52 Matching Annotations
  1. Last 7 days
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway
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    1. scibot 27 Jul 2024
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      DOI: 10.1016/j.isci.2024.110285

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    ncbi.nlm.nih.gov/pmc/articles/PMC11267025/
  3. Jul 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer
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    1. scibot 19 Jul 2024
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    sciencedirect.com/science/article/pii/S2666634024002484
  5. Jun 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity
    1
    1. scibot 08 Jun 2024
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      DOI: 10.1158/2326-6066.CIR-23-1078

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    ncbi.nlm.nih.gov/pmc/articles/PMC11148535/
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    Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice
    1
    1. scibot 04 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114284

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    sciencedirect.com/science/article/pii/S2211124724006120
  8. May 2024
  9. 52.53.155.43 52.53.155.43
    cir-23-1078-html.html
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    1. scibot 23 May 2024
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    52.53.155.43/ee0bd7762d373e957152429ed1d9032329c895e5/cir-23-1078-html.html
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    ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity
    1
    1. scibot 21 May 2024
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      DOI: 10.1016/j.cell.2024.04.025

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    sciencedirect.com/science/article/pii/S0092867424004513
  11. www.biorxiv.org www.biorxiv.org
    Viral mimicry and memory deficits upon microglial deletion of ATRX
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    1. scibot 16 May 2024
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      DOI: 10.1101/2024.05.07.592875

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    biorxiv.org/content/10.1101/2024.05.07.592875v1
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    Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
    1
    1. scibot 10 May 2024
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      DOI: 10.1101/2024.01.24.577107

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    biorxiv.org/content/10.1101/2024.01.24.577107v1
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    Intratumoral delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR, and CD8+ T cell-dependent anti-tumor immunity
    1
    1. scibot 10 May 2024
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      DOI: 10.1016/j.xcrm.2024.101560

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    sciencedirect.com/science/article/pii/S2666379124002520
  14. Apr 2024
  15. www.sciencedirect.com www.sciencedirect.com
    Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
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    1. scibot 30 Apr 2024
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    sciencedirect.com/science/article/pii/S2666379124001976
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    Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
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    1. scibot 26 Apr 2024
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    sciencedirect.com/science/article/pii/S1535610824001284
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    Blocking cGAS-STING pathway promotes post-stroke functional recovery in an extended treatment window via facilitating remyelination
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    1. scibot 25 Apr 2024
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      DOI: 10.1016/j.medj.2024.03.018

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    sciencedirect.com/science/article/pii/S2666634024001302
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    IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling
    1
    1. scibot 11 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114088

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    sciencedirect.com/science/article/pii/S2211124724004169
  19. Mar 2024
  20. www.sciencedirect.com www.sciencedirect.com
    HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
    2
    1. scibot 01 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113870

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      DOI: 10.1016/j.celrep.2024.113870

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    sciencedirect.com/science/article/pii/S2211124724001980
  21. Feb 2024
  22. www.sciencedirect.com www.sciencedirect.com
    SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
    1
    1. scibot 02 Feb 2024
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      DOI: 10.1016/j.cell.2024.01.008

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    sciencedirect.com/science/article/pii/S0092867424000102
  23. Jan 2024
  24. www.sciencedirect.com www.sciencedirect.com
    CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise
    1
    1. scibot 07 Jan 2024
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      DOI: 10.1016/j.celrep.2023.113626

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    sciencedirect.com/science/article/pii/S2211124723016376
  25. Nov 2023
  26. www.sciencedirect.com www.sciencedirect.com
    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
    1
    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113352

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    sciencedirect.com/science/article/pii/S2211124723013645
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    Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity
    1
    1. scibot 02 Nov 2023
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      DOI: 10.1016/j.immuni.2023.09.012

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    sciencedirect.com/science/article/abs/pii/S107476132300417X
  28. Oct 2023
  29. www.sciencedirect.com www.sciencedirect.com
    Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.molcel.2023.09.007

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    sciencedirect.com/science/article/pii/S1097276523007025
  30. Aug 2023
  31. www.sciencedirect.com www.sciencedirect.com
    4-Octyl itaconate restricts STING activation by blocking its palmitoylation
    1
    1. scibot 25 Aug 2023
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      DOI: 10.1016/j.celrep.2023.113040

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    sciencedirect.com/science/article/pii/S2211124723010513
  32. Jul 2023
  33. www.sciencedirect.com www.sciencedirect.com
    Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112852

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    sciencedirect.com/science/article/pii/S221112472300863X
  34. Jun 2023
  35. www.sciencedirect.com www.sciencedirect.com
    Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response
    1
    1. scibot 27 Jun 2023
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      DOI: 10.1016/j.isci.2023.107090

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    sciencedirect.com/science/article/pii/S2589004223011677
  36. www.sciencedirect.com www.sciencedirect.com
    Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
    1
    1. scibot 23 Jun 2023
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      DOI: 10.1016/j.cell.2023.05.039

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    sciencedirect.com/science/article/pii/S0092867423005913
  37. www.sciencedirect.com www.sciencedirect.com
    Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
    1
    1. scibot 02 Jun 2023
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      DOI: 10.1016/j.ccell.2023.05.005

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    sciencedirect.com/science/article/pii/S1535610823001733
  38. May 2023
  39. journals.aai.org journals.aai.org
    cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway
    1
    1. scibot 13 May 2023
      RRID:AB_2799008

      DOI: 10.4049/jimmunol.2200351

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    journals.aai.org/jimmunol/article/210/8/1098/263495/cGAS-Mediates-Inflammation-by-Polarizing
  40. Mar 2023
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast Cancer
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    1. scibot 29 Mar 2023
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      DOI: 10.1158/2767-9764.CRC-22-0302

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    ncbi.nlm.nih.gov/pmc/articles/PMC10035514/
  42. www.sciencedirect.com www.sciencedirect.com
    Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS
    1
    1. scibot 28 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112309

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    sciencedirect.com/science/article/pii/S2211124723003200
  43. Feb 2023
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model
    1
    1. scibot 04 Feb 2023
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      DOI: 10.3389/fmolb.2023.1058825

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    ncbi.nlm.nih.gov/pmc/articles/PMC9893022/
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    Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS
    1
    1. scibot 02 Feb 2023
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      DOI: 10.1016/j.immuni.2023.01.001

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    sciencedirect.com/science/article/pii/S1074761323000110
  46. Dec 2022
  47. www.embopress.org www.embopress.org
    DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma
    2
    1. scibot 31 Dec 2022
      RRID:AB_2799008

      DOI: 10.15252/embj.2022111961

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      DOI: 10.15252/embj.2022111961

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    embopress.org/doi/10.15252/embj.2022111961
  48. www.sciencedirect.com www.sciencedirect.com
    Cancer cell-derived type I interferons instruct tumor monocyte polarization
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      DOI: 10.1016/j.celrep.2022.111769

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    sciencedirect.com/science/article/pii/S2211124722016527
  49. Nov 2022
  50. www.sciencedirect.com www.sciencedirect.com
    Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis
    1
    1. scibot 16 Nov 2022
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      DOI: 10.1016/j.neuron.2022.10.028

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    sciencedirect.com/science/article/pii/S0896627322009618
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    Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy
    1
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      DOI: 10.1016/j.celrep.2022.111582

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    sciencedirect.com/science/article/pii/S2211124722014474
  52. Sep 2022
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    cGAS-STING Activation by Cytosolic Mitochondrial DNA Contributes to Podocyte Injury in Diabetic Kidney Disease
    1
    1. scibot 30 Sep 2022
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      DOI: 10.1016/j.isci.2022.105145

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    ncbi.nlm.nih.gov/pmc/articles/PMC9513272/
  54. Jul 2022
  55. www.sciencedirect.com www.sciencedirect.com
    Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling
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    1. scibot 14 Jul 2022
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      DOI: 10.1016/j.immuni.2022.06.007

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    sciencedirect.com/science/article/pii/S1074761322002801
  56. Jun 2022
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SETDB1–TRIM28 complex suppresses antitumor immunity
    1
    1. scibot 07 Jun 2022
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      DOI: 10.1158/2326-6066.CIR-21-0754

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    ncbi.nlm.nih.gov/pmc/articles/PMC8647838/
  58. May 2022
  59. www.sciencedirect.com www.sciencedirect.com
    Protocol to induce and assess cGAS-STING pathway activation in vitro
    1
    1. scibot 18 May 2022
      RRID:AB_2799008

      DOI: 10.1016/j.xpro.2022.101384

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    sciencedirect.com/science/article/pii/S2666166722002647
  60. Jan 2022
  61. www.sciencedirect.com www.sciencedirect.com
    STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses
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    1. scibot 05 Jan 2022
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      DOI: 10.1016/j.cmet.2021.12.007

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    sciencedirect.com/science/article/pii/S1550413121006264
  62. Nov 2021
  63. www.sciencedirect.com www.sciencedirect.com
    APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis
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    1. scibot 09 Nov 2021
      AB_2799008

      DOI: 10.1016/j.immuni.2021.10.004

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    sciencedirect.com/science/article/pii/S1074761321004106
  64. Aug 2021
  65. www.sciencedirect.com www.sciencedirect.com
    Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA
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    1. scibot 25 Aug 2021
      RRID:AB_2799008

      DOI: 10.1016/j.celrep.2021.109537

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    sciencedirect.com/science/article/pii/S2211124721009712
  66. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm
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    1. scibot 15 Aug 2021
      RRID:AB_2799008

      DOI: 10.1002/advs.202100779

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    onlinelibrary.wiley.com/doi/10.1002/advs.202100779
  67. Jul 2021
  68. www.nature.com www.nature.com
    Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C
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    1. scibot 31 Jul 2021
      31659

      DOI: 10.1038/s41586-021-03762-2

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  69. May 2021
  70. www.sciencedirect.com www.sciencedirect.com
    The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake
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    1. scibot 12 May 2021
      RRID:AB_2799008

      DOI: 10.1016/j.immuni.2021.04.019

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    sciencedirect.com/science/article/pii/S1074761321001813
  71. Apr 2021
  72. www.sciencedirect.com www.sciencedirect.com
    MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
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    1. scibot 22 Apr 2021
      RRID:AB_2799008

      DOI: 10.1016/j.ccell.2020.11.004

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    sciencedirect.com/science/article/pii/S1535610820305961
  73. Feb 2021
  74. www.sciencedirect.com www.sciencedirect.com
    DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity
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    1. scibot 28 Feb 2021
      RRID:AB_2799008

      DOI: 10.1016/j.ccell.2020.11.006

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    sciencedirect.com/science/article/pii/S1535610820305985
  75. www.mdpi.com www.mdpi.com
    Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes
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    1. scibot 27 Feb 2021
      RRID:AB_2799008

      DOI: 10.3390/antiox10020334

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    mdpi.com/2076-3921/10/2/334
  76. www.sciencedirect.com www.sciencedirect.com
    Disruption of DNA polymerase ζ engages an innate immune response
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    1. scibot 25 Feb 2021
      RRID:AB_2799008

      DOI: 10.1016/j.celrep.2021.108775

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    sciencedirect.com/science/article/pii/S2211124721000887
  77. Dec 2020
  78. www.sciencedirect.com www.sciencedirect.com
    Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5
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    1. scibot 12 Dec 2020
      RRID:AB_2799008

      DOI: 10.1016/j.celrep.2020.108490

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    sciencedirect.com/science/article/pii/S2211124720314790
  79. Sep 2020
  80. www.sciencedirect.com www.sciencedirect.com
    Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP
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    1. scibot 14 Sep 2020
      RRID:AB_2799008

      DOI: 10.1016/j.immuni.2020.01.014

      Resource: (Cell Signaling Technology Cat# 31659, RRID:AB_2799008)

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    sciencedirect.com/science/article/pii/S107476132030042X
  81. Jan 2020
  82. www.sciencedirect.com www.sciencedirect.com
    Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity
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    1. scibot 13 Jan 2020
      RRID:AB_2799008

      DOI: 10.1016/j.celrep.2019.09.065

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    sciencedirect.com/science/article/pii/S2211124719312628