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Targeting Cancer-Associated PCNA with AOH1996 Induces Mitotic Catastrophe and Enhances Cisplatin Therapy in Cervical Cancer

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  DOI: 10.1158/2767-9764.CRC-25-0648
  
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aacrjournals.org/cancerrescommun/article/6/5/1220/785408/Targeting-Cancer-Associated-PCNA-with-AOH1996
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Centrosome linker protein CEP68 modulates cellular stress responses via nuclear condensate formation and HSP27 interaction

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  DOI: 10.1016/j.isci.2026.116491
  
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sciencedirect.com/science/article/pii/S2589004226018663
Jun 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The γ-Tubulin Ring Complex promotes mitotic spindle integrity and acts as a microtubule minus-end cap during mitosis

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  DOI: 10.64898/2026.04.10.717779
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13082017/
May 2026
www.biorxiv.org www.biorxiv.org

Heterotrimeric kinesin-2 autoinhibition mediated by interactions of the CC2 and proximal tail domains with the motor domains is essential for cilium formation and maintenance

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1. scibot 28 May 2026
  
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  DOI: 10.64898/2026.05.19.726381
  
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biorxiv.org/content/10.64898/2026.05.19.726381v1
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Camsap3-mediated microtubules maintain transzonal projections essential for soma–germ communication during ovarian follicle maturation in mice

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1. scibot 27 May 2026
  
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  DOI: 10.1016/j.isci.2026.115911
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13200047/
Apr 2026
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1-s2.0-S2589004226012861-main-html.html

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1. scibot 30 Apr 2026
  
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54.241.53.176/1c1037772988bb50f984ccc378e26d269970bf0e/1-s2.0-S2589004226012861-main-html.html
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Epigenetic regulation of chromosomal instability by EZH2 methyltransferase.

1
1. scibot 23 Apr 2026
  
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  DOI: 10.1158/2159-8290.CD-25-0947
  
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aacrjournals.org/cancerdiscovery/article/16/1/135/771226/Epigenetic-Regulation-of-Chromosomal-Instability
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DHX9 inhibition enhances paclitaxel sensitivity by inducing mitotic failure in ovarian and endometrial cancers

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1. scibot 23 Apr 2026
  
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  DOI: 10.1158/1535-7163.MCT-25-1196
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13098759/
Mar 2026
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Mouse germline cysts contain a fusome-like structure that mediates oocyte development

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1. scibot 18 Mar 2026
  
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  DOI: 10.7554/eLife.109358
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12978699/
Nov 2025
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1-s2.0-S2589004225024654-main-html.html

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.isci.2025.114204
  
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sciencedirect.com/science/article/pii/S2589004225024654
Oct 2025
www.biorxiv.org www.biorxiv.org

Dishevelled drives Wnt-stimulated disassembly of primary cilia through a unique PDZ-mediated binding mode with Daple and Girdin

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1. scibot 07 Oct 2025
  
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  DOI: 10.1101/2025.09.26.678488
  
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biorxiv.org/content/10.1101/2025.09.26.678488v1
Sep 2025
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The kinesin motor Kif9 regulates centriolar satellite positioning during interphase

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1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.cub.2025.08.064
  
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sciencedirect.com/science/article/pii/S0960982225011303
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Nuclear-cytoplasmic translocation of MCIDAS couples transcription with massive de novo centriole biogenesis in multiciliated cells

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1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116321
  
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  DOI: 10.1016/j.celrep.2025.116321
  
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sciencedirect.com/science/article/pii/S2211124725010927
52.53.155.43 52.53.155.43

rajeevan-et-al-2025-aurora-a-regulates-the-material-property-of-spindle-poles-to-orchestrate-nuclear-organization-at-html.html

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1. scibot 16 Sep 2025
  
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  DOI: 10.1038/s44318-025-00564-4
  
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52.53.155.43/3d79dc73d22a782c26af2bd1e412c87bbe5039ed/rajeevan-et-al-2025-aurora-a-regulates-the-material-property-of-spindle-poles-to-orchestrate-nuclear-organization-at-html.html
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Redistribution of fragmented mitochondria ensures symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes

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1. scibot 13 Aug 2025
  
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  DOI: 10.7554/eLife.99936
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12339001/
Jul 2025
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Protocol for immunostaining of non-adherent cells and cellular structures using centrifugal filter devices

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.xpro.2025.103934
  
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sciencedirect.com/science/article/pii/S2666166725003405
Jun 2025
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Screening a living biobank identifies cabazitaxel as a strategy to combat acquired taxol resistance in high-grade serous ovarian cancer

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1. scibot 04 Jun 2025
  
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  DOI: 10.1016/j.xcrm.2025.102160
  
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sciencedirect.com/science/article/pii/S2666379125002332
May 2025
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Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity

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1. scibot 31 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115766
  
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sciencedirect.com/science/article/pii/S2211124725005376
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A conserved role for centriolar satellites in translation of centrosomal and ciliary proteins

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1. scibot 23 May 2025
  
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  DOI: 10.1083/jcb.202408042
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12094185/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Forebrain Eml1 depletion reveals early centrosomal dysfunction causing subcortical heterotopia

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1. scibot 28 Mar 2025
  
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  DOI: 10.1083/jcb.202310157
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11450323/
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Targeting WEE1 kinase as a therapeutic strategy in ATIP3-deficient breast cancers

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  DOI: 10.1016/j.canlet.2025.217665
  
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sciencedirect.com/science/article/pii/S0304383525002319
Feb 2025
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OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival

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1. scibot 27 Feb 2025
  
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  DOI: 10.1038/s44319-024-00361-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11850729/
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CENP-E inhibition induces chromosomal instability and synergizes with diverse microtubule-targeting agents in breast cancer

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-23-3332
  
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aacrjournals.org/cancerres/article/84/16/2674/746877/CENP-E-Inhibition-Induces-Chromosomal-Instability
Jan 2025
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Targeted localization of the mother centrosome in CD8+ T cells undergoing asymmetric cell division promotes memory formation

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1. scibot 07 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115127
  
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sciencedirect.com/science/article/pii/S2211124724014785
Nov 2024
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CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2

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1. scibot 21 Nov 2024
  
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  DOI: 10.1038/s44318-024-00240-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11574021/
Sep 2024
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Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair–Deficient Uterine Leiomyosarcoma

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1. scibot 05 Sep 2024
  
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  DOI: 10.1158/1078-0432.CCR-23-3720
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11369621/
Jul 2024
www.cell.com www.cell.com

A mammalian model reveals inorganic polyphosphate channeling into the nucleolus and induction of a hyper-condensate state

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1. scibot 11 Jul 2024
  
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  DOI: 10.1016/j.crmeth.2024.100814
  
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cell.com/cell-reports-methods/fulltext/S2667-2375(24)00179-6
Jun 2024
onlinelibrary.wiley.com onlinelibrary.wiley.com

A comparative analysis of paxillin and Hic-5 proximity interactomes

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1. scibot 06 Jun 2024
  
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  DOI: 10.1002/cm.21878
  
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onlinelibrary.wiley.com/doi/10.1002/cm.21878
May 2024
52.53.155.43 52.53.155.43

Centriolar satellites are sites of translation of centrosomal and ciliary proteins

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  DOI: 10.1101/2024.02.22.581531
  
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52.53.155.43/b4facf67b457be9515b769549e8e513b0c45add0/2024.02.22.581531v1.full-html.html
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response

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1. scibot 20 Apr 2024
  
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  DOI: 10.1016/j.ebiom.2024.105129
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11052917/
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The Golgi checkpoint: Golgi unlinking during G2 is necessary for spindle formation and cytokinesis

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1. scibot 19 Mar 2024
  
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  DOI: 10.26508/lsa.202302469
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10941482/
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AurkA/TPX2 co-overexpression in nontransformed cells promotes genome instability through induction of chromosome mis-segregation and attenuation of the p53 signalling pathway

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1. scibot 08 Mar 2024
  
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  DOI: 10.1016/j.bbadis.2024.167116
  
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sciencedirect.com/science/article/pii/S0925443924001054
Feb 2024
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Kin17 regulates proper cortical localization of Miranda in Drosophila neuroblasts by regulating Flfl expression

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1. scibot 23 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113823
  
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sciencedirect.com/science/article/pii/S2211124724001517
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3D matrix adhesion feedback controls nuclear force coupling to drive invasive cell migration

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1. scibot 08 Feb 2024
  
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  DOI: 10.1016/j.celrep.2023.113554
  
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Nanoscale organization of the endogenous ASC speck

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Asymmetric inheritance of centrosomes maintains stem cell properties in human neural progenitor cells

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Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage

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Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method

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Centrosome amplification fine tunes tubulin acetylation to differentially control intracellular organization

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Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation

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MYO10 regulates genome stability and cancer inflammation through mediating mitosis

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Protein quality control machinery supports primary ciliogenesis by eliminating GDP-bound Rab8-family GTPases

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A tri-specific killer engager against mesothelin targets NK cells towards lung cancer

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Feb 2023
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Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates

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Microglia reactivity entails microtubule remodeling from acentrosomal to centrosomal arrays

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Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain

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Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congression

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Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development

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Protocol to measure centrosome cohesion deficits mediated by pathogenic LRRK2 in cultured cells using confocal microscopy

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Expansion microscopy of the chick embryo neural tube to overcome molecular crowding at the centrosomes-cilia

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Antiviral function and viral antagonism of the rapidly evolving dynein activating adaptor NINL

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Pericentriolar matrix (PCM) integrity relies on cenexin and polo-like kinase (PLK)1

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A high-throughput electron tomography workflow reveals over-elongated centrioles in relapsed/refractory multiple myeloma

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Self-assembly of pericentriolar material in interphase cells lacking centrioles

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Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement

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Distribution of prototypical primary cilia markers in subtypes of retinal ganglion cells

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Carboxypeptidase E Independently Changes Microtubule Glutamylation, Dendritic Branching, and Neuronal Migration

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Gravin-associated kinase signaling networks coordinate γ-tubulin organization at mitotic spindle poles

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A light-switching pyrene probe to detect phase separated biomolecules

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Differences in Mitotic Spindle Architecture in Mammalian Neural Stem Cells Influence Mitotic Accuracy during Brain Development

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Untitled document

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TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity

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The SUN1-SPDYA interaction plays an essential role in meiosis prophase I

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May 2021
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14–3-3γ prevents centrosome duplication by inhibiting NPM1 function

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Multimerization of Zika Virus-NS5 Causes Ciliopathy and Forces Premature Neurogenesis

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RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis

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Acto-myosin network geometry defines centrosome position

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Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells

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E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes

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  rabbit anti-pericentrin
  
  DOI: 10.1073/pnas.2015794118
  
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The Aurora-A/TPX2 Axis Directs Spindle Orientation in Adherent Human Cells by Regulating NuMA and Microtubule Stability

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1. scibot 10 Dec 2020
  
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  DOI: 10.1016/j.cub.2020.10.096
  
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Nov 2020
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De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment

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1. scibot 20 Nov 2020
  
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  rabbit polyclonal anti-pericentrin
  
  DOI: 10.1016/j.ajhg.2020.10.012
  
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A Genetic Toggle for Chemical Control of Individual Plk1 Substrates

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1. scibot 26 Sep 2020
  
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  DOI: 10.1016/j.chembiol.2020.01.007
  
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A Model of Differential Mammary Growth Initiation by Stat3 and Asymmetric Integrin-α6 Inheritance

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1. scibot 16 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.02.079
  
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Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit

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1. scibot 16 Sep 2020
  
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Centrosome anchoring regulates progenitor properties and cortical formation

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1. scibot 05 Sep 2020
  
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  DOI: 10.1038/s41586-020-2139-6
  
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mcr.aacrjournals.org mcr.aacrjournals.org

Drug targeting the actin cytoskeleton potentiates the cytotoxicity of low dose vincristine by abrogating actin-mediated repair of spindle defects

1
1. scibot 03 Sep 2020
  
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  rabbit anti-pericentrin
  
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mcr.aacrjournals.org/content/18/7/1074
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Differences in Mitotic Spindle Architecture in Mammalian Neural Stem Cells Influence Mitotic Accuracy during Brain Development

1
1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cub.2019.07.061
  
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VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells

1
1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cels.2019.05.009
  
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CCDC74A/B are K-fiber crosslinkers required for chromosomal alignment

1
1. scibot 13 Jan 2020
  
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  RRID:AB_304461
  
  DOI: 10.1186/s12915-019-0694-9
  
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The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype

1
1. scibot 13 Jan 2020
  
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  RRID:AB_304461
  
  DOI: 10.1016/j.chembiol.2018.11.014
  
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Constitutive Cdk2 activity promotes aneuploidy while altering the spindle assembly and tetraploidy checkpoints

1
1. scibot 05 Nov 2018
  
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  antibody directed towards pericentrin
  
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Untitled document

1
1. scibot 05 Nov 2018
  
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Trisomy 21 Represses Cilia Formation and Function

1
1. scibot 05 Nov 2018
  
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Nek9 Phosphorylation Defines a New Role for TPX2 in Eg5-Dependent Centrosome Separation before Nuclear Envelope Breakdown

1
1. scibot 05 Nov 2018
  
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  RRID: AB_304461
  
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elifesciences.org elifesciences.org

Untitled document

1
1. scibot 05 Nov 2018
  
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Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Method for the Acute and Rapid Degradation of Endogenous Proteins

2
1. scibot 05 Nov 2018
  
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  RRID:AB_304461
  
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2. scibot 05 Nov 2018
  
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Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps

1
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Nov 2017
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Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy

1
1. scibot 09 Nov 2017
  
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  AB_304461
  
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Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells

1
1. scibot 08 Nov 2017
  
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PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex

1
1. scibot 08 Nov 2017
  
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  RRID:AB_304461
  
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Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals

1
1. scibot 08 Nov 2017
  
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A Splice Variant of Centrosomin Converts Mitochondria to Microtubule-Organizing Centers

1
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Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated

1
1. scibot 08 Nov 2017
  
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onlinelibrary.wiley.com onlinelibrary.wiley.com

Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria

1
1. scibot 08 Nov 2017
  
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onlinelibrary.wiley.com/doi/10.1002/jcp.25839/full
bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com

The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing

2
1. scibot 08 Nov 2017
  
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2. scibot 08 Nov 2017
  
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bmcbiol.biomedcentral.com/articles/10.1186/s12915-016-0292-z

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