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May 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Heterogeneous endocrine cell composition defines human islet functional phenotypes

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1. scibot 20 May 2026
  
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  DOI: 10.1038/s41467-026-70689-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13168233/
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Chronic attenuation of brain leptin signalling is associated with early metabolic dysfunction in lean rats

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1. scibot 12 May 2026
  
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  DOI: 10.1113/JP290832
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP290832
Feb 2026
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Messenger RNA delivery to islet β cells using conjugated lipid nanoparticles

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1. scibot 24 Feb 2026
  
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  DOI: 10.1016/j.xcrm.2026.102634
  
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sciencedirect.com/science/article/pii/S2666379126000510
Jan 2026
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Limiting ER-associated degradation capacity triggers acute and chronic effects on insulin biosynthesis

1
1. scibot 23 Jan 2026
  
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  DOI: 10.1172/JCI187341
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12807472/
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PDX1 phosphorylation at S61 by mTORC1 links nutrient signaling to β cell function and metabolic disease

1
1. scibot 13 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116811
  
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sciencedirect.com/science/article/pii/S2211124725015839
Nov 2025
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Protocol for in vivo assessment of glucose metabolism in mouse models

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  DOI: 10.1016/j.xpro.2025.104192
  
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sciencedirect.com/science/article/pii/S2666166725005982
Oct 2025
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Human assembloid of human blood vessel organoids with pancreatic islets improves insulin secretion over time ex vivo

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  DOI: 10.1016/j.celrep.2025.116378
  
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sciencedirect.com/science/article/pii/S2211124725011490
Aug 2025
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inline-supplementary-material-2-html.html

1
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  DOI: 10.1136/jitc-2025-011818
  
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52.53.155.43/100e14b90da09131bf5c9cf9d4efd569ae25716b/inline-supplementary-material-2-html.html
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Reconstruction of endocrine subtype-complete human pluripotent stem cell-derived islets with capacity for hypoglycemia protection in vivo

1
1. scibot 09 Aug 2025
  
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  DOI: 10.1016/j.stem.2025.07.006
  
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sciencedirect.com/science/article/pii/S1934590925002632
Jul 2025
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Imeglimin suppresses glucagon secretion and induces a loss of α cell identity

1
1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102254
  
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cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00327-1
May 2025
52.53.155.43 52.53.155.43

CCNA2 and CCND2 are differentially involved in β-cell proliferation in perinatal Japanese autopsied subjects

1
1. scibot 30 May 2025
  
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  DOI: 10.1210/clinem/dgaf308
  
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52.53.155.43/390b5ee5ea671eaf2b63696a8879f903be0e7a68/dgaf308-html.html
Apr 2025
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The extra-islet pancreas supports autoimmunity in human type 1 diabetes

1
1. scibot 19 Apr 2025
  
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  DOI: 10.7554/eLife.100535
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11999700/
Feb 2025
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Metabolic rate and insulin-independent glucose uptake increase in a TDP-43Q331K mouse model of amyotrophic lateral sclerosis.

1
1. scibot 06 Feb 2025
  
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  DOI: 10.1016/j.heliyon.2025.e42482
  
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sciencedirect.com/science/article/pii/S240584402500862X
Jan 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225001166-main-html.html

1
1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.isci.2025.111856
  
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52.53.155.43/f7a3e96df7edf052e7c2acc984abc4e530aec8c5/1-s2.0-S2589004225001166-main-html.html
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Heterogeneous endocrine cell composition defines human islet functional phenotypes

1
1. scibot 21 Dec 2024
  
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  DOI: 10.1101/2024.11.20.623809
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11601672/
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Cycling alpha cells in regenerative drug-treated human pancreatic islets may serve as key beta cell progenitors

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1. scibot 05 Dec 2024
  
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  DOI: 10.1016/j.xcrm.2024.101832
  
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cell.com/cell-reports-medicine/abstract/S2666-3791(24)00603-7
Sep 2024
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IGFBP7 is upregulated in islets from T2D donors and reduces insulin secretion

1
1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110767
  
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sciencedirect.com/science/article/pii/S2589004224019928
Apr 2024
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Structure-Function Analysis of p57KIP2 in the Human Pancreatic Beta Cell Reveals a Bipartite Nuclear Localization Signal

1
1. scibot 04 Apr 2024
  
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  DOI: 10.1210/endocr/bqad197
  
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dx.doi.org/10.1210/endocr/bqad197
Feb 2024
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Characterization of Metabolic Alterations in the Lean Metabolically Unhealthy Alpha Defensin Transgenic mice.

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1. scibot 08 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.108802
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10839648/
Jan 2024
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SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells

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1. scibot 18 Jan 2024
  
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  DOI: 10.1016/j.isci.2023.108725
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10788290/
Dec 2023
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Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes

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  DOI: 10.1016/j.cmet.2023.11.011
  
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sciencedirect.com/science/article/pii/S1550413123004436
Apr 2023
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Steroidogenic factor 1 protects mice from obesity-induced glucose intolerance via improving glucose-stimulated insulin secretion by beta cells

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  DOI: 10.1016/j.isci.2023.106451
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10068556/
Mar 2023
europepmc.org europepmc.org

β-Cell glucokinase expression was increased in type 2 diabetes subjects with better glycemic control

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1. scibot 29 Mar 2023
  
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  DOI: 10.1111/1753-0407.13380
  
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europepmc.org/article/med/36942376
Dec 2022
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A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes

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  DOI: 10.1016/j.ebiom.2022.104379
  
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sciencedirect.com/science/article/pii/S2352396422005618
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Glycemic control releases regenerative potential of pancreatic beta cells blocked by severe hyperglycemia

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  DOI: 10.1016/j.celrep.2022.111719
  
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sciencedirect.com/science/article/pii/S2211124722015972
Nov 2022
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Liver autophagy-induced valine and leucine in plasma reflect the metabolic effect of sodium glucose co-transporter 2 inhibitor dapagliflozin

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  DOI: 10.1016/j.ebiom.2022.104342
  
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sciencedirect.com/science/article/pii/S2352396422005242
academic.oup.com academic.oup.com

Ageing Impairs Adaptive Unfolded Protein Response and Drives Beta Cell Dedifferentiation in Human

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  DOI: 10.1210/clinem/dgac535
  
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academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac535/6705055
Oct 2022
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GPCR-Mediated Regulation of Fuel and Energy Metabolism in Peripheral Tissues: Glucagon receptor signaling at white adipose tissue does not regulate lipolysis

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1. scibot 27 Oct 2022
  
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  DOI: 10.1152/ajpendo.00078.2022
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9576180/
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Exocrine and Endocrine Inflammation Increases Cellular Replication in the Pancreatic Duct Compartment in Type 1 Diabetes

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1. scibot 26 Oct 2022
  
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  DOI: 10.1210/jendso/bvac136
  
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academic.oup.com/jes/article/6/11/bvac136/6691224
Aug 2022
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Differentiation of beta-like cells from human induced pluripotent stem cell-derived pancreatic progenitor organoids

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1. scibot 31 Aug 2022
  
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  DOI: 10.1016/j.xpro.2022.101656
  
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sciencedirect.com/science/article/pii/S2666166722005366
Jul 2022
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Small RNAs derived from tRNA fragmentation regulate the functional maturation of neonatal β cells

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1. scibot 13 Jul 2022
  
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  DOI: 10.1016/j.celrep.2022.111069
  
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sciencedirect.com/science/article/pii/S2211124722008671
Apr 2022
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Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation

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1. scibot 21 Apr 2022
  
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  DOI: 10.1016/j.devcel.2017.04.004
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5425251/
Mar 2022
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An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function

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  DOI: 10.1016/j.celrep.2022.110425
  
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sciencedirect.com/science/article/pii/S2211124722001498
Dec 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Integrated analysis of the pancreas and islets reveals unexpected findings in human male with type 1 diabetes

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1. scibot 04 Dec 2021
  
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  DOI: 10.1210/jendso/bvab162
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8633619/
Oct 2021
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Preproglucagon Products and Their Respective Roles Regulating Insulin Secretion

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1. scibot 01 Oct 2021
  
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  DOI: 10.1210/endocr/bqab150
  
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academic.oup.com/endo/article/162/10/bqab150/6329397
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 08 Aug 2021
  
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  DOI: 10.7554/eLife.39689
  
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  DOI: 10.7554/eLife.39689
  
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elifesciences.org/articles/39689
Jul 2021
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Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrPC, in type 1 diabetes

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  DOI: 10.1007/s00125-021-05501-8
  
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link.springer.com/article/10.1007/s00125-021-05501-8
Jun 2021
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SARS-CoV-2 infects human pancreatic β-cells and elicits β-cell impairment

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  DOI: 10.1016/j.cmet.2021.05.013
  
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May 2021
academic.oup.com academic.oup.com

Proper mTORC1 activity is required for glucose sensing and early adaptation in human pancreatic beta cell

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1. scibot 10 May 2021
  
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  DOI: 10.1210/clinem/dgaa786
  
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academic.oup.com/jcem/article/106/2/e562/5943203
Mar 2021
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Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis

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  DOI: 10.1016/j.celrep.2021.108830
  
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Feb 2021
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Using a reporter mouse to map known and novel sites of GLP-1 receptor expression in peripheral tissues of male mice

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  DOI: 10.1210/endocr/bqaa246
  
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academic.oup.com/endo/article/162/3/bqaa246/6054985
Jan 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21

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Dec 2020
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Autosomal Dominant Diabetes Associated with a Novel ZYG11A Mutation Resulting in Cell Cycle Arrest in Beta-Cells

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  anti-glucagon
  
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Nov 2020
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SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells

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ncbi.nlm.nih.gov/pmc/articles/PMC7664344/
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Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19

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ncbi.nlm.nih.gov/pmc/articles/PMC7664515/
Sep 2020
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Dapagliflozin does not directly affect human α or β cells

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  DOI: 10.1210/endocr/bqaa080
  
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academic.oup.com/endo/article/161/8/bqaa080/5840747
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Tetraspanin‐7 regulation of L‐type voltage‐dependent calcium channels controls pancreatic β‐cell insulin secretion

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1. scibot 11 Sep 2020
  
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  mouse anti‐glucagon
  
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Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion

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Microsoft Word - DB190554SupplementaryData.doc

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  DOI: 10.2337/db19-0554
  
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diabetes.diabetesjournals.org/content/diabetes/suppl/2019/10/09/db19-0554.DC1/DB190554SupplementaryData.pdf
Jan 2020
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Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention

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Decreased beta cell proliferation and vascular density in a subpopulation of low-oxygenated male rat islets

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  DOI: 10.1210/js.2019-00101
  
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academic.oup.com/jes/article/3/8/1608/5516552
Nov 2018
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Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development

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Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes

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Nov 2017
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Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata

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Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation

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1. scibot 08 Nov 2017
  
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Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation

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1. scibot 08 Nov 2017
  
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A Single-Cell Transcriptome Atlas of the Human Pancreas

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