Hypothesis

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Histone lactylation in fibroblast-like synoviocytes drives CXCL1-mediated immune cell recruitment in rheumatoid arthritis

1
1. scibot 07 Nov 2026
  
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  DOI: 10.1016/j.isci.2026.118108
  
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sciencedirect.com/science/article/pii/S2589004226034917
Oct 2026
54.241.53.176 54.241.53.176

metabolicepigenetic-coupling-links-glycolysis-to-html.html

1
1. scibot 28 Oct 2026
  
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  DOI: 10.4103/nrr.nrronline-d-26-00965
  
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54.241.53.176/30fcb36b01360467e7e3e8d9086fb0db5ad6148f/metabolicepigenetic-coupling-links-glycolysis-to-html.html
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Lactate-driven histone lactylation by AARS1 promotes pulmonary arterial hypertension

1
1. scibot 22 Oct 2026
  
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  DOI: 10.1016/j.isci.2026.117911
  
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sciencedirect.com/science/article/pii/S2589004226032943
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H3K18 lactylation promotes Treg/Th17 imbalance via PTPRM-STAT3 axis in hepatocellular carcinoma

1
1. scibot 22 Oct 2026
  
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  RRID:AB_2909438
  
  DOI: 10.1016/j.isci.2026.117896
  
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sciencedirect.com/science/article/pii/S2589004226032797
Aug 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Glycolytic enolase 1-induced H4K12 lactylation activates quiescent breast cancer stem-like cells in triple-negative breast cancer

1
1. scibot 24 Aug 2026
  
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  DOI: 10.1038/s41392-026-02916-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13493833/
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CCR5 drives glucose metabolic reprogramming to control microglial synaptic pruning via histone lactylation in a mouse model of depression

1
1. scibot 01 Aug 2026
  
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  RRID:AB_2909438
  
  DOI: 10.1016/j.celrep.2026.117749
  
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sciencedirect.com/science/article/pii/S2211124726008272
Jun 2026
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Histone lactylation-driven intratumoral IGFBP2+ NK cells promote tumor immune evasion

1
1. scibot 26 Jun 2026
  
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  RRID:AB_2909438
  
  DOI: 10.1016/j.celrep.2026.117612
  
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sciencedirect.com/science/article/pii/S221112472600690X
Apr 2026
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SIRT6-mediated immunometabolic reprogramming of macrophages drives neutrophilic asthma via LDHA-dependent glycolysis

1
1. scibot 24 Apr 2026
  
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  RRID:AB_2909438
  
  DOI: 10.1016/j.celrep.2026.117294
  
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sciencedirect.com/science/article/pii/S2211124726003724
advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com

m5C-Modified tRF3b-CysGCA-23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4

1
1. scibot 02 Apr 2026
  
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  RRID:AB_2909438
  
  DOI: 10.1002/advs.202522294
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202522294
Mar 2026
54.241.53.176 54.241.53.176

1-s2.0-S2589004226007479-main-html.html

1
1. scibot 20 Mar 2026
  
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  RRID:AB_2909438
  
  DOI: 10.1016/j.isci.2026.115372
  
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54.241.53.176/e72524355eb321529f4dd9a65278a0820d03292a/1-s2.0-S2589004226007479-main-html.html
Jun 2025
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Lactate regulates cell differentiation of erythroid progenitor cells via histone lactylation modification

1
1. scibot 21 Jun 2025
  
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  RRID:AB_2909438
  
  DOI: 10.1016/j.isci.2025.112842
  
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sciencedirect.com/science/article/pii/S2589004225011034
May 2025
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Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury

1
1. scibot 18 May 2025
  
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  RRID:AB_2909438
  
  DOI: 10.1016/j.neuron.2025.04.003
  
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sciencedirect.com/science/article/pii/S0896627325002594
www-cell-com.utokyo.idm.oclc.org www-cell-com.utokyo.idm.oclc.org

Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory

1
1. scibot 16 May 2025
  
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  RRID:AB_2909438
  
  DOI: 10.1016/j.cell.2025.03.048
  
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www-cell-com.utokyo.idm.oclc.org/cell/fulltext/S0092-8674(25)00400-3
Feb 2025
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Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice

7
1. scibot 07 Feb 2025
  
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  RRID:AB_2909438
  
  DOI: 10.1016/j.devcel.2024.12.021
  
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2. scibot 06 Feb 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
3. scibot 05 Feb 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
4. scibot 04 Feb 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
5. scibot 03 Feb 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
6. scibot 02 Feb 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
7. scibot 01 Feb 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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sciencedirect.com/science/article/pii/S1534580724007603
Jan 2025
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Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice

25
1. scibot 31 Jan 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
2. scibot 30 Jan 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
3. scibot 29 Jan 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
4. scibot 28 Jan 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
5. scibot 27 Jan 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
6. scibot 26 Jan 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
7. scibot 25 Jan 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
8. scibot 24 Jan 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
9. scibot 23 Jan 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
10. scibot 22 Jan 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
11. scibot 21 Jan 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
12. scibot 20 Jan 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
13. scibot 19 Jan 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
14. scibot 18 Jan 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
15. scibot 17 Jan 2025
  
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  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
16. scibot 16 Jan 2025
  
  in Public
  
  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
17. scibot 15 Jan 2025
  
  in Public
  
  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
18. scibot 14 Jan 2025
  
  in Public
  
  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
19. scibot 13 Jan 2025
  
  in Public
  
  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
20. scibot 12 Jan 2025
  
  in Public
  
  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
21. scibot 11 Jan 2025
  
  in Public
  
  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
22. scibot 10 Jan 2025
  
  in Public
  
  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
23. scibot 09 Jan 2025
  
  in Public
  
  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
24. scibot 08 Jan 2025
  
  in Public
  
  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
25. scibot 07 Jan 2025
  
  in Public
  
  RRID:AB_2909438
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2909438
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sciencedirect.com/science/article/pii/S1534580724007603
Dec 2024
www.sciencedirect.com www.sciencedirect.com

Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis

1
1. scibot 06 Dec 2024
  
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  RRID:AB_2909438
  
  DOI: 10.1016/j.cmet.2024.11.005
  
  Resource: (PTM BIO Cat# PTM-1406RM, RRID:AB_2909438)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2909438
  
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sciencedirect.com/science/article/pii/S1550413124004510
Nov 2024
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ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion

1
1. scibot 24 Nov 2024
  
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  RRID:AB_2909438
  
  DOI: 10.1016/j.cmet.2024.10.015
  
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sciencedirect.com/science/article/pii/S155041312400411X
Oct 2024
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Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis

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  DOI: 10.1016/j.isci.2024.110911
  
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Jul 2024
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Hypoxia promotes histone H3K9 lactylation to enhance LAMC2 transcription in esophageal squamous cell carcinoma

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  DOI: 10.1016/j.isci.2024.110188
  
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May 2024
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Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation

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  DOI: 10.1016/j.celrep.2024.114180
  
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Feb 2024
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Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation

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  DOI: 10.1016/j.celrep.2024.113746
  
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Jan 2024
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Histone lactylation inhibits RARγ expression in macrophages to promote colorectal tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling

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  DOI: 10.1016/j.celrep.2024.113688
  
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Augmentation of scleral glycolysis promotes myopia through histone lactylation

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  DOI: 10.1016/j.cmet.2023.12.023
  
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Dec 2023
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BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development

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  DOI: 10.1016/j.devcel.2023.11.018
  
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Nov 2023
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Progesterone activates histone lactylation-Hif1α-glycolysis feedback loop to promote decidualization

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1. scibot 18 Nov 2023
  
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  DOI: 10.1210/endocr/bqad169
  
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  DOI: 10.1210/endocr/bqad169
  
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Aug 2023
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The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity

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Jul 2023
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Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis

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  DOI: 10.1016/j.cmet.2023.06.013
  
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Feb 2023
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Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation

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  DOI: 10.1016/j.celrep.2023.112033
  
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Mar 2022
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Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

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  DOI: 10.1016/j.molcel.2022.02.033
  
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