 potently disrupts the MYC-regulated network

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1. scibot 28 Mar 2025
  
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  DOI: 10.1016/j.chembiol.2025.03.001
  
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sciencedirect.com/science/article/pii/S2451945625000674
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Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination

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1. scibot 06 Mar 2025
  
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  DOI: 10.1016/j.molcel.2025.02.007
  
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sciencedirect.com/science/article/pii/S1097276525001339
Dec 2024
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The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.10.046
  
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sciencedirect.com/science/article/pii/S1097276524008852
Oct 2024
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Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition

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1. scibot 02 Oct 2024
  
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  DOI: 10.1016/j.xcrm.2024.101752
  
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sciencedirect.com/science/article/pii/S2666379124004828
Sep 2024
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Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer

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1. scibot 25 Sep 2024
  
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  RRID:AB_2235415
  
  DOI: 10.1016/j.ccell.2019.09.004
  
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sciencedirect.com/science/article/pii/S1535610819304246
Aug 2024
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Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies

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1. scibot 20 Aug 2024
  
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  DOI: 10.1016/j.chembiol.2024.07.005
  
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sciencedirect.com/science/article/pii/S2451945624003076
Jul 2024
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Retinoic acid enhances HIV-1 reverse transcription and transcription in macrophages via mTOR-modulated mechanisms

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1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114414
  
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sciencedirect.com/science/article/pii/S2211124724007435
Apr 2024
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Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence

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1. scibot 18 Apr 2024
  
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  DOI: 10.1016/j.stem.2024.03.015
  
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cell.com/cell-stem-cell/fulltext/S1934-5909(24)00096-1
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SAFB restricts contact domain boundaries associated with L1 chimeric transcription

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1. scibot 11 Apr 2024
  
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  DOI: 10.1016/j.molcel.2024.03.021
  
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sciencedirect.com/science/article/pii/S1097276524002314
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DDX21 mediates co-transcriptional RNA m6A modification to promote transcription termination and genome stability

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  DOI: 10.1016/j.molcel.2024.03.006
  
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  DOI: 10.1016/j.molcel.2024.03.006
  
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sciencedirect.com/science/article/pii/S1097276524001886
Mar 2024
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Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape

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1. scibot 29 Mar 2024
  
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  DOI: 10.1016/j.molcel.2024.02.032
  
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sciencedirect.com/science/article/pii/S1097276524001758
Feb 2024
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Enhancer-promoter activation by the Kaposi sarcoma-associated herpesvirus episome maintenance protein LANA

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1. scibot 29 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113888
  
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sciencedirect.com/science/article/pii/S221112472400216X
Dec 2023
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Chromosome-specific maturation of the epigenome in the Drosophila male germline

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1. scibot 02 Dec 2023
  
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  DOI: 10.7554/eLife.89373
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10688970/
Oct 2023
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Protocol for rapidly inducing genome-wide RNA Pol II hyperphosphorylation by selectively disrupting INTAC phosphatase activity

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1. scibot 22 Oct 2023
  
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  DOI: 10.1016/j.xpro.2023.102640
  
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  DOI: 10.1016/j.xpro.2023.102640
  
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sciencedirect.com/science/article/pii/S266616672300607X
Jul 2023
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Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1

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1. scibot 06 Jul 2023
  
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  DOI: 10.1016/j.molcel.2023.06.007
  
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sciencedirect.com/science/article/pii/S1097276523004306
May 2023
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Disruption of CDK7 signaling leads to catastrophic chromosomal instability coupled with a loss of condensin-mediated chromatin compaction

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1. scibot 18 May 2023
  
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  DOI: 10.1016/j.jbc.2023.104834
  
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sciencedirect.com/science/article/pii/S0021925823018628
Apr 2023
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RNA Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits

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1. scibot 27 Apr 2023
  
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  DOI: 10.1016/j.molcel.2023.02.028
  
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INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II

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  DOI: 10.1016/j.molcel.2023.03.022
  
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sciencedirect.com/science/article/pii/S1097276523002125
Dec 2022
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SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia

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1. scibot 01 Dec 2022
  
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  DOI: 10.1016/j.celrep.2022.111727
  
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sciencedirect.com/science/article/pii/S2211124722016059
Jun 2022
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Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy

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1. scibot 10 Jun 2022
  
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  DOI: 10.1016/j.cell.2022.04.031
  
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sciencedirect.com/science/article/pii/S0092867422005293
Apr 2022
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RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex

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1. scibot 27 Apr 2022
  
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  DOI: 10.1016/j.celrep.2022.110732
  
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sciencedirect.com/science/article/pii/S2211124722004934
Jan 2022
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Multi-CUT&Tag to simultaneously profile multiple chromatin factors

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1. scibot 21 Jan 2022
  
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  Cell Signaling TechnologyCat#13499
  
  DOI: 10.1016/j.xpro.2021.101100
  
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sciencedirect.com/science/article/pii/S2666166721008066
Oct 2021
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Simultaneous profiling of multiple chromatin proteins in the same cells

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1. scibot 12 Oct 2021
  
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  RRID:AB_2798238
  
  DOI: 10.1016/j.molcel.2021.09.019
  
  Resource: (Cell Signaling Technology Cat# 13499, RRID:AB_2798238)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S109727652100753X
Sep 2021
www.sciencedirect.com www.sciencedirect.com

SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape

1
1. scibot 17 Sep 2021
  
  in Public
  
  RRID:AB_2798238
  
  DOI: 10.1016/j.molcel.2021.08.029
  
  Resource: (Cell Signaling Technology Cat# 13499, RRID:AB_2798238)
  
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sciencedirect.com/science/article/pii/S1097276521006961
Jul 2021
www.embopress.org www.embopress.org

CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1‐ErbB‐PI3K signaling

1
1. scibot 30 Jul 2021
  
  in Public
  
  p‐Rpb1 CTD
  
  DOI: 10.15252/embr.201948058
  
  Resource: (Cell Signaling Technology Cat# 13499, RRID:AB_2798238)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2798238
  
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  RRID:AB_2798238 RRIDCUR:Missing
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embopress.org/doi/10.15252/embr.201948058
www.sciencedirect.com www.sciencedirect.com

RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control

1
1. scibot 28 Jul 2021
  
  in Public
  
  Pol II Ser2P
  
  DOI: 10.1016/j.molcel.2019.05.007
  
  Resource: (Cell Signaling Technology Cat# 13499, RRID:AB_2798238)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2798238
  
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  RRIDCUR:Missing RRID:AB_2798238
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sciencedirect.com/science/article/pii/S1097276519303600
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Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer

1
1. scibot 22 Jul 2021
  
  in Public
  
  RRID:AB_2798238
  
  DOI: 10.1016/j.celrep.2021.109394
  
  Resource: (Cell Signaling Technology Cat# 13499, RRID:AB_2798238)
  
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sciencedirect.com/science/article/pii/S2211124721007920
Apr 2021
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Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma

1
1. scibot 28 Apr 2021
  
  in Public
  
  RRID:AB_2798238
  
  DOI: 10.1016/j.celrep.2021.109013
  
  Resource: (Cell Signaling Technology Cat# 13499, RRID:AB_2798238)
  
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sciencedirect.com/science/article/pii/S2211124721003272
Feb 2021
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Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1

1
1. scibot 24 Feb 2021
  
  in Public
  
  RRID:AB_2798238
  
  DOI: 10.1016/j.celrep.2021.108749
  
  Resource: (Cell Signaling Technology Cat# 13499, RRID:AB_2798238)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2798238
  
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  RRID:AB_2798238 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124721000620
Dec 2020
www.sciencedirect.com www.sciencedirect.com

CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci

1
1. scibot 24 Dec 2020
  
  in Public
  
  RRID:AB_2798238
  
  DOI: 10.1016/j.celrep.2020.108545
  
  Resource: (Cell Signaling Technology Cat# 13499, RRID:AB_2798238)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2798238
  
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  RRIDCUR:Validated RRID:AB_2798238
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sciencedirect.com/science/article/pii/S2211124720315345
Nov 2020
elifesciences.org elifesciences.org

SON and SRRM2 are essential for nuclear speckle formation

1
1. scibot 21 Nov 2020
  
  in Public
  
  RRID:AB_2798238
  
  DOI: 10.7554/eLife.60579
  
  Resource: (Cell Signaling Technology Cat# 13499, RRID:AB_2798238)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2798238
  
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  RRID:AB_2798238 RRIDCUR:Validated
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elifesciences.org/articles/60579
Sep 2020
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LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice

1
1. scibot 08 Sep 2020
  
  in Public
  
  RRID:AB_2798238
  
  DOI: 10.1016/j.molcel.2020.01.002
  
  Resource: (Cell Signaling Technology Cat# 13499, RRID:AB_2798238)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2798238
  
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  RRID:AB_2798238 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276520300022
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Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma

1
1. scibot 04 Sep 2020
  
  in Public
  
  phospho-Rbp1 CTD (Ser2) rabbit mAb
  
  DOI: 10.1016/j.celrep.2020.03.049
  
  Resource: (Cell Signaling Technology Cat# 13499, RRID:AB_2798238)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2798238
  
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  RRID:AB_2798238 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S2211124720303636