16 Matching Annotations
  1. Aug 2026
  2. www.sciencedirect.com www.sciencedirect.com
    The structural basis for LRRK2’s activation and autoinhibition
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    sciencedirect.com/science/article/pii/S0092867426008251
  3. Jul 2026
  4. 54.241.53.176 54.241.53.176
    LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death
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    54.241.53.176/0f38fc1e7fe7e28d4caf2728d0ad871f97ce0b85/jcs264977-html.html
  5. Mar 2026
  6. 54.241.53.176 54.241.53.176
    cells-4107752-supplementary-html.html
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    54.241.53.176/52bb6540682af33d3eb91153c6081fb5f37f9169/cells-4107752-supplementary-html.html
  7. Jul 2025
  8. www.science.org www.science.org
    Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2
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    science.org/doi/10.1126/sciadv.adt2050
  9. Jun 2025
  10. www.science.org www.science.org
    Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2
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    science.org/doi/10.1126/sciadv.adt2050
  11. Sep 2024
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Type-II kinase inhibitors that target Parkinson’s Disease-associated LRRK2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11565912/
  13. Jun 2024
  14. www.sciencedirect.com www.sciencedirect.com
    A designed ankyrin-repeat protein that targets Parkinson’s disease-associated LRRK2
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    sciencedirect.com/science/article/pii/S0021925824019707
  15. Mar 2024
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10959120/
  17. May 2023
  18. www.sciencedirect.com www.sciencedirect.com
    Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity
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    sciencedirect.com/science/article/pii/S2211124723004588
  19. www.sciencedirect.com www.sciencedirect.com
    Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes
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    sciencedirect.com/science/article/pii/S221112472300459X
  20. Dec 2022
  21. www.nature.com www.nature.com
    Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules
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    nature.com/articles/s41594-022-00863-y
  22. Nov 2022
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parkinson’s disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila
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    ncbi.nlm.nih.gov/pmc/articles/PMC9672966/
  24. Sep 2022
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding
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    ncbi.nlm.nih.gov/pmc/articles/PMC9472821/
  26. Jun 2022
  27. www.sciencedirect.com www.sciencedirect.com
    Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement
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    sciencedirect.com/science/article/pii/S2589004222007477
  28. Mar 2021
  29. www.sciencedirect.com www.sciencedirect.com
    Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes
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    sciencedirect.com/science/article/pii/S0960982221003055
  30. Nov 2020
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations
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    ncbi.nlm.nih.gov/pmc/articles/PMC7609054/