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Activation of T cell-intrinsic p53 by acetylation elicits antitumor immunity to boost cancer immunotherapy

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1. scibot 23 Apr 2026
  
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  DOI: 10.1158/2159-8290.CD-25-0649
  
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aacrjournals.org/cancerdiscovery/article/16/1/155/771238/Activation-of-T-Cell-Intrinsic-p53-by-Acetylation
Apr 2026
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Targeting RNase H2: A dual-mechanism strategy to elevate replication stress, DNA damage, and antitumor immunity in TNBC

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1. scibot 22 Apr 2026
  
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  DOI: 10.1016/j.xcrm.2026.102750
  
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sciencedirect.com/science/article/pii/S2666379126001679
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An autochthonous CRISPR activation screening platform for characterizing tissue-specific oncogene selection

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1. scibot 18 Apr 2026
  
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  DOI: 10.1016/j.xcrm.2026.102759
  
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sciencedirect.com/science/article/pii/S266637912600176X
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Regulatory elements in the Sox9 locus license the initiation of pancreatic ductal adenocarcinoma

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1. scibot 16 Apr 2026
  
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  DOI: 10.1016/j.celrep.2026.117176
  
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sciencedirect.com/science/article/pii/S2211124726002548
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Pan-cancer macrophage atlas uncovers that MHC-IIhigh TAMs induce Treg activation through physical interactions

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  DOI: 10.1016/j.celrep.2026.117230
  
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sciencedirect.com/science/article/pii/S2211124726003086
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Metabolic stress sensing by epithelial RXRα links westernization of diet with Crohn’s disease

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1. scibot 01 Apr 2026
  
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  DOI: 10.1016/j.cmet.2025.11.008
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13034575/
Mar 2026
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Piezo1-mediated mechanotransduction in choroid plexus epithelial cells governs ciliogenesis and cerebrospinal fluid homeostasis

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1. scibot 31 Mar 2026
  
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  DOI: 10.1016/j.neuron.2026.02.033
  
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Immunogenic tumor cell death and T-cell-derived IFN-γ elicit tumoricidal macrophages to potentiate OX40 immunotherapy

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1. scibot 27 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102699
  
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sciencedirect.com/science/article/pii/S2666379126001163
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Deletion of miR-130b/301b cluster promotes macrophage efferocytosis and resolution of adipose tissue inflammation

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1. scibot 24 Mar 2026
  
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  DOI: 10.1016/j.isci.2026.115307
  
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sciencedirect.com/science/article/pii/S2589004226006826
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Mitochondrial control of glycerolipid synthesis by a PEP shuttle

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1. scibot 20 Mar 2026
  
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  DOI: 10.1016/j.cell.2026.02.017
  
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sciencedirect.com/science/article/pii/S0092867426002242
Feb 2026
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Colorectal cancer-derived osteopontin rewires macrophages into a pro-metastatic M2 state via the PI3K/AKT/CSF1-CSF1R axis

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1. scibot 14 Feb 2026
  
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  DOI: 10.1038/s41420-026-02945-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12894849/
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1-s2.0-S2589004226002336-main-html.html

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1. scibot 10 Feb 2026
  
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  DOI: 10.1016/j.isci.2026.114858
  
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54.241.53.176/e86b13a815c53c6ac4146180b2283f50e62e856a/1-s2.0-S2589004226002336-main-html.html
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FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD-L1 and T Cell Senescence

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1. scibot 06 Feb 2026
  
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  DOI: 10.1002/advs.202506239
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202506239
Jan 2026
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Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth

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1. scibot 23 Jan 2026
  
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  DOI: 10.1016/j.ccell.2025.12.021
  
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sciencedirect.com/science/article/pii/S1535610825005550
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Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors

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1. scibot 05 Jan 2026
  
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  DOI: 10.1016/j.cell.2025.12.002
  
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sciencedirect.com/science/article/pii/S0092867425013789
Dec 2025
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BPS Publications

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1. scibot 23 Dec 2025
  
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  DOI: 10.1111/bph.70295
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70295
Nov 2025
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1-s2.0-S258900422502499X-main-html.html

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.isci.2025.114238
  
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54.241.53.176/d973bd832e5fc1e042df276d91beea49ad7cbf89/1-s2.0-S258900422502499X-main-html.html
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IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing antitumor efficacy

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.immuni.2025.10.021
  
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sciencedirect.com/science/article/pii/S1074761325004753
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Single-cell quantification of senescence burden reveals cell type-specific ageing dynamics across organs

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1. scibot 18 Nov 2025
  
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  DOI: 10.1101/2025.11.14.688272
  
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biorxiv.org/content/10.1101/2025.11.14.688272v1
Oct 2025
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TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis

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1. scibot 23 Oct 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-4224
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7618269/
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Adipocyte lipolysis activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling

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1. scibot 23 Oct 2025
  
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  DOI: 10.1016/j.cmet.2025.09.012
  
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sciencedirect.com/science/article/pii/S1550413125003973
Sep 2025
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Tumors hijack macrophages for iron supply to promote bone metastasis and anemia

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1. scibot 04 Sep 2025
  
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  DOI: 10.1016/j.cell.2025.08.013
  
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sciencedirect.com/science/article/pii/S0092867425009274
Aug 2025
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A preclinical model for the identification of therapeutically active transgenes in local cancer immunotherapy

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1. scibot 21 Aug 2025
  
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  DOI: 10.1080/2162402X.2025.2543620
  
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tandfonline.com/doi/full/10.1080/2162402X.2025.2543620
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SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition

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1. scibot 19 Aug 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-1970
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12355175/
Jul 2025
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ARID1A mutation drives gastric tumorigenesis via activating type 2 immune dominant microenvironment

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1. scibot 31 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.113117
  
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Gut substrate trap of D-lactate from microbiota improves blood glucose and fatty liver disease in obese mice

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1. scibot 30 Jul 2025
  
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  DOI: 10.1016/j.cmet.2025.07.001
  
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Progesterone signaling in oviductal epithelial cells modulates the immune response to support preimplantation embryonic development

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1. scibot 25 Jul 2025
  
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  DOI: 10.1126/sciadv.adt6113
  
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science.org/doi/10.1126/sciadv.adt6113
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Multimodal analysis stratifies genetic susceptibility and reveals the pathogenic mechanism of kidney injury in diabetic nephropathy

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102249
  
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sciencedirect.com/science/article/pii/S2666379125003222
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CINTER-seq: Chemical profiling reveals interaction-dependent cell landscapes and gene signatures in vivo

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1. scibot 17 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.011
  
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Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.cell.2025.06.027
  
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sciencedirect.com/science/article/pii/S0092867425007287
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Combined KRAS inhibition and immune therapy generates durable complete responses in an autochthonous PDAC model

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1. scibot 15 Jul 2025
  
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  DOI: 10.1158/2159-8290.CD-24-0489
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11858029/
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Activated T Cells Break Tumor Immunosuppression by Macrophage Reeducation

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1. scibot 08 Jul 2025
  
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  DOI: 10.1158/2159-8290.CD-24-0415
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12223510/
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Cardiolipin-mimic lipid nanoparticles without antibody modification delivered senolytic in vivo CAR-T therapy for inflamm-aging

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1. scibot 02 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102209
  
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sciencedirect.com/science/article/pii/S2666379125002824
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AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis

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1. scibot 02 Jul 2025
  
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  DOI: 10.1016/j.jid.2023.12.017
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11193656/
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Role of Macrophage PARP1 in the Regulation of Crosstalk between Adipose Immune Cells and Adipocytes during Diet-induced Obesity

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1. scibot 01 Jul 2025
  
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  DOI: 10.1101/2025.06.20.660762
  
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Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment

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Deficiency of estrogen receptor 2 expression enhances disorganization of the mouse uterus with age

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Trametinib potentiates anti-PD-1 efficacy in tumors established from chemotherapy-primed pancreatic cancer cells

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Inhibition of IRE1α Alleviates Renal Fibrosis and Downregulates M1 Macrophage Activation via the p38 MAPK Pathway

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12-Lipoxygenase inhibition improves glycemia and obesity-associated inflammation in male human gene replacement mice

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Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity

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Progesterone signaling in oviductal epithelial cells modulates the immune response to support preimplantation embryonic development

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Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice

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Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis

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BPS Publications

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1-s2.0-S2352345X25000529-main-html.html

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Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism

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RSAD2: A pathogenic interferon-stimulated gene at the maternal-fetal interface of patients with systemic lupus erythematosus

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Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosis

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The potential of lazertinib and amivantamab combination therapy as a treatment strategy for uncommon EGFR-mutated NSCLC

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Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring

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Endocrine-targeting therapies shift the breast microbiome to reduce estrogen receptor-α breast cancer risk

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The Impact of a Ketogenic Diet on Late-Stage Pancreatic Carcinogenesis in Mice: Efficacy and Safety Studies

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Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity

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Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn’s disease

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Zinc promotes microbial p-coumaric acid production that protects against cholestatic liver injury

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Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages

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Granulocyte colony stimulating factor promotes scarless tissue regeneration

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Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation

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Adipose ADM2 ameliorates NAFLD via promotion of ceramide catabolism

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SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation

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FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia

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ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells

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Anti-tumor efficacy of HRS-4642 and its potential combination with proteasome inhibition in KRAS G12D-mutant cancer

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Development of a PCSK9-targeted nanoparticle vaccine to effectively decrease the hypercholesterolemia

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Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer

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Immunotherapy-activated T cells recruit and skewlate-stage activated M1-like macrophagesthat are critical for therapeutic efficacy

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linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability

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Monocyte bioenergetics: An immunometabolic perspective in metabolic dysfunction-associated steatohepatitis

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A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1

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Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression

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ATGL mediated adipocyte lipolysis exacerbates acute pancreatitis severity in mouse models and patients

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Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis

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Cancer immunotherapy via synergistic co-activation of myeloid receptors CD40 and Dectin-1

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Macrophage-coated tumor cluster aggravates hepatoma invasion and immunotherapy resistance via generating local immune deprivation

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Defects of renal tubular homeostasis and cystogenesis in the Pkhd1-knockout

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Intratumor microbiome-derived butyrate promotes lung cancer metastasis

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Targeting Tryptophan Catabolism in Ovarian Cancer to Attenuate Macrophage Infiltration and PD-L1 Expression

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Engagement of CD99 activates distinct programs in Ewing sarcoma and macrophages

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Loss of TIM4-Dependent Efferocytosis in Kupffer Cells Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

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Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans

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Dietary folate and cofactors accelerate age-dependent p16 epimutation to promote intestinal tumorigenesis

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PPARγ Deacetylation Suppresses Aging-Associated Atherosclerosis and Hypercholesterolemia

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AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis

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FGFR3 alterations in bladder cancer stimulate serine synthesis to induce immune-inert macrophages that suppress T-cell recruitment and activation

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A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas

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Hepatic Huwe1 loss protects mice from non-alcoholic fatty liver disease through lipid metabolic rewiring

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The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer

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Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1

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Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer

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MiR-337-3p improves metabolic-associated fatty liver disease through regulation of glycolipid metabolism

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Host-microbiome interactions in distinct subsets of preterm labor and birth

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Fibroblast Growth Factor 23 Neutralizing Antibody Ameliorates Abnormal Renal Phosphate Handling in Sickle Cell Disease Mice

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Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease

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TGFB1 induces fetal reprogramming and enhances intestinal regeneration

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CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions

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HDL inhibits pancreatic acinar cell NLRP3 inflammasome activation and protect against acinar cell pyroptosis in acute pancreatitis

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Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma

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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

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Effects of butyl benzyl phthalate exposure during pregnancy and lactation on the post-involution mammary gland

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Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis

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PIIS2589004223017029-html.html

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Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling

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A CSF-1R-blocking antibody/IL-10 fusion protein increases anti-tumor immunity by effectuating tumor-resident CD8+ T cells

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Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression

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Sublethal necroptosis signaling promotes inflammation and liver cancer

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DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer

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Activating an Adaptive Immune Response with a Telomerase-mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma

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mct-23-0039-html.html

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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

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Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors

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Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFNγ-Secreting Lymphocytes and IL12-Producing Dendritic Cells

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Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers

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Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload

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Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma

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Circadian regulator CLOCK promotes tumor angiogenesis in glioblastoma

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ARID1A loss in pancreas leads to islet developmental defect and metabolic disturbance

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Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer

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A single-cell atlas of murine reproductive tissues during preterm labor

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GABA regulates IL-1β production in macrophages

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Mouse placenta fetal macrophages arise from endothelial cells outside the placenta

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Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis

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Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis

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Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice

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Human colon cancer-derived Clostridioides difficile strains drive colonic tumorigenesis in mice

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cd-21-0680-html.html

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Neutrophil Extracellular Traps Mediate Acute Liver Failure in Regulation of miR-223/neutrophil Elastase Signaling in Mice

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Modeling of cancer-related body-wide effects identifies LTB4 as a diagnostic biomarker for pancreatic cancer

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WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy

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Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer

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Spatial CRISPR genomics identifies regulators of the tumor microenvironment

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A murine model of cerebral cavernous malformations with acute hemorrhage

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Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop

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Feb 2022
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A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis

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ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue

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TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment

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Aug 2021
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Sex- and age-dependent outcomes of 9-hour time-restricted feeding of a Western high-fat high-sucrose diet in C57BL/6J mice

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1. scibot 18 Aug 2021
  
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  RRID:AB_2799771
  
  DOI: 10.1016/j.celrep.2021.109543
  
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sciencedirect.com/science/article/pii/S2211124721009773
May 2021
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Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice

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1. scibot 12 May 2021
  
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  RRID:AB_2799771
  
  DOI: 10.1038/s41586-021-03461-y
  
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nature.com/articles/s41586-021-03461-y
Apr 2021
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Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo

1
1. scibot 29 Apr 2021
  
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  RRID:AB_2799771
  
  DOI: 10.1016/j.cmet.2020.09.006
  
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sciencedirect.com/science/article/pii/S1550413120304848
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The multitargeted kinase inhibitor KW-2449 ameliorates cisplatin-induced nephrotoxicity by targeting RIPK1-mediated necroptosis

1
1. scibot 06 Apr 2021
  
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  anti-mouse-F4/80
  
  DOI: 10.1016/j.bcp.2021.114542
  
  Resource: (Cell Signaling Technology Cat# 70076, RRID:AB_2799771)
  
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  RRID:AB_2799771 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S0006295221001386
Mar 2021
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 03 Mar 2021
  
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  RRID: AB_2799771
  
  DOI: 10.1111/bph.15277
  
  Resource: (Cell Signaling Technology Cat# 70076, RRID:AB_2799771)
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15277
Jan 2021
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Interleukin-24 protects against liver injury in mouse models

1
1. scibot 28 Jan 2021
  
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  RRID:AB_2799771
  
  DOI: 10.1016/j.ebiom.2021.103213
  
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sciencedirect.com/science/article/pii/S2352396421000062
Dec 2020
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Cell-Type-Specific Gene Regulatory Networks Underlying Murine Neonatal Heart Regeneration at Single-Cell Resolution

1
1. scibot 13 Dec 2020
  
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  RRID:AB_2799771
  
  DOI: 10.1016/j.celrep.2020.108472
  
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sciencedirect.com/science/article/pii/S2211124720314613
Sep 2020
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Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer

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1. scibot 14 Sep 2020
  
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  RRID:AB_2799771
  
  DOI: 10.1016/j.ccell.2020.01.011
  
  Resource: (Cell Signaling Technology Cat# 70076, RRID:AB_2799771)
  
  Curator: @ethanbadger
  
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sciencedirect.com/science/article/pii/S1535610820300507

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