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The binding of OTULIN restrains LUBAC activity to prevent TNF-driven immunopathology

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1. scibot 17 Oct 2026
  
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  DOI: 10.1016/j.molcel.2026.09.039
  
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sciencedirect.com/science/article/pii/S1097276526007045
Sep 2026
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TBK1 phosphorylates HDAC3 to promote NDP52 deacetylation and accelerate intracellular bacterial clearance

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1. scibot 04 Sep 2026
  
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  DOI: 10.1016/j.celrep.2026.117927
  
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sciencedirect.com/science/article/pii/S2211124726010053
Jun 2026
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Phosphorylation tunes p62 condensates to drive autophagic degradation of ubiquitinated proteins

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1. scibot 18 Jun 2026
  
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  DOI: 10.1038/s44318-026-00785-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13270050/
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DPY30 is an epigenetic decoupler linking replication stress to immunoediting in pancreatic cancer

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1. scibot 17 Jun 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3849
  
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aacrjournals.org/cancerres/article/86/12/2837/785625/DPY30-Is-an-Epigenetic-Decoupler-Linking
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Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple-Negative Breast Cancer to PD-1 Blockade

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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202521541
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STING-OPTN signaling confers cytoprotection through TBK1-dependent mitophagy

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sciencedirect.com/science/article/pii/S2211124726005930
May 2026
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Ablation of the adhesion G protein-coupled receptor ADGRL1 activates anti-tumor immune response via cDC1-T cell hub formation

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1. scibot 27 May 2026
  
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sciencedirect.com/science/article/pii/S2211124726004870
Apr 2026
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Dual-targeted microspheres reshape the metabolic-immune microenvironment to reverse post-embolization dilemmas in hepatocellular carcinoma

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  DOI: 10.1016/j.xcrm.2026.102748
  
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sciencedirect.com/science/article/pii/S2666379126001655
Mar 2026
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STING signaling modulation by COPII cargo recognition

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1. scibot 26 Mar 2026
  
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  DOI: 10.1016/j.cell.2026.02.029
  
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sciencedirect.com/science/article/pii/S0092867426002679
Feb 2026
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Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosis in EAE mice

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1. scibot 20 Feb 2026
  
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  DOI: 10.1016/j.intimp.2026.116364
  
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sciencedirect.com/science/article/pii/S1567576926002080
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Asparagine sensing by TBK1 controls its phase separation to drive antiviral innate immune responses

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1. scibot 10 Feb 2026
  
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  DOI: 10.1016/j.molcel.2026.01.010
  
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sciencedirect.com/science/article/pii/S1097276526000304
Jan 2026
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Cysteine allostery and autoinhibition govern human STING oligomer functionality

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1. scibot 22 Jan 2026
  
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  DOI: 10.1038/s41589-025-01951-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12810159/
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MAVS signaling exacerbates chondrocytes extracellular matrix degradation in osteoarthritis

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1. scibot 06 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116778
  
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sciencedirect.com/science/article/pii/S2211124725015505
Nov 2025
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Development of D2HG biosensors inspired by the molecular mechanism of D2HG regulation of DhdR

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1. scibot 18 Nov 2025
  
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  DOI: 10.1016/j.chembiol.2025.10.004
  
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Trilaciclib triggers a neutrophil-related immune response and sensitizes non-small cell lung cancer to anti-PD-1 therapy

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1. scibot 06 Nov 2025
  
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sciencedirect.com/science/article/pii/S2666379125005075
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Phospho-proteome profiling in human neurons reveals targets of TBK1 in ALS/FTD-associated autophagy networks

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1. scibot 01 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116494
  
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sciencedirect.com/science/article/pii/S2211124725012653
Jul 2025
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A fluorescent STING ligand sensor for high-throughput screening of compounds that can enhance tumor immunotherapy

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.crmeth.2025.101106
  
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sciencedirect.com/science/article/pii/S2667237525001420
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TBK1 phagosomal recruitment enhances antifungal immunity via positive feedback regulation with SRC

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.115972
  
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cell.com/cell-reports/abstract/S2211-1247(25)00743-0
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Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12281435/
May 2025
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KSHV miRNAs target STING to evade innate immunity and facilitate KSHV lytic reactivation from latency

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1. scibot 29 May 2025
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00512-1
Mar 2025
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The actin and microtubule network regulator WHAMM is identified as a key kidney disease risk gene

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1. scibot 29 Mar 2025
  
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sciencedirect.com/science/article/pii/S2211124725002335
Jan 2025
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Aberrant STING activation promotes macrophage senescence by suppressing autophagy in vascular aging from diabetes

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  DOI: 10.1016/j.isci.2024.111594
  
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sciencedirect.com/science/article/pii/S2589004224028219
Dec 2024
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Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis

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1. scibot 14 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115060
  
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sciencedirect.com/science/article/pii/S2211124724014116
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Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening

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1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.cels.2024.11.004
  
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sciencedirect.com/science/article/pii/S2405471224003375
Nov 2024
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Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence-Associated Pathologies

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  DOI: 10.1002/advs.202404109
  
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onlinelibrary.wiley.com/doi/full/10.1002/advs.202404109
Sep 2024
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Targeting APT2 improves MAVS palmitoylation and antiviral innate immunity

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May 2024
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Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING

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RGD Targeted Magnetic Ferrite Nanoparticles Enhance Antitumor Immunotherapeutic Efficacy by Activating STING Signaling Pathway

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  DOI: 10.1016/j.isci.2024.109062
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11039334/
Apr 2024
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1-s2.0-S2589004224002839-main-html.html

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52.53.155.43/e4b4251b496f91f14f0400600f97646c0efe1fb3/1-s2.0-S2589004224002839-main-html.html
Mar 2024
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Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity

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1. scibot 23 Mar 2024
  
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  DOI: 10.7554/eLife.88122
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10945704/
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1-s2.0-S2589004224002839-main-html.html

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1. scibot 06 Mar 2024
  
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  DOI: 10.3892/ijo.2023.5518
  
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  DOI: 10.3892/ijo.2023.5518
  
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52.53.155.43/e4b4251b496f91f14f0400600f97646c0efe1fb3/1-s2.0-S2589004224002839-main-html.html
Feb 2024
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The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation

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  DOI: 10.1016/j.celrep.2024.113792
  
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sciencedirect.com/science/article/pii/S2211124724001207
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p53 promotes antiviral innate immunity by driving hexosamine metabolism

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1. scibot 07 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113724
  
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sciencedirect.com/science/article/pii/S2211124724000524
Nov 2023
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AGC kinase inhibitors regulate STING signaling through SGK-dependent and SGK-independent mechanisms

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.chembiol.2023.10.008
  
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sciencedirect.com/science/article/abs/pii/S2451945623003690
Oct 2023
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Blocking oligomerization is the most viable strategy to inhibit STING

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1. scibot 20 Oct 2023
  
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Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells

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Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival

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Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD

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SARS-CoV-2 Nsp15 suppresses type I interferon production by inhibiting IRF3 phosphorylation and nuclear translocation

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STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages

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A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer

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Unconventional initiation of PINK1/Parkin mitophagy by Optineurin

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4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

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Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner

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Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer

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The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging

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Irradiation combined with PD-L1-/- and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING mediated T cell activation

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EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion

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