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A caspase-3-activated protein expression system for apoptosis visualization and apoptosis–pyroptosis conversion to boost antitumor activity

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1. scibot 20 Aug 2026
  
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  DOI: 10.1016/j.tibtech.2026.06.009
  
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cell.com/trends/biotechnology/fulltext/S0167-7799(26)00249-0
Aug 2026
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Cofilin1-driven cytoskeletal remodeling modulates pan-cancer CD8+ T cell immunotherapy responses

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  DOI: 10.1016/j.xcrm.2026.102984
  
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sciencedirect.com/science/article/pii/S2666379126004015
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Torsins organize CLCC1 assembly to safeguard ER bilayer and lipid homeostasis

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  DOI: 10.1016/j.molcel.2026.07.017
  
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The ARLA1A-NAC089 module coordinates ER phagy with the unfolded protein response to maintain cellular homeostasis in plants

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  DOI: 10.1016/j.devcel.2026.07.007
  
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A CEBPB-IPO4-FASN-MAVS axis limits innate immune activation and viral pneumonia

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  DOI: 10.1016/j.celrep.2026.117783
  
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The ADAP-TRIM21-ZEB2 axis regulates CD8+ T cell effector expansion and central memory-like differentiation

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1. scibot 03 Aug 2026
  
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  DOI: 10.1016/j.isci.2026.117016
  
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sciencedirect.com/science/article/pii/S2589004226023941
Jul 2026
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ADAR1 regulates radiosensitivity in ESCC through cIAP2-NF-κB signaling and C16orf46 editing

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  DOI: 10.1016/j.isci.2026.116952
  
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N-acetyltransferase 10 regulates chemokine expression in keratinocytes and promotes atopic dermatitis

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1. scibot 23 Jul 2026
  
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  DOI: 10.1016/j.chembiol.2026.06.012
  
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DNAJB9 promotes epithelial-mesenchymal transition in the nasal epithelium of chronic rhinosinusitis by enhancing TRIM22-mediated IκBα degradation

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1. scibot 18 Jul 2026
  
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  DOI: 10.1016/j.isci.2026.116681
  
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EFO2 promotes triple-negative breast cancer progression and reduces CD8+ T cell-mediated killing by acetylating USF1 to enhance SLC2A1-mediated glycolysis

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1. scibot 16 Jul 2026
  
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  DOI: 10.1016/j.bcp.2026.118260
  
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FOSL1-mediated super-enhancer facilitates pathological scarring

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1. scibot 11 Jul 2026
  
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  DOI: 10.1016/j.celrep.2026.117667
  
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ZDHHC17-mediated IKKβ palmitoylation suppresses NF-κB signaling to mitigate the progression of liver fibrosis

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1. scibot 04 Jul 2026
  
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  DOI: 10.1016/j.isci.2026.116360
  
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Jun 2026
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ID4 suppresses proliferation and macrophage polarization in esophageal carcinoma through interaction with TCF4

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1. scibot 24 Jun 2026
  
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  DOI: 10.1158/1541-7786.MCR-25-0686
  
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aacrjournals.org/mcr/article/24/6/458/785396/ID4-Suppresses-Proliferation-and-Macrophage
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Lactate-driven H3K18 lactylation promotes cisplatin resistance in bladder cancer via HNRNPF-Parkin mediated mitophagy

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1. scibot 16 Jun 2026
  
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  DOI: 10.1016/j.drup.2026.101435
  
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sciencedirect.com/science/article/pii/S1368764626000865
May 2026
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OTUB2 induces M2 tumor-associated macrophage polarization and increases CD274 expression in gastric cancer cells to aggravate the progression of gastric cancer

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1. scibot 29 May 2026
  
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  DOI: 10.1038/s41419-026-08743-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13201613/
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Adaptive Regulation of dNTP Homeostasis Confers Osimertinib Resistance in EGFR-Mutant Non–Small Cell Lung Carcinoma

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1. scibot 27 May 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3237
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13198874/
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“Membrane-Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

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1. scibot 21 May 2026
  
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  DOI: 10.1002/advs.75554
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.75554
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S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis

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1. scibot 13 May 2026
  
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  DOI: 10.1016/j.molcel.2026.04.016
  
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HOXD11-NMDAR signaling drives neuroendocrine prostate cancer and enables potential therapeutic intervention as a target of memantine

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  DOI: 10.1016/j.celrep.2026.117330
  
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Hepatic expression of APOE3 Christchurch mitigates APOE4-related Alzheimer’s disease pathologies in mice

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1. scibot 07 May 2026
  
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  DOI: 10.1016/j.neuron.2026.04.027
  
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Accumulated sotorasib-bound KRASG12C reactivates the MAPK pathway and drives sotorasib resistance via the DHX9-RAC1-PAK1 axis

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  DOI: 10.1016/j.celrep.2026.117338
  
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Apr 2026
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Acyltransferase ZDHHC22 promotes N-Myc transcriptional activation to drive neuroblastoma progression and chemoresistance

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  DOI: 10.1016/j.molcel.2026.04.002
  
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USP15 stabilizes c-Myc to drive sunitinib resistance by suppressing cuproptosis in clear cell renal cell carcinoma

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1. scibot 29 Apr 2026
  
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  DOI: 10.1016/j.celrep.2026.117328
  
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Ubiquilin1 restricts influenza viral replication through trapping vRNP in the late endosomes

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  DOI: 10.1016/j.celrep.2026.117310
  
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advs74967-sup-0001-suppmat.docx-html.html

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1. scibot 11 Apr 2026
  
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  DOI: 10.1002/advs.202522764
  
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54.241.53.176/8f7474ccb0db38ef3abc02e1f9942a511c5917ed/advs74967-sup-0001-suppmat.docx-html.html
Mar 2026
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Mycobacterial metallophosphatase MmpE acts as a nucleomodulin to regulate host gene expression and promote intracellular survival

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  DOI: 10.7554/eLife.108037
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12999176/
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Oligodendrocyte-encoded lactate dehydrogenase A couples glycolysis to remyelination via protein lactylation

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  DOI: 10.1016/j.neuron.2026.02.032
  
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Jan 2026
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AAVLINK: A potent DNA-recombination method for large cargo delivery in gene therapy

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  DOI: 10.1016/j.cell.2025.12.039
  
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Proteomic Landscape of Sweat Glands in Neuronal Intranuclear Inclusion Disease Reveals a Pathogenic Triad of Abnormal Autophagy, Mitochondrial Dysfunction, and a Failed Oxidative Stress Response

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  DOI: 10.1111/jnc.70352
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.70352
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The UFL1-AKT positive feedback loop promotes breast cancer progression by enhancing lipid synthesis

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  DOI: 10.1038/s41467-026-68492-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12820292/
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SNAP23 deficiency triggers Trim21 mitochondrial translocation to suppress TFAM-mediated oxidative metabolism and drive chemoresistance in colorectal cancer

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  DOI: 10.1038/s41419-025-08252-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12811313/
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p57 increases immunotherapy efficacy by promoting cGAS-STING-mediated innate sensing in hepatocellular carcinoma

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  DOI: 10.1016/j.celrep.2025.116769
  
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sciencedirect.com/science/article/pii/S2211124725015414
Dec 2025
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Mitochondrial glutamine import sustains electron transport chain integrity independently of glutaminolysis in cancer

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.molcel.2025.12.001
  
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ZAP inhibits double-stranded RNA virus infection by degrading negative-strand RNA and blocking the elongation phase of viral protein synthesis

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116742
  
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TRIM36 inhibits lung fibroblast activation and pulmonary fibrosis through the degradation of phospho-AKT1

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Depletion of LINC01133 from cancer-associated fibroblasts exacerbates the progression of gastric adenocarcinoma

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Liquid-liquid phase separation of ATXN2L enhances mRNA translation in hepatocellular carcinoma

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Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation

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Structural assembly of the subcortical maternal complex SCMC

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CPNE5 Overexpression Inhibits Cardiomyocytes Apoptosis by Promoting the Degradation of FAS Receptor

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NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer

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SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer

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TRIM6 ablation reverses ICB resistance in MSS gastric cancer by unleashing cGAS-STING-dependent antitumor immunity

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USP8 deubiquitylation-boosted NSUN4 potentiates lung squamous cell carcinoma progression by m5C methylation of DHCR24

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The Tacrine‐Induced Endoplasmic Reticulum Stress in AChE‐Expressed Cells Leads to Improper Assembly and Transport of the Oligomeric Enzyme: Reversal by Trehalose

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kong-et-al-adipose-tissue-secreted-spz5-promotes-distal-tumor-progression-via-toll-6-mediated-hh-pathway-activation-in-html.html

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Adipose tissue-secreted Spz5 promotes distal tumor progression via Toll-6-mediated Hh pathway activation in Drosophila

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VCPIP1 potentiates innate immune responses by non-catalytically reducing the ubiquitination of IRAK1/2

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Cingulin is an RNA-binding protein promoting pancreatic cancer through enhancing importin 7-mediated phospho-ERK nuclear translocation

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Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury

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Microneedle delivery of CAR-M-like engineered macrophages alleviates intervertebral disc degeneration through enhanced efferocytosis capacity

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O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles

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BCG-trained macrophages couple LDLR upregulation to type I IFN responses and antiviral immunity

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LAMP2A-mediated neuronal hyperexcitability by enhancing NKAβ1 degradation underlies depression-induced allodynia

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Discovery of targeting USP10-mediated proline metabolism arrangement to inhibit hepatocellular carcinoma progression

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Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism

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ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity

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Role of HNF4A-AS1/HNRNPC-mediated HNF4A Ubiquitination Protection against Ritonavir-induced Hepatotoxicity

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RIOK3 mediates the degradation of 40S ribosomes

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STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma

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Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance

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Cutin formation in tomato is controlled by a multipartite module of synergistic and antagonistic transcription factors

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Exercise-induced adipokine Nrg4 alleviates MASLD by disrupting hepatic cGAS-STING signaling

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Tubulointerstitial nephritis antigen-like 1 promotes the progression of liver fibrosis after HCV eradication with direct-acting antivirals

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ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma

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  DOI: 10.1016/j.celrep.2024.114962
  
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Type I IFN drives unconventional IL-1β secretion in lupus monocytes

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P16INK4A drives RB1 degradation by UTP14A-catalyzed K810 ubiquitination

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A pro-metastatic tRNA fragment drives aldolase A oligomerization to enhance aerobic glycolysis in lung adenocarcinoma

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Hypoxia promotes histone H3K9 lactylation to enhance LAMC2 transcription in esophageal squamous cell carcinoma

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Jun 2024
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Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer

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CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1

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Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin

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Prostate cancer cell-derived exosomal IL-8 fosters immune evasion by disturbing glucolipid metabolism of CD8+ T cell

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Pan-cancer tRNA-derived fragment CAT1 coordinates RBPMS to stabilize NOTCH2 mRNA to promote tumorigenesis

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JUN mediates Glucocorticoid Resistance by stabilizing HIF1a in T-Cell Acute Lymphoblastic Leukemia

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Jul 2023
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An HBV susceptibility variant of KNG1 modulates the therapeutic effects of interferons α and λ1 in HBV infection by promoting MAVS lysosomal degradation

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ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway

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May 2023
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Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation

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A non-canonical target-binding site in Munc18-1 domain 3b for assembling the Mint1-Munc18-1-syntaxin-1 complex

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