413 Matching Annotations
  1. Dec 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Reduced lung metastasis in endothelial cell-specific transforming growth factor β type II receptor-deficient mice with decreased CD44 expression
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  3. 52.53.155.43 52.53.155.43
    can-24-2608-html.html
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    Microbiome and metabolomics reveal the effect of gut microbiota on liver regeneration of fatty liver disease
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    1. scibot 10 Dec 2024
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      DOI: 10.1016/j.ebiom.2024.105482

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    sciencedirect.com/science/article/pii/S2352396424005188
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    Microbiota-derived short-chain fatty acids determine stem cell characteristics of gastric chief cells
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    sciencedirect.com/science/article/pii/S1534580724006725
  6. www.science.org www.science.org
    Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer
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    1. scibot 03 Dec 2024
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      DOI: 10.1126/scisignal.adp1375

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    science.org/doi/10.1126/scisignal.adp1375
  7. Nov 2024
  8. www.sciencedirect.com www.sciencedirect.com
    Pericancerous cross-presentation to cytotoxic T lymphocytes impairs immunotherapeutic efficacy in hepatocellular carcinoma
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    1. scibot 21 Nov 2024
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      DOI: 10.1016/j.ccell.2024.10.012

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    sciencedirect.com/science/article/pii/S1535610824004008
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chelating drug-induced labile Zn2+ with nanoparticle-encapsulated TPEN at low dose enhances lung cancer chemotherapy through inhibiting ABCB1
    1
    1. scibot 10 Nov 2024
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      DOI: 10.1016/j.isci.2024.111072

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    pmc.ncbi.nlm.nih.gov/articles/PMC11539588/
  10. Oct 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ProDiVis: a method to normalize fluorescence signal localization in 3D specimens
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    1. scibot 09 Oct 2024
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      DOI: 10.3389/fcell.2024.1420161

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    ncbi.nlm.nih.gov/pmc/articles/PMC11456528/
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Quiescence and aging of melanocyte stem cells and a novel association with PD-L1
    2
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      DOI: 10.1016/j.isci.2024.110908

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      DOI: 10.1016/j.isci.2024.110908

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    ncbi.nlm.nih.gov/pmc/articles/PMC11440800/
  13. www.sciencedirect.com www.sciencedirect.com
    Midkine as a driver of age-related changes and increase in mammary tumorigenesis
    1
    1. scibot 04 Oct 2024
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  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Postnatal development of rat retina: a continuous observation and comparison between the organotypic retinal explant model and in vivo development
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    1. scibot 02 Oct 2024
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      DOI: 10.4103/NRR.NRR-D-23-01557

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    ncbi.nlm.nih.gov/pmc/articles/PMC11433907/
  15. Sep 2024
  16. www.sciencedirect.com www.sciencedirect.com
    A living organoid biobank of patients with Crohn’s disease reveals molecular subtypes for personalized therapeutics
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    1. scibot 27 Sep 2024
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      DOI: 10.1016/j.xcrm.2024.101748

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    sciencedirect.com/science/article/pii/S2666379124004786
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    Regenerative potential of mouse neonatal intervertebral disc depends on collagen crosslink density
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    sciencedirect.com/science/article/pii/S2589004224021084
  18. www.sciencedirect.com www.sciencedirect.com
    Augmenting the therapeutic efficacy of adenosine against pancreatic cancer by switching the Akt/p21-dependent senescence to apoptosis
    1
    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.ebiom.2019.08.068

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    sciencedirect.com/science/article/pii/S2352396419305900
  19. www.sciencedirect.com www.sciencedirect.com
    Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer
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    1. scibot 17 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724011021
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    Synergistic Anti-tumorigenic Effect of Diosmetin in Combination with 5-Fluorouracil on Human Colon Cancer Xenografts in Nude Mice
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    sciencedirect.com/science/article/pii/S0006291X24012130
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    Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma
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      DOI: 10.1016/j.ccell.2024.08.009

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  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting AKR1B10 by drug repurposing with epalrestat overcomes chemoresistance in non-small cell lung cancer patient-derived tumor organoids
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    1. scibot 05 Sep 2024
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      DOI: 10.1158/1078-0432.CCR-23-3980

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    ncbi.nlm.nih.gov/pmc/articles/PMC11369614/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Melatonin mitigates chemotherapy-induced small intestinal atrophy in rats and reduces cytotoxicity in murine intestinal organoids
    1
    1. scibot 05 Sep 2024
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      DOI: 10.1371/journal.pone.0307414

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    ncbi.nlm.nih.gov/pmc/articles/PMC11371236/
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    Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma
    1
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      DOI: 10.1016/j.xcrm.2024.101706

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    sciencedirect.com/science/article/pii/S2666379124004270
  25. Aug 2024
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mast Cell Infiltration and Subtype Promote Malignant Transformation of Oral Precancer and Progression of Oral Cancer
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11339667/
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    Neuroepithelial bodies and terminal bronchioles are niches for distinctive club cells that repair the airways following acute notch inhibition
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      DOI: 10.1016/j.celrep.2024.114654

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    sciencedirect.com/science/article/pii/S2211124724010052
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8+ T cell exhaustion and anti-PD-1 resistance
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    ncbi.nlm.nih.gov/pmc/articles/PMC11384939/
  29. www.sciencedirect.com www.sciencedirect.com
    FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia
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      DOI: 10.1016/j.devcel.2024.07.021

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    sciencedirect.com/science/article/pii/S1534580724004830
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    A single-cell transcriptomic census of mammalian olfactory epithelium aging
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  31. www.sciencedirect.com www.sciencedirect.com
    A liquid-like coat mediates chromosome clustering during mitotic exit
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      DOI: 10.1016/j.molcel.2024.07.022

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    Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD
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    sciencedirect.com/science/article/pii/S1535610824002721
  33. www.sciencedirect.com www.sciencedirect.com
    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
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    sciencedirect.com/science/article/pii/S1535610824002708
  34. www.cell.com www.cell.com
    Activated dormant stem cells recover spermatogenesis in chemoradiotherapy-induced infertility
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      DOI: 10.1016/j.celrep.2024.114582

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    cell.com/cell-reports/fulltext/S2211-1247(24)00911-2
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma
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      DOI: 10.1186/s12885-024-12691-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC11292958/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chromatin architectural factor CTCF is essential for progesterone dependent uterine maturation
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      DOI: 10.1096/fj.202300862R

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    ncbi.nlm.nih.gov/pmc/articles/PMC10372848/
  37. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Evidence that the central canal lining of the spinal cord contributes to oligodendrogenesis during postnatal development and adulthood in intact rats
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      DOI: 10.1002/cne.23590

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    onlinelibrary.wiley.com/doi/10.1002/cne.23590/full
  38. link.springer.com link.springer.com
    Table 1 | Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells | SpringerLink
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      DOI: 10.1007/s43032-019-00019-2

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    link.springer.com/article/10.1007/s43032-019-00019-2/tables/1
  39. elifesciences.org elifesciences.org
    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling
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      DOI: 10.7554/eLife.17047

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  40. Jul 2024
  41. www.sciencedirect.com www.sciencedirect.com
    Protocol to evaluate rat and mouse cardiomyocyte proliferation in vitro and in vivo
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      DOI: 10.1016/j.xpro.2024.103204

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    sciencedirect.com/science/article/pii/S2666166724003691
  42. www.sciencedirect.com www.sciencedirect.com
    An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cells
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      DOI: 10.1016/j.celrep.2024.114247

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    sciencedirect.com/science/article/pii/S2211124724005758
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
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      DOI: 10.7554/eLife.91766

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    ncbi.nlm.nih.gov/pmc/articles/PMC11257678/
  44. www.sciencedirect.com www.sciencedirect.com
    A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model
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    sciencedirect.com/science/article/pii/S2589004224016511
  45. rupress.org rupress.org
    Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling
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      DOI: 10.1084/jem.20231512

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    rupress.org/jem/article/221/8/e20231512/276787/Coxsackievirus-A10-impairs-nail-regeneration-and
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MicroRNA-7 regulates endocrine progenitor delamination and endocrine cell mass in developing pancreatic islets
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    miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow–derived neural crest cells
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    Construction of multilayered small intestine-like tissue by reproducing interstitial flow
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  50. www.cell.com www.cell.com
    Enhanced and Sustained T Cell Activation in Response to Fluid Shear Stress
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    Secretion of WNT7A by UC-MSCs assist in promoting the endometrial epithelial regeneration
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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defining cis-regulatory elements and transcription factors that control human cortical interneuron development
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  53. May 2024
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuraminidase inhibition promotes the collective migration of neurons and recovery of brain function | EMBO Molecular Medicine
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    FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation
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    Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation
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    CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma
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    An Orally Efficacious Thyrotropin Receptor Ligand Inhibits Growth and Metastatic Activity of Thyroid Cancers
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  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma
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  62. Apr 2024
  63. www.sciencedirect.com www.sciencedirect.com
    BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice
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    Mice Mutated in the First Fibronectin Domain of Adhesion Molecule L1 Show Brain Malformations and Behavioral Abnormalities
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    Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases
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    DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice
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    The antiprotozoal drug nitazoxanide improves experimental liver fibrosis in mice
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    Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/β-catenin signaling
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    The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells
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    Defects of renal tubular homeostasis and cystogenesis in the Pkhd1-knockout
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    Protocol to encapsulate cerebral organoids with alginate hydrogel shell to induce volumetric compression
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  73. Mar 2024
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Machine learning unveils immune-related signature in multicenter glioma studies
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TLR2 regulates hair follicle cycle and regeneration via BMP signaling
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    One-step rapid tracking and isolation of senescent cells in cellular systems, tissues, or animal models via GLF16
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    PRMT1 promotes pancreatic cancer development and resistance to chemotherapy
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    SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions
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    Disruption of H3K36 methylation provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis
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  80. Feb 2024
  81. www.cell.com www.cell.com
    Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma
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    Sphingolipid metabolism controls mammalian heart regeneration
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A small-molecule degrader selectively inhibits the growth of ALK-rearranged lung cancer with ceritinib resistance
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    AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments
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    An alternative splicing signature defines the basal-like phenotype and predicts worse clinical outcome in pancreatic cancer
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    Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality in mice
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    A Promising New Model: Establishment of Patient-Derived Organoid Models Covering HPV-Related Cervical Pre-Cancerous Lesions and Their Cancers
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    Histone lactylation inhibits RARγ expression in macrophages to promote colorectal tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling
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    Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis
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    Differential contribution of TrkB and p75NTR to BDNF-dependent self-renewal, proliferation, and differentiation of adult neural stem cells
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    Evaluation of pro-regenerative and anti-inflammatory effects of isolecanoric acid in the muscle: Potential treatment of Duchenne Muscular Dystrophy
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    The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling
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    Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
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    Econazole selectively induces cell death in NF1-homozygous mutant tumor cells
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  103. Nov 2023
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    Preclinical Long-Term Safety of Intraspinal Transplantation of Human Dorsal Spinal GABA Neural Progenitor Cells
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    Microbial-dependent recruitment of immature myeloid cells promotes intestinal regeneration.
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    Incorporation of human iPSC-derived stromal cells creates a pancreatic cancer organoid with heterogeneous cancer-associated fibroblasts
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    TGFB1 induces fetal reprogramming and enhances intestinal regeneration
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    Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring
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    SIRT1 is an actionable target to restore p53 function in HPV-associated cancer therapy
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    Volumetric compression by heterogeneous scaffold embedding promotes cerebral organoid maturation and does not impede growth
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    A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells
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    Doxorubicin-induced senescence promotes resistance to cell death by modulating genes associated with apoptotic and necrotic pathways in prostate cancer DU145 CD133+/CD44+ cells
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    TET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression
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  119. Sep 2023
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    Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition
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    LSR targets YAP to modulate intestinal Paneth cell differentiation
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    The MORC2 p.S87L mutation reduces proliferation of pluripotent stem cells derived from a patient with the spinal muscular atrophy-like phenotype by inhibiting proliferation-related signaling pathways
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    Integrating single-cell imaging and RNA sequencing datasets links differentiation and morphogenetic dynamics of human pancreatic endocrine progenitors
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    Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+
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  131. Jul 2023
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    Generation of mouse hippocampal brain organoids from primary embryonic neural stem cells
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    MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice
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    Derivation of CD8+ T-cell Infiltration Potentiators in Non-Small Cell Lung Cancer Through Tumor Microenvironment Analysis
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    Novel Frizzled-specific antibody-based Wnt mimetics and Wnt superagonists selectively activate WNT/β-catenin signaling in target tissues
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    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
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    Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss
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    Mammary Tumor Growth and Proliferation Are Dependent on Growth Hormone in Female SV40 C3(1) T-Antigen Mice
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    Preclinical Evaluation of ON203, A Novel Bioengineered mAb Targeting Oxidized Macrophage Migration Inhibitory Factor as an Anticancer Therapeutic
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    KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
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    Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation
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    Diet suppresses glioblastoma initiation in mice by maintaining quiescence of mutation-bearing neural stem cells
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    Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy
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    PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1
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    Table 1 Primary antibody list.
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    A Pilot Study on the Co-existence of Diabetes and Endometriosis in Reproductive-Age Women: Potential for Endometriosis Progression
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    Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain
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    Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner
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    The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer
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  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Genome-wide screen identifies PDPK1 as a target to enhance the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma
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    Failure of digit tip regeneration in the absence of Lmx1b suggests Lmx1b functions disparate from dorsoventral polarity
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    Human cortical interneurons optimized for grafting specifically integrate, abort seizures, and display prolonged efficacy without over-inhibition
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    Immunoediting instructs tumor metabolic reprogramming to support immune evasion
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    Embryogenic stem cell-derived intestinal crypt fission directs de novo crypt genesis
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    The mitochondrial UPR regulator ATF5 promotes intestinal barrier function via control of the satiety response
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    Staphylococcus aureus extracellular adherence protein (Eap) reduces immune cell phenotype in developing but not in established atherosclerotic lesions
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    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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    Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer
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    Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex
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    Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in mice
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    FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer
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    The combined impact of testosterone and Western-style diet on endometriosis severity and progression in rhesus macaques
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  196. Oct 2022
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    Follicle stimulating hormone glycosylation variants distinctly modulate pre-antral follicle growth and survival
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    GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
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    Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation
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  200. Sep 2022
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    Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells
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    Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
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    Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer
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    A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice
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  205. Aug 2022
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    RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs
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    In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system
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    Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression
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    Alterations of serine racemase expression determine proliferation and differentiation of neuroblastoma cells
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    Multiregional single-cell proteogenomic analysis of ccRCC reveals cytokine drivers of intratumor spatial heterogeneity
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  211. Jul 2022
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    Gender-based effect of absence of gut microbiota on the protective efficacy of Bifidobacterium longum-fermented rice bran diet against inflammation-associated colon tumorigenesis
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    Protocol to photoactivate adipose-derived stem cell differentiation using a tightly-focused femtosecond laser
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    Potassium channel Kir4.1 regulates oligodendrocyte differentiation via intracellular pH regulation
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  215. Jun 2022
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    GCN5 participates in KLF4-VEGFA feedback to promote endometrial angiogenesis
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    Embigin is a fibronectin receptor that affects sebaceous gland differentiation and metabolism
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    Diploid hepatocytes drive physiological liver renewal in adult humans
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