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A CCL5+CD20+CD8+ T cell subset drives pathogenic transformation of synoviocytes in rheumatoid arthritis via JAK-STAT signaling

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Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity

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  DOI: 10.1016/j.ccell.2025.12.018
  
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NFAT mediates pro-tumorigenic inflammation in cancer-associated fibroblasts in pancreatic ductal adenocarcinoma

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  DOI: 10.1016/j.celrep.2025.116849
  
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sciencedirect.com/science/article/pii/S2211124725016213
Jan 2026
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Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer

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Uridine depletion impairs CD8⁺ T cell antitumor activity through N-glycosylation

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  DOI: 10.1016/j.cmet.2025.11.016
  
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sciencedirect.com/science/article/pii/S1550413125005303
Dec 2025
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Hepatic adaptation to chronic metabolic stress primes tumorigenesis

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  DOI: 10.1016/j.cell.2025.11.031
  
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Targeting CTGF overcomes resistance to CSF1R inhibitors by preventing CAF activation in colorectal cancer

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54.241.53.176 54.241.53.176

1-s2.0-S2589004225025933-main-html.html

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Extracellular vesicles from obese visceral adipose promote pancreatic cancer development and resistance to immune checkpoint blockade therapy

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Nov 2025
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MHC-II-restricted neoantigen vaccine reverses immune microenvironment and overcomes resistance to immune-checkpoint inhibitors in cold tumors

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Hybrid apoptotic body decorated supramolecular hydrogel system for melanoma cancer immunoediting

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.cej.2025.171086
  
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Regulatory T cell stability determines the efficiency of bile duct regeneration during cholangitis

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1. scibot 18 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116557
  
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Oct 2025
54.241.53.176 54.241.53.176

2025.10.24.684274v1.full-html.html

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1. scibot 30 Oct 2025
  
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  DOI: 10.1101/2025.10.24.684274
  
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Combination of racotumomab immunotherapy with programmed death-1 blockade in a preclinical model of non-small cell lung cancer

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1. scibot 25 Oct 2025
  
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  DOI: 10.21037/tlcr-2025-230
  
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Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis

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1. scibot 01 Oct 2025
  
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  DOI: 10.1016/j.xcrm.2025.102371
  
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Phocaeicola vulgatus induces immunotherapy resistance in hepatocellular carcinoma via reducing indoleacetic acid production

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  DOI: 10.1016/j.xcrm.2025.102370
  
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Sep 2025
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Lactate Blocks Tertiary Lymphoid Structure Formation by Inhibiting B Cell Chemotaxis

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1. scibot 10 Sep 2025
  
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  DOI: 10.1101/2025.08.30.673054
  
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biorxiv.org/content/10.1101/2025.08.30.673054v1
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NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer

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1. scibot 04 Sep 2025
  
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  DOI: 10.7554/eLife.103904
  
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elifesciences.org/articles/103904
Aug 2025
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Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapy

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  DOI: 10.1016/j.xcrm.2025.102317
  
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Biomimetic nanoimmunotherapy boosts spatiotemporal PANoptosis and reshapes desmoplastic tumor microenvironment

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  DOI: 10.1016/j.xcrm.2025.102312
  
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Engineered T cells stimulate dendritic cell recruitment and antigen spreading for potent anti-tumor immunity

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  DOI: 10.1016/j.xcrm.2025.102307
  
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High-dose ascorbic acid selectively induces pyroptosis in LKB1-deficient lung cancer and sensitizes immunotherapy

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  DOI: 10.1016/j.xcrm.2025.102291
  
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USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment

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  DOI: 10.1158/2326-6066.CIR-24-1194
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12314529/
Jul 2025
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PLT012, a humanized CD36-blocking antibody, is effective for unleashing anti-tumor immunity against liver cancer and liver metastasis

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1. scibot 30 Jul 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1409
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617665/
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Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer

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  DOI: 10.1016/j.xcrm.2025.102251
  
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Inhibition of KAT6A Enhances Immunotherapy Efficacy in Colorectal Cancer by Activating Interferon Response

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  DOI: 10.1016/j.canlet.2025.217946
  
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Ce6 derivative photodynamic therapy triggers PANoptosis and enhances antitumor immunity with LAG3 blockade in cutaneous squamous cell carcinoma

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  DOI: 10.1016/j.xcrm.2025.102239
  
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Jun 2025
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A CXCR4 partial agonist improves immunotherapy by targeting immunosuppressive neutrophils and cancer-driven granulopoiesis

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1. scibot 28 Jun 2025
  
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  DOI: 10.1016/j.ccell.2025.06.006
  
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Cisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in experimental cancer models

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  DOI: 10.1016/j.ccell.2025.05.014
  
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sciencedirect.com/science/article/pii/S1535610825002235
May 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225010132-main-html.html

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  DOI: 10.1016/j.isci.2025.112752
  
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52.53.155.43/9003c45fae7689dd9660ec2260acff69b9d30974/1-s2.0-S2589004225010132-main-html.html
52.53.155.43 52.53.155.43

PDF-html.html

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  DOI: 10.1158/2159-8290.cd-24-1409
  
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52.53.155.43/449eeec941982dcbbbd18cfe95d7f2b03d57e236/PDF-html.html
Apr 2025
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Carvedilol sensitizes chemotherapy by targeting STING to boost anti-tumor immunity

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  DOI: 10.1016/j.celrep.2025.115572
  
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52.53.155.43 52.53.155.43

1-s2.0-S0016508525005426-main-html.html

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  DOI: 10.1053/j.gastro.2025.03.019
  
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Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion

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1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.ccell.2025.03.015
  
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Combination of Bremachlorin PDT and Immune Checkpoint Inhibitor Anti–PD-1 Shows Response in Murine Immunological T-cell–High and T-cell–Low PDAC Models

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1. scibot 04 Apr 2025
  
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  DOI: 10.1158/1535-7163.MCT-23-0733
  
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PAI-1-driven SFRP2high cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy

1
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PRMT3 drives PD-L1-mediated immune escape through activating PDHK1-regulated glycolysis in hepatocellular carcinoma

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Carbon minibeam radiation therapy results in tumor growth delay in an osteosarcoma murine model

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Systemic IFN-I combined with topical TLR7/8 agonists promotes distant tumor suppression by c-Jun-dependent IL-12 expression in dendritic cells

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Signatures of H3K4me3 modification predict cancer immunotherapy response and identify a new immune checkpoint-SLAMF9

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Antibody-based delivery of interleukin-2 modulates the immunosuppressive tumor microenvironment and achieves cure in pancreatic ductal adenocarcinoma syngeneic mice

1
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Phenotypic plasticity and increased infiltration of peripheral blood-derived TREM1+ mono-macrophages following radiotherapy in rectal cancer

1
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Clonally expanded, targetable, natural killer-like NKG7 T cells seed the aged spinal cord to disrupt myeloid-dependent wound healing

1
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Neoadjuvant chemotherapy by liposomal doxorubicin boosts immune protection of tumor membrane antigens-based nanovaccine

1
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Nov 2024
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strobl-et-al-2024-jak-stat1-as-therapeutic-target-for-egfr-deficiency-associated-inflammation-and-scarring-alopecia-html.html

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JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia

2
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CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8+ T cells via JAK2/STAT3 pathway

1
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Voluntary exercise sensitizes cancer immunotherapy via the collagen inhibition-orchestrated inflammatory tumor immune microenvironment

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TLR3 activation enhances abscopal effect of radiotherapy in HCC by promoting tumor ferroptosis | EMBO Molecular Medicine

1
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Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response

1
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Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE2 production

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Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity

1
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Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity

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Next-generation anti-PD-L1/IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal toxicity

1
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TLR3 activation enhances abscopal effect of radiotherapy in HCC by promoting tumor ferroptosis

1
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Apr 2024
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QDPR deficiency drives immune suppression in pancreatic cancer

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Mar 2024
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Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity

1
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A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer

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Feb 2024
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Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege

1
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Jan 2024
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Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors

1
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A GAPDH serotonylation system couples CD8+ T cell glycolytic metabolism to antitumor immunity

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Rebalancing TGF-β/PGE2 breaks RT-induced immunosuppressive barriers by enhancing tumor-infiltrated dendritic cell homing

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Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression

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Preventive Treatment with PD-1 Antibody Increases Tissue-Resident Memory T Cells Infiltration and Delays Esophageal Carcinogenesis

1
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  DOI: 10.1158/1940-6207.CAPR-23-0196
  
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52.53.155.43 52.53.155.43

capr-23-0196-html.html

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Nov 2023
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Prostate cancer cell-derived exosomal IL-8 fosters immune evasion by disturbing glucolipid metabolism of CD8+ T cell

1
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Oct 2023
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SSRN-id4540281-html.html

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Sep 2023
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Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity

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  DOI: 10.1016/j.xcrm.2023.101206
  
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Aug 2023
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can-23-1252-html.html

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1. scibot 11 Aug 2023
  
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  AB_2890649
  
  DOI: 10.1158/0008-5472.CAN-23-1252
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
  Curator: @scibot
  
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52.53.155.43/ea1e2390c2d37ea00d2075acaef6f5d93e41dc17/can-23-1252-html.html
May 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling

1
1. scibot 23 May 2023
  
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  RRID:AB_2890649
  
  DOI: 10.1186/s13046-023-02696-z
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10199643/
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Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma

1
1. scibot 20 May 2023
  
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  RRID:AB_2890649
  
  DOI: 10.1016/j.bcp.2023.115612
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
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sciencedirect.com/science/article/pii/S0006295223002034
Apr 2023
www.biorxiv.org www.biorxiv.org

Steroid Receptor Coactivator-3 is a Key Modulator of Regulatory T Cell-Mediated Tumor Evasion

1
1. scibot 20 Apr 2023
  
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  RRID:AB_2890649
  
  DOI: 10.1101/2023.03.28.534575
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
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biorxiv.org/content/10.1101/2023.03.28.534575v1
52.53.155.43 52.53.155.43

Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomas

1
1. scibot 05 Apr 2023
  
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  RRID:AB_2890649
  
  DOI: 10.1101/2023.02.13.528351
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
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52.53.155.43/f4b0048cc7a871a681c39b83d20e963f1e4d0c2b/2023.02.13.528351v1.full-html.html
Feb 2023
www.sciencedirect.com www.sciencedirect.com

Periostin deficiency reduces PD-1+ tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer

1
1. scibot 11 Feb 2023
  
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  RRID:AB_2890649
  
  DOI: 10.1016/j.celrep.2023.112090
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
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sciencedirect.com/science/article/pii/S2211124723001018
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Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS

1
1. scibot 02 Feb 2023
  
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  AB_2890649
  
  DOI: 10.1016/j.immuni.2023.01.001
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
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sciencedirect.com/science/article/pii/S1074761323000110
Jan 2023
www.sciencedirect.com www.sciencedirect.com

Integrated multi-omics profiling yields a clinically relevant molecular classification for esophageal squamous cell carcinoma

1
1. scibot 28 Jan 2023
  
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  RRID:AB_2890649
  
  DOI: 10.1016/j.ccell.2022.12.004
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1535610822005906
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Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma

1
1. scibot 10 Jan 2023
  
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  RRID:AB_2890649
  
  DOI: 10.1016/j.immuni.2022.11.014
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
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sciencedirect.com/science/article/pii/S1074761322006045
Dec 2022
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EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer

1
1. scibot 18 Dec 2022
  
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  RRID:AB_2890649
  
  DOI: 10.1016/j.celrep.2022.111827
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
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sciencedirect.com/science/article/pii/S2211124722017193
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Across-cancer immune responses induced by nanovaccines or microvaccines to prevent different cancers and cancer metastasis

1
1. scibot 02 Dec 2022
  
  in Public
  
  RRID:AB_2890649
  
  DOI: 10.1016/j.isci.2022.105511
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2890649
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9682363/
Nov 2022
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CD16+ fibroblasts foster a trastuzumab-refractory microenvironment that is reversed by VAV2 inhibition

1
1. scibot 16 Nov 2022
  
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  RRID:AB_2890649
  
  DOI: 10.1016/j.ccell.2022.10.015
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1535610822005062
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Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer

1
1. scibot 10 Nov 2022
  
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  RRID:AB_2890649
  
  DOI: 10.1016/j.celrep.2022.111596
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
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sciencedirect.com/science/article/pii/S2211124722014619
Oct 2022
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PARP-inhibition reprograms macrophages toward an anti-tumor phenotype

1
1. scibot 13 Oct 2022
  
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  RRID:AB_2890649
  
  DOI: 10.1016/j.celrep.2022.111462
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
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sciencedirect.com/science/article/pii/S2211124722013079
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Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas

1
1. scibot 07 Oct 2022
  
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  RRID:AB_2890649
  
  DOI: 10.1016/j.molcel.2022.09.007
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
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sciencedirect.com/science/article/pii/S1097276522008966
Aug 2022
www.sciencedirect.com www.sciencedirect.com

Butyrate-producing Eubacterium rectale suppresses lymphomagenesis by alleviating the TNF-induced TLR4/MyD88/NF-κB axis

1
1. scibot 12 Aug 2022
  
  in Public
  
  RRID:AB_2890649
  
  DOI: 10.1016/j.chom.2022.07.003
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1931312822003493
Jul 2022
link.springer.com link.springer.com

The immunometabolite S-2-hydroxyglutarate exacerbates perioperative ischemic brain injury and cognitive dysfunction by enhancing CD8+ T lymphocyte-mediated neurotoxicity

1
1. scibot 09 Jul 2022
  
  in Public
  
  RRID:AB_2890649
  
  DOI: 10.1186/s12974-022-02537-4
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2890649
  
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link.springer.com/article/10.1186/s12974-022-02537-4
Dec 2021
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AMP-activated protein kinase alpha1 promotes tumor development via FOXP3 elevation in tumor-infiltrating Treg cells

1
1. scibot 21 Dec 2021
  
  in Public
  
  RRID:AB_2890649
  
  DOI: 10.1016/j.isci.2021.103570
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2890649
  
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sciencedirect.com/science/article/pii/S2589004221015406
Sep 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Original research: CXCR6 is required for antitumor efficacy of intratumoral CD8+ T cell

1
1. scibot 18 Sep 2021
  
  in Public
  
  RRID:AB_2890649
  
  DOI: 10.1136/jitc-2021-003100
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2890649
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8407215/
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Effects of exercise and anti-PD-1 on the tumour microenvironment

1
1. scibot 08 Sep 2021
  
  in Public
  
  ab217344
  
  DOI: 10.1016/j.imlet.2021.08.005
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2890649
  
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  RRIDCUR:Missing RRID:AB_2890649
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RRIDCUR:Missing

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sciencedirect.com/science/article/abs/pii/S0165247821001401
Aug 2021
www.sciencedirect.com www.sciencedirect.com

The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer

1
1. scibot 06 Aug 2021
  
  in Public
  
  RRID:AB_2890649
  
  DOI: 10.1016/j.ccell.2021.07.007
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
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sciencedirect.com/science/article/pii/S1535610821003846
Jun 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection

1
1. scibot 18 Jun 2021
  
  in Public
  
  RRID:AB_2890649
  
  DOI: 10.1016/j.isci.2021.102555
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
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  SciCrunch record: RRID:AB_2890649
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8188550/
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Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome

1
1. scibot 02 Jun 2021
  
  in Public
  
  RRID:B_2890649
  
  DOI: 10.1016/j.celrep.2021.109201
  
  Resource: (Abcam Cat# ab217344, RRID:AB_2890649)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2890649
  
  Curator comments: Recombinant Anti-CD8 alpha antibody [EPR21769] Abcam Cat# ab217344
  
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  RRIDCUR:Unresolved RRIDCUR:Incorrect RRID:AB_2890649
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sciencedirect.com/science/article/pii/S2211124721005507

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