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Engineering oral commensal nanovaccines to activate mucosal-systemic immune cascades against tumor

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  DOI: 10.1016/j.chom.2026.06.021
  
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sciencedirect.com/science/article/pii/S1931312826002817
Jul 2026
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A poly(I:C)/QS-21-based in situ vaccine synergizes with anti-PD-1 therapy to overcome tumor immunoresistance

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sciencedirect.com/science/article/pii/S2666379126003496
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Tryptophan degradation by intestinal Bacteroides induces anti-tumor immunity and limits melanoma growth

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  DOI: 10.1016/j.xcrm.2026.102921
  
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sciencedirect.com/science/article/pii/S2666379126003381
Jun 2026
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Multi-tier signaling and chromatin remodeling coordinate microglia inflammatory states and activities associated with demyelination

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sciencedirect.com/science/article/pii/S2211124726006479
May 2026
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VEGF-C-mediated cardiac lymphangiogenesis promotes inflammation resolution in autoimmune acute myocarditis in mice

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1. scibot 15 May 2026
  
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  DOI: 10.1093/cvr/cvag057
  
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dx.doi.org/10.1093/cvr/cvag057
Apr 2026
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Activation of T cell-intrinsic p53 by acetylation elicits antitumor immunity to boost cancer immunotherapy

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  DOI: 10.1158/2159-8290.CD-25-0649
  
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aacrjournals.org/cancerdiscovery/article/16/1/155/771238/Activation-of-T-Cell-Intrinsic-p53-by-Acetylation
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Targeting RNase H2: A dual-mechanism strategy to elevate replication stress, DNA damage, and antitumor immunity in TNBC

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Jan 2026
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Inhibition of PAK2 in endothelial cells suppresses tumor angiogenesis and promotes immune sensitization through CXCL10

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Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors

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sciencedirect.com/science/article/pii/S0092867425013789
Dec 2025
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An organotypic model of ductular reaction reveals a mevalonate-dependent vulnerability in reactive biliary cells

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sciencedirect.com:5037/science/article/pii/S2211124725014536
Nov 2025
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IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing antitumor efficacy

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.immuni.2025.10.021
  
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sciencedirect.com/science/article/pii/S1074761325004753
Oct 2025
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TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis

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1. scibot 23 Oct 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-4224
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7618269/
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The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function

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1. scibot 18 Oct 2025
  
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  DOI: 10.1016/j.neuron.2025.09.032
  
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sciencedirect.com/science/article/pii/S0896627325007457
Sep 2025
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Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype

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1. scibot 07 Sep 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1208
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12409281/
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Bifidobacteria-derived exopolysaccharide promotes anti-tumor immunity

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  DOI: 10.1016/j.celrep.2025.116223
  
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sciencedirect.com/science/article/pii/S2211124725009945
Aug 2025
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Biomimetic nanoimmunotherapy boosts spatiotemporal PANoptosis and reshapes desmoplastic tumor microenvironment

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102312
  
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sciencedirect.com/science/article/pii/S2666379125003854
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A preclinical model for the identification of therapeutically active transgenes in local cancer immunotherapy

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1. scibot 21 Aug 2025
  
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  DOI: 10.1080/2162402X.2025.2543620
  
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tandfonline.com/doi/full/10.1080/2162402X.2025.2543620
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Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer

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1. scibot 15 Aug 2025
  
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  DOI: 10.1016/j.ccell.2025.07.013
  
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sciencedirect.com/science/article/pii/S1535610825003198
Jul 2025
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Ce6 derivative photodynamic therapy triggers PANoptosis and enhances antitumor immunity with LAG3 blockade in cutaneous squamous cell carcinoma

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  DOI: 10.1016/j.xcrm.2025.102239
  
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sciencedirect.com/science/article/pii/S266637912500312X
Jun 2025
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Targeting the CD40 costimulatory receptor to improve virotherapy efficacy in diffuse midline gliomas

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  DOI: 10.1016/j.xcrm.2025.102204
  
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sciencedirect.com/science/article/pii/S2666379125002770
May 2025
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Activation of the endoplasmic reticulum stress regulator IRE1α compromises pulmonary host defenses

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  DOI: 10.1016/j.celrep.2025.115632
  
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Mar 2025
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Anti-vascular endothelial growth factor treatment potentiates immune checkpoint blockade through a BAFF- and IL-12-dependent reprogramming of the TME

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1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.immuni.2025.02.017
  
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sciencedirect.com/science/article/pii/S1074761325000846
Feb 2025
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Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2

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  DOI: 10.1016/j.cell.2025.01.025
  
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sciencedirect.com/science/article/pii/S0092867425000947
Nov 2024
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cir-24-0324-html.html

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  DOI: 10.1158/2326-6066.cir-24-0324
  
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52.53.155.43/d81834c4f435bac92597aa4fc554551b530ce2ba/cir-24-0324-html.html
Aug 2024
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TLR3 activation enhances abscopal effect of radiotherapy in HCC by promoting tumor ferroptosis | EMBO Molecular Medicine

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embopress.org/doi/full/10.1038/s44321-024-00068-4
Jul 2024
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Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer

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  DOI: 10.1126/science.adh4567
  
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science.org/doi/10.1126/science.adh4567
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Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer

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  DOI: 10.1016/j.medj.2024.06.002
  
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Cenicriviroc Suppresses and Reverses Steatohepatitis by Regulating Macrophage Infiltration and M2 Polarization in Mice

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  DOI: 10.1210/endocr/bqae069
  
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dx.doi.org/10.1210/endocr/bqae069
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Mitochondrial DNA-boosted dendritic cell-based nanovaccination triggers antitumor immunity in lung and pancreatic cancers

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  DOI: 10.1016/j.xcrm.2024.101648
  
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cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00362-8
Jun 2024
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Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer

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  DOI: 10.1016/j.cmet.2024.05.013
  
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sciencedirect.com/science/article/pii/S155041312400189X
May 2024
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TLR3 activation enhances abscopal effect of radiotherapy in HCC by promoting tumor ferroptosis

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embopress.org/doi/10.1038/s44321-024-00068-4
Apr 2024
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SETD2 loss and ATR inhibition synergize to promote cGAS signaling and immunotherapy response in renal cell carcinoma

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  DOI: 10.1158/1078-0432.CCR-23-1003
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10592192/
Feb 2024
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Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury

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1. scibot 23 Feb 2024
  
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  DOI: 10.1016/j.stem.2024.01.013
  
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  DOI: 10.1016/j.stem.2024.01.013
  
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sciencedirect.com/science/article/pii/S1934590924000432
Dec 2023
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CAR T-cell design-dependent remodeling of the brain tumor-immune microenvironment modulates tumor-associated macrophages and anti-glioma activity

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1. scibot 06 Dec 2023
  
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  DOI: 10.1158/2767-9764.CRC-23-0424
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10689147/
Jun 2023
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Activating an Adaptive Immune Response with a Telomerase-mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma

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  DOI: 10.1158/1535-7163.MCT-23-0039
  
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mct-23-0039-html.html

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Apr 2023
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Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma

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  DOI: 10.1016/j.ccell.2023.03.015
  
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Mar 2023
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Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination

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  DOI: 10.1016/j.celrep.2023.112293
  
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Characteristic gene expression in the liver monocyte-macrophage-DC system is associated with the progression of fibrosis in NASH

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  DOI: 10.3389/fimmu.2023.1098056
  
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Oct 2022
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TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways

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1. scibot 28 Oct 2022
  
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  DOI: 10.1016/j.cell.2022.09.033
  
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Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization

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  DOI: 10.1016/j.chembiol.2022.09.002
  
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Mar 2022
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Spatial CRISPR genomics identifies regulators of the tumor microenvironment

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  DOI: 10.1016/j.cell.2022.02.015
  
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May 2021
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Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity

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  DOI: 10.1016/j.molcel.2020.10.015
  
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Mar 2021
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COX2 regulates senescence secretome composition and senescence surveillance through PGE2

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Feb 2021
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Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy

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  DOI: 10.1016/j.celrep.2021.108706
  
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Sep 2020
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Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer

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  DOI: 10.1016/j.ccell.2020.01.011
  
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