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Sep 2025
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RSK1 reprograms the ubiquitin pathway to promote immune suppression

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1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116323
  
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sciencedirect.com/science/article/pii/S2211124725010940
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T cell-intrinsic cGAS-CTCF regulation maintains regulatory T cell development and function

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1. scibot 17 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116302
  
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sciencedirect.com/science/article/pii/S2211124725010733
journals.plos.org journals.plos.org

Microglial deficiency in the ATRX chromatin remodeler elicits a viral mimicry immune response that impacts neuronal function and behavior

1
1. scibot 16 Sep 2025
  
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  DOI: 10.1371/journal.pbio.3002659
  
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BPS Publications

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1. scibot 16 Sep 2025
  
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  DOI: 10.1111/bph.70174
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70174
Aug 2025
jeccr.biomedcentral.com jeccr.biomedcentral.com

TRIM6 ablation reverses ICB resistance in MSS gastric cancer by unleashing cGAS-STING-dependent antitumor immunity

1
1. scibot 19 Aug 2025
  
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  DOI: 10.1186/s13046-025-03513-5
  
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jeccr.biomedcentral.com/articles/10.1186/s13046-025-03513-5
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Riluzole Enhancing anti-PD-1 Efficacy by Activating cGAS/STING Signaling in Colorectal Cancer

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1. scibot 17 Jul 2025
  
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  RRID:AB_279900
  
  DOI: 10.1158/1535-7163.MCT-24-0289
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11695182/
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A fluorescent STING ligand sensor for high-throughput screening of compounds that can enhance tumor immunotherapy

1
1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.crmeth.2025.101106
  
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sciencedirect.com/science/article/pii/S2667237525001420
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MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction

1
1. scibot 03 Jul 2025
  
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  DOI: 10.1016/j.molcel.2025.06.005
  
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sciencedirect.com/science/article/pii/S1097276525005052
May 2025
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PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammation

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115735
  
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sciencedirect.com/science/article/pii/S2211124725005066
Apr 2025
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Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway

1
1. scibot 09 Apr 2025
  
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  DOI: 10.1016/j.immuni.2025.03.005
  
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sciencedirect.com/science/article/pii/S1074761325001244
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Cancer-cell-derived cGAMP limits the activity of tumor-associated CD8+ T cells

1
1. scibot 03 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115510
  
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sciencedirect.com/science/article/pii/S2211124725002815
Mar 2025
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The actin and microtubule network regulator WHAMM is identified as a key kidney disease risk gene

1
1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115462
  
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sciencedirect.com/science/article/pii/S2211124725002335
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Lactylation orchestrates ubiquitin-independent degradation of cGAS and promotes tumor growth

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1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115441
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00212-8
Feb 2025
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OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity

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1. scibot 27 Feb 2025
  
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  DOI: 10.1016/j.immuni.2025.01.016
  
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sciencedirect.com/science/article/pii/S1074761325000652
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RBM43 controls PGC1α translation and a PGC1α-STING signaling axis

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1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.cmet.2025.01.013
  
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sciencedirect.com/science/article/pii/S1550413125000130
Jan 2025
onlinelibrary.wiley.com onlinelibrary.wiley.com

Mechanical Force-Induced cGAS Activation in Carcinoma Cells Facilitates Splenocytes into Liver to Drive Metastasis

1
1. scibot 11 Jan 2025
  
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  DOI: 10.1002/advs.202401127
  
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onlinelibrary.wiley.com/doi/10.1002/advs.202401127
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Structures of ATP-binding cassette transporter ABCC1 reveal the molecular basis of cyclic dinucleotide cGAMP export

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1. scibot 07 Jan 2025
  
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  DOI: 10.1016/j.immuni.2024.12.002
  
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sciencedirect.com/science/article/pii/S1074761324005661
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Aberrant STING activation promotes macrophage senescence by suppressing autophagy in vascular aging from diabetes

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1. scibot 03 Jan 2025
  
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  DOI: 10.1016/j.isci.2024.111594
  
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sciencedirect.com/science/article/pii/S2589004224028219
Dec 2024
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MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling

1
1. scibot 18 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.026
  
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Spatial organizations of heterochromatin underpin nuclear structural integrity of ventricular cardiomyocytes against mechanical stress

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1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115048
  
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sciencedirect.com/science/article/pii/S2211124724013998
Nov 2024
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Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy

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1. scibot 07 Nov 2024
  
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  DOI: 10.3389/fonc.2024.1441935
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11513249/
Oct 2024
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Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

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1. scibot 02 Oct 2024
  
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  DOI: 10.1016/j.neuron.2024.09.006
  
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sciencedirect.com/science/article/pii/S0896627324006548
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

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1. scibot 27 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110285
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11267025/
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Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer

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1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.medj.2024.06.002
  
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sciencedirect.com/science/article/pii/S2666634024002484
Jun 2024
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The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity

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1. scibot 08 Jun 2024
  
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  DOI: 10.1158/2326-6066.CIR-23-1078
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11148535/
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Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice

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1. scibot 04 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114284
  
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sciencedirect.com/science/article/pii/S2211124724006120
May 2024
52.53.155.43 52.53.155.43

cir-23-1078-html.html

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  DOI: 10.1158/2326-6066.cir-23-1078
  
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52.53.155.43/ee0bd7762d373e957152429ed1d9032329c895e5/cir-23-1078-html.html
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ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity

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1. scibot 21 May 2024
  
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  DOI: 10.1016/j.cell.2024.04.025
  
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sciencedirect.com/science/article/pii/S0092867424004513
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Viral mimicry and memory deficits upon microglial deletion of ATRX

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  DOI: 10.1101/2024.05.07.592875
  
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biorxiv.org/content/10.1101/2024.05.07.592875v1
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Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

1
1. scibot 10 May 2024
  
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  DOI: 10.1101/2024.01.24.577107
  
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biorxiv.org/content/10.1101/2024.01.24.577107v1
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Intratumoral delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR, and CD8+ T cell-dependent anti-tumor immunity

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1. scibot 10 May 2024
  
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  DOI: 10.1016/j.xcrm.2024.101560
  
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sciencedirect.com/science/article/pii/S2666379124002520
Apr 2024
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Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity

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1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.xcrm.2024.101528
  
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sciencedirect.com/science/article/pii/S2666379124001976
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Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers

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1. scibot 26 Apr 2024
  
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  DOI: 10.1016/j.ccell.2024.04.004
  
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sciencedirect.com/science/article/pii/S1535610824001284
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Blocking cGAS-STING pathway promotes post-stroke functional recovery in an extended treatment window via facilitating remyelination

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1. scibot 25 Apr 2024
  
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  DOI: 10.1016/j.medj.2024.03.018
  
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sciencedirect.com/science/article/pii/S2666634024001302
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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

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1. scibot 11 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114088
  
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sciencedirect.com/science/article/pii/S2211124724004169
Mar 2024
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HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

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SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion

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CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise

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Nov 2023
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HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation

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Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity

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Oct 2023
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Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy

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4-Octyl itaconate restricts STING activation by blocking its palmitoylation

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Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy

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Jun 2023
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Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response

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Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

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May 2023
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cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway

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Mar 2023
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Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast Cancer

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Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS

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Feb 2023
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Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model

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Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS

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DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma

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Cancer cell-derived type I interferons instruct tumor monocyte polarization

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Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

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Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy

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cGAS-STING Activation by Cytosolic Mitochondrial DNA Contributes to Podocyte Injury in Diabetic Kidney Disease

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Jul 2022
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Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

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The SETDB1–TRIM28 complex suppresses antitumor immunity

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Protocol to induce and assess cGAS-STING pathway activation in vitro

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Jan 2022
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STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

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APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis

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Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA

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Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm

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Jul 2021
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Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C

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May 2021
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The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

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Apr 2021
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MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

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Feb 2021
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DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity

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Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes

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Disruption of DNA polymerase ζ engages an innate immune response

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Dec 2020
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Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5

1
1. scibot 12 Dec 2020
  
  in Public
  
  RRID:AB_2799008
  
  DOI: 10.1016/j.celrep.2020.108490
  
  Resource: (Cell Signaling Technology Cat# 31659, RRID:AB_2799008)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2799008
  
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  RRIDCUR:Validated RRID:AB_2799008
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scibot

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sciencedirect.com/science/article/pii/S2211124720314790
Sep 2020
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Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

1
1. scibot 14 Sep 2020
  
  in Public
  
  RRID:AB_2799008
  
  DOI: 10.1016/j.immuni.2020.01.014
  
  Resource: (Cell Signaling Technology Cat# 31659, RRID:AB_2799008)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2799008
  
  What is this?
  
  RRIDCUR:Validated RRID:AB_2799008
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sciencedirect.com/science/article/pii/S107476132030042X
Jan 2020
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Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2799008
  
  DOI: 10.1016/j.celrep.2019.09.065
  
  Resource: (Cell Signaling Technology Cat# 31659, RRID:AB_2799008)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2799008
  
  What is this?
  
  RRID:AB_2799008 RRIDCUR:Validated
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RRID:AB_2799008

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scibot

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sciencedirect.com/science/article/pii/S2211124719312628

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