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  1. Last 7 days
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    Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A
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    1. scibot 21 Dec 2024
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      DOI: 10.1016/j.molcel.2024.11.034

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    sciencedirect.com/science/article/pii/S1097276524009894
  3. Dec 2024
  4. academic.oup.com academic.oup.com
    CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation
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    1. scibot 13 Dec 2024
      AB_2175

      DOI: 10.1093/nar/gkae1068

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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1068/7903364
  5. Sep 2024
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    TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival
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      DOI: 10.1016/j.cell.2024.08.020

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    cell.com/cell/fulltext/S0092-8674(24)00911-5
  7. Aug 2024
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    Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication
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    sciencedirect.com/science/article/pii/S1097276521000046
  9. Jul 2024
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of the main barriers to Ku accumulation in chromatin
    1
    1. scibot 30 Jul 2024
      AB_302873

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    ncbi.nlm.nih.gov/pmc/articles/PMC11411529/
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    FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
    1
    1. scibot 17 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114464

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    sciencedirect.com/science/article/pii/S2211124724007939
  12. May 2024
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    Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors
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    1. scibot 16 May 2024
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      DOI: 10.1016/j.celrep.2024.114205

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    sciencedirect.com/science/article/pii/S2211124724005333
  14. Apr 2024
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    RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells
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      DOI: 10.1016/j.celrep.2024.114116

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      DOI: 10.1016/j.celrep.2024.114116

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    sciencedirect.com/science/article/pii/S2211124724004443
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    Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates
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      DOI: 10.1016/j.celrep.2024.114064

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    sciencedirect.com/science/article/pii/S2211124724003929
  17. Feb 2024
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    A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis
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    sciencedirect.com/science/article/pii/S1097276524000984
  19. 52.53.155.43 52.53.155.43
    53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication
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    1. scibot 22 Feb 2024
      RRID:AB_302873

      DOI: 10.1101/2023.09.27.559698

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    52.53.155.43/9b07aa3872d935df1f2ff4d73fc96f76996bcf22/2023.09.27.559698v1.full-html.html
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    SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
    1
    1. scibot 13 Feb 2024
      AB_302873

      DOI: 10.1016/j.celrep.2024.113778

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  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma
    1
    1. scibot 08 Feb 2024
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      DOI: 10.1016/j.isci.2024.108925

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    ncbi.nlm.nih.gov/pmc/articles/PMC10844834/
  22. Jan 2024
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    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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      DOI: 10.1016/j.molcel.2023.12.039

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    sciencedirect.com/science/article/pii/S1097276523010857
  24. Dec 2023
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    53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication
    1
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      RRID:AB_302873

      DOI: 10.1016/j.celrep.2023.113412

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    sciencedirect.com/science/article/pii/S2211124723014249
  26. Oct 2023
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    Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability
    1
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      DOI: 10.1016/j.cell.2023.09.008

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    sciencedirect.com/science/article/abs/pii/S0092867423010309
  28. Sep 2023
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    The interplay of TARG1 and PARG protects against genomic instability
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      DOI: 10.1016/j.celrep.2023.113113

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    sciencedirect.com/science/article/pii/S2211124723011245
  30. Aug 2023
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress
    2
    1. scibot 26 Aug 2023
      AB_302873

      DOI: 10.1158/2767-9764.CRC-23-0268

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      AB_302873

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    ncbi.nlm.nih.gov/pmc/articles/PMC10434289/
  32. 52.53.155.43 52.53.155.43
    crc-23-0268-html.html
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      AB_302873

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  33. Jul 2023
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    Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
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      DOI: 10.1016/j.molcel.2023.06.025

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    sciencedirect.com/science/article/pii/S1097276523004720
  35. Jun 2023
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    Detection of endogenous translesion DNA synthesis in single mammalian cells
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      DOI: 10.1016/j.crmeth.2023.100501

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    sciencedirect.com/science/article/pii/S2667237523001303
  37. Apr 2023
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    ERCC6L2 mitigates replication stress and promotes centromere stability
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    sciencedirect.com/science/article/pii/S2211124723003406
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    TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX deficient cells
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      DOI: 10.1016/j.isci.2023.106405

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    ncbi.nlm.nih.gov/pmc/articles/PMC10066556/
  40. Mar 2023
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX deficient cells
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      DOI: 10.1016/j.isci.2023.106405

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    ncbi.nlm.nih.gov/pmc/articles/PMC10066556/
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    Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination
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      DOI: 10.1016/j.celrep.2023.112296

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    sciencedirect.com/science/article/pii/S2211124723003078
  43. Feb 2023
  44. www.sciencedirect.com www.sciencedirect.com
    RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1
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      DOI: 10.1016/j.celrep.2023.112032

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    sciencedirect.com/science/article/pii/S2211124723000438
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    GEN1 promotes common fragile site expression
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    sciencedirect.com/science/article/pii/S2211124723000736
  46. Dec 2022
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    The ADP-ribose hydrolase NUDT5 is important for DNA repair
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    sciencedirect.com/science/article/pii/S2211124722017624
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    Quantification of protein enrichment at site-specific DNA double-strand breaks by chromatin immunoprecipitation in cultured human cells
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      DOI: 10.1016/j.xpro.2022.101917

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    sciencedirect.com/science/article/pii/S2666166722007973
  49. Nov 2022
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    POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells
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    sciencedirect.com/science/article/pii/S2211124722015947
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    Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2
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    sciencedirect.com/science/article/pii/S2211124722015443
  52. Aug 2022
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    A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
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      DOI: 10.1016/j.ccell.2022.07.012

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    sciencedirect.com/science/article/pii/S1535610822003257
  54. Jul 2022
  55. www.sciencedirect.com www.sciencedirect.com
    Guiding ATR and PARP inhibitor combinationswith chemogenomic screens
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      DOI: 10.1016/j.celrep.2022.111081

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    sciencedirect.com/science/article/pii/S2211124722008798
  56. May 2022
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    A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination
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      DOI: 10.1016/j.molcel.2022.04.031

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    sciencedirect.com/science/article/pii/S109727652200394X
  58. Apr 2022
  59. www.sciencedirect.com www.sciencedirect.com
    CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair
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      DOI: 10.1016/j.molcel.2022.03.031

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    sciencedirect.com/science/article/pii/S1097276522002696
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress
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      DOI: 10.1038/s41598-022-09308-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC8971416/
  61. Mar 2022
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    BMI-1 regulates DNA end resection and homologous recombination repair
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      DOI: 10.1016/j.celrep.2022.110536

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    sciencedirect.com/science/article/pii/S2211124722002777
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    Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation
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  64. Oct 2021
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    Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe
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  69. Jul 2021
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    The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures
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  71. pubs.acs.org pubs.acs.org
    Differential Sensitivity to CDK2 Inhibition Discriminates the Molecular Mechanisms of CHK1 Inhibitors as Monotherapy or in Combination with the Topoisomerase I Inhibitor SN38
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  73. www.cell.com www.cell.com
    Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
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  74. Jun 2021
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  76. May 2021
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    Homology-directed repair protects the replicating genome from metabolic assaults
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  78. Mar 2021
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    ER-directed TREX1 limits cGAS activation at micronuclei
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  80. Feb 2021
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    Differential Sensitivity to CDK2 Inhibition Discriminates the Molecular Mechanisms of CHK1 Inhibitors as Monotherapy or in Combination with the Topoisomerase I Inhibitor SN38
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  82. Jan 2021
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    DCAF14 promotes stalled fork stability to maintain genome integrity
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  84. Dec 2020
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    RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions
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  86. Oct 2020
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    MutSβ Stimulates Holliday Junction Resolution by the SMX Complex
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  88. Sep 2020
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    Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome
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  91. Jan 2020
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    RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres
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    RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer
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    SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance
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    Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity
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    PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells
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    Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling
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  101. Nov 2018
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    CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress
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    Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair
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    POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication
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    BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency
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    Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors
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    Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling
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  109. Nov 2017
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    RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks
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    RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination
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    RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health
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